#=GF ID   Rac1
#=GF AC   PF09632.14
#=GF DE   Rac1-binding domain
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   pdb_2h7o
#=GF GA   25.00 25.00;
#=GF TC   557.80 557.80;
#=GF NC   21.70 21.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   16959567
#=GF RT   Yersinia virulence depends on mimicry of host Rho-family
#=GF RT   nucleotide dissociation inhibitors. 
#=GF RA   Prehna G, Ivanov MI, Bliska JB, Stebbins CE; 
#=GF RL   Cell. 2006;126:869-880.
#=GF DR   INTERPRO; IPR019093;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The Rac1-binding domain is the C-terminal portion of YpkA from
#=GF CC   Yersinia. It is an all-helical molecule consisting of two
#=GF CC   distinct subdomains connected by a linker. the N-terminal end,
#=GF CC   residues 434-615, consists of six helices organised into two
#=GF CC   three-helix bundles packed against each other. This region is
#=GF CC   involved with binding to GTPases. The C-terminal end, residues
#=GF CC   705-732. is a novel and elongated fold consisting of four
#=GF CC   helices clustered into two pairs, and this fold carries the
#=GF CC   helix implicated in actin activation. Rac1-binding domain mimics
#=GF CC   host guanidine nucleotide dissociation inhibitors (GDIs) of the
#=GF CC   Rho GTPases, thereby inhibiting nucleotide exchange in Rac1 and
#=GF CC   causing cytoskeletal disruption in the host [1]. It is usually
#=GF CC   found downstream of Pfam:PF00069.
#=GF SQ   2
#=GS U3C1X8_9VIBR/433-729  AC U3C1X8.1
#=GS YPKA_YERPE/440-732    AC Q9RI12.1
U3C1X8_9VIBR/433-729             ESPVKEKALQDAYHNLREHLTASSTNNLRQGYAFNDLVTTLTLLNKAESQGLSSSDKFRSLDNLMTKTNKVMVDYVKRNLANDGTNSGELSIKFQDGIEGKSTQSFLANIERGLEAPSSFADIRSLEREQQLVETMFTVLLSSTEKDKTPIRAEIYSLLNHLAEVKKALSSRVDTLKAEQANAASSVVSLLDSSQEWFTQAKQTLENFDKVTPRVKFGTNESVQAHQQMISAHATMALQEVSQSIGKIKQFAHDARPLLVALGERPLVDHSLTFQRERLREAATVAERLSRLEFEWV
YPKA_YERPE/440-732               ITPKKLRELSDL---LRTHLSSAATKQLDMGGVLSDLDTMLVALDKAEREGGVDKDQLKSFNSLILKTYRVIEDYVKGREGDTKNSSTEVSPYHRSNFMLSIVEPSLQRIQKHLDQTHSFSDIGSLVRAHKHLETLLEVLVTLSQQ-GQPVSSETYGFLNRLTEAKITLSQQLNTLQQQQESAKAQLSILINRSGSWADVARQSLQRFDSTRPVVKFGTEQYTAIHRQMMAAHAAITLQEVSEFTDDMRNFTVDSIPLLIQLGRSSLMDEHLVEQREKLRELTTIAERLNRLEREWM
#=GC seq_cons                    .oPhK.+tLpDh...LRpHLouuuTppLc.GhshsDLsThLshLsKAEppGhsspDph+ShssLhhKT.+Vh.DYVKtp.usstssSsElS.hapssh.hp.sps.LtpIp+tL-tspSFuDItSL.RtpphlEThhpVLlo.opp.tpPlpuEhYuhLN+LsEsKhsLSpplsTLptpQtsAtupls.LlspStpWhs.A+QoLppFDpspPhVKFGTpp.sthHpQMhuAHAshsLQEVSp.hsch+pFshDuhPLLltLGcpsLhDcpLs.QRE+LREhsTlAERLsRLEhEWh
//