#=GF ID   RdRP_5
#=GF AC   PF07925.15
#=GF DE   Reovirus RNA-dependent RNA polymerase lambda 3
#=GF AU   Fenech M;0000-0001-7933-4617
#=GF SE   Pfam-B_9372 (release 14.0)
#=GF GA   19.00 19.00;
#=GF TC   19.10 1322.00;
#=GF NC   18.40 18.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12464184
#=GF RT   RNA synthesis in a cage--structural studies of reovirus
#=GF RT   polymerase lambda3. 
#=GF RA   Tao Y, Farsetta DL, Nibert ML, Harrison SC; 
#=GF RL   Cell 2002;111:733-745.
#=GF DR   INTERPRO; IPR012915;
#=GF DR   SCOP; 1n35; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The sequences in this family are similar to the reoviral minor
#=GF CC   core protein lambda 3 (Swiss:P17378), which functions as a
#=GF CC   RNA-dependent RNA polymerase within the protein capsid.         
#=GF CC          It is organised into 3 domains. N- and C-terminal domains
#=GF CC   create a 'cage' that encloses a conserved central catalytic
#=GF CC   domain within a hollow centre; this catalytic domain is arranged
#=GF CC   to form 'fingers', 'palm' and 'thumb' subdomains.  Unlike other
#=GF CC   RNA polymerases, like HIV reverse transcriptase and T7 RNA
#=GF CC   polymerase, lambda 3 protein binds template and substrate with
#=GF CC   only localised rearrangements, and catalytic activity can occur
#=GF CC   with little structural change. However, the structure of the
#=GF CC   catalytic complex is similar to that of other polymerase
#=GF CC   catalytic complexes with known structure [1].
#=GF SQ   21
#=GS A0A3G1DHL6_9VIRU/3-1261  AC A0A3G1DHL6.1
#=GS A0A0S2EGR3_9VIRU/6-1284  AC A0A0S2EGR3.1
#=GS RDRP_REOVD/1-1263        AC P0CK31.1
#=GS A0A0A0QRY1_9VIRU/6-1257  AC A0A0A0QRY1.1
#=GS A0A0B4UKM8_9REOV/4-1274  AC A0A0B4UKM8.1
#=GS G0YZM0_9VIRU/4-1259      AC G0YZM0.1
#=GS E7DDK4_9VIRU/5-1273      AC E7DDK4.1
#=GS D6MM22_9VIRU/1-1261      AC D6MM22.1
#=GS W0FVJ2_9VIRU/6-1257      AC W0FVJ2.1
#=GS H9XH55_9REOV/4-1272      AC H9XH55.1
#=GS W8P8Z8_9VIRU/4-1259      AC W8P8Z8.1
#=GS A0A193BJ70_9VIRU/4-1274  AC A0A193BJ70.1
#=GS RDRP_REOVL/1-1263        AC P0CK32.1
#=GS RDRP_AQRVC/4-1274        AC Q8JU61.1
#=GS RDRP_REOVJ/1-1263        AC P17377.1
#=GS A0A1S6PCV7_9VIRU/4-1275  AC A0A1S6PCV7.1
#=GS RDRP_AQRVG/4-1274        AC B2BNE0.1
#=GS A0A0B5CSU4_9VIRU/1-1263  AC A0A0B5CSU4.1
#=GS A0A1B2FIA1_9REOV/5-1282  AC A0A1B2FIA1.1
#=GS A0A0A1CEX9_9VIRU/4-1094  AC A0A0A1CEX9.1
#=GS A0A0A1EBD3_9VIRU/4-1257  AC A0A0A1EBD3.1
A0A3G1DHL6_9VIRU/3-1261             .....sp---IVPQVYHTFQEALSGLRDLQNDLFVHAAIELSKTDRSEVYKWLDNIQFTVHLS..LPLTLFNKPSYGDYYYIDGsDRVRR..-RQLLDDDDVYVPNCRMNDVLE.EVKDL.PGYGRLKTVIDTAAKDGHRP-SRMAATFYHTATSQARQIKG-PIERYLQALLIAET.CP.LAAdP..CDLDQTDPP..GLE..ENLPLL......LIR...EIAKRIMDGEPSRTPWMFTAADVMWTLSP.---LMTSAIPPLMTDLANLAILKQMCRIPNVLIEQACLMFLNAADSGSYAWYVLKTKSIFPSNTLHNCYREPV-EGYVPEIEWLLPRTDYRFSLRGARALTSDDKNN...SESNE...KKNVDLGKQFGCLDVVTKLRNLTRSIDKHDHDSVKFLRNAMACTSSIFIVRAPSETVMKEYTQSPVILKPIPPQDFEPPIGKVKYLKRDST.S.IALHLSNAW.EKAAS.AV.ANDnR.NW-DPLFQAIMRSQYVTSRGGSGAALRDTLKSVDVELPTFSGVKVKPSTKIMQAAQVANVPFYKLSRAVVSPLSMGLRNQVQRRPRTIMPMNVVQQQVSAIHTLVADYINKYMNLSTTSGSAVIEKVVPLGLCASAPPNQAINIDIKACDASITNQFFLSVIMGAIHRGVSQSNLQRPFMGVPTDRVRYIGSDGITSSIAISGMQNMAQHLAGLYDRGFTYNVNDHFSPGNVFVHHTTTFPSGSTATSTEHTANNSTMMDIFLRLWLPDNTKDVNLLKFAKSISIKSNYVCQGDDGIMMIDGNVTRMVSGETIRAFCDKLVEFGKEFGWNYDIEHNGSAEYLKLFFIFGCRVPNVSRHPIIGKERATAERAEVWPATLDVLMGIYWNGVHDMFHWRQWIRFCWVLAAQFSRQRS-RHKQKT.V.SIQYPMWSFIYWGLPPIRVFGCPPYKISMYMPTGDMGMYALLTI....LR....PYLLSYANAR.-G..YNCNKDGVLGPIDHERLFNDECLYQGYYMAQLPRSPIRTNRVGEKNETQAFLKALSEYLYIDPALKGRVMEGKMRWRRAGFTAISH----PPSLDDVAERWYRGAQEADVATADEIAAMDDILLNAYTHKYQSFSKLLEAYLRVEWDAGE.II..E.PKIDLRVPLCAGVDPVNSDHFLKLYAIGPMMESTKRYFSQTLFMHRTVSGLDVEQIDRALLKLRALGAPREAVIAQLMMVGLEESDAATLASKIMVQDIHNVQLAKVVNLAIPDSWMTLDFDSLLKYNV...........KFNTRTV.RSL.TTDIP..TDLSWLRPIFRFLGAAVIMTQAGVAPEVHLAHVRGGVRSLGVKFKRWMA--ae
A0A0S2EGR3_9VIRU/6-1284             .......LVNQLPEDLKNLSVALSGTIELTADIWTNASKTFRTTQRHEVYDIINKIEFIDSFL..VPSSLFQPPPHKRYWDVDVrQRVVR..VPKCAVPDDVYLPHANLTDVLEiNTESI.HKYGQLRKEIQAAAKRLDPT-ARIAETFYNLSVYQANQIKF-PLERFLLCLVVSYA.HElSPS.P..LLIDEQNVNflTIE..ANPALS......ALK...TIMLHFMEYGKYKPPFLKTSRDIVFALYD.DKRPLSSQIAPLMIDLVNYAIVIYSCNISRLISVPTVRMMLKAAGTTSYNHTQLKLKKIIPAASLLSVYHGET-VGRVPIVVWEEPREEYRFRLDGARDLPRGWKNElqgAKKAI...EDASDLASSYGMTAEFEELRSQYSKISVHNGVGMKMIRDALAGVSSVFITRTPTDTVLQEYVHAPVIERPIPPQDWTDPVGVVKYLKNDTQ.HyVARNLYATW.REAAV.QV.ANN.P.DNWDPNTQAILRSQYVTPRGGSGSSVKKVLTDKGVILKNFSKSGAKSSTKIVQAAQLASIPFTQYQDTIMAPVSHGVRIQVQRRSRTIMPFSVPQQQVSAPHTLCGNYINKFLNKSTTSGSNVTEKVIPLGIFASSPPTRAVNIDIKACDSSITWGFFLSVICGAMHEGMDGINVGTPFLGVPATLVEDGLDLGIVGTRSISGMQNMVQKLSQLYERGFEYEVKDAFSPGNAFTHHTTTFPSGSTATSTEHTANNSTMMKTFLMHWLPNHTKDLELIDFVKKLDVNRNYVCQGDDGIMILPTNDGRPISSHHVESMLELLSVFGKESGWVFDIEFNGSAEYLKLLFLNGCRIPNVGRHPVVGKERASRDQDVIWPGGIDAFIGMYNNGVEDQFHWRRWLKFSWSMACFLSSKAV-FIKGKS.D.VIQYPSWSFVYLGLPPIRIFDSPPWIFSPYTPGGDLGMYSIMVT....GKkyivDRMQSSGYQKdNT..DLSNESTFFRGYDYVKFMNDCGVLPGYYMSQIPRSPDKTKRKVIGPESRDLIDSLRNYLFSDQKLTIRVNYGHRIVTDYPGRLPRK----LPSLDDVPQRWFDTAVEADMASTYEIEAMDVHLLRGQFSRYQSFSKVLEAYLSVDWELTDlNI..P.AGLSLDVPLVAGCDPTNGEPYYKMMGLGPMMESIQTYFHGTVFMSRAVSGLDVESIDVALLKMKALKVPTEVITGFLMTCGLSKPKASTVATKINFQDMKTVQVAKLTGLNVSDKWMSMNFDRLLHSY-...........VDVKTYV.SDS.SNQIRlpGGAGWLRGVIRFLGAGVVMTRVGPPQPVRISVIYGGGARLHSKFLNWMV--sd
RDRP_REOVD/1-1263                   .......MSSMILTQFGPFIESISGITDQSNDVFEDAAKAFSMFTRSDVYKALDEIPFSDDAMlpIPPTIYTKPSHDSYYYIDAlNRVRR..-KTYQGPDDVYVPNCSIVELLE.PHETL.TSYGRLSEAIENRAKDGDSQ-ARIATTYGRIAESQARQIKA-PLEKFVLALLVAE-.--.--A.G..GSLYDPVLQ..KYD..EIPDLSh...ncPLWcfrEICRHISGPLPDRAPYLYLSAGVFWLMSP.---RMTSAIPPLLSDLVNLAILQQTAGLDPSLVKLGVQICLHAAASSSYSWFILKTKSIFPQNTLHSMYESLE-GGYCPNLEWLEPRSDYKFMYMGVMPLSAKYARS...APSND...KKARELGEKYGLSSVVGELRKRTKTYVKHDFASVRYIRDAMACTSGIFLVRTPTETVLQEYTQSPEIKVPIPQKDWTGPIGEIRILKDTTS.S.IARYLYRTWyLAAAR.MA.AQP.R.TW-DPLFQAIMRSQYVTARGGSGAALRESLYAINVSLPDFKGLPVKAATKIFQAAQLANLPFSHTSVAILADTSMGLRNQVQRRPRSIMPLNVPQQQVSAPHTLTADYINYHMNLSPTSGSAVIEKVIPLGVYASSPPNQSINIDISACDASITWDFFLSVIMAAIHEGVASSSIGKPFMGVPASIVNDESVVGVRAARPISGMQNMIQHLSKLYKRGFSYRVNDSFSPGNDFTHMTTTFPSGSTATSTEHTANNSTMMETFLTVWGPEHTDDPDVLRLMKSLTIQRNYVCQGDDGLMIIDGTTAGKVNSETIQNDLELISKYGEEFGWKYDIAYDGTAEYLKLYFIFGCRIPNLSRHPIVGKERANSSAEEPWPAILDQIMGVFFNGVHDGLQWQRWIRYSWALCCAFSRQRT--MIGES.VgYLQYPMWSFVYWGLPLVKAFGSDPWIFSWYMPTGDLGMYSWISL....IRplmtRWMVANGYVT.--..--DRCSTVFGNADYRRCFNELKLYQGYYMAQLPRNPKKSGRAASREVREQFTQALSDYLMQNPELKSRVLRGRSEWEKYGAGIIHN----PPSLFDVPHKWYQGAQEAAIATREELAEMDETLMRARRHSYSSFSKLLEAYLLVKWRMCE.AR..E.PSVDLRLPLCAGIDPLNSDPFLKMVSVGPMLQSTRKYFAQTLFMAKTVSGLDVNAIDSALLRLRTLGADKKALTAQLLMVGLQESEADALAGKIMLQDVNTVQLARVVNLAVPDTWMSLDFDSMFKHHVkllpkdgrhlnTDIPPRM.G--.-----..----WLRAILRFLGAGMVMTATGVAVDIYLEDIHGGGRSLGQRFMTWMRQE..
A0A0A0QRY1_9VIRU/6-1257             fddatls-----------YAQSISGVIPMTNKLFEQASASIRALPRSHVYALLDDVNFSVTCV..IPNRIFHHPDHSEYFYVDAvNRVRR..-KQVIDPDDVFVPNCNLQGLIT.PMERL.PNYGQLSEIISSNARDGLPS-ARIAATFYNISVSQARQVKA-PLESFLLPLLLSE-.--.--T.C..PLSDDPCGF..DTT..ASPPIHa...nlALWvlrEISRTICGSSKDRSPWLLLDSGVAWFMSP.---LMSSAIPPLMADLTNLAIYKQICSVSDELHSLAVQVVLQAAASQSYGHYILQTKSIFPQNTLHNMFRTLT-DGIVPVIDWLEPRSNYRFMLQGARKVTSDDANQ...APDNT...DAAEQLGRRMGCLDVVRSLRKMSSSITVHSHDAMTFVRDAMSCTSGIFITRQPTETVLKEYTQAPTIEVPIPQSDWSPPIGSLRYLSDACS.L.PAVYLARAW.RRAASaVV.DNP.R.TW-DPLYQAILRSQYVTSRGGSGAALRDALKAAEVELPQYPGVSVKVATKIYQAAQTADVPFDKLSRAVLAPLSMGLRNQVQRRPRTIMPMNVVQQQISAAHTLSADYINYHMNLSTTSGSAVIEKVVPLGMYASCPPAQAVNIDIKACDASITYQYFLSVIVGAIHEGAAGRRVSSSFMGVPPSVLSVVDASGVTSSMPISGFQVMCQWLAKLYQRGFEYQVTDTFSPGNIFTHHTTTFPSGSTATSTEHTANNSTMMDGFLRAWIPSSGASDVLKKFCKSISIQRNYVCQGDDGLMVVDGLSTGKLSGEIIDEFVKELRAYGKSFGWNYDIEFTGNAEYLKLYFLNGCRIPNVSRHPICGKERASGDKLEMWPSTIDIFNGIFVNGVHDGLPWRRWLRYCWALALMCSGKTVRH-DDSE.V.LIQYPMWSFVYWGLPPVSAFGSDPWIFSPYMPTGDHGFYSMLTL....VR....PLIT-----N.LS..PSSDTSGLFGQCDHNVLFNSELVYQGYYMAQCPRQPSRSNRRDDPDSVQRFVKALESYLYISPELKSRVRLGRDRWQKLVGYTEKS----PPSLDDVAFKWFRSAQEADLPTATEIQSMDLALLAARRRTYQGFSKLLNTYLRVTWDLSD.PV..E.HAVDPRVPLCAGVSPSNSEPFLKLYSVGPMMQSTRKYFSNTLFIHRTVSGLDVDVVDRALLRLRALNAPDDVVVAQLLMVGLSEAEAATLAAKIRTMDINAVQLARVVNLSIPDSWMTMDFDRLIRDIV...........SITPLTV.RSL.TTDLP..SGVPWARAILQFLGAGVAMTAVGPSRRPYLHSVAGGMSSFIKQFRRWMRA-e.
A0A0B4UKM8_9REOV/4-1274             .......LFNALPPELQHLSLALSGSEPLTDKIFTAAADAWHVRPRSQAYHLLDSLTFRSSVV..IPNSIFVGRIWSDYWALQD.NIVVR..ISPEGAKDADYCHNSNIAPILS.PLKTI.PEYGTLHPTIDKDASERGYPTARMASSFFKLASSQARQVKIDPTRFLEFLLVVNAT.PR.TPS.G..VDSDQPNPW..SPE..SSPALQ......AIW...QIMQRYKIGSNYFAPALIVNTGAVWWIPP.PGRTNCVTVQFLLTDLINLAVNAFATRLSPELEMCAVRLYLAAAATPNYAHALLDLKSVFPNLSLHSMYREGQFGGKCPRIEWTEPRASYRFKWVGVTQLHEGLRPL...TPARD...EKAMEKMRAYGLSDVAQVIINMRRAHPRHNADSVRFVRDVLSLTSGMYLVRPPTMSVLREYSQTPQIGEPIPPDWWTGAVGSLAYFNERAK.G.PLAHLYSVW.LEAAR.QV.VMD.P.STHDPLTQAIYKTQFVTPRGGSSAALKQALAESKVELPDFTSTGVKRSSKIYQTAQLAHLSFQSLIPAIMGQVTLGIRNQVQRRARSIMPMSNPQQTVSVPHTLVANYINKHMNRSTTSGSAVQDKVIPLLLYASTPPRTVINVDIKACDASITYAAFLAPICGAMHQGFDLGDPSAPFMNVPSSTQYDRRNPAAPYNRPVSGLQTMTQHLAKLYQAGFSYKVDDPFSSGNSFVFPTTTFPSGSTATSTEHTANNGAMADYFLREYVPQHAKSSTLKFIVKDMTIQNNYVCQGDDGMLILPDLGTKRISLEDLTELMELLERYGRGFGWVYDIDSSDSAEYLKLYALFGARIPNISRHLPVGKEYASPETGEIWPSLVNIAMGSFYNGVTDCLEWRDWLRFSWAFVCFASRGSFHPKIGPR.V.DAQYPVWSFIYMGLPPILLPGQTPFLTSVYMPAGDQGMFAILHQ....WR....DYLIARATAD.YP..PLTRRHPVWQLADVPTLLAELGVYRGYWAAQVSRRPEPSPEDADPSNVEAMSAALSTYLLKDPVLRDRVVRGTNAWRRLTDSHPGRLPSRVPSLLDVPTRWIKAGRDAEKPRPSAVGQMMKDIQRAARSPRKDFSRLLELYLHVHVHLGP.PV..P.LAVDPEVPHVAGADILNDDHWYKVTSLGPIAQSTKKYFDATLFVGKTVSGLDVEAVDATLLRLSILGAEPEEYHAFLAGIGMSDAEAHRIASAISLADAQIVQLARTVNLAVPSSWMSLDFDTLIRSHS...........YPRQPGI.SDS.STLVR..ERASWINSVLRLLCATVAMSRVGPVCQATVSSVDGGVNQIVGCLRAWMRD-v.
G0YZM0_9VIRU/4-1259                 ..ipals-------ELLSFQRAISGDLDLTDDIFRESAIKLYQYSRSSVYNWLDHVEFAVDFN..IPVSLFHHPLHDRYYHIDGaNRVRR..-SQIIDEDDVFVPNCRLTDLLV.PHSKF.LEYGTLSPKILEQAKNGHGP-SRIAATCYLTATNLARQIKM-PLEVFIKSLIVSET.CE.L--.-..--GVDPCNV..DKE..VSPPLKtnlplyLIH...KISKIIMQNYKSRTPYMFTASDVLWSLSP.---LMSTAIPPLMVDLTNLAIMRQMNNMDDTLVRHACQMFLHAATSQSYCHYILATKSIFPGCSLNLLYKNSV-SGYTLDMDWLEPRHEYKFAVTGIRRLLDEDRND...APFNE...DKYMQIGVKYGCADTINYLMKETRKFNHHDDISMKWVRDCMACTSGNFIVRAPTETVLKEYTHFVKIEKPLTQQDISGYVGEVGLISSMSQ.P.NVRYLHHTW.KEATS.RV.VHD.A.SIYDPLNQAILRSQYITSRGGSGAALRDTLKMIDIDIPEYKGLKIKNSTKIMQAAQIANIPFNLSQRAVLAPLSMGLRNQIQRRARTIMPLNIVQQQISAIHTQVSDYINKHLNLSTTSGSAVTEKVIPLGMYASLPPNQTINVDIKACDSSITYDYFLSVITSALHQGSTGLSESAPYMGVPTTVVRSIDSAGIGSTEVLSGIQHMVQLLALLYKRGFEYKVNDHFSPGNNFTHHTMTFPSGATSTSTEHTANNSTMMDNFLTNWVFDNSDDIEIHKLVHHLTIKRNYICQGDDGILIVNGNNNHKVSSKSIIKLCHLLSKYGQEFGWNYDIDFSGTTEYLKLYFINGCRVPNLSRHSICGKERATADRAEIWPRMIDLIMGIYNNGIHDGIHWRRWLRWCWSLAACT---AVVKRKDTN.K.LVYYPMWAFIYKGLSPIRVFGCPAYSFSVYRPTGDMGMYSLLTI....LK....PYLLSFANTH.-G..YNASVDSAFGPIDFIRLFNDYKVFQGYYAAQLPTQAHHKEDSSDPEIKKQFIKALDDYVFLDSALRARVAEGMNKYAKS-GYIGLN---KAPTLHDVSKNWYKGALEADNPTMKDVMSLYDSIESAYQHHYNGFSELLNTYLNVEWECDT.AI..E.PVIDIRVPLCAGIDMRNSDHYFKLYSIGPMMESSKKYFQNTLFLQKTLSGLDVNAVDKVLLRLRALNAPSEVITSQLMMLGLSKPAAHTMASKILTMDVKSVQLARVVNLGVPDSWMMTNFDRVINQCV...........HTYPKDA.LNK.EVNIP..PDISWLRPILRMLGAALIYTMPGVGAHVYIRSNRGGMRNMSRKFRQWMAK-e.
E7DDK4_9VIRU/5-1273                 .....vy--QGLSQSLRDFIPFLRGEKDINDNDFSRASADWHGHQRSYATSLLSKIPFTTCIR..VSHEIFVRRDWRKYYRIDEsGRVRR..VPVIDD-EDVFVPNADISPLLV.PMRSQ.PDYGILHPDIQSGADAGVGS-DRMAAAFFKTASSQVRQLKMDVSRPLLALLLAWCS.EG.STS.Q..VITDISTSR..DIA..TCPPLH......ALQ...QVLSYYTKDNVPLLPTMIVRSGPLWIVPP.TGKSIPSHIPLLIADLVNLSILGYVCNIDDELLACGVEVFLAAARSESYSHTLLACKALFPALSLHALYRDGFIGGKVPVMEWAEPRNKYTFKWVGSRVISADILNM...PPVDY...TDVDRICERYGLGIIKTRIGKHVSACNMHNHASMKLVRDVMALTSGTFIVRSATESVLKEYAQPPLIKQPIRESDWSGYIGNVRYLKATAP.G.PAQYLWSRW.RDAAM.RL.LAS.P.RLDDPLSQAILRTQYVTARGGSGANMRDALISAGAKLPNYAGVGVKMSTKIVQVAQIADLPFELQAAGVDAAVAMGSRNQVQRRTRVIMPLSPIQQNVSAIHTITADVINKEMNLSTTSGSAVQEKVVPLLMYASIPPNRVINIDIKACDASITPDYFLSVICGAIHHGLSNEAGYSPFMGVPPADVIDATFPTNPGGRRITGKQNMVQHLARLYKKPFQYDVNDPFSPGNKFQFDTTVFPSGSTATSTEHTANNSTMFDYFLTHYVPQNAQSPTLKHIVRGMSIQRNYVCQGDDGICILDHYGGRRVSNEDINEFIQLLIDYGGLFGWRYDIDFHGNAEFLKLCCLLGCRVPNASRHAPVGREHATADASEAWPGMIDIVIGMYVNDISDAYDWRKWLRFTWALLCFVSRASI-NHLDRR.I.TVQFPVWTFVYLGVPPISAFGSGPYMFSSYMPQGDLGIYSLITL....RK....EWIMQRCVDL.NY..STTHVSRAFGDCDVRKLFAGLGIYAGYYAAQMPRTPPRQRQSTTPEVREEFIGALNRFLFYDKELTRRVERGRMLWDKFGQTIAGKYIRRVPSLRDVPSKWFSDAREADTATQGDIFRLASDLERRFKLHPQHFSDLLEAYLRVEWHAGD.VV..P.PAIDPDVPVVAGIDLTNDDLFFKLVSVGPLMQSVRRYFQQTLFVGKTVSGMDVEHLDATLLRLKILGAPPEAFNGVLQMAGFSDTQANEIYSKVVFADARLVQIARVVNLHVPDKWMLLNFDYLLRDVI...........SHQQLLI.TDR.NSKLP..ARRPWMRAILKVLGAGVVKTQVGPVRYMYVKQIKGGGAALSNLFEMWMRR-v.
D6MM22_9VIRU/1-1261                 ...mgdy----VPPVFAAFQRYLSGLEDLDYGVFSNTAMNLQLSDRSELYRWLDKVQFRVNFS..IPVTLFNKPSHAMFYYIDGaNLVRR..-RQLNGELDLYVPNCKLFELLE.PTERL.PNYGRLRKVLNTAAADGHVE-SRIAVSYYNTVNSQARQIKG-PLERFLQCLLIAEScPL.GND.PthVEDNDGVLP..IET..NLP-LY......VLR...EVARRITGNSGDRAPWLFTATEILWFMSP.---LMTSAIAPLMIDLANLAIMRQICRLPDVVTRAAVTMYLNAADSHSYSQYVLETKGLLMGASLHSMYRTAV-SGIVPVVEWSEPRSKYKFSYQGVRNLTSRDYNH...SWLCD...DDLLQRAAKFGLRDVINDILTCSKKVDKHDFESVKWIRNVMAGTSSIFIVRAPTETVIAEYSQTPVILEPIPEEALTMPIGEVRCLRNVAP.S.TPKFLYDVW.RDAAR.DV.CNRsQ.TW-DALEQVIMRSQYVTARGGSGAALRDVLKNANIELPSFNGVKVKSSTKIVQAAQVAGLSFMQLKDAILAPLSMGLRNQIQRRQRSIMPLNVVQQQVSAIHTLVADHINKHVNLSTTSGSAVIEKVLPMGMYASSPPNQTINIDIKACDASITCQYFLSIICGAIFDGCHNVRVTSPYMGVPPTRLRVIGDDGIASTMPISGMQHMVQSLATLYNRGFAYKVNDPFCPGNTFTHHTLTFPSGSTATSTEHTANNSTMMDGFLRIWLPDHCKEKDVLALAERMSIQRNYVCQGDDGIMIIDSNNIDMIDGDLIKRFCQYLKQYGETFGWNYDIDFNGTTEYLKLYFIYGCRIPNISRHPVINKERATQERSELWPATIDIMMGVFWNGVHDGLHWRQWIRFCWCLAALYSRKINRDAL-TP.R.VIQYSPWAFVYLGLPPIRAFGSHPYPISVYLPTGDMGFYALLTV....LK....PFILAYADAR.-G..YNADSEGLFGPIDHVRLFNDLKLYQGYYMAQLPRRPVKTSRTISSNDRARFLTALHGYVFEDPVLRMRVARGRHMWHMSGFEKVK----HPPSLEDVPRKWLEGAQEADVATLEEINAMDDVLMNAMRHTYSSFSKLLECYLSVEWDYEY.GS..E.PAIDLRVPICAGYDPENADMYFKMTSLGPMMSSTKKYFSDKLFIGKTVSGLDVEAVDKSLLRLRALGAPRDAIIGQLMMLGYDFGAASTLAGRILLQNVHAVQLAKVVNLAVPDSWMIFDFDRMLHERI...........CVFPKVS.RKA.FTDIA..PHHAWIKGVLRLLGGAVAMSIPGVVPKLYLSEIRGGSRSMSLKLRHWMAK-e.
W0FVJ2_9VIRU/6-1257                 fddatla-----------YARSISGLISMSNDLFERASLSMRSFPRSHAYDILDKVEFSVSCV..IPNAIFHHPDHVEYFYIDAvNRVRR..-KHVIDSDDVFVPNCNFQGLLT.PMDKL.PNYGQLSEVISSNARDGLAS-ARIANTFYNIAVSQARQVKA-PLESFLLPLLLSE-.--.--T.C..PLSDDPCGL..DTS..PSPPISr...nlALWvlrELSRTICGSSGDRSPWLLLDSGVAWFLSP.---LMSSAIPPLMADLTNLAIYKQVCSVSDDMHSLAVQMVLQAAASQSYGHYVLQTKAVFPQNTLHNMFRTIT-DGLVPVIDWLEPRSNYRFMLQGARKVTSDDANQ...SPDNT...EAAEKVGHKMGCLDVVRSLRKMSSAITVHSHDAMTFVRDAMSCTSGIFITRQPTETVLKEYTQAPTIEVPIPQTDWSPPIGSLRYLSDACA.L.PAVYLARSW.RRAAS.AVvDNP.H.TW-DPLYQAILRSQYVTSRGGSGAALRDALKAAEVELPQYPGVSIKVATKIYQAAQTADVPFDKLSRAVLAPLSMGLRNQVQRRPRTIMPMNVVQQQVSAAHTLSADYINYHMNLSTTSGSAVIEKVVPLGMYASCPPAQAVNIDIKACDASITYQYFLSVIVGAIHEGAAGRRVSSSFMGVPPSVLSVVDSSGVTSSMPISGFQVMCQWLAKLYQRGFEYQVTDTFSPGNIFTHHTTTFPSGSTATSTEHTANNSTMMDGFLRSWVPSSGASDILKKFCRSISIQRNYVCQGDDGLMIVDGLSTGKLSGEVIAEFVKELRAYGKSFGWNYDIEFTGNAEYLKLYFLNGCRVPNVSRHPICGKERASGDKLEMWPSTIDIFNGIFVNGVHDGLPWRRWLRYCWALATLYSGKRV-RHENVE.V.SIQYPMWSFIYWGLPPVSVFGSDPWIFSPYMPTGDHGFYSMLTL....VR....PLITA-----.LS..PSSSMDGLFGQCDHNALFNSEMVYQGYYMAQCPRQPSRSNRRDDPESVQRFVRALESYLYISPELKARVRLGRDRWQKLVGYTEKS----PPSLDDVAHKWFRSAQEADLPTTSEIQAMDLALIAARRKTYQGFSKLLNTYLRVTWDLTE.PI..E.HAVDPRVPLCAGISPSNSEPFLKLYSIGPMMQSTRKYFSNTLFIHRTVSGLDVDVVDRALLRLRALNAPDEVVIAQLLMVGLSEAEAATLAAKIRTMDINAVQLARVVNLSIPDSWMTMDFDRLIRDIV...........STTPLTI.RSL.TTDLP..SGVPWVRAILQFLGAGVAMTAVGPVRRPYLHSVAGGMSSFIKQFRRWMRA-e.
H9XH55_9REOV/4-1272                 .hddlav---------ERLINCLTGELELTDDIFLAANSALRSRDRSYVYRQLNAIPFHTPVY..VTRAILVNRDHRDYYHIDSrGLVRRklSVTVGADDDVYVPCCNIGPLLA.PHRTL.EGYGILDPKFAA---TIKDPASRIAITFAKSATVQARQVKDDITRFLQALLLMNGK.QA.IVG.D..EYADRSPTP..PCE..TCPALH......AVS...QVIQLLGFAPPNLSPFLALPAGGLWHMPG.TAKVMPVQVPQLLNDLVNLAILRVMLRIPDELTYFGVRVLLAAAYSESYSWAVLQCKHFFPDLSVHAMYKTNFSGGYAPIFDWPSPRSDYRFTYLGHRTMTSEDKPV...LPLDL...KKVDETARKFDLVDVAERMKTYLADINTHTHASMKYAHHVMALTSSSFTVQTATESVYAEYTQNPVIEQPIPPDSWTGPIGYLRLLKTDAP.A.PALSLHRTW.RNAAV.AV.AKD.M.RQMDPLQQAIMRTQYVTPRGGSGYSLRTSLEAANVAIRDFRNAGVKISTKIYQAAQTAQIPFEVLLPAVLAAVTLGTRFQVQRRPRAIMPLNIVQQTVSAIHTIVADYINKHMNLSTTSGSAVQEKVIPLVLFASTTPTTVVNVDVKACDACVTYSYFLSVICAAMYEGLNPHGDPRPFMGVPVLP-YTNRVSSAMMTDEASGMQVMVQQLARLYQNGFRYMVSDPMAPGNIFELPTLTFPSGSTATSTEHTANNSTMMDHFITTWLPEHTTNPELKAIVRQMSIRDNYVCQGDDGMCIIDNVSGRRISAESLTEFTTLLNKYGRQFGWVYDIDASGCAEYLKIYAVNGCRVPNCSRHPILGKEMANPDAYDPWPQIINALMGLWRSGLTDAYDTVDWTRYMWALVTIYASGSMTTTKGQR.L.RLAYPMSTFITLGIPPIRIWGCDPFTVSVYMPPGDMGVYALINV....LR....HHLYTTIAAH.GDkyRQDRGDDMFDGHNVLQFLHDTRFTHGYFAAAHHRVPLRESREVDAKARLDMISALSDFLYHDPELRFRVIAGRRLWDTYGQGQHGAYLHRVPSLDDVPHRWYEEAREADRATLSDEERLFKSLHRAITRPSLMLSKLLMAYLRVRWDIGE.LM..P.AAVSPQVPLTAGMHPQNPDMFMKMTSLGPFLERVGQYFHDALFVKRVVSGMDVNTLDAALLKLRILGAPANALVGVIMQSGFSESEAAEIAGRIQLKDARTVQIARVVNLSVPDTWMLFNFHLLLHATV...........--NPHGMyGQTtFTKIP..PSMPWLRSILLFLGSSINMTRVGPIHQVYLARIHGTGASLARQFQQWMS--sa
W8P8Z8_9VIRU/4-1259                 ..gyvpp-------VYDQLQQALSGLIDLTDDIFSQTANHLLSTDRSTAYKWLDNIEFKNTIY..IQPTIFQKPSHTEYYYIDGaTRVRR..-KRLLDDDDVFVPNCSMLDVLR.EVDDL.PGYGKLNPILDVAARKDDDPNARMSVTFYQTATSQARQIKA-PIERFIQSLLIAE-.--.--S.C..PLAPDPTGY..DDS..QPPPLDtnlplyVLR...EVAKIVTSGSSNRSPWMFTATDVMWSLSP.---RMTSAIPPLMTDLTNLAILRQVCRIPDDLCAHAVSVYLNAAGSQSYAWYILKTKALFPMNTLHHAYRKPV-EGIVPQMQWLDPRTDYRFMISGARRLTNNDFNQ...SADNL...DKAIKLGEDFECLEIVQSLRKSTSEMKTHSHESVKWIRDAMACTSGIFITRAPTETVLKEYTQAPKIEKPLLDKDFSSPVGSVRYLNKDID.S.PAVFLNDTW.EAAAN.EV.SND.SaTW-DPLNQAIMRSQYVTSRGGSGAALRDVLAAADVSLPTFPGVRVKPSTKIVQAAQTSGVPFDKLSRAVLAPLSMGLRNQVQRRPRTIMPMNVVQQQVSAIHTLVADYINKHMNLSTTSGSAVIEKVIPLGMYASSPPTQTINIDIKACDASITFQYFLSVITGAIHRGVGTTSVKRPFMGVPPTRV----STGYNSSLSISGMQHMAQKLSQLYQRGFDYKVNDHFSPGNAFNLQTTTFPSGSTATSTEHTANNSTMMNAFLTYWLPRNCDDDNVLKLASSMSIKSNYICQGDDGIMVLDANLLNMISGNTVNKLCECLTRFGKQFGWNYDIEFNGSTEYLKLYFLYGCRIPNVSRHPIVGKERATSERAEIWPATIDIMLGVYTNGVHDMLHWRQWIRFNWVLACMYSRQTT-SDKTRT.R.TVQFPMWAFIYLGLPPIKVFGCEPYLFSVYTPTGDMGMYAILSI....LR....PYIFQYAKDH.-G..YISSTEGPFGMVDHVKLFNDRKVYQGYYIAQLQRNPIRTDVTSKPEDVRRFKNALRDYLFHDPILKMRVEEGKRRWRQSGQDYLSN----PPSLDQVADKWYKGAQDADIPTTDEIRAMDEMLYRATSHKYVSFSRLLEAYLRVEWDYDD.EI..PtPVIDLRAPLCAGVDTSNSDHFLKLYGVGPMMESTKRYFNQTLFMHRTISGLDVDEIDKALLKLRTLGAPREALVSQLMMVGLDENDASTLAGKIMVQDIGSVQLARVVNLAIPDSWMVLDFDYLLKYRI...........KFITNTV.RSL.TTDIP..SDLSWMRPIFRFLGASLSMSTVGLPMTMKIRKVRYGVRNLSILFKRWMI--ae
A0A193BJ70_9VIRU/4-1274             .......LFNALPPELQHLSLALSGSQPLTDKIFTTAADAWHVRPRSQAYHLLDTLTFRSSVV..IPNSIFVGRIWSDYWALQD.NIVIR..ISPEGAKDADYCHNSNIAPVLS.PLKTI.PEYGTLHPTIDKDASERGYPAARMASSFFKLASSQARQVKIDPTRFLEFLLVTAAS.PR.VYS.G..VDSDQPNPW..TPE..TSPALQ......AIW...QIMQRYKVGSSYHAPALIVNTGAVWWIPP.PGRSNCVTVQFLLTDLINLAVNAFATRLSPELEMCAVRLYLAAAATPNYAHALLDLKSVFPNLSLHSMYRNGQFGGKCPRIEWTEPRSSYRFKWVGVTQLHDGLKPL...TPSRD...EKALDKMRAYGLTDVAQIIIRMRQSHPRHDADSVRFVRDVLSLTSGMYLVRPPTMSVLREYSQTPLIGEPIPPDWWTGAVGFLSYFNERAK.G.PLAHLYSVW.LEAAR.QV.VMD.P.STHDPLTQAIYKTQFVTPRGGSSAALKQALAESKVELPDFTSTGVKRSSKIYQTAQLAHLSFQALIPAIMGQVTLGIRNQVQRRARSIMPMSNPQQTVSVPHTLVANYINKHMNRSTTSGSAVQDKVIPLLLYASTPPRTVINVDIKACDASITYAAFLAPICGAMHQGFDLGDPSAPFMNVPSSTQYDRRNPAAPYNRPVSGLQTMTQHLARLYQAGFSYKVDDPFSSGNSFVFPTTTFPSGSTATSTEHTANNGAMADYFLREYVPQHAKSSTLKFIVKDMTIQDNYVCQGDDGMLIIPDLGTKRISAADLTELMSLLEAYGRGFGWVYDIDSSDSAEYLKLYALFGARIPNISRHPPVGKEYASPETGEIWPSIVNIAMGSFYNGVTDCLEWRDWLRFSWAFACFASRGSFRPKVGPR.V.DAQYPVWSFIYMGLPPILLPGQTPFLTSVYMPAGDQGIFAILHQ....WR....DYLTARAASD.YP..PLTRRHPVWHLSDVPSLLADLGVYRGYWAAQVSRRPEPSPDDADPTSVEAMSAALSTYLLKDPVLRDRVVRGTNAWRRLTDSHPGRLPSRVPSLLDVPTRWIKAGRDAEKPKPSAVAMMMKDIQRAASSTRKDFSRLLELYLHVHVHLGA.PV..P.LAVDPEVPHVAGADILNDDHWYKVTSLGPIAQSTKKYFDATLFVGKTVSGLDVEAVDATLLRLSILGAEPEEYHAFLAGIGMSDAEAHRIASAISLADAQIVQLARTVNLAVPSSWMSLDFDTLIRSHS...........YPRQPGI.SDS.STLVR..ERASWINSVLRLLCATVAMTRVGPVCQATVSSVDGGVNQIVGCLRAWMRD-v.
RDRP_REOVL/1-1263                   .......MSSMILTQFRPFIESISGITDQSNDVFEDAAKAFSMFTRSDVYKALDEIPFSDDAMlpIPPTIYTKPSHDSYYYIDAlNRVRR..-KTYQGPDDVYVPNCSIVELLE.PHETL.TSYGRLSEAIENRAKDGDSQ-ARIATTYGRIAESQARQIKA-PLEKFVLALLVSE-.--.--A.G..GSLYDPVLQ..KYD..EIPDLSh...ncPLWcfrEICRHISGPLPDRAPYLYLSAGVFWLMSP.---RMTSAIPPLLSDLVNLAILQQTAGLDPSLVKLGVQICLHAAASSSYAWFILKTKSIFPQNTLHSMYESLE-GGYCPNLEWLEPRSDYKFMYMGVMPLSTKYARS...APSND...KKARELGEKYGLSSVVSELRKRTKTYVKHDFASVRYIRDAMACTSGIFLVRTPTETVLQEYTQSPEIKVPIPQKDWTGPVGEIRILKDTTS.S.IARYLYRTWyLAAAR.MA.AQP.R.TW-DPLFQAIMRSQYVTARGGSGAALRESLYAINVSLPDFKGLPVKAATKIFQAAQLANLPFSHTSVAILADTSMGLRNQVQRRPRSIMPLNVPQQQVSAPHTLTADYINYHMNLSTTSGSAVIEKVIPLGVYASSPPNQSINIDISACDASITWDFFLSVIMAAIHEGVASGSIGKPFMGVPASIVNDESVVGVRAARPISGMQNMIQHLSKLYKRGFSYRVNDSFSPGNDFTHMTTTFPSGSTATSTEHTANNSTMMETFLTVWGPEHTDDPDVLRLMKSLTIQRNYVCQGDDGLMIIDGNTAGKVNSETIQKMLELISKYGEEFGWKYDIAYDGTAEYLKLYFIFGCRIPNLSRHPIVGKERANSSAEEPWPAILDQIMGIFFNGVHDGLQWQRWIRYSWALCCAFSRQRT--MIGES.VgYLQYPMWSFVYWGLPLVKVFGSDPWIFSWYMPTGDLGMYSWISL....IRplmtRWMVANGYAT.--..--DRCSPVFGNADYRRCFNEIKLYQGYYMAQLPRNPTKSGRAAPREVREQFTQALSDYLMQNPELKSRVLRGRSEWEKYGAGIIHN----PPSLFDVPHKWYLGAQEAATATREELAEMDETLMRARRHSYSSFSKLLEAYLLVKWRMCE.AR..E.PSVDLRLPLCAGIDPLNSDPFLKMVSVGPMLQSTRKYFAQTLFMAKTVSGLDVNAIDSALLRLRTLGADKKALTAQLLMVGLQESEADALAGKIMLQDVSTVQLARVVNLAVPDTWMSLDFDSMFKHHVkllpkdgrhlnTDIPPRM.G--.-----..----WLRAILRFLGAGMVMTATGVAVDIYLEDIHGGGRALGQRFMTWMRQE..
RDRP_AQRVC/4-1274                   .......LFNALPQPLQQLSLALAGEIPLTDHIFEQAASTWHVQPRSLTYKLLDHIPFSTPVV..VPPSIYHSLDWSKCFAVNQ.DRVER..VPTIDDPDDVYVPNSDIGPLLT.SLHTI.PDYGFLHPAIENDATTLRAERARCASTFYKIASSQARQVKLDPIRMLGFLLLVQAR.PR.VPS.G..LVTDQPTRR..DPT..QSPALH......AIW...QVMQYYKVAGVYYAPALVVPSGAIWWIPP.PGKRNVVSVQYLLTDLINLAILAHMTDMSPTLELTGVLMYLRAASSHSHAYTLLQMKSVFPALSLRSMYRNKGFGGKAPAIEWTEPRSKYKFRWTGVTQLHDGLRPR...SPSMD...VPTLEVLTKYELVDIGHIIIRERNAHPRHNHDSVRFVRDVMALTSGMYLVRQPTMSVLREYSQVPDIKDPIPPSAWTGPIGNVRYLLPSVQ.G.PARHLYDTW.RAAAR.QI.AQD.P.QWHDPLNQAIMRAQYVTARGGSSASLKFALKVTGIVLPEYDDSKVKKSSKIYQAAQIARIAFMLLIAAIHAEVTMGIRNQVQRRARSIMPLNVIQQAISAPHTLVANYINKHMNLSTTSGSVVTDKVIPLILYASTPPNTVVNVDIKACDASITYNYFLSVICGAMHEGFEVGNADAAFMGVPSTIVSDRRSSVAPYSRPISGLQTMVQHLADLYAAGFRYSVSDAFSSGNKFSFPTSTFPSGSTATSTEHTANNSTMMEYFLNVHAPSHVKSASLKRILTDMTIQRNYVCQGDDGILLLPHEAASKISADDMNELLTCLRDYGQLFGWNYDIDWSDTAEYLKLYALMGCRIPNTSRHPPVGKEYAAPQTDEIWPSLIDIVIGHHLNGVTDVLNWREWLRFSWAFACYSSRGGYTNPKGQS.F.SAQYPWWTFVYLGIPPILLPGQTPFIHSCYMPPGDQGMFSILNG....WR....DWLISHASTT.LP..PLRHNHPVWGLSDVPSLLSQFGVYAGYHAAQHYRRPKPAPETASSDSINQITSDLTEYLFYDSALKARVMKGRYNWERLSSSLSLNVGSRVPSLFDVPGKWVAAGRDAEKPPPSSVEDMFTSLNRCIRRPTHSFSRLLELYLRVHVTLGE.SI..P.LAIDPDVPQVAGADPANDDHWFKYTCLGDIPSATRNYFGESLFVGRVVSGLDVEAVDATLLRLKILGAPPEAFIAVLNGIGMSDSEAHQIAGRISLANAQLVQIARVVHLSIPSSWMTLNTGPYIHHHA...........YDFKPGI.TQP.SAKSR..DKSIWMSPILKLLCTSYAMTVAGPVRTSIVTEIDGSAAALSGNLRVWMRD-v.
RDRP_REOVJ/1-1263                   .......MSSTILTQFGPFIESISGIIDQSNDIFEEAAKAFSAFTRSDVYKALDEIPFHDHATvhIPPTIYSKPSHDSYYYVDAlNRVRR..-RTYQGDDDVYVPNCSIVELLE.PHETL.TSYGRLSSAIEARAKEGDPQ-ARIATTYARISESQARQIKA-PLEKFVLALLVAE-.--.--S.G..DALYDPILQ..KYD..DVADLTh...ncPLWcfrEICRHVSGPLPDRAPYLYLSAGVFWLMSP.---RMTSAIPPLLSDLVNLAILQQTAGLDPSLVKMGVQVCLQAAASASYAWYVLKTKSVFPQNTLHSMYETLE-GGFCPNLAWLEPRSDYKFMYMGATPLSGKYART...APSNE...TRARQLGEKYGLSTIIGDLRQRTRQFTKHDFASVRYIRDAMACTSGIFLVRTPTETVLQEYTQSPEIKVPIPQKDWTGPIGEIRVLKDTTS.S.IARYLYRTWyLAAAR.MA.SQP.R.TW-DPLFQAIMRSQYVTARGGSGAALRESLYAINVSLPDFKGLPVKAATKIFQAAQLANLPFSHTSVAILADTSMGLRNQVQRRPRSIMPLNVPQQQVSAPHTLTADYINYHMNLSTTSGSAVIEKVIPLGVYASSPPNQSINIDISACDASITWDFFLSVIMAAIHEGVASSSIGKPFMGVPASIVNDESVVGVRAARPISGMQNMVQHLSKLYKRGFSYRVNDSFSPGNDFTHMTTTFPSGSTATSTEHTANNSTMMETFLNVWGPEHTNDPDVLRLMRSLTIQRNYVCQGDDGLMIIDGTTAGKVSSETIQKMLELISAYGEEFGWKYDIAYDGTAEYLKLYFIFGCRIPNLSRHPIVGKERANSSAEEPWPAILDQVMGIFFNGVHDGLQWQRWIRYCSSLCCAFSRQRT-MIGEEV.R.YLQYPMWSFVYWGLPPVKLFGSDPWIFSWYMPTGDLGMYSWISL....IRplmtRWMVANGYVS.--..--ERCSSIFGNADYRRCFNDIRLYQGYYMARLPRNPKKSGRAAPRETREQFTQALSDYLMQNPELKSRVLRGRSEWEKYGAGIIHN----PPSLFDVPHKWYQGAQEAATATREELSDMDDTLLRSRRHTYSSFSKLLEAYLRVRWRMCE.AR..E.PSVDLRLPLCAGIDPLNSDPFLKMVSVGPMLQSTRKYFAQTLFMAKTVSGLDVNAIDSALLRLRTLGADKKALTAQLLMVGLQESEADALAGKIMLQDVNTVQLARVVNLAVPDTWMSLDFDSMFKHHVnllpkdgrhlnTDIPPRM.G--.-----..----WLRAILRFLGAGVAMTATGVAVNVYLEDIDGGGRSLGQRFMTWMRQE..
A0A1S6PCV7_9VIRU/4-1275             .......LFNALPIPLQHLSQALAGEKPITDYIFSHAADAWHSQSRSSVYSLLDSLNFSVSVV..IPGSIFVGRQWQDYWALDG.DIVIR..ISPEGAKDADYCHNSDITPILS.PLKSI.SDYGTLNPAIEKSATERAQPTARMASSFFKLASSQARQVKLDPARMLSFLLVVNAT.KR.VPS.G..VDTDQSNPW..TPE..SSPALY......AIH...RIMQHYKVNGQYYAPALIVNTGAVWWIPPvAGKTNCVSVQFILTDLVNLAINAFASRLSPTLEMCAVRMYLAAAATPNYAHALLDLKAIFPNLSLHSMYRNGNFGGKCPRIEWLEPRSNYKFRWIGVTHLHHGLRPL...SPSRD...VPALEKLTTYGLRDVGMTIIQLRDAHPRHTMDATRFVRDVMSLTSGMYLVRPPTMSVRREYSQTPDIQDPIPPDWWSGAVGHLRYFNEKAT.G.PAKWLYDTW.MEAAR.KV.MAD.P.NTHDPLNQAIFKTQFVTPRGGSSAALKQALAQDEVELPDFTGTNVKRSSKIYQVAQLARLPFQALIPAVLGQVTLGIRNQVQRRARSVMPMSTPQQTVSVPHTMVANYINKHMNRSTTSGSAVHDKVIPLLLYASTPPRTVINVDIKACDASITFAWFLSIICGAIHQGFDIGNPSSSYMNVPPTTWYDRRNPAAPYNRAVSGLQTMTQHLARLYQAGFSYKVDDPFTSGNSFDFPTSTFPSGSTATSTEHTANNGAMASYFLKTYVPTHAKSETLKFVVRDMSIQDNYVCQGDDGMLIIPDLGDKRVSQEDMEELIDLLTRYGRGFGWIYDVDHSDSAEYLKMYALFGCRIPNISRHPPIGKEYASPETGEIWPSLINIVMGLFLNGVTDCLEWRDWLRFMWAFACFSSRGSFHPKDGQR.I.DAQYPWWSFVYLGLPPILLEGMTPFAISPYMPAGDQGFYAVISS....WK....SVLIGLATVR.YP..ATTRLHQIWGHADVPSLLSDLGVYKGYWAAQLPRRPEPSPEDADPTAVESMKSALSDYLLQDPVLRERVQRGTTNWRRLSESNPGRLPVRVPSLLDVPDRWIKSGRDAEKPRPSSVHRMMQDIQKVSRSPRRGFSRLLELYLHVDVVLGA.PI..P.LAVDPEVPHVAGADVLNDDHWFKVTGLGPVSQSTRRYFDATLFVGKTVSGLDVEAVDATLLRMKILGAEPAEFHAVLGGIGMSDAEAHQVTSGISLANAQNVQLARTVNLAIPSTWMPLDFDSLIRMHT...........FPRQAGI.SDH.TTIVR..ERSSWVNSVLRLLCASVAMSRAGPVCESTVAHVSGGVGQLTGLLREWMRD-v.
RDRP_AQRVG/4-1274                   .......LFNALPQPLQQLSLALAGEIPLNDELFQAAASTWHTRQRSETYHLLDRLRFSTPIV..TPQAIYRDLPWRNCYRINQ.DRVER..IPTTNASDDVYVPNSDISTLLS.PLFSI.PTYGTLHPSIEKDALELRADSARCASTFYKIASSQARQVKLDPTRMLEFLLLLVAT.PR.VNS.G..LDTDQPSMR..DPT..KSPALH......AIW...QIMQYYKVDSKYHAPALIVSTGAVWWIPP.PGKRNVVSVQYLLTDLVNLAIIARMTDMHPTLGLCAARVYIQAATTDSYTHTLLKLKGVFPALSIHSMYRQKGFGGKAPDIQWTEPRTKYQFKWVGVTHLHDGLRPR...APVRD...EAVRKLLTEYQLADIMAPIVEMRNQHKHHDHDSVRFVRDVMALTSGMYLVRQPTMSVLQEYSQVPDIKQPIPPSAWTGTVGNVRYLNKDVT.G.PARWLYNTW.REAAQ.EI.AQD.R.TWHDPVNQFIMGSQYVTARGGSGSSLKHSLTVTGLVLPEFSESSVKRSSKIYQAAQIARIPFTLLTAAIHAEVVMAIRNQVQRRARSIMPLNVVQQAVSAPHTLVANYINKHMNMSTTSGSVVTDKVVPLLLYASTPPRTVVNVDIKACDASITYDYFLSLICGAMHEGFEVGDNHASFMGVPSSIIMDKRSALAPYSRTVSGLQTMVQHLSQMYANGFRYSVTDAFSSGNKFSFPTSTFPSGSTATSTEHTANNSTMMSYFLAVHAPQHIKSPNMKRVLSDMTIQRNYVCQGDDGVLLLPDEAASKISAEDMDELLTCLKDYGTSFGWVYDIDWSDSAEYLKLFALCGCRVPNVSRHPPVGKEYASPTTDEIWPSLIDIVVGHHLNGVMDLMNWREWLRFSWAFACYASRGAYTDKYGET.H.IAQYPWWTFVYLGIPPILLPGQTPFIHSLFMPPGDQAMFAILNN....WR....DLISTNTTTT.FP..PLKHPHHTWHLADVPTLLDSYGVYAGYHAAQHPRRPVAQPETANSESIEQITGALTDYLLYDPILKARVNTGRHNWSQLSQSIGLNIGGRVPSLMDVPGKWVAAGREAEKPPPSAIVYMFKSLNRTIRRPSKHFSKLLELYIRVKVVLGA.PK..P.LAIDPDIPQVAGADPHNDDPWFKYVGLGDIPTSTRRYFGESLFVGRVVSGLDVEAVDAALLRLKILGAPPAAYIALLNGIGMSNSEANQIAGRVSLANAQTVQIGRVVNLSTPSSWMTLDTAPYIQYHT...........YDFKPGV.TNP.SAQSR..EKFIWLSPILKLLCATAAMSIAGPVREAYVLDIHGSAASLSGNFREWMRA-a.
A0A0B5CSU4_9VIRU/1-1263             .......MSSMILTQFGPFIESISGITDQSNDVFEDAAKAFSMFTRSDVYKALDEIPFSDDAMlpIPPTIYTKPSHDSYYYIDAlNRVRR..-KTYQGPDDVYVPNCSIVELLE.PHETL.TSYGRLSEAIENRAKDGDSQ-ARIATTYGRIAESQARQIKA-PLEKFVLALLVAE-.--.--A.G..GSLYDPVLQ..KYD..EIPDLSh...ncPLWcfrEICRHISGPLPDRAPYLYLSAGVFWLMSP.---RMTSAIPPLLSDLVNLAILQQTAGLDPSLVKLGVQICLHAAASSSYAWFILKTKSIFPQNTLHSMYESLE-GGYCPNLEWLEPRSDYKFMYMGVMPLSAKYARS...APSND...KKARELGEKYGLSSVVGELRKRTKTYVKHDFASVRYIRDAMACTSGIFLVRTPTETVLQEYTQSPEIKVPIPQKDWTGPIGEIRILKDTTS.S.IARYLYRTWyLAAAR.MA.AQP.R.TW-DPLFQAIMRSQYVTARGGSGAALRESLYAINVSLPDFKGLPVKAATKIFQAAQLANLPFSHTSVAILADTSMGLRNQVQRRPRSIMPLNVPQQQVSAPHTLTADYINYHMNLSTTSGSAVIEKVIPLGVYASSPPNQSINIDISACDASITWDFFLSVIMAAIHEGVASSSIGKPFMGVPASIVNDESVVGVRAARPISGMQNMIQHLSKLYKRGFSYRVNDSFSPGNDFTHMTTTFPSGSTATSTEHTANNSTMMETFLTVWGPEHTDDPDVLRLMKSLTIQRNYVCQGDDGLMIIDGTTAGKVNSETIQKMLELISKYGEEFGWKYDIAYDGTAEYLKLYFIFGCRIPNLSRHPIVGKERANSSAEEPWPAILDQIMGVFFNGVHDGLQWQRWIRYSWALCCAFSRQRT--MIGES.VgYLQYPMWSFVYWGLPLVKAFGSDPWIFSWYMPTGDLGMYSWISL....IRplmtRWMVANGYVT.--..--DRCSPVFGNADYRRCFNELKLYQGYYMAQLPRNPKKSGRAAPREVREQFTQALSDYLMQNPELKSRVLRGRSEWEKYGAGIIHN----PPSLFDVPHKWYQGAQEAAIATREELAEMDETLMRARRHSYSSFSKLLEAYLLVKWRMCE.AR..E.PSVDLRLPLCAGIDPLNSDPFLKMVSVGPMLQSTRKYFAQTLFMAKTVSGLDVNAIDSALLRLRTLGADKKALTAQLLMVGLQESEADALAGKIMLQDVNTVQLARVVNLAVPDTWMSLDFDSMFKHHVkllpkdgrhlnTDIPPRM.G--.-----..----WLRAILRFLGAGMVMTATGVAVDIYLEDIHGGGRSLGQRFMTWMRQE..
A0A1B2FIA1_9REOV/5-1282             ......f-VNRLPLELKTLAHALSGETELTNDIWIQGARSIRSSRRSEVYSWLDDIQFTDSFL..YPASLFSPLSHKQFWKIDErLRVVR..QPREGIPDDVYLPNGNLTDVLE.EDNTTnHKYGVLRQDIRSGAKSGKPS-ARISETFYNLAVYQANQIKF-PLERFLTCLMIAYQ.HG.ISE.G..ALQADKQRD..DPDpaDNPALS......ALR...QLLRHFQEHGQYKPPFLKTSKGVVFCLYE.DRRPLSAQVPPLLIDLVNYAIMIYACDIDRDISVPTVRMMIKASGTPSYNHTQLKLKKVIPAASLYTIYENGC-SGTVPIINWEEPRPDYRFRLDGIRPIPNKWKND...LPGATelrKKGENLAKEYAMESEFHAIRKIFSQMSEHGHSSMKMLRDALAGVSSLFITRSPTDTVLQEYTHAPVIRRPIPEGDWKNPVGAVRYLKADAQhD.VARSLYGVW.KEAAI.HV.AND.P.KMWDPNEQAILRSQYVTPRGGSGHSVKKSLSDSGYTLKAFSKSGAKGSTKIVQAAQLADVPFSVYRDAIFAPVSHGVRIQVQRRSRTIMPLSIPQQQVSAPHTLCANYINKKMNLSTTSGSNVTEKVVPLGMYASTPPTRSVNIDIKACDSSITYSFFLSLICGAMHEGFEGVNADRPFLGVPSTTVDDGSDMGLSGVRTISGMQTCVQWLSRLYQQGFEYEVKDAFSPGNAFIHDTTTFPSGSTATSTEHTANNSSMMNIFLRQWLPSHTDNNDVLHLASKLDIRRNYICQGDDGLLVIPSMDGRAMDADVIATLLEKLEEFGLESGWQFDIEFAGNTEYLKLLFINGCRIPNAGRHPVVGKERASREQDVIWPGGIDAFIGMFNNGLDDKFVWRRWLKFCWSVACFLSSKVVETSRGPS.-.VIQYPIWSFVYLGMPPVRVLDADPWTTSVYMPSGDLGFYAIIKNhattFR....KRMETNGYQL.EN..TEREVSKAFPAFDFVKFLNDEQILPGYYMAQVQRTPDKSERKKANDEARLMIDQLDRYLFEDPMLRIRVNYGNAQLNSYSGKLPRK----MPSLEDVPRRWFDSAVEADVATPMEIALMDTHLLRAQTTRYRGFSKVLEAYLMVDWEFTS.TKspP.PAMDLHTPLNAGTDEFNSDHFYKFHGLGPMMESTRTYFAGTLFIARSVSGLDSESIDQTLLRMKAMNVPIEVISGFLMTCGLSKGEASAIATKINFQDMKTVQIAKVTGLNISDKWMTLNFDRLLHDY-...........VDVRTYV.SDA.HEMIRmpGKAGWLRAVFRFLGAAVVMTRVGPPQPVGIRSIRGGAQRLYHRFLTWMRS-v.
A0A0A1CEX9_9VIRU/4-1094             .kglddv--------LLEYAASISGTAPMSNSLFEKAADIINSKRRSFPYELLSSIDFSVSTV..IPQNIFHPPPCDDFYYIDGlNRVRR..-RRIIDDDDVFVPNCSIFPLLS.QMELL.PNYGQLNPIIAANSKDGLAS-ARILHTFYNTATNQARQVKC-PLETFLLALLLSE-.--.--S.S..PMSADPTGL..DES..SSPPLSs...nlPLYvlrRLSEILTNGFEDKSPWLLLDVGVAWIRSP.---LLSASIPPLMADLTNLAIYRQICPLDDDLTSMAVQMYLQAAASGSYAHYILKTKAIFPQNTLHNMFRQLT-GGLVPIVSWLEPRSDYKFFLQGSRMVTSQDVNQ...TPDNT...EVAEKVGHDYGCLDVVKRLRSKTATYTKSDHSAMTFVRDAMACTSGIFITRAPTETVMKEYTQAPSIEVPIPSRDWSSPIGSLRYLRPSCV.L.PAKFLWDTW.RRAAS.AV.ADS.PsTW-DPLTQAIMRSQYVTSRGGSGAALRDALRSADVELPTFPGVSVKVSTKIYQAAQTADVPFEKLSRAVLAPLSMGLRNQVQRRPRTIMPMNVVQQQVAAVHTLSADYINYHLNLSTTSGSAVIEKVVPLGMYASSPPAQAINIDIKACDASITYSYFLSVIVGAIHSGVSGRRVTSPFMGVPPSVISLTDDTGVNSVMPLSGMQVMAQWLAKLYSRGFEYQVTDSFSPGNVFTHHTTTFPSGSTATSTEHTANNSTMMECFLKEWIPRSQCSDNLRKFCSMITTRNNYVCQGDDGMLIVDGLSAGKVSGDILMEFVTEIRAYGKTFGWNYDVEFTGNAEYLKLYFLNGCRIPNISRHPICGKERASGDKLEMWPSSIDIFLGIYVNGVHDCLHWRRWLRFIWALALSYSRRVV--KHGDVpR.VIQYPMWSFVYWGIPPVSAFNSDPWMFSPYMPPGDHGMYSLLSL....LR....PYIMVSCDAS.--..---DVDGPFGLVDHISLFNADHLFQGYYMAQLPRSPVRSNRRDDPSAVRKFTHALDQYLFNSPELRARVRFGRDRWQKLMGD---S-LGRPPSLDDVAVKWFKGAQEADVPSSDEIQAMDLQLIKARQHNYTGFSSLLNAYLKVSWGLCE.SM..Q.VVVDPRVPLCAGVNPDNSELFLKLYSVGPMMQ-------------------------------------------------------------------------------------------------...........-------.---.-----..---------------------------------------------------..
A0A0A1EBD3_9VIRU/4-1257             .kglddv--------LLEYAASISGTAPMSNSLFEKAADIINSKRRSFPYELLSSIDFSVSIV..IPQNIFHPPPCDDFYYIDGlNRVRR..-RRIIDDDDVFVPNCSIFPLLS.QMELL.PNYGQLNPIIAANSKDGLAN-ARILHTFYNTATNQARQVKC-PLETFLLALLLSE-.--.--S.S..PMSVDPTGL..DES..SSPPLSs...nlPLYvlrRLSEILTNGFEDKSPWLLLDVGVAWIRSP.---LLSASIPPLMADLTNLAIYRQICPLDDDLTSMAVQMYLQAAASGSYAHYILKTKAIFPQNTLHNMFRHLT-GGLVPIVSWLEPRSDYKFALQGSRMVSSQDVNQ...TPDNT...EVAEKVGHDYGCLDVVKRLRSKTATYTKSDHSAMTFVRDAMACTSGIFITRAPTETVMKEYTQAPSIEVPIPSRDWSSPIGSLRYLRPSCV.L.PAKFLWDTW.RRAAS.AV.ADS.PsTW-DPLTQAIMRSQYVTSRGGSGAALRDALRSADVELPTFPGVSVKVSTKIYQAAQTADVPFEKLSRAVLAPLSMGLRNQVQRRPRTIMPMNVVQQQVAAVHTLSADYINYHLNLSTTSGSAVIEKVVPLGMYASSPPAQAINIDIKACDASITYSYFLSVIVGAIHSGVSGRRVTSPFMGVPPSVISLTDDTGVNSVMPLSGMQVMAQWLAKLYSRGFEYQVTDSFSPGNVFTHHTTTFPSGSTATSTEHTANNSTMMECFLKEWIPRSQCSDNLRKFCSMITTRNNYVCQGDDGMLIVDGLSSGKVSGDILMEFVTEIRAYGKTFGWNYDVEFTGNAEYLKLYFLNGCRIPNISRHPICGKERASGDKLEMWPSSIDIFLGIYVNGVHDCLHWRRWLRFIWALALSYSRRVV--KHGDVpR.VIQYPMWSFVYWGIPPVSAFNSDPWMFSPYMPPGDHGMYSLLSL....LR....PYIIVSCDAS.--..---DVDGPFGSVDHISLFNADHLFQGYYMAQLPRSPVRSNRRDDPSAVRKFTHALDQYLFNSPELRARVRFGRDRWQKLMGD---S-LGRPPSLDDVAVKWFKGAQEADVPSSDEIQAMDLQLIKARQHKYTGFSSLLNAYLKVSWGLCE.SM..Q.VVVDPRVPLCAGVNPDNSELFLKLYSVGPMMQSTKKYFNNTLFIHRTVSGLDVDTIDKSLLRLRSLNVPNDAIIAQLMMVGLSESDAATMAAKVRTADINAVQLARVVNLSVPDTWMSLDFDHLLKYVV...........DLTPPSV.RTL.TTDIP..SGHSWVRAILQFLGAGVAMTAVGPVRRTVLLSVHGGMSSFIRQFRKWMRA-s.
#=GC seq_cons                       ...........l...htphtpulSG.hslosclFppAApshpspsRSpsYchLDcIsFosshs..IPsoIFppPsascYYaIDuhsRVRR...pphtssDDVYVPNCsIssLLp.Phcol.ssYGpLpssIpssA+-Gcss.ARIAsTFaplAsSQARQlKh.PlEpFlhsLLlup.......o.s..s.ss-Pss...c.s..ssPsLp......sLa...clhcplpsssss+uPaLhlssGlhWhhsP....hhouuIPPLhsDLlNLAIhpphsslsssLsthuVphhLpAAuSsSYuahlLcsKulFPpsoLHuMYRshs.GGhsPhl-WhEPRScY+FthhGsptLosp.tsp...uPsss...ccApcluccYGhtDVsppl+phspshs+HsasSh+alRDsMAsTSGlFlVRsPTETVLpEYTQsPpIcpPIPppDWouPlGplRYLpssss.u.sA+aLacTW.ccAAp.tV.ups...oW.DPLpQAIhRSQYVTuRGGSGAALR-uLtsssVpLPsFsGlsVKsSTKIaQAAQlAslPFppLpsAlLAslSMGlRNQVQRRsRoIMPhNVsQQQVSAsHTLsADYINKHMNLSTTSGSAVhEKVlPLGhYASoPPspsINIDIKACDASITasaFLSVIsGAIHcGhsssssssPFMGVPsohlpstsssGlsuscsISGhQsMsQ+LA+LYpRGFpYcVsDsFSPGNsFoH.TTTFPSGSTATSTEHTANNSTMM-tFLphWlPpHscssslh+ls+shoIQRNYVCQGDDGlhIlDuhssp+lSu-slpchlchLpcYGcpFGWsYDI-asGoAEYLKLYFlhGCRIPNlSRHPllGKERAos-ptEhWPuhIDlhhGlahNGVcDsLpWRcWLRFsWALAChhSRpss..ptGps.h.slQYPhWSFVYhGLPPlplFGssPahaSsYMPsGDhGMYullol....lR....salhupuhsp..s....scscssFG.sDahpLFN-htlYpGYYhAQlPRpPp+osRsssscshcpFhpALscYLapDPtL+sRVhcGRspWc+hussh.ts....sPSL.DVPpKWacuApEA-hsTssElttMDpsLhRAtp+sYpuFS+LLEsYL+VcWchs-.sh....sulD.+VPLsAGhDPhNuDhFhKhhSlGPMhpST++YFspTLFlu+TVSGLDV-ulDtuLLRL+sLGAPt-slhA.LhhlGhS-uEAsslAuKI.ltDspsVQLARVVNLulPDoWMoLDFDpll+ppl...........hsh.ssl.ss..ps.l...tthsWlRuILRhLGAulsMTtsGsstpshlpslcGGspuLstpFcpWMRt...
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