#=GF ID Relaxase_C
#=GF AC PF11083.12
#=GF DE C-terminal helical hairpin domain from relaxase
#=GF PI Streptin-Immun;
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE Pfam-B_43518 (release 22.0)
#=GF GA 30.00 30.00;
#=GF TC 30.00 37.40;
#=GF NC 29.60 29.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 31039174
#=GF RT The bacteriocin from the prophylactic candidate Streptococcus
#=GF RT suis 90-1330 is widely distributed across S. suis isolates and
#=GF RT appears encoded in an integrative and conjugative element.
#=GF RA Sun Y, Veseli IA, Vaillancourt K, Frenette M, Grenier D, Pombert
#=GF RA JF;
#=GF RL PLoS One. 2019;14:e0216002.
#=GF DR INTERPRO; IPR021112;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This entry represents a C-terminal helical domain hairpin found
#=GF CC in some relaxase enzymes. Proteins found related to this domain
#=GF CC have been previously misannotated as a lantibiotic immunity
#=GF CC protein SrtI [1].
#=GF SQ 41
#=GS A0A3L8GNM7_STRIN/404-528 AC A0A3L8GNM7.1
#=GS Q8DZ67_STRA5/485-608 AC Q8DZ67.1
#=GS A0A7G3MPI3_9CAUD/485-608 AC A0A7G3MPI3.1
#=GS A5MBR5_STREE/483-606 AC A5MBR5.1
#=GS A0A7X1Z6C0_9LACT/415-524 AC A0A7X1Z6C0.1
#=GS A0A347WMH9_9LACT/483-606 AC A0A347WMH9.1
#=GS A0A7X1Z7Y4_9LACT/393-454 AC A0A7X1Z7Y4.1
#=GS T0SIQ1_LACLC/187-296 AC T0SIQ1.1
#=GS F9PYH5_9STRE/25-148 AC F9PYH5.1
#=GS J0VC17_STREE/86-209 AC J0VC17.1
#=GS A0A1G6AM21_9STRE/402-526 AC A0A1G6AM21.1
#=GS G5K466_9STRE/411-534 AC G5K466.1
#=GS A0A1T4KTU6_9ENTE/437-560 AC A0A1T4KTU6.1
#=GS Q8CYS8_STRR6/60-183 AC Q8CYS8.1
#=GS A0A7X2CZU1_9LACT/434-543 AC A0A7X2CZU1.1
#=GS G5K2G3_9STRE/120-243 AC G5K2G3.1
#=GS A0A1G6BN91_9STRE/407-530 AC A0A1G6BN91.1
#=GS A0A4Y9J502_9LACT/410-529 AC A0A4Y9J502.1
#=GS Q8E0T6_STRA5/1-52 AC Q8E0T6.1
#=GS A4VUU0_STRSY/484-607 AC A4VUU0.1
#=GS A0A3L8G4B9_STRIN/411-534 AC A0A3L8G4B9.1
#=GS Q82YL3_ENTFA/421-546 AC Q82YL3.1
#=GS G5KG21_9STRE/483-606 AC G5KG21.1
#=GS A0A7X6N3F5_9STRE/78-201 AC A0A7X6N3F5.1
#=GS A0A380KFT9_9STRE/409-532 AC A0A380KFT9.1
#=GS F5X6Y1_STRPX/485-608 AC F5X6Y1.1
#=GS A0A4Y9HG91_9BACL/420-543 AC A0A4Y9HG91.1
#=GS A0A4Y9J267_9LACT/34-150 AC A0A4Y9J267.1
#=GS A0A139NGI4_9STRE/425-549 AC A0A139NGI4.1
#=GS A0A380K960_9STRE/409-532 AC A0A380K960.1
#=GS A0A3L8GPG3_STRIN/407-530 AC A0A3L8GPG3.1
#=GS A0A7G3MM44_9CAUD/485-608 AC A0A7G3MM44.1
#=GS A0A3L8GBB1_STRIN/485-608 AC A0A3L8GBB1.1
#=GS A0A1G6AEZ9_9STRE/483-606 AC A0A1G6AEZ9.1
#=GS A0A7X6S030_9STRE/407-531 AC A0A7X6S030.1
#=GS Q99ZT7_STRP1/78-201 AC Q99ZT7.1
#=GS S1QZN1_9ENTE/433-556 AC S1QZN1.1
#=GS A0A7X6S0Z3_9STRE/483-606 AC A0A7X6S0Z3.1
#=GS A0A069CVF1_WEIOS/420-530 AC A0A069CVF1.1
#=GS A0A7X6MZM0_9STRE/15-121 AC A0A7X6MZM0.1
#=GS A0A841C574_9LACT/433-564 AC A0A841C574.1
A0A3L8GNM7_STRIN/404-528 ....SKLDQLLKEFEYLSDHDVTS.GEQFEELGDSFMEQLEAVEKVLDRIDETIAQRHKIASALVDYNA..SEGTNKVHALEILNQ.LEVSP....TLNPERIQKEITELTIERKALRDKLESITGEYEKYEAVKTN.....
Q8DZ67_STRA5/485-608 ...v-SLQQKIEEINLLMTLNIQN.-KSFLELKDELVGDIAQLDIELTNLQDKNTTLNKMAEVVVNLQS..DNQDTKQLAKYECSK.MNLSQ....NVTIGQIESEIEMIQNQLDNKIEEYENAVRKLDEYVRVLN-m....
A0A7G3MPI3_9CAUD/485-608 ...d-TLKKKIEEINLLIELGTEN.-KSYQDIKDEIIKDIAQLDLTITEIQEHIDHLNKVAEVLLNLDN..NDIENRRLAKYDYAK.MNLTA....AIKLEQVEKEIEIYQIKLDKSIDDYEYLIRRLEKFVKILNE.....
A5MBR5_STREE/483-606 ....ERLQEKISEISLLIELTETD.-KKYQDIKDNLVSEIAELDIKLTQTNEKIATLNKMAEVLIDSKS..EGSGSQKLARHEFSK.LNMTE....STTLEQVNEELLKLQQEFGNVLDEYEKTIRKLGQLFKVFD-e....
A0A7X1Z6C0_9LACT/415-524 ....STIDELTDAINFLASHGVTEgGEQLVRLEQQLLEVVQEAKDRLNELDQKIRDLNESAKELIVSND..D--------------.--GVE....DEALEQIKSQINSVKVSRDLLKERYDEAISEGNIYQELI--sy...
A0A347WMH9_9LACT/483-606 ....ERLQEKISEINLLIELTETD.-KKYQDIKDELVKEIAELDIKLTQINEKITTLNKIAEVLINLKS..EEPNSRKLAKYEFSK.LNLTE....SITLEQVSEKIRVMQEDLSQYLYEYEGLARKLETLIERL--ni...
A0A7X1Z7Y4_9LACT/393-454 ..tn--VHTLFDAMNLLSRHGITG.QNSFKHLGEDFISEMQKVEQALDELNEKIARQTAVVK-------..---------------.-----....-----------------------------------------fdqhn
T0SIQ1_LACLC/187-296 ....STIDELTEAINFLASHGVTEgGEQLVRLEQQLLEAVQEAKKRLKALEQKIRDLNVLAKERIVSS-..---------------.NERTK....DEELEQIKNQIASVKVSQRLLKGRYNETISQIDEYQEILQ-a....
F9PYH5_9STRE/25-148 ....SSMRELIKEYNFLVEHGVTD.GTQFQHLEERFNEKIEATQEELRQLDERLGRYHKIEGALLAIQ-..QSPENSLAAVQLLDD.LGVPK....DMGLEDVSQLIKQFQIEKGALQEFFDDTLKHYTDYRDIKEH.....
J0VC17_STREE/86-209 ...k-SLKEKISEINLMIELSNTN.-KQYQEIKDELVLEIAEIDMQLEETQEKIATLNKMAEVLINLKS..EDHETRKLAKYDFDQ.MNMTE....SIMLDRLNTDILKLQQELGNEINKYEEIARRLDLFVKIIN-t....
A0A1G6AM21_9STRE/402-526 ....SKLDLLVKEYNYLVSHGVSE.SDQFYELRDRFLEQIEETQESLNRLDEKVEHLNKIASALEDISS..DNPIDAKVAYQILEE.LNISS....SVNPKEIEKQVVEVSIERKALKEKFDSIIKDFTQYEKLERH.....
G5K466_9STRE/411-534 ...t-ELERLVEEFNFLSANKVTN.SKQFQEMQERFLEQLEKTDQTLAQLDSKVAYLNKVLGALSDYQ-..DGLVPSEVTMAILEK.AKVAK....NTDRNLIRKEIKELQIEREALQEARDRIVKDYDFANEMEQ-s....
A0A1T4KTU6_9ENTE/437-560 ....STMNDLVSALNFLASHDVTD.GTQLQNLEKKLLASFEEAEGKLKELDSKILEYTQVTKLLLMSEI..--SEVEQEELNTFKEnLRLPE....DVTQNQLFEELKQAKVSREILKEAVKETAAAVNAFHDIEA-g....
Q8CYS8_STRR6/60-183 ...k-SLQEKISEINLMIELSNTN.-KQYQEIKDELVLEIAEIDMKLEETQEKIATLNKMAEVLINLKS..EDEIGRKLAKYDFDQ.MNMTE....SIMLDRLNTDILKLQQELSNEINKYEEIARRLDLFVKIIN-t....
A0A7X2CZU1_9LACT/434-543 ....STINELTEAINFLASHGVTEgGNQLVRLEQQLLEAVQEAKERLKELDQKIRDLNNSAKELIVRN-..-------------DD.GVLEE....--ALEQIRNQINSVKVSHDLLKQKYEDTIGEINKYQQII--he...
G5K2G3_9STRE/120-243 ....SSMRELIKEYNFLVEHHVTD.GEQFQNLEERFNNKIEETHQELQTLDERLAYYHKVEGALLAIA-..QTPENSLPSMQLLDE.LGLPK....DIAISDIRQTIQQFEIEKDALQEFFDDTLKTYTTYQEMKE-q....
A0A1G6BN91_9STRE/407-530 ...t-KLERLVQEYNFLARNKVTN.SEQFQEMQERFLLQLEETDQTLKQLDDKTAYLNKVLGALSDYQ-..DGLVPSEVTLAILEK.AKVDK....NMDRSHLRKEIKELQIEREALRETRNRIVKDYDFAHKMKQ-e....
A0A4Y9J502_9LACT/410-529 ....NRLNTLIEEFSYLSAKGVSD.GRHFNQLRDSFNKQFHDTKKELDKLDERIAKLNKLYSVLLSDNP..------LIQQSILDEaVKDYG....TSNKHDIHKLLQEVIIEREILRETFDKVADEYDQLTMIYEH.....
Q8E0T6_STRA5/1-52 ...m--------------------.--------------------------------------------..----------QLLDE.LVLPK....DITIADVSQSIQEFEIERDALQEFFDDMLKTYTTYQEMKD-y....
A4VUU0_STRSY/484-607 ....KELQEKIAEVNLLIELNVTN.-RAYTDIKDELVAEIATYDVSMSELNEKNATLNKMAEVLVNLKS..HDIERRRLARYEFSK.LNLTE....SVTLEQIEREISNTQDQLSKLLDNYEESVRKLETFVAVLN-r....
A0A3L8G4B9_STRIN/411-534 ...t-ELERLVEEFNFLSANKITN.SKQFQEMQERFLDQLEKTDQTLEQLDDKVSYLNKVLGALSDYQ-..DGLVPSDVTMAILEN.AKVAK....HTDRNLIRKEIKELQIEREALQEARDRIVKDYDFSHKLTQ-e....
Q82YL3_ENTFA/421-546 ....QTIDELVSAINFLAANEIED.TRQLKLLEEKLEVAFLEAEKTLETLDEKMLELHQLSNLLLENELqgDPELIQKKLKTLLPD.ATLAE....-FSYEDVRGEIEAIKTSQTLLESKLERTRNEINQLHEIQA-v....
G5KG21_9STRE/483-606 ...a-RLQEKISEINFLIELTETD.-KKYQEIKDNLVAEIAELDIKLTQTNEKIATLNKMAEVLINLKS..DEPISRKLAKYDFSK.FNLTE....SITLEQVNDEIRVLQEELGHYLDEYEGLARKLEMFVSLLN-k....
A0A7X6N3F5_9STRE/78-201 ...d-TFQKKIEEINLLIELDTEN.-KSYQEVKDEIFNDIARLDLTITELQDHIAHLNKVTEVLLNLNN..NDIENRRLTRYDNAK.ISLTA....AIKLEQVEKEIEIYQIKLDKSIDDNEYLIRRLEKFVKILNE.....
A0A380KFT9_9STRE/409-532 ....SKLDRLVDELNFLSVNHVTN.SEQFRDLEKNFLEQLDKTDQELERLSDKIAELNKLYGAIVQYQ-..STLVPSQTSLALLEK.ARLDK....NTNPDLLKKELKEYQIEREALATHRDQIVADYDFSQKLKE-e....
F5X6Y1_STRPX/485-608 ...d-TLKKKIEEINLLIELGTEN.-KSYQDIKDEIIKDIAQLDLTITEIQEHIDHLNKVAEVLLNLDN..NDIENRRLAKYDYAK.MNLTA....AIKLEQVEKEIEIYQIKLDKSIDDYEYLIRRLEKFVKILNE.....
A0A4Y9HG91_9BACL/420-543 ...n-ALDRLLEEFSFLSKNNVTG.YSTFVDFQNRLQDTLEKTQNELNRLDSRIAELNKVHALLLKNE-..KSNQSNKVVTDIFKK.LRIPK....NTNRKELDRLLKEVRQERSILNSKFNSIVHEYKYAKDIEKN.....
A0A4Y9J267_9LACT/34-150 nttn-------EEFSYLSAKGVSD.GRHFNQLRDSFNKQFHDTKKELDKLDERIAKLNKFYSVLLSDNP..------VMQQSILDEaVKDYG....TSNKHDIHKLLQEVIIEREILRETFDKVANEYDQLTMIYEH.....
A0A139NGI4_9STRE/425-549 ....SELDQLVREFNFLSAHGVSD.GQQFDNLLERFEEEFEAVEQELSKLDNRLGELNKIQSALLGLES..DNPYEVSLAQAILEE.MAVHP....STSKREIDKFIKEVTFERAALRQRVQEITKNYNMRQEIERN.....
A0A380K960_9STRE/409-532 ....SKLDRLVDELNFLSVNHVTN.SEQFKDLEKNFLEQLDKTDQELERLSDKIAELNKLYGALVQYQ-..STLVPSETTLALLEK.ARLDK....NINPDLLKKELKEYQIEREALATHRDKIVADYDFSQKLKE-e....
A0A3L8GPG3_STRIN/407-530 ....SSMRELIKEYNFLVEHGVTD.GIQFQNLEEQFNDKIESTHQELQRLDERLAYYHKIEGALLAIE-..QTPENSLSAIQLLDE.LGLPK....DIAIEDIHQTIQQFEIEKDALQEFFDDTLKTYTTYQEMKDN.....
A0A7G3MM44_9CAUD/485-608 ...d-TLKKKIEEINLLIELGTEN.-KSYQDIKDEIIKDIAQLDLTITEIQEHIDHLNKVAEVLLNLDN..NDIENRRLAKYDYAK.MNLTA....AIKLEQVEKEIEIYQIKLDKSIDDYEYLIRRLEKFVKILNE.....
A0A3L8GBB1_STRIN/485-608 ...d-TLKKKIEEINLLIELGTEN.-KSYQDIKDEIIKDIAQLDLTITEIQEHIDHLNKVAEVLLNLDN..NDIENRRLAKYDYAK.MNLTA....AIKLEQVEKEIEIYQIKLDKSIDDYEYLIRRLEKFVKILNE.....
A0A1G6AEZ9_9STRE/483-606 ...e-SLQKKITEINLLIELTETD.-KKYQAIKDELVAEIAELDIVLNQTNEKIATLNKMAEVLINLKS..DDPSSRKLAKYDFLK.LNLTE....SITLEQVTEEIRVLQEELGHYLDEYEGLVSKLEIFIKLLNN.....
A0A7X6S030_9STRE/407-531 ....SKLDELIREFNFLNQHQVSN.STQLDELANRFIEQLDQTDKSLDLLDDKLATLNKIRGALTDYQE..GGLAEQMIAQEVLNS.LSIPL....DYSLEHLDKEMVEISIERTQLKETVDQISFEYRKLATLKE-h....
Q99ZT7_STRP1/78-201 ...d-TLKKKIEEISLLIELDTEN.-KPYQDIKDDIVKDMAQLDLTITELQDHIAHLNKVAEVLLNLNN..NDIENRRLARYDYAK.MNLTA....AIKIEEVEKEIETSQNELNISIDEYEYLVRRLEKFGEILS-d....
S1QZN1_9ENTE/433-556 ....ETIHQLVDAINFLAKHDITA.-TQTGNMERKLEEALNEAKLRLKEIDQLIETQTEQGKIIYQIEMtdNELEKQRLQNQLEDRgMQL--....-LSIDKINSLIKATKQQRQFLYDTFNETVKDLEKYHELKY-a....
A0A7X6S0Z3_9STRE/483-606 ...e-SLQKKITEINLLIELTETD.-KKYQDIKDELVSEIAELDIKLTQTNEKIATLNKMAEVLINLKS..SDYESRNLAKYDFTK.MNMTE....SITLDRLNSDILKLQQELGNDINKYEEVARRLETFVKLL--sd...
A0A069CVF1_WEIOS/420-530 ....STIDEMMKAINFLADHGVTS.GAQVDNATQKLKVAVQEAQDKLNELDSKIIELNQTVKKIIAGDI..V--------------.ENIEQ....GITSDLLGAEIAANQTSRKLLDKKLNQTVNEFEYLNEVVM-t....
A0A7X6MZM0_9STRE/15-121 lifv--------------------.-KYYQEVKNELIKDIAQLDLTITDLQDKVAHLNKVSEGLLNLSD..ADPENRQLVRYDYAK.MNLTA....VITLEKVEQEVKQCQEELRKLIDDYEHRVRRLEKFV-----sqia.
A0A841C574_9LACT/433-564 ....STINQLVDAINFLAEHDVTT.GNQMVNLEQQLNAALEAARDKLSELDEKIIELNEAAKHFVTEDYqeDDGEDLILEKAEEEKeKNETKsqyaTMSFVELQQELVSARASRQLLRDKFNSTVDELNKFYEIKS-a....
#=GC seq_cons .....pLcchlcElNhLhphslTs..cpapclc-cllppltch-.pLscLs-KIupLNKlspsLlshp...ss..spplsh..hsc.hslsp....shsl-plcp-Ipphph-hstLh-ca-phl+ch-pahclhp......
//
