#=GF ID Reov_VP3_GTase
#=GF AC PF20790.1
#=GF DE Reovirus VP3 protein, guanylyltransferase (GTase)
#=GF PI Reovirus_GTase;
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF SE ECOD:3258.1.1
#=GF GA 27.00 27.00;
#=GF TC 41.30 40.30;
#=GF NC 23.20 22.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RC Paper describing PDB structure 3cnf
#=GF RN [1]
#=GF RM 18449192
#=GF RT 3.88 A structure of cytoplasmic polyhedrosis virus by
#=GF RT cryo-electron microscopy.
#=GF RA Yu X, Jin L, Zhou ZH;
#=GF RL Nature. 2008;453:415-419.
#=GF RC Paper describing PDB structure 3iz3
#=GF RN [2]
#=GF RM 21220303
#=GF RT Atomic model of a cypovirus built from cryo-EM structure
#=GF RT provides insight into the mechanism of mRNA capping.
#=GF RA Cheng L, Sun J, Zhang K, Mou Z, Huang X, Ji G, Sun F, Zhang J,
#=GF RA Zhu P;
#=GF RL Proc Natl Acad Sci U S A. 2011;108:1373-1378.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain family is found at the N-terminal end of Turret
#=GF CC protein (TP), also known as VP3, from Reovirus. This GTase
#=GF CC domain, responsible for the catalysis of the first step of RNA
#=GF CC capping, consists of two subdomains, which form a deep and
#=GF CC narrow cleft. This domain is rich in beta strands and adopts a
#=GF CC pentameric assembly [1,2].
#=GF SQ 18
#=GS W6EKC5_CPVOP/8-275 AC W6EKC5.1
#=GS A0A0A7E6A5_9VIRU/6-279 AC A0A0A7E6A5.1
#=GS A0A0K1YWH9_9REOV/1-268 AC A0A0K1YWH9.1
#=GS B8YM32_CPVBM/8-279 AC B8YM32.1
#=GS A0A0A0U955_9VIRU/1-255 AC A0A0A0U955.1
#=GS D3JWE7_CPVBM/8-279 AC D3JWE7.1
#=GS A0A0H4LUQ0_9REOV/8-281 AC A0A0H4LUQ0.1
#=GS B2X7Q8_9VIRU/8-275 AC B2X7Q8.1
#=GS VP4_LDCPR/8-279 AC Q91ID8.1
#=GS A0A1L3KP00_9VIRU/8-275 AC A0A1L3KP00.1
#=GS VP5_APRVF/1-255 AC Q2Y0E6.1
#=GS E3VL85_9REOV/9-291 AC E3VL85.1
#=GS A0A385LMP0_9VIRU/10-277 AC A0A385LMP0.1
#=GS VP2_RRSVT/17-297 AC O56043.1
#=GS A0A2Z4N6W8_9REOV/9-274 AC A0A2Z4N6W8.1
#=GS Q91IE9_9VIRU/9-280 AC Q91IE9.1
#=GS H6BDX7_9REOV/9-277 AC H6BDX7.1
#=GS W6EKD3_9VIRU/6-280 AC W6EKD3.1
W6EKC5_CPVOP/8-275 .....IEDARAELDVLTIELKQFIKKRLRkg..rdYNYYYDVERNEHSLSMNGLWGMFILSDRDKQDELFKMT.AEADWEPLDPKKLDRNINKFIETIN.LPS..RPTH...IEDKYNWMLATSLRAKNYTGNDGRAVVINPELLNYTEESN...AFANIFLAIEDD.........YIDIPMPSTN.WFTQNDDKVIVR.........VWS.PKFDRPEALIPQAQKH......................RRSCMHI.DFHLKTPHTFVYPDDSSQLRHVAANIIKDWRQEKKLRDGGAEVVERICERLVILSGSEKVRKIAAIGNLY...................
A0A0A7E6A5_9VIRU/6-279 .....LIDFRGKEDPHPNDYVSYLQNNVN......FSITWNY-LGEPSARLTNFGKYIHLTEHDRQHPFIYYI.QETEKNKYDKDYAYKLFSQLRQSIV.YPV.lINHE...PTKRLSMLLADGHRCGILPANLSTLITRDPSILLYDQHLG..qHLLSIIDMIGTSykg..tkfrYIDIPTLNPV.IIGKQLNPYIVR.........YFNaRTSSDISILLNLVYND......................GFQTCHVeTFAFNVFHVFIYPTQDAMLQHCWDRLLESWRDMYKWLGVSVTNLKRRTELLIPLCDNRPAYYTMILASLY...................
A0A0K1YWH9_9REOV/1-268 .....------------NQIIALLSNPIQ......FQYHYNKVTGTHSLKLQGLWASFYPCSLDMSQPLFEK-.LRNPNEEIVIEELIRLLKEMQLSIT.LPVptHPME...HGFRYCYMLAWVARAYEYTGHVWAEILKRPEILCYNPDQNq.kPLDEFMNLCDAAq.......tFTRVFGLKAY.LLPGEVG-----.........---.VDLGSYTSVSASMSKKrvawvraidffndfsynhiptnCWCAIHQ.TWAYDTPHFILFNSKQTFADYLIQKIRENRICFKEFYDGLGGQMNRVTEAVAVFCKND------------fqllklari..........
B8YM32_CPVBM/8-279 ....n-NDTRVALDPKPNQIRTITKPNTVpqlgtdYLYTFNSQRRSHTLRLLGPFQYFNSSETDRGHPLFRLP.LKYPSKAIPADELIDNLHSWMRSVHlLHV..RSED...NTLRYNWMLGVYARSTNYTTPVGQLVVNAPAILNYSNPQD...AFNSVFVALGID.........YIDIPITNSN.IFDDSSTPYNVR.........IWHaPTMTEVNHILALMRKS......................TLVSTHS.SWHWNVLHTFHYRSESDMIDHFAAKILEDWRQKEKLDKGALVEADRVIQRLIPLSSSTYVQRLAAIGALY...................
A0A0A0U955_9VIRU/1-255 .....MIDLRLEEDILTATLPEFLSTRPK......YRYAYTN-TKQQDIRFQGPMRHVRLTHLYKQTKLWNL-.-QYIERELAISEIDDALDEFIQTFS.LPY..VIEQ...GTYKYNMLLGMHAHNVNYQDDVSELIANNPQLLNYLDDN-...PFSAIFELVNVD.........-LQIYQYGQN.IFNNEAEHTILF.........---.LKDNTNYGVIQALQKH......................PFSATHI.NWHLHK-HIFVFHSREQLLNKLLSAGLEDSQLYQRQKTYSTKRGDRPTERMVTYIEDDHIRRIQAVFPL-l..................
D3JWE7_CPVBM/8-279 ....n-NDTRVALDPKPNQIRTITKPNTVpqlgtdYLYTFNSQRRSHTLRLLGPFQYFNSSETDRGHPLFRLP.LKYPSKAIPADELIDNLHSWMRSVHlLHV..RSED...NTLRYNWMLGVYARSTNYTTPVGQLVVNAPAILNYSNPQD...AFNSVFVALGID.........YIDIPITNSN.IFDDSSTPYNVR.........IWHaPTMTEVNHILALMRKS......................TLVSTHS.SWHWNVLHTFHYRSESDMIDHFAAKILEDWRQKEKLDKGALVEADRVIQRLIPLSSSTYVQRLAAIGALY...................
A0A0H4LUQ0_9REOV/8-281 ....i-LNDRADLDPQPNQVKSLLRRSFR......YTYHFDTDTYKHTLQLHGLGKYLLFGPQDHQHTLFSLP.IKYHNIPIPTQDLNFQLTEFLRTIN.LPV.aLTDD...PNVRYNWLLASYLRSVA-RNHAHVKYKSNTAILNYVYGEN...PFYKILQLIHADnpiqerirtSISIPQIQPN.IFDQTTNTRLTT.........FWNvYHEQEINTLIGYLVGR......................GLRTTHI.SHSWNAFHTFDYADVNDMYEHQCRTLLESWRDFRDLQIRTKRSVNRRSQILLQLSDNELSIMIQALTSVY...................
B2X7Q8_9VIRU/8-275 .....IEDARAELDVLTIELKQFIKKRLRkg..rdYNYYYDVERNEHSLSMNGLWGMFILSDGDKQDELFKMT.AEADREPLDPKKLDRNINKFIETIN.LPS..RPTH...IEDKYNWMLATSLRAKNYTGNDGRAVVINPELLNYIEESN...AFANIFSAIEDD.........YIDIPMPSTN.WFTQSDDKVIVR.........VWS.PKFDRPEALIPQAQKH......................RRSCMHI.DFHLKTPHTFVYPDDPSQLRHVAANIIKDWRQEKKLRDGGAEVVERICERLVILSGSEKVRKIAAIGNLY...................
VP4_LDCPR/8-279 ....n-NDTRVALDPKPNQIRTITKPNTVpqlgtdYLYTFNPQRRSHTLRLLGPFQYFNFSETDRGHPLFRLP.LKYPSKTIPTDELVDNLHSWMRSVHlLHT..RSDD...NSLRYNWMLGVYARSTNYTTPVGQLVVKTPAILNYANPQD...AFNSVFIALGID.........YIDIPITNSN.IFDDGSTPYNVR.........IWHaPTMTEVNHILTLMRKS......................TLVSTHS.SWHWNVLHTFHYRSESDMIDHFSAKILEDWRQKEKFDKGALVEADRVIQRLIPLSSSTYVQRLAAIGALY...................
A0A1L3KP00_9VIRU/8-275 .....IEDSRAELDVLSIELKSFLSKRLRkg..rdYVYNYNYETNEHSLYFRGLWSMFIPSDMDKQHALFALK.NNEKWEKIDDEILNREINKFIETVS.LPV..KPET...NEDKYNWMLATAVRSKNFSGNDGRIVLDNPSILNYVEESN...AFIGLFSILEDD.........YIDIKVPPSN.WFAIEEESMKIR.........IWN.PKFDRPEMLIPEAQRN......................IRTCMHI.DFHLKTPHTFIYPDDLSQMRHVATNIIKDWKQEKKLRDGGAAIVERICERLHVLSGGLQVRKLAALGNVY...................
VP5_APRVF/1-255 .....MIDLRLEEDILTATLPEFLTTRPK......YRYAYTN-TKQQDLRLLGPMRHVRLTHLYKHTKLWNL-.-QYIERELTNIEIDDALDEFMQTFS.LPY..TIEQ...GTYKYNMLLGMHAHNIGYQDDVSELIANNPQLLNYLNDN-...PLASIFELIDID.........-LQIYQYGQN.IFNNEVEHMILF.........---.LKDNTYHGVIQALQKH......................PFSATHV.TWHLHK-HIFVFHSREKLLNKLLATGLEDSQLYQRQKTYSTKRGDRPTERMITYIEDDHIRRIQAVLPL-l..................
E3VL85_9REOV/9-291 .....LIDQRLLKDPHPNQVSQLLKNPIQ......YDYSYHEITNQHSLRLRGIWGGYYPTTLDLRSNLFET-.LRSENSEIPRERMIQMLRELQLSIK.LPL.pKIKDasfSSMKYCYLLGWIARAFEYHGPVWGRIGSDPTIVCYRTASNv.hPLQRFMELCDREa.......sSVQLYGCRAY.YLPGEQS-----.........---.PDLAQYQSINQVMADRyvawmhpedwrrnfsylhvpptALCAIHH.TWMYDLPHMTFFSNRIKMVEYLLVKVSENHKCFRKFNDGQGEEIDRVSEAVGTFRKNDT-----------pflilhllq..........
A0A385LMP0_9VIRU/10-277 ....f-EDSRKRLELLSTDVPEFLQRRLIrd..rdYIYTFNALTRVHTLRLFGLYKYTLFSESDKQHALFSLP.ISSRNEAIDADVLEYEINAFVQQLSsLPY..HREE...-GALYNWLLASAARANNYAEPWARAVAKDPRLCNYMQERN...AFERIFEIINNE.........SLDIPNATSN.WFSFERAGVIMR.........IFT.PTLDMQTIITKVMNGK......................VEAACHV.TYHFNAPHVFIYSHINAMYSHFIDNLYHDWNQERNLRSGAVIILERICERLIPLNANEEIRKLSALGNVY...................
VP2_RRSVT/17-297 .....ISDERMMLDPLPSEVSAVLDAPIN......YSYRYNELRRTHSLKLFGVWSGYIPSHADKHLMIFQL-.-LQQEKELTGDEIRLALRQMQGSIK.LPIndKLLD...SLDRYSLIFAWIAYAGCLDSAFWQQVCADPKCLVYNPDDN..lKFSLMFSLARQYs.......aTTRICSADGL.RIPSQIS-----.........---.PDLGQLAFDLVFNSSVrqtvwfhandfpafdfytkdvgTMVTFHV.NFLYNMTHCVPFKTKQSCAEYLIQKAHEAWSVYCGVLNDTIRHRLRLVEGVGIVTLDVDLQILAAVGWY-l..................
A0A2Z4N6W8_9REOV/9-274 lsdfs-----SGSDPIPSNVKDILDKPT-......LRFEHDEKTGKNTITPTGMWKYVRIST-DAIARIEKYKtTRNILQPYDESEIANV---FRLSVV.QPS.fQPETlinANKRFAIGIWTTLVTTSTNNELRELLIKEPELLCWNADETtsgKLDNLIYRVDSIsksryndmpYVIIPSYGSNdVFAPSEEPFNTY.........WFMsKDSPNIVNSLKQLLTD......................TNSVMHS.IPKYGNPHIISHKSKAELGSHVLRSCIENLIQLDETW-GKYVSVSRECETLMT-----------------gtiepw.............
Q91IE9_9VIRU/9-280 ....k-IDDRVQQDPRPNEILALRTQTIDrlssnsYTYDYDATLRSHSLQFKAPWNYVQYTASDYSHKLFQLP.TKYADRRIPTDELQTNIKDFRNTIQlLAV..MSND...PDVKYNLMMGLYARAERDSWQIAKLLNESPQLLNYVQPNE...TFVKIMRILNIQ.........SIELPILNTN.IFDTSAAVIKMR.........IWNvESPKTLRHLMYSLNNK......................GFATTHM.SWHYNIVHTFHYTSGDIMMQHVASKIYEDWKQKIELNNSGFKIIDRVCQRLIPLCQHEQVRRITAVGSLY...................
H6BDX7_9REOV/9-277 ....i-FDARANEDPTADLFMIQMKEKIR......YVYHFDSSNLTHDLKLQGLWARYHPSPATLSDVRFSQ-.-LYSQDPLDQKSLDKLVTWLQSSVP.VPK..FPPGc.sPNARVSMLTFWMGQAND-WGGTWKRYLTDPWRLLYEYGTS...PVEWLFGNHRVQ.........YL-LSTPKHA.NIAYSPSVRRTI.........WFK.SDVFMRSDWEQLINESip..................lgSVLCMHH.TYTWNHPHGTLIGEYADLVIYLSEKIVDQILIQKNMFSGVGFQITRAMEGVALL----------------gdvirddraihllralpml
W6EKD3_9VIRU/6-280 .....YYDKRGNSDPSPNDLSRIFDNITAs....nYYHRYDKIQMKHDFRFTGILRYLDLTTSDLGTPLF-VR.LEKQEDFKDPQELLLLVQQFFSTFT.LLV..STTDv.tSRTRYNWIIANALRAGVLKPEVANAIYADPRLINYELGEN...PFQKFIISYGQD.........--IIPGIRSF.HIPNSGVYRSLRyarytydliFIDaYDNDQIDDVTKRLYNH......................GIFGMHV.TWSWNAFHIFKYTDIESLRHHLCTRILETWTEFRNVELNRADDIQRPTQVIVPLLDDKICSTLIAYAQAY...................
#=GC seq_cons .......DtRsp.DPhssplpphlcpphp......YpYpass.pppHoL+LpGhapahhhoctD+pcsLFpl..hchtpctlssc-Ltctlppahpols.LPs..psc-...ssh+YNahLushuRussasssluphlspsPplLNYspsps...sFsplFphlst-.........hlcIPthssN.hFsspss.h.hp.........hap.schsphstllthhpcc......................shsshHh.oa+ass.HsFhYsscsshhcHlhspllEsWpphcchpsGustpl-RlsEpLlsLspsc.lppltAluslY...................
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