#=GF ID Reovirus_L2_6th
#=GF AC PF21060.1
#=GF DE Reovirus core-spike protein lambda-2 (L2), 6th domain
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF SE Pfam-B_7350 (release 9.0)
#=GF GA 27.00 27.00;
#=GF TC 28.60 119.00;
#=GF NC 25.10 21.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF CL CL0159
#=GF RN [1]
#=GF RM 11531411
#=GF RT Mammalian reovirus L2 gene and lambda2 core spike protein
#=GF RT sequences and whole-genome comparisons of reoviruses type 1
#=GF RT Lang, type 2 Jones, and type 3 Dearing.
#=GF RA Breun LA, Broering TJ, McCutcheon AM, Harrison SJ, Luongo CL,
#=GF RA Nibert ML;
#=GF RL Virology 2001;287:333-348.
#=GF RN [2]
#=GF RM 10801118
#=GF RT Structure of the reovirus core at 3.6 A resolution.
#=GF RA Reinisch KM, Nibert ML, Harrison SC;
#=GF RL Nature. 2000;404:960-967.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a
#=GF CC pentamer that mediates enzymatic reactions in 5' capping of the
#=GF CC viral plus-strand transcripts [1]. It forms a hollow cylinder
#=GF CC with projecting turrets. Each VP1/L2 monomer consists of eight
#=GF CC domains with the most N-terminal domain at the base of the
#=GF CC turret and the most C-terminal domain at the top. This entry
#=GF CC represents the sixth domain which, together with the seventh and
#=GF CC eighth (Pfam:PF06016) domains forms a three-domain flap at the
#=GF CC top of the turret, that may serve as a gate to retard exit of
#=GF CC the 5' terminus of the mRNA [2]. This domain has a Ig-like fold,
#=GF CC resembling the V of an antibody light chain [2].
#=GF SQ 6
#=GS VP1_AQRVC/1033-1130 AC Q8JU62.1
#=GS LMBD2_REOVJ/1025-1121 AC Q91RA4.1
#=GS LMBD2_REOVL/1026-1122 AC Q91RA6.1
#=GS VP1_AQRVG/1034-1131 AC B2BND9.1
#=GS LMBD2_REOVD/1026-1122 AC P11079.2
#=GS A0A0B5CUT9_9VIRU/1026-1122 AC A0A0B5CUT9.1
VP1_AQRVC/1033-1130 PPLRV..NPVPTPLNQQCAIRITSLDPAAVLSVQHNGVEVIGGTPGNVISVAGAAALQYILANQEFLLQFTPTLPGIFDV.FLTTLGQPPVPRGSFTITPP
LMBD2_REOVJ/1025-1121 LPMNKsgNFV---VGQNCSLTIPGFNAQDTFNCYYNSALAFS-TEDVNAAMIPSVTATFDNAKNEWTLDMVFSDAGIYTMqAVVGVNASPIALGSFVVDSP
LMBD2_REOVL/1026-1122 LPMEKqgNFI---VGQNCSLTIPGFNAQDVFNCYFNSALAFS-TEDVNSAMIPQVTAQFDANKGEWSLDMVFSDAGIYTMqALVGSNANPVSLGSFVVDSP
VP1_AQRVG/1034-1131 APLRV..NPIPTPLGQQCAIRIPTNDPAAVLDAKHRGVPVITGTPAALTSLMGNAALQYIQANNEFLLQLTPTLAGIFDV.TLTSAGQPPIPRGSFTITAP
LMBD2_REOVD/1026-1122 LPMEKrgNFI---VGQNCSLVIPGFNAQDVFNCYFNSALAFS-TEDVNAAMIPQVSAQFDATKGEWTLDMVFSDAGIYTMqALVGSNANPVSLGSFVVDSP
A0A0B5CUT9_9VIRU/1026-1122 LPMEKrgNFI---VGQNCSLVIPGFNAQDVFNCYFNSALAFS-TEDVNAAMIPQVSAQFDATKGEWTLDMVFSDAGIYTMqALVGSNANPVSLGSFVVDSP
#=GC seq_cons LPMcKpGNFI...VGQNCSLsIPGFNAQDVFNCYaNSALAFS.TEDVNuAMIPpVoAQFDssKsEWoLDMVFSDAGIYTMQALVGuNAsPVuLGSFVVDSP
//
