#=GF ID Reovirus_L2_MT1
#=GF AC PF21065.1
#=GF DE Reovirus core-spike protein lambda-2 (L2), methyltransferase-1
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF SE Pfam-B_7350 (release 9.0)
#=GF GA 27.00 27.00;
#=GF TC 32.60 190.60;
#=GF NC 24.40 23.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF CL CL0063
#=GF RN [1]
#=GF RM 11531411
#=GF RT Mammalian reovirus L2 gene and lambda2 core spike protein
#=GF RT sequences and whole-genome comparisons of reoviruses type 1
#=GF RT Lang, type 2 Jones, and type 3 Dearing.
#=GF RA Breun LA, Broering TJ, McCutcheon AM, Harrison SJ, Luongo CL,
#=GF RA Nibert ML;
#=GF RL Virology 2001;287:333-348.
#=GF RN [2]
#=GF RM 10801118
#=GF RT Structure of the reovirus core at 3.6 A resolution.
#=GF RA Reinisch KM, Nibert ML, Harrison SC;
#=GF RL Nature. 2000;404:960-967.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a
#=GF CC pentamer that mediates enzymatic reactions in 5' capping of the
#=GF CC viral plus-strand transcripts [1]. It forms a hollow cylinder
#=GF CC with projecting turrets. Each VP1/L2 monomer consists of eight
#=GF CC domains with the most N-terminal domain at the base of the
#=GF CC turret and the most C-terminal domain at the top. This entry
#=GF CC represents the methyltransferase-1 domain [2] which adds a
#=GF CC methyl group to the N7 of the guanosine added by the GTase [2].
#=GF SQ 21
#=GS A0A193BJ69_9VIRU/396-689 AC A0A193BJ69.1
#=GS A0A3G1DHK4_9VIRU/393-687 AC A0A3G1DHK4.1
#=GS D6MM21_9VIRU/392-683 AC D6MM21.1
#=GS W8P1A7_9VIRU/386-675 AC W8P1A7.1
#=GS A0A0A0QQA8_9VIRU/390-682 AC A0A0A0QQA8.1
#=GS A0A0B5CUT9_9VIRU/393-685 AC A0A0B5CUT9.1
#=GS LMBD2_REOVD/393-685 AC P11079.2
#=GS W0G078_9VIRU/390-676 AC W0G078.1
#=GS VP1_AQRVG/398-690 AC B2BND9.1
#=GS A0A0A1ECX6_9VIRU/391-683 AC A0A0A1ECX6.1
#=GS G0YZL9_9VIRU/390-670 AC G0YZL9.1
#=GS H9XH54_9REOV/391-683 AC H9XH54.1
#=GS A0A0B4ULB8_9REOV/396-689 AC A0A0B4ULB8.1
#=GS LMBD2_REOVL/393-685 AC Q91RA6.1
#=GS VP1_AQRVC/397-689 AC Q8JU62.1
#=GS A0A0A1CJI2_9VIRU/391-683 AC A0A0A1CJI2.1
#=GS A0A1S6PCV8_9VIRU/396-689 AC A0A1S6PCV8.1
#=GS LMBD2_REOVJ/393-684 AC Q91RA4.1
#=GS E7DDK3_9VIRU/397-689 AC E7DDK3.1
#=GS A0A0S2EGR0_9VIRU/426-685 AC A0A0S2EGR0.1
#=GS A0A1B2FIA2_9REOV/415-705 AC A0A1B2FIA2.1
A0A193BJ69_9VIRU/396-689 ....................PLPFLPQYRQATV.NKNNAR...ASYQANALP.....GLPIYHGFALTGGAFFQSRDITG.DPAnV.WPVNTL.PDLPQDYFSIPARQRRELLSRLRSPSDRSLVKDTHNISFASTVL.NPVNNQIIL.TEGFSMAYLGAASTHGSSDQPLIIDALKTGAVPGVPVPS.KITQFGYDVANGSIMDATLAPPTGTFSFVYSDVDQVEDAGLSIVAANRVAAAVTHVALSMTTAGGLTVVKVNFPTPAFWTQLFRQHATHARALYILKPLIVNSVEVFLLFVS...RTSD.GNLVSSPSLRQFLVQLFDRSAQL-s.............................
A0A3G1DHK4_9VIRU/393-687 ....................PVQALLQYTPATI.ANYDAD...HAANVASTL.....PITPEYDDFWVGKPLFTSYAHHN.SDV.E.VLQNQL.PDLPSDYFSHDDIYFRALFNSYRGIKDKSYHKDLANLQFVATLM.NA-DNKPYL.TSKTAVLYMGASGTHPHIQQPTVIKPWTEGALPGVPKAL.YVRQVGYDVVFGRMCNVRHPLPIGTFPYIYSDVDQVVDAGDDLYKANRVAIDVYENIVRTLPRYGSFCMKVNFPTAFVMSVLLERIIEQFHSYAISKPMINNNVEVYVHGFGklpRHAN.PDAKLRAGVVLFLRQLFNRYKTL-k.............................
D6MM21_9VIRU/392-683 ....................PIRVGIQYKHELV.SKCDAL...SAMAEVSSS.....AIPIVFNDFWVGEPFTFSYVFSF.LDL.A.RDLHDI.PNIPHEYFSLEHQYARDVFSKYRGLIDRSYYKDKAILRHVYSIK.DPNDVL-FM.HDHMNVAYFGASGTHP-AREPTILREWRDGKLDGVSPPI.KVTQFGYDVTKGMIIDVSVPFRSSVYTYIYSDIDQVVDGGDDIDAATRVLFRCLDNMLGQLSHEGNITFKVNFPTTAVWRRLGQHYFPRFASFSIVKPMIANNIEIYVSCYG...YETRrPRCDVRMGVHLFMASLYRRYAV--fn............................
W8P1A7_9VIRU/386-675 ....................PVQILMQYGLNTV.SLAEAR...AAYDSKSTL.....PITPEYHDFWTGGALMHATRAVA.ADA.D.VNTTQF.PSMPPYYFERAQIRSRGIFTSYRGVVDRSLAKDTSNLIFAYGQY.-GLTGDKYL.KANESVAYLGASGAHQPRPEPSIISKWKEGSIPTVPAAA.RIRQIGYDVTLGQIADLRFPLPVGTFTYVYSDVDQVVNGGNDQNVANRVALELLDTCIQLVSVRGSMCMKINFPDGIHFGRMIRSLATNFESHAITKPMIGNNMEVYIHGFS...KLQN.SVPRS-------------------pkassvvfmreirnryl.............
A0A0A0QQA8_9VIRU/390-682 ..................av--GWMPQFDPATS.YNPDLS...LDSLSRATT....lPLRAKYSTFWSGPALFSFASCDR.HNG.V.YDIQFM.AQFPPTYFSDDDAFSRSRFSSYRAVKDRSLLKDTANLMYISNLS.-SSHDHRLV.PDSKTMIYVGSSGTHAD-NQPSIIKPLLAGSLPGVFRPL.SVKQIGWEVTNGTICDIELPLATGTFFFVYSDVDQVQSGDSDLDASSRRFCSQLDMLMKLTFTGGSLVVKCNFPTNLVWRHIFSTISPYFSSIHLMKPLVSNNLELYLLFAE...R---.------------------------lpvpdaafrpsadvvvfwrsqlqryrvl..
A0A0B5CUT9_9VIRU/393-685 ....................PVQWLPQY-----.TIDQAA...MDEGDLMVSrltqlPLRPDYGNIWVGDALSYYVDYNR.SHR.V.VLSSEL.PQLPDTYFDGDEQYGRSLFSLARKIGDRSLVKDTAVLKHAYQAI.DPNTGKEYL.RSGQSVAYFGASAGHSGADQPLVIEPWIQGKISGVPPPS.SVRQFGYDVARGAIVDLARPFPSGDYQFVYSDVDQVVDGHDDLSISSGLVESLLSSCMHATAPGGSFVVKINFPTRPVWHYIEQKILPNITSYMLIKPFVTNNVELFFVAFG...VHQH.SSLTWTSGVYFFLVDHFYRYETLS..............................
LMBD2_REOVD/393-685 ....................PVQWLPQY-----.TIDQAA...MDEGDLMVSrltqlPLRPDYGNIWVGDALSYYVDYNR.SHR.V.VLSSEL.PQLPDTYFDGDEQYGRSLFSLARKIGDRSLVKDTAVLKHAYQAI.DPNTGKEYL.RSRQSVAYFGASAGHSGADQPLVIEPWIQGKISGVPPPS.SVRQFGYDVARGAIVDLARPFPSGDYQFVYSDVDQVVDGHDDLSISSGLVESLLSSCMHATAPGGSFVVKINFPTRPVWHYIEQKILPNITSYMLIKPFVTNNVELFFVAFG...VHQH.SSLTWTSGVYFFLVDHFYRYETLS..............................
W0G078_9VIRU/390-676 ...................s-IGWMPQFDPATSyDPEMAA...ESLAKATTL.....PLRAKFSSFWSGPALFSAASCDR.HNG.V.YDLRFM.PPFPSTYFGEDDVFSRSRFSSDRAVRDRSLLKDTANLMYVSNLS.NSH-DQRLL.PESKTMVYVGASGTHTD-NQPSIIKPLLDGTLPGVFKPL.SVKQVGWEVTNGTICDIELPLATGTFFFVYSDVDQVQSGDSDLVSSSRRFCLQLDMLMKLTYTSGSVIVKCNFPTDLVWRHIFSTISPYFMSIHLMKPLVSNNLELYILFAE...----.------------------------klsvpdapfnpsadvvtfwrsql.......
VP1_AQRVG/398-690 ....................PLRVLPQYRAATI.LPAQAT...QAYEDHVIA.....PININHGYCISGGVYFTADDISI.DPT.P.FPARDL.AQLPQNYFDPNRMARRELLRRLRVPSDRSYLKDNAVFTFLASLV.NPATALPAL.QPGFSLAYLGASAAHAKSDEPTILADLRNGSIPGLPIPS.RIAQFGYDVVHGSLLDLTRAVPTGTFGLVYADLDQVEDAGTDLPAANRAALAMLGTTLQMCTAGGVAVLKVNFPTVEFWTQLFNQYATFATTLHVVKPIVVNSSEVFVVMSG...RQSA.GNLTCTTSLQRALLAMYARNAAID..............................
A0A0A1ECX6_9VIRU/391-683 ...................s-VRWQPQFDDSTS.SPVDLA...LNLMNSALT....lPVTPDYGYAWTGSPLFSYAVSDR.HDA.A.VPIDLV.PDFPADYFSTEQQDARARFRDYRLIADRSLHKDTANLACVSQQQ.D-ALGNRFV.FNGMSVAYMGASGTHPD-DQPSVITPWLSGKLASVFKPS.SIRQFGWDVTKGVILDVTHSIASGDFGFVYSDVDQVQCNSDDLVSSTRAFILQCQNLLTLVQVGGSLIVKCNFPTSRVLAWVYTELSPWFNRIIVMKPLLSNNLEIYVGLL-...----.------------------------qklaitsppfgpsssvvvfltkqirryssl
G0YZL9_9VIRU/390-670 .................pvi---MMKQYGLTWI.DQQDGE...LSWKKRNKL.....PVSPLYGKAISGKAICYRVKSNDqKVR.A.VSSDHL.PDLTESYFSKEESALRDKFKSYRLAADRSLLKDICNWTFLYSFI.DD-LGKDAI.PSGINACYLGASGNHP-TNEPTIITKIRKNEIAGVKQVA.NIAQFGYDVTKGIVCDLNYPISTGTYDLVYCDVDQVQSASNSYKSSDQLTISLFDRASELISPSGSICFKINFPTRTVMSWILRRLSSMFTVYGITKPLVMNNVEVFVVGV-...----.------------------------kklkqykqpvilnnmcvf............
H9XH54_9REOV/391-683 ....................PLRWLPAYTGMDV.LITDAD...AIRDEYEVI.....NVPVVNLFAYEGPVLVSVSSYDP.AEG.V.APVSAL.NLVPQHYFDADQSRNRATFSRYRRSSHRSLYKDVAVLTQAFRVV.DDVTGLPVC.ANGYSMAYLGASSAHPDSNGPEILEQLRSGSIPGFPQPS.SISQYGYDTERGAVTDLTSHPPTGTFTLVYADVDQVINGRNSMAAATNTAINLINVALNMVTSGGIVCFKVNFPDTNFWTQFFRQFSRRIGGLTMVKPFIVNNVEVFLVLGP...IGGI.DVPTPTTSIAIHASKIAARYQCLD..............................
A0A0B4ULB8_9REOV/396-689 ....................PLPFLPQYRQATV.NKNNAE...ASYAENALP.....GLPIYHGFALTGGAFFQARDVTG.DPAnV.WPVNTL.PTLPRDYFSIQSRQRRELLSRLRTPSDRSYIKDVHNISFASTVL.NPVNNQIVL.TEGFSMAYLGAASTHGSTDEPLVIDALKNGSIPGVPVPS.KIVQFGYDVANGSIMDATLAPPTGTFSFVYSDVDQVEDAGLSIAAANRVAIAVTSVALSMTTAGGLTIVKINFPTPAFWTQLFRQHATHARSLYILKPLIVNSVEVFLLFVS...RASD.GNLVSSPALRQFLVQLFDRST---ylt...........................
LMBD2_REOVL/393-685 ....................PIQWLPQY-----.TIEQAA...VDEGDLMVSrltqlPLRPDYGSIWVGDALSYYVDYNR.SHR.V.VLSSEL.PQLPDTYFDGDEQYGRSLFSLARKIGDRSLIKDTAVLKHAYQAI.DPNTGKEYL.RAGQSVAYFGASAGHSGADQPLVIEPWTQGKISGVPPPS.SVRQFGYDVAKGAIVDLARPFPSGDYQFVYSDVDQVVDGHDDLSISSGLVESLLDSCMHATSPGGSFVMKINFPTRTVWHYIEQKILPNITSYMLIKPFVTNNVELFFVAFG...VHQQ.SALTWTSGVYFFLVDHFYRYETLS..............................
VP1_AQRVC/397-689 ....................PLRLLPQYRNATI.TVQQAD...DAYEDTALS.....PLITTHGFCVTGGVSTSIYDISG.DPT.A.YPPAQL.VDTPNDYFDRERMARRDLFRRLRAPADRSAIKDRAVFDFLASLV.NPTTANPVL.DTSFSMAYLGASSAHANADEPVILADIRSGSIPGLPIPR.RIVQFGYDVVHGSLLDLSRAVPTGTFGLVYADLDQVEDAGTDMPAANRAAIAMLGTALQMTTAGGVSVLKVNFPTRAFWTQVFNLYATHATTLHLVKPTIVNSSEVFLVFGG...RQSN.GALRSTTALQRALLSLYARNAAID..............................
A0A0A1CJI2_9VIRU/391-683 ...................s-VRWQPQFDDSTS.SPVDLA...LNLMNSALT....lPVTPDYGHAWTGSPLFSYAVSDR.HDA.A.VPIDLV.PDFPADYFSTEQQDARARFRDYRLIADRSLHKDTANLTCVSQQQ.D-ALGNKFV.FNGMSVAYMGASGTHPD-DQPSVIAPWLSGKLASVFKPS.SIRQFGWDVTRGVILDVTHSIASGDFSFVYSDVDQVQCNSDDLVSSTRAFILQCQNLLTLVQVGGSLVVKCNFPTSRVLAWVYAELSSWFNRVVVMKPLLSNNLEIYIGLL-...----.------------------------qklaiasppfgpsssvvvfltkqirryssl
A0A1S6PCV8_9VIRU/396-689 ...................a-LQFLPQYRRATV.TKPNSQ...ASYEEQQLL.....PLSIFHGHAITAGTYFTNANITG.DPT.ApWPVATL.PPMPARYFSSASKTRRELLSRLRAPSDRSYLKDQANFGFLASLL.NPINNEPLL.REGLSIAYLGAASTHSTANQPLIITDLEQGLVPGVPIPS.KISQYGYDAESGALMDATQASPTGTFGLVYSDVDQVEDAGDRIQIAERVAIDTIYTALQMTTMGGVTLAKVNFPTPAFWTTLFARFPTMARTMHILKPMIVNSVEVFIVFAG...RAND.GALTCSPALHQYLTELFARV----vnvm..........................
LMBD2_REOVJ/393-684 ....................PVAWLPQY-----.TIDQTA...LEDGDMVGHms.qlPLRPEYGSMWVGEALSYYVDYNQ.SHR.V.VAAKEL.PQLPDTYFDGDEQYGRSLFSLARRIGDRSLIKDTAVLKHAYQAI.DPSTGREYL.RAGQSVAYFGASAGHSGADQPLVIEPWLQGKISGVPSPA.SIRQFGYDVAKGAIVDLARPFPSGDYQFVYSDVDQVVDGHDDLSISSNLVESILSSCMQATSPGGSFVAKINFPTRSIWYYIEQKILPNITSYMIIKPFVTNNVEVFFVAFG...VHRQ.SSLTWTSGVYFFLVDHFYRYETLS..............................
E7DDK3_9VIRU/397-689 ....................PLRWQPQWSDIST.QTLGDD...DDYQHALVK.....GKVYKLGVGFSGGAFIRTWSSSS.GGM.V.IRDDDM.PELPLEYFGVQQQHRRSIFSQLRKTGDKSLLKDAAVLQFVSTVM.DPHAGEPVL.KDDFSMLYLGASNIHTSSNEPLILDRLRKGTVPGVPGTT.HITQMGYEVVHGPVIDARKPIPTGTYTLVYSDVDQIVNGGEDMVAATETAKRVTLVALSCTTLGGITVVKINFPNRRWWTVFFNTFRQSARDYALVKPMIVNNVEVYLVMMH...RTMS.GNLPPTTNLRLFLGQLMTRYREID..............................
A0A0S2EGR0_9VIRU/426-685 tisniwdglplvdfakfgna-------------.------...---------.....-----------------------.AAT.P.VDPRLR.KEFPNDYFDREQSINRMLFRGYRKTIDRSWAKDQAVLETIFSIAgNWLTAN---.-KSYTAAYFGASGIHPNDDQPLVIDPWSKGTIFGVPAPSsKVSQYGYDVSNGVITDLTRPSPSGTFSFIYCDVDQVQDAGDDLGVCYQIVRSLFDTINDALTTGGSFVMKINFPTRQIMDYLVEVVAPKFTDGVLIKPVVSNNLELFVGFFC...KVDN.RGCHWNSDCSRFMFRLHNRYNHLD..............................
A0A1B2FIA2_9REOV/415-705 ....................PIKWSPPSRDALG.DLTEAKetiTEYEDLNVS.....---QSVEAVWDGDAFVDIALFTS.KNQ.F.QQSLELvPEFPGDYFDDVESMDRMIFRNARKSGDRSLTKDTAVLQS----V.FANTGDWVLvNENYTAAYFGASGDHPTANEPLVIEPWMKGRIAGVPAPSgKIAQFGYDVTNGVICDLRYPAPSGTYAFIYSDVDQVLDGGDSLARCYDAVGKLVSTIMDSLSPGGSFVMKVNFPTTDIIEKLVDILSLAFSAGMLIKPMVANNTEIYVAMLR...LGGP.G-CFWTSECTRFMRRLYDRYY---hma...........................
#=GC seq_cons ....................PlpahPQYp.ss..shspAs...hshtctsl......PlpspaGthasGsshhphsshst.sss.s.hssspL.PphPssYFst-pphsRslFophRtsuDRSLlKDsAsLpashshh.ssssup.hL.psuhShAYhGASusHsssspPhlIcshppGplsGVPhPo.pIpQFGYDVspGsIhDlspPhPoGTFsaVYSDVDQV.DuusDlssuscsshsllssshphsosGGShlhKlNFPTstlWshlhpplusphsohhllKPhlsNNlElallhhs...http.sshh.sssl..ahhpha.R.t.................................
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