#=GF ID   Reovirus_M2
#=GF AC   PF05993.16
#=GF DE   Reovirus major virion structural protein Mu-1/Mu-1C (M2)
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_5584 (release 9.0)
#=GF GA   25.00 25.00;
#=GF TC   277.30 277.10;
#=GF NC   21.40 21.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   1328674
#=GF RT   A carboxy-terminal fragment of protein mu 1/mu 1C is present in
#=GF RT   infectious subvirion particles of mammalian reoviruses and is
#=GF RT   proposed to have a role in penetration. 
#=GF RA   Nibert ML, Fields BN; 
#=GF RL   J Virol 1992;66:6408-6418.
#=GF DR   INTERPRO; IPR009113;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several Reovirus major virion structural
#=GF CC   protein Mu-1/Mu-1C (M2) sequences. This family is family is
#=GF CC   thought to play a role in host cell membrane penetration [1].
#=GF SQ   21
#=GS A0A193BJ74_9VIRU/2-650  AC A0A193BJ74.1
#=GS A0A0A1CEU1_9VIRU/3-636  AC A0A0A1CEU1.1
#=GS W8PTM5_9VIRU/2-673      AC W8PTM5.1
#=GS Q5IW22_9VIRU/2-676      AC Q5IW22.1
#=GS A0A3G1HJT8_9VIRU/2-673  AC A0A3G1HJT8.1
#=GS A0A0B4ULC4_9REOV/2-650  AC A0A0B4ULC4.1
#=GS MU1_REOVJ/2-674         AC P12397.3
#=GS H9XH59_9REOV/2-636      AC H9XH59.1
#=GS VP4_AQRVG/2-649         AC B2BNE4.1
#=GS MU1_REOVD/2-674         AC P11078.4
#=GS A0A0S2EGQ7_9VIRU/2-658  AC A0A0S2EGQ7.1
#=GS G0YZM3_9VIRU/2-673      AC G0YZM3.1
#=GS E7DDL3_9VIRU/2-648      AC E7DDL3.1
#=GS A0A1B2FIA3_9REOV/2-652  AC A0A1B2FIA3.1
#=GS VP4_AQRVC/2-647         AC Q8JU57.1
#=GS A0A1S6PCU2_9VIRU/2-649  AC A0A1S6PCU2.1
#=GS D6MM24_9VIRU/2-672      AC D6MM24.1
#=GS W0FYR2_9VIRU/2-675      AC W0FYR2.1
#=GS A0A0A1ED71_9VIRU/3-674  AC A0A0A1ED71.1
#=GS MU1_REOVL/2-674         AC P11077.4
#=GS A0A0B5CN15_9VIRU/2-674  AC A0A0B5CN15.1
A0A193BJ74_9VIRU/2-650             .GNVQTSTNVYNVNGDNNAFTPNSEMVASASPAIDLKPGVLNPNGKLYQLES..GS.AP...DPS..NL............................VIVVDAtEG.DFSYI.TNNTWETLNKSALETNSWEPLFAVTMTGCGPLKLNDYTV.TMSGYVGASADDAFDGGVVEDGMFISSRRLKNFKLMLSNRCEAIAKWNTSLNQAMSLLTPDLLAGSGSCKWKSILQYMQATLPADNEVLQYPDEFYTVAVSKYPALKPGA.S-PNTPLPVAGPLGEIASVMNAASSSVGLMNGSSALLTSAMDTLAAKNLDLVCAEAPLPVATFAPSLVPRDYRPAFIKDADAHWITSVDP..SA..I..IRVTT...A.LS.GR.D.YTVQLGP...........GA.TKLIDMNRMVDADLLLDVSGMPINWL.......DNP...DYATAVAAIVLLEAKVPATEINVAADITGVS..V.V.........ASSPLSIV....NST.INV......R..GQSYLEMLHLRTTFERET..IAG.K...P...YIYGFGCLM.LLSPTTSSNTRNP..TLMDGLLTVTPILLRETTYKGEIVEEIVPSDILGNHTSEEMAVALANDAVFLMENSLKEVAEVIGSAVPIASDIDDSA........TASVVSRLAIAETIsmRARS.GNYRA.FP.DFGALWKKAKRAASLFVSNPKSVLQVGVPVLASAGVLDALTSAVGTSVRTGNIGKGVQDAVSILRARNSVTKLRQGFFSKIEELWP-v..
A0A0A1CEU1_9VIRU/3-636             .GNATSIVQNFNIKGDGNTFSPSAETASSAVPSLSLNPGLLNPGGKAWTLIDptVP.AT...APG..SLrlmttedvpaalgtsilgsngaapssgmYLVP-V.KE.TLNVV.TDHAIAQFEKLQSAYELDRDYLDEKGVAPESVSFKNYLT.YVDCYVGVSARQAATNFQKHVPVVTKS-KMMSFMTSAQNILSLLGPWEKSIREVLTMLPSSTPYGTLKCDMKAIVAMLEEQLPEGNLCRLYPQAAACSIARRNGGVR--W.KEPNSDEAPSLATNDVAASTMGALANTTPLADKSNTTEESMRLVSESSVDLICSRRPISASVWARTVEPKSYNIRTLKVSEALWLRQSQV..SA..G..FDVAY...N.LNdST.Q.RHFWITT...........G-.TTVINLEQTGSMMFEVNIEGK--DYK.......KGS..fQPNGATLVLLVMQSRLPFETWTVSSQIEGIA..Q.V.........ASIVVTAG...sGST.VNTs....iI..GSTSLSY-----LFERET..ITT.A...NtevNTYLLCTWQ.SSSVCTDAD-SWP..DAWDAVTTLTPLTTGTVTVKGSTVEKVTPVDLIGSYTPESLTAALPNDAGNILALRAETLAKAVKNE--DDSVTDESSp......fSAPIQGILALQQKE..TEGT.AGTPD.PK.PPGTLQKIASRAMHMFLGDPKSVLKQTTPVLKDPQVWTSFVQGVRDGIR--------------------------------------...
W8PTM5_9VIRU/2-673                 .GNASSLVQNFNITGDGNSFAPTADQTSSAVPTLSLQPGILNPGGLAFKLID.pTKdPT...DPG..ALaimttedlpelai.tdtnnsagalpisgMYLDSK.PE.KLTVV.TDHALEQMRKNESAVEISRPYLSRIAVMPQSTFFTDYVVkIKGCYVGASATQASRTYVEGPYVITQSRMTTYMS-IMATASNALSKWSRAVTEVLNIIPTTTPYGKTECDMRSIIKFLDQVLPEDHLARDYPEEMAETVAKINGGIR--W.KDELTGKATSLAINDVAAPTMATLSNTMPLAEKSETTTDSLSLINDADVDLMSCDRPISSTVWARTVEPKDYNIRVLPLEASMWLRTAAL..TA..NfvVSWKS...K.ES.DA.T.NYIKIMT...........G-.ARVINLEQTGTMTFTVDLEGK--NYK.......TTS..fDPNGKTVGLVAMQSKVPFEQWTAASMVIGAT..M.V.........ASEVLVAA....QSS.--T......P..GASIIAKTALTYIFERET..IPL.AdteV...NTYLFCGFV.LTETPTESNYPWY..DVWDATTTLTPMTTGTVTVNGSTVNEVVPTSLIGAYTPTAMSAALPNDAGVILQGRAEKLAKAIKNEDDS-------Vade.astySMPIMGVLALQD--..AGKP.TMRAK.FD.PVGLL-KKASRAFQMFLGNPKSILDMTTPVMKDPAVWRALAQGVRDGIRNKSMGAGVKSIFDKVSATKSVQKWKQGILTQIQTLYP-p..
Q5IW22_9VIRU/2-676                 .GNATSVVQNFNIQGDGNHFAPSAETTSSAVPSLSLNPGLLNPGGKAWVLID..SS.LN...ASDpsSLrlmtsadlstlsq.saignstgflptsgMYAVTA.KE.TLSVI.TEHAISQFDKLQMACELDRDYLDARGVSPESVNIHNYIV.YVDCFVGVSARQAASNFRQHVPVITKSRMTQFMT-SAQNVLQVLGPWERDVRELLTILPTSTTAGKITCDMRSVVTFIDDQLSDTSLCRMYPECAAAAVARRNGGIRWKT.PETDEAP--SLATNDIAASTMGALANTTPLAEKSDSGEESMRLVNDVGVDIVCSRAPISSSVWSRTVEPRSYNIRTLRVEEALWLRECQA..TTgfD..VQYTL...P.DQ.AT.H.KHFWLQK...........GS.-VVINLEQTGSMMFDVNIAGK--DYK.......KGT..fNPDNRKLVLLVMQSKIPFESWTVASQITGIA..Q.V.........AEVTVHAA...dSST.PNQ......KiiGETSLSY-----LFERET..VTT.S...DteiNTYLLCTWQ.LDDKQSNDANVWP..DAWDGITTLTPLTSGTVTIKGTSVDSVVPSDLVGAYTPESLAAALPNDAGLILANKATKLADAI-------KKEDDSVvde.sspfSTPIQGVLAVQQ-L..DTVGtRGARA.LQ.PPSILKRIASRALHMFLGDPRSILKQAIPVLRDPDVWTGFVQGVRDGIRTKSLSAGVRSVYNNVTATQSVQTWKQGFLTKIQMLF--kps
A0A3G1HJT8_9VIRU/2-673             .GTASSLVQNFNIYGNGNVFRPTADQVSTAVPTLSLQPGVLNPGGLAWRRINpdVD.PT...APG..ALiqmttddiptasl.tctenasglvpvnaMYMMLK.KE.ELVVV.TDHAIDQMHKLEYAMELSRAYLNEKSILPQSTSFDSYVI.RVDCYVGASALQAARNFVRGAPLITRSRMVAYMT-AIQNAFEILSDWESDIREAMNLIPSTTPYGATTCDMQSVIKFLDENLPENSLVRLYPQQAADSIARRNGGIR--W.KDEVTGDVPSLATNTVAAATLGVINNTVPLGEKSDVTSEAMSLVTVVKPDLVTSMRPVSSSVFATTVSPKTYNIRAQPVMEALWLRTAAAgvDM..V..VGWWS..eE.HA.AT.H.YTV-IRP...........-G.TKVINLQQTGSMLITVDLVDK--DYR.......TVH..fNPDGQTVILLLLQSKIPFEQLTSPTELIGVA..Q.V.........ASVVLSAS....DSS.--T......E..GSAIINNTNLSYLFEREI..LRG.P...DtevNTYLLCGFR.TDSQPTKENMPWY..DAWDAKTTLTPLTTGEVTLNGAAVPFVTPMSLIGAYTPEAMQGALPNDAGILLAERAMNLAEAI--KLEDDSMADEASp......fSAPIQGVLAIQQ--..HEPG.EGVKAwLG.PFDIL-RKAARAIQVFLGNPKSVLMQGVPVVSDPNVWIAMVQGIRDGIRNKSLSVGVRTALDNLNAVQSVRTWKSDFLTKVEKYYP-p..
A0A0B4ULC4_9REOV/2-650             .GNVQTSTNVYNINGDNNAFTPNSEMVASASPAIDLKPGVLNPNGKLYQLEA..GS.AP...DPS..NL............................VLAVDAsEG.DFSYL.TTNTWETLSKSALETNSWEPLFAVTMTGCGPLKLADYTV.TMSGYVGASPSDAFDGGVVEDGMFISSRRLKNFKLMLSNRCEAIAKWNTSLNQAMSLLTPDLLAGSGSCQWKSILQYMQKALPPDNEVLQYPDEFYTVAVSKYPALKPGTsPDT--PAPAAGPLGEIACVMNAASASVGLMSGSSALLTSAMDTLAAKNLDLVCAEAPLPVATFTPSLAPRDYRPAFIKDADAHWITSINP..SS..N..IRVTT...T.LS.GR.T.YTVQLGP...........GA.TKVLDMNRMVDADLLLDVSGMPINWL.......DNP...DYATAVASIVLLEARVPATEIDAAGDILGVS..V.V.........ASSPLSIV....NST.VNV......R..GQTFLEMLHLRTTFERET..IAG.K...P...YIYGFGCLL.LLSPTTSSNTRNP..TLMDGLMTVTPILLRETTYKGEIVEEIVPSDILGNHTSEEMAVALANDAVVLMENSLKEVAEVIGNAVPIASDLDDSA........TASVVSRLAVSETSslRSRS.GNPRA.LP.DFGALWKKAKRAASLFVSNPKSVLQAGVPVLASAGVIDALTSAVGTSVRTGNIGKGVQDALSILRARNSVTKLRQGFFSKIEELWP-v..
MU1_REOVJ/2-674                    .GNASSIVQTINVTGDGNVFKPSAETSSTAVPSLSLSPGMLNPGGVPWIAIGdeTS.VT...SPG..ALrrmtskdipetai.intdnssgavpsesALVPYN.DE.PLVVV.TEHAIANFTKAEMALEFNREFLDKLRVLSVSPKYSDLLT.YVDCYVGVSARQALNNFQKQVPVITPTRQTMYVD-SIQAALKALEKWEIDLRVAQTLLPTNVPIGEVSCPMQSVVKLLDDQLPDDSLIRRYPKEAAVALAKRNGGIQ--W.MDVSEGTVMNEAVNAVAASALAPSASAPPLEEKSKLTEQAMDLVTAAEPEIIASLVPVPAPVFAIPPKPADYNVRTLKIDEATW------..--..-..LRMIP...K.TM.NT.P.FQIQVTDntgtswhmnlrGG.TRVVNLDQIAPMRFVLDLGGK--SYK.......ETS..wDPNGKKVGFIVFQSKIPFELWTAASQIGQAT..V.VnyvqlyaedSSFTAQSIiattSLA.YNYepeqlnK..TDPEMNY-----------..---.-...-...--YLLAAFI.DSAAISTSNMTQP..DVWDALLTMSPLSAGEVTVKGAVVSEVIPADLVGSYTPESLNASLPNDAARCMIDRASKIAEAI--------KIDDDAgpdeyspnSVPIQGQLAISQ--..LETG.YGVRI.FN.PKGILSKIASRAMQAFIGDPSTIITQAAPVLSDKNNWIALAQGVKTSLRTKSLSAGVKTAVSKLSSSESIQSWTQGFLDKVSTHFPA...
H9XH59_9REOV/2-636                 .GNAQTSVTNVTVNGDGNVIRPSAEFQATAAPSFDLNPGVLNPNGNLYIEQPdmDA.TV...TAQ..SL............................VLLHDK.TGsPYAYV.ADNTRETLDKIVNYIANFQPLLEASGLTCPPRMISFYCE.RMSGYVGTSAITAINN-PVEDGEFITQAKMAQFRKQLGLFYDKVKDWHVDLKMAQAMLPLNVPTGTYQLEFTSYRDFMTEYLPESNICKLYPDEALEVAANLIPAIRTGL.T-KEI--SDVNSTGLIAGAIMAPQEGGGSLTDGSNTGTSLLQDVASMNANVITASSTIPVSSLNVIPEPKSFSYDSLAPDEVYWIQQV-P..SV..Q..VRFSV...D.VE.TV.T.YYMGFEP...........AQvNTVIDLRECSSASFVFDLTGT----Q.......FAA...DYPTSKLGLLMIRLTDSITAVTPSTEIKANV..LeI.........SDATIQQR....S-R.KAV......S..GLSQLATTVLTYTYEREV..LPNdD...A...YYYLVPCTM.QPTAYTA--LNYP..CSVGGTLTVTPIDNTEVTVNGIMVDSIIPSELIGSQTEEEQMTCLPNEAAELLKHKVQICAGTIAKMDPSGVSEDTPA........VAAVAGILALQN--..----.ETRAV.RL.DIKSLFSKARRAINMLVGRPSTVLGLAKPVISDPNVWMQIATGVAEAVASGNVNSAMRDSARRLAALRSVSGAKGKLLSLVAQRFP-p..
VP4_AQRVG/2-649                    .GNVQTSTNVYNIDGNGNTFAPSSQMASTASPAIDLKPGVLNPTGKLWQTMG..TG.AP...SAD..SL............................VLVVDN.KG.EYTYL.SENMRETLNKAVTDVNMWQPLFQATKSGCGPVVLANFTT.ISTGYVGATADDAFSNGLVSNGPFLATMHIMELQKTIAARMRDVAIWQKHLDTAMTLMTPDVSAGDVTCKWRSLLEFAQDILPLDNLCRSYPNEFYTVAAQRYPAIRPGQ.PDTQVALPQPHPLGEVAGSFNAPTSEVGSLVGAGAALSDAISTLASKDLDLVEADTPLPVSVFTPSLAPRTYRPAFIDPQDAAWIAQWNG..DA..N..IRIIT...T.YQ.ST.D.YTVQLGP...........GP.TRVIDMNAMIDAKLTLDVSGTILPFQ.......ENN...DLSSAIPAFVLIQTKVPLHSVTQASDVEGIT..V.V.........SAAESSAI....NLS.VNV......R..GDPRFDMLHLHAMFERET..IAG.I...P...YIYGIGTFL.IPSITSSSSFCNP..TLMDGELTVTPLLLRETTYKGAVVDTVTPSEVMANQTSEEVASALANDAVLLVSGQLERLATVVGDVIPIASGEDDAA........TSAIVGRLAIEATM.rARHG.GDTRA.LP.NFGQLWKRAKRAASMFASNPALALQVGVPVLADSGILSALTSGVSTAIRTGSLGKGVSDASSKLNARQSLTLARKTFFKKVEELWPS...
MU1_REOVD/2-674                    .GNASSIVQTINVTGDGNVFKPSAETSSTAVPSLSLSPGMLNPGGVPWIAVGdeTS.VT...SPG..ALrrmtskdipetai.intdnssgavpsesALVPYI.DE.PLVVV.TEHAITNFTKAEMALEFNREFLDKMRVLSVSPKYSDLLT.YVDCYVGVSARQALNNFQKQVPVITPTRQTMYVD-SIQAALKALEKWEIDLRVAQTLLPTNVPIGEVSCPMQSVVKLLDDQLPDDSLIRRYPKEAAVALAKRNGGIQ--W.MDVSEGTVMNEAVNAVAASALAPSASAPPLEEKSKLTEQAMDLVTAAEPEIIASLAPVPAPVFAIPPKPADYNVRTLRIDEATW------..--..-..LRMIP...K.SM.NT.P.FQIQVTDntgtnwhlnlrGG.TRVVNLDQIAPMRFVLDLGGK--SYK.......ETS..wDPNGKKVGFIVFQSKIPFELWTAASQIGQAT..V.VnyvqlyaedSSFTAQSIiattSLA.YNYepeqlnK..TDPEMNY-----------..---.-...-...--YLLATFI.DSAAITPTNMTQP..DVWDALLTMSPLSAGEVTVKGAVVSEVVPADLIGSYTPESLNASLPNDAARCMIDRASKIAEAI--------KIDDDAgpdeyspnSVPIQGQLAISQ--..LETG.YGVRI.FN.PKGILSKIASRAMQAFIGDPSTIITQAAPVLSDKNNWIALAQGVKTSLRTKSLSAGVKTAVSKLSSSESIQNWTQGFLDKVSAHFPA...
A0A0S2EGQ7_9VIRU/2-658             .GNYQTSNNQFWVTGDGNDFSAEGGLDSTNAASLDFKAGKTNPGGHMYVISGdnTSdVV...KWD..SL............................TPLYGI.DG.QMVVVlTAVAMSTFEKMVNLIEMYRPLLEASQQMACYRDWKKDIV.LLDGYVGSTPQSAVTNF-VTGASVINLRELRSLGKMYQNILGVIANYDRDIQVALSLIPHSTPIGSLSADMHSILRMFSLSLKPTNVCYLYPEAALQVIRAISPTVR--N.VDTQQGGSIVETLNLFEPVFNGTGPNQPPLTDQSEVRAIARSDASLAQLSLISSTEPIEARALKSGTPTKTYDIRLVDPLTTPWVSKASAlaEK..T..ARIQF...T.DS.GRkT.WYTAVGK...........G-.TLALHLDDITSMSITMDLGGESYYYKtlannaaETV...DPESATVAFILFSVTRPLEEITTASELQTGK..I.V.........-AFEKLMV....AN-.SSV......Q..GAKIIANTSLKYNFDHNS..ISG.D...KselNHYLLCQLL.FNNLSASTTYTQQ..DAWAGKTTMQSLDSDKVTVKGVEVDRVIPAGAFGNYTTAEQKSSLPNDLHSVMATHLERAAKAM-TAID---DEDQEGgs....tiANAIFGALISKE--..SPVA.GPIPW.KNiKFDELRVLSDKAASSFKRDPSQALISHDPVLGDSAVMTSLLGGIGNAVKTKGLSAACKDTKSALTAAQSGRSVRQTILDKIEKLFP-p..
G0YZM3_9VIRU/2-673                 g-AGSSVVQHFEVYGDGNVFSPDARQATSAVPQLDLNIGDINPGGICFTLVSgaRD.PS...SAG..ALrrlttrdvsqqa....frdqthrisnddEFLSDN.TE.VYFAL.TEHAIEQFGKLENACEIDRAYLNANGLLTTTFQLRHYYY.THSCYVGVSAEQAAKNFVK-DAKIMSSRQLISYFSAVQNALTALAQWEVSIRQVMNLIPMTTPFGSTKCDMTSVVQFLDANLPEEHPVRYFPYEAALSISRRNGGIR--F.KD-KRGETLSNAVNAVSSAAGAPLSNALSPAYKSSIARQALNDLDVADIDVLSSSRPIASSVLARSMEPQQYNIRALPASSTMWLRQLYQ..NV..SfeVGWEN...T.ET.HT.R.HYFEIK-...........FG.TKAIHLNSMGSMNVLVNYGNK--SYS.......APG..fDPDHKQVYLLLVQSKIPFEDWKRAEDIIAIL..P.L.........ASTTLHAE....EGSfYNT......K..L---LDETALNVLFEKEL..IAE.SgdeV...NSYMLCTFV.SDQGRVGGNAITPfaDAWDANTTFFPLTLGDVSVNGTSTHRVTPSVLFGSYTPDILHSALPNEAGLIIGRRMARVAGAI--------KADDSTnpgevsvySTPITGRLILQQSR..AQNV.RGTAM.PH.HKGALFKLGSRALHMFMGRPESVMLSQTPIVRDSSVMVGLLQGARDGLRNKSISAEPKISNDSIGAMRSVQLLHQGLLNEVQTLYP-p..
E7DDL3_9VIRU/2-648                 .GNVQTNNTTVNINGDGNSFGAESGMQSTAAPEIMLSPGKLNPNGLAWMKVA..RS.GT...GPG..SL............................QIVHAT.DGsPYCYI.PPDAMSSMEKSAGAVNLWEPLFAAIFETCSTVNVSDFTD.EFSAYVGVSEPEALKK-YIEKGVFMSTSQAKNFLGTLGQRMARIKGWSEDIRTAAAMIPVDTPHGSVTCDWKSLLRFWDENLPVDNVCKQYQNAVYEVALKIYPALRAGN.S----GSLLSDVVGVLAGGAAGTTASGVSMVEGVTRNEQVSRILTSADVDILTSSAPVPVSALRTPPVELSYQPSALSAKTTPWLVRYPG..TT..A..IEKTFdvgT.TS.KT.T.YYLSMGNs.........gGG.DLVIDLKRLPACGLEYSLRGIPIIYD.......TNLtaaKLAKVTPALLMLQTAKPLSAEITAADIQAITplV.V.........GTDKLNTLv..tTGF.GNI......R..NIADFSM---SAIWEPET..VSA.A...G...NYYLWPTVIgDASMTSDWGTIST..SLANGRLRVAPLDLTHALHKGNVVESIVPSDVLGNASPEEMRSALPADVLTAFKAKLTTVASVVGRALNPNDSAHAPS........SGTVLGPLAIEN--..----.KAQSK.PK.PVSDLWIAARRGVNLFVASPSASLQTGVPVMGDSSVLTSLTGGATTALNTGDMGTPSLEATAKRAARVAGGLLRQRVMDKLTRYWP-p..
A0A1B2FIA3_9REOV/2-652             .GNYQTSNNQFWVTGDNNTFEAAGGLDSTNAASLDLKAGRTNPGGYLYVVTE..TD.VSgvvKWQ..NL............................TPLRGM.DG.QYVVVlTAAATDAFDKMVNLIEMYRPLLDAGQQMTCYQDWKKQVV.IMDGYVGVSAQAAVNN-YVKDAVTINLTQLQNLGRMYQNMFGTIAKYDRDIQAALATIPHSTSIGGLTTDMHSLLLLYSKSLKKDNVVYLYPEAAIAVIRKISPTLRN-T.A--DDNTAVVETVNIFEPVFNGTGPEQPPLTDQSEIRSIARSDASRAQLSLITSTEPIEAKALKSGTPSKTYNLRLLDAVTTPWVSKASA..LT..K..ITRIT...V.QD.SA.KkSWYTVVS...........KD.TTALHLDDITSMAITLDIGGESYYYK.......KADkevDPKKATLAFLYFTSTKPLEEIAVATDIQSAK..I.Vat....eklTSATSSIA....GAS.IVS......N..TALHYNFSHKMLRSDRTE..VN-.-...-...-HYLLAQLL.FETLDQDTDYPQP..DAWAGRTTLQSLDSDKVTVKGVEVDRVIPATAFGNYTPAEQKSALPNDLHNVMSVHLERAAKAL-TAI---DDEDTEGvs....tiSNSVYGALIAAQ-S..PAPG.PMPWK.NI.KFEELREQANKAVSSFKRDPSQALVAHDPVLGDSTVMTSLLNGVGSAVKTKGLSTASKDSRSMLTAAQSGQELKQKILDKMAALFPA...
VP4_AQRVC/2-647                    .GNVQTSVNTYNITGDGNSFTPTSDMTSTAAPAIDLKPGVLNPTGKLWRPVG..TS.VA...TID..SL............................AIVSDR.FG.QYSFV.NEGMRETFSKALFDINMWQPLFQATKTGCGPIVLSSFTT.TTSGYVGATAGDALDN-PVTNGVFISTVQVMNLQRTIAARMRDVALWQQHLDTAMTMLTPDISAGSASCNWKSLLAFAKDILPLDNLCLTYPNEFYNVAIHRYPALKPGN.PDTKLPDAQAHPLGEVAGAFNAATSEVGSLVGSSSTLSQAISTMAGKDLDLIEADTPLPVSVFTPSLAPRSYRPAFIKPEDAKWIAEFNN..SS..L..IRKTL...T.YS.GA.T.YAVQLGP...........GP.TRVIDMNAMIDSVLTLDVSGTILPYD.......TNP...DLSTSVPAFVLIQTSVPIQQVTTAANITAIT..V.V.........SAAGASAI....NLA.INV......R..GQPRFNMLHLQATFERET..ITG.I...P...YIYGLGTFL.IPSPTSSSNFSNP..TLMDGLLTVTPVLLRETTYKGEVVDAIVPATVMANQTSEEVASALANDAIVLVSNHLNKLANVVGDAIPVASKTDDSA........TSAIVSRLAVQHKL..SQVG.QTSPT.PP.DYPLLWRRAKRAASMFVSNPSLALQVGIPVLTQSGMLSALTSGVGTALRTGSLGKGVTDASEKLRARQSLTVAKQAFFDQIGSLWPG...
A0A1S6PCU2_9VIRU/2-649             .GNVQTSTSVYNINGDGNSFAPTSEMVASASPAIDLKPGVLNPNGKLYVLSG..SS.AP...SPD..NL............................VLYVTQ.KG.DYSYI.VTNTHDTLSKAALESNSWEPLFTVTRTGCGPLQLSDYTS.HHSGYVGANADDAFANGPVDEGEFISSTDLKNFKTTLANRMQSVAEWSQYLDQAMSLLTPDIMAGTAGCKWKSVLEFLTSILPLDNLVLTYPNEFYTVAVGKYPALKPGT.TPS-SPPPSAGPLGEIASVMNAASSSVGLMNGSSAVLAAAMDKIAAKNLDLISSDSPLPVATFTPSLAPRSYRPAFIKQDDAHWISVMNP..TA..I..IRVKT...E.VS.AA.H.YTVQIGP...........GP.TKMLDMNRMIDSTLLLDISGAHIDFM.......DNP...DYSSAVPAIVLLETRVPYDEVQLAADIVGVS..A.I.........AAASLAVI....NMN.VNV......R..GKSFIEMQHLQATFERET..IVG.K...P...YVYGFGCLL.LASATASSNFKNP..TLMDGELTVTPILLRETTYKGDVVDSIIPSDIMGNQTTEELAVALANDAVVLMENNLSEIAKVIGDVVPVASDVNEAA........TSAVVSRLAIAETMsvRARS.GNPRA.FP.DFSALWSKAKRAASLFVSNPKAVLQAGVPILASSGVIDAMTSAIGTTVRTGSIGKGVQDAVSVLRARNSITRLRQGFFKKVEELWP-v..
D6MM24_9VIRU/2-672                 .GNYSSIVQNYNIRGDGNVFRPTADQRSSAVPTLQLRPGILNPGGLAWRLLEgqTD.PT...APG..ALvqvttldyptlnv.cnannktgllpvsgQFIKNV.KE.EVIVI.EQSAICEFQKLQNAIELNRDYLSEQGILPQSANFSDYVV.YIDCYVGLSAEQASRNFLRSVPTTTRSRTTAYIT-IVQAALAQLNKWESALREVMTILPTSTSFGELECDMKSVVAYVDAVLPDDNLCRLYPEQAAAAIAMRTGAVR--W.KDTTTGDTPLQASNSITSVTQSVIGNAVPLGEKSDASIESLALVAKSNPDLVCSDRPTMGSVWSMLVPSKDYNIRAIPVLEAMWLRTTGD..KVgfD..ISWEE...K.AF.NN.T.YHIAIRT...........G-.MKALFLDEISSCVLSVDFKDK--NYT.......TPQ..fNPSGKVVSLLVLSSKLPLEQITKPDDIMGIV..E.V.........SNVTLRAA....PSS.--T......Q..GASVIATTSLTYVFEREVlpIDK.S...V...HSYLLCMFR.SNEPTNATNYPWF..DAWDANTTISMLTAGEVTLNGVVTDTIVPTSLIGAYTPEVLASALPNDAGEIMTARAQILAEAI-------KREDDTMvde.aspfSAPILGQLALQT--..KTIG.VGSIR.GW.DPPRWLKQASRALQMFLGNPKSILSVTTPVLKDPNVWVGLAQGVYDAISTKSMSAGWRKAADRLNAAQSVRQWKQKVLGKIQKGFP-p..
W0FYR2_9VIRU/2-675                 .GNATSVVQNFNIQGDGNHFSPSAETTSSAAPSLSLNPGLLNPGGKAWTLIDptLN.AS...DPS..SLrlmtsadlstlsq.saignstgllptsgMYTVAN.KE.TLSVV.TNHALSQFEKLQMACELDRDYLDARGVSPESVDIYNYIV.YVDCFVGVSARQAASNFQQHVPVITKSRMTQFMT-SAQNMLQVLGPWERDVRELLTILPTSTTAGKITCDMKSVVNFVNDQLSDTSLCRLYPECAASAVAKRNGGIRWKQ.PDTDEAPSL--ATNDVAASTMGALANTTPLAEKSNSGEESMRLVNDVGVDIICSRAPVSSSVWSRTVEPKSYNIRTLRVEEALWLRECQT..SDgfD..VQYTL...P.DQ.ST.H.KHFWLQK...........GS.-IVINLEQTGSMMFEVNISGK--DYK.......KGT..fDPDNQKLVLLVMQSKIPFESWTSAAQITGIA..Q.V.........AEVTVHAA....DSS.TPGr...kiI..GETSLSY-----LFERET..VTT.A...NtevNTYLFCTWQ.LDDAQSNGDNAWQ..DAWDGITTLTPLTSGTVTVKGTSVDSVVPTDLVGSYTPEALAAALPNDAGRILANKAIKLADAI-------KKEDDSVide.sspfSTPIQGVLAVQQ-L..DTVGtRGVRI.VQ.PPSFLKRVASRALHMFLGDPQSILKQATPVLRDPDVWTGFIQGVRDGIRTKSLSAGVRSVYNNVTATQSVQTWKQGFLTKIQTLF--kp.
A0A0A1ED71_9VIRU/3-674             .GNATSIVQNFNIKGDGNTFSPSAETASSAVPSLSLNPGLLNPGGKAWTLIDptVP.AT...APG..SLrlmttedfpaalgtsilgsngaapssgmYLVP-V.KE.TLNVV.TEHAIAQFEKLQSAYELDRDYLDAKGVAPESVSFKNYLS.HVDCYVGVSARQAATNFQKNVPVITKS-KMMSFMTSAQNILSLLGPWEKSVREVLTMLPSSTPYGTLKCDMKAIVAMLEEQLPEDNLCRLYPQAAACSIARRNGGVR--W.KEPTSDEAPSMATNDVAASTMGALANTTPLAEKSNTTEESMRLVAESSVDLICSRRPISASVWARTVEPKSYNIRTLKVSEALWLRQSQV..TT..G..FDVAY...TlTD.ST.K.KHFWITK...........G-.TTVINLEQTGSMMFEVNIEGK--DYK.......KGS..fDPNGSTLVLLVMQSRLPFETWTVASQIEGIA..Q.V.........ASIVVTAG...sGST.VNTs....iI..GSTSLSY-----LFERET..ITT.S...NtevNTYLLCTWQ.SPTECVDAN-SWP..DAWDAITTLTPLTTGTVTVKGSTVEKVTPVDLIGSYTPESLTAALPNDAGNILALRAETLAKAVKNE--DDSVTDESSp......fSAPIQGILALQQKE..TEGT.AGSPD.PK.PPGTLQKIASRAMHMFLGDPKSVLKQTTPVLKDPQVWTSFVQGVRDGIRNKSLSAGVRSIVDNLSAVQSVKEWKQNVLGKIQKLF--kp.
MU1_REOVL/2-674                    .GNASSIVQTINVTGDGNVFKPSAETSSTAVPSLSLSPGMLNPGGVPWIAIGdeTS.VT...SPG..ALrrmtskdipetai.intdnssgavpsesALVPYN.DE.PLVVV.TEHAIANFTKAEMALEFNREFLDKLRVLSVSPKYSDLLT.YVDCYVGVSARQALNNFQKQVPVITPTRQTMYVD-SIQAALKALEKWEIDLRVAQTLLPTNVPIGEVSCPMQSVVKLLDDQLPDDSLIRRYPKEAAVALAKRNGGIQ--W.MDVSEGTVMNEAVNAVAASALAPSASAPPLEEKSKLTEQAMDLVTAAEPEIIASLVPVPAPVFAIPPKPADYNVRTLKIDEATW------..--..-..LRMIP...K.TM.GT.P.FQIQVTDntgtnwhlnlrGG.TRVVNLDQIAPMRFVLDLGGK--SYK.......ETS..wDPNGKKVGFIVFQSKIPFELWTAASQIGQAT..V.VnyvqlyaedSSFTAQSIiattSLA.YNYepeqlnK..TDPEMNY-----------..---.-...-...--YLLATFI.DSAAITPTNMTQP..DVWDALLTMSPLSAGEVTVKGAVVSEVVPAELIGSYTPESLNASLPNDAARCMIDRASKIAEAI--------KIDDDAgpdeyspnSVPIQGQLAISQ--..LETG.YGVRI.FN.PKGILSKIASRAMQAFIGDPSTIITQAAPVLSDKNNWIALAQGVKTSLRTKSLSAGVKTAVSKLSSSESIQNWTQGFLDKVSTHFPA...
A0A0B5CN15_9VIRU/2-674             .GNASSIVQTINVTGDGNVFKPSAETSSTAVPSLSLSPGMLNPGGVPWIAVGdeTS.VT...SPG..ALrrmtskdipetai.intdnssgavpsesALVPYI.DE.PLVVV.TEHAITNFTKAEMALEFNREFLDKMRVLSVSPKYSDLLT.YVDCYVGVSARQALNNFQKQVPVITPTRQTMYVD-SIQAALKALEKWEIDLRVAQTLLPTNVPIGEVSCPMQSVVKLLDDQLPDDSLIRRYPKEAAVALAKRNGGIQ--W.MDVSEGTVMNEAVNAVAASALAPSASAPPLEEKSKLTEQAMDLVTAAEPEIIASLVPVPAPVFAIPPKPADYNVRTLRIDEATW------..--..-..LRMIP...K.SM.NT.P.FQIQVTDntgtnwhlnlrGG.TRVVNLDQIAPMRFVLDLGGK--SYK.......ETS..wDPNGKKVGFIVFQSKIPFELWTAASQIGQAT..V.VnyvqlyaedSSFTAQSIiattSLT.YNYepeqlnK..TDPEMNY-----------..---.-...-...--YLLATFI.DSAAITPTNMTQP..DVWDALLTMSPLSAGEVTVKGAVVSEVVPADLIGSYTPESLNASLPNDAARCMIDRASKIAEAI--------KIDDDAgpdeyspnSVPIQGQLAISQ--..LETG.YGVRI.FN.PKGILSKIASRAMQAFIGDPSTIITQAAPVLSDKNNWIALAQGVKTSLRTKSLSAGVKTAVSKLSSSESIQNWTQGFLDKVSAHFPA...
#=GC seq_cons                      .GNspo.VpsaNlsGDGNsFsPoA-hsSoAsPoLsLpPGlLNPGGhsWhhls..su.so...uPu..uL............................hllsst.ct.shsVV.T-pAhssFsKhthAhEh.RshLssptlhssosphscals.hhssYVGsSAcpAhsNa.hpsslhhsoRphh.hp.slQsthpslupW-pcl+pAholLPsssshGsloCcM+Sllpalc-pLP-DsLsRhYPcpAhsslA+RssulR..h.hDsppuss.stulNslAuushustusssPLs-pSshsppAhshlsssslDllsSpsPlsuuVauhsstP+sYNlRsLcsp-AhWlpphts..ss..t..lchts...s.pp.us.s.aplplss...........Gs.T+VlsLcphusMthslDluGc..sYc.......css..hDPsspplulllhQS+lPhEphTsAopItuls..h.V.........uosslpuh....sso.hNs......c..Gpsplsh....hhFEREs..lss.t...s....hYLLssal..ssssosoNhspP..DsWDuhhTloPLsss-VTlKGssV-pVlPu-LlGuYTPEplsuALPNDAuhlhts+hpclAcAI.......pctD-sus.......SssI.GtLAlpp....tpsu.tsstt.ht.shuhLh+hAsRAhphFlGsPpolLptusPVLuDssVhsuLspGVpsulRTKSlusGV+susspLsAppSlpph+QshLsKlpphaP....
//