#=GF ID Reprolysin_3
#=GF AC PF13582.10
#=GF DE Metallo-peptidase family M12B Reprolysin-like
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE manual
#=GF GA 22.40 22.40;
#=GF TC 22.40 22.40;
#=GF NC 22.30 22.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0126
#=GF DR MEROPS; M12;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This zinc-binding metallo-peptidase has the characteristic
#=GF CC binding motif HExxGHxxGxxH of Reprolysin-like peptidases of
#=GF CC family M12B.
#=GF SQ 735
#=GS B4MYD0_DROWI/335-483 AC B4MYD0.2
#=GS A0A1H7I060_9GAMM/45-175 AC A0A1H7I060.1
#=GS A0A8B7P0P7_HYAAZ/369-517 AC A0A8B7P0P7.1
#=GS A0A7R9M4M5_9ACAR/339-490 AC A0A7R9M4M5.1
#=GS A0A6J1WAS7_GALME/387-535 AC A0A6J1WAS7.1
#=GS A0A6H5IYK9_9HYME/214-362 AC A0A6H5IYK9.1
#=GS A0A519G7F1_9MICO/155-263 AC A0A519G7F1.1
#=GS A0A4E0RTZ6_9GAMM/224-335 AC A0A4E0RTZ6.1
#=GS A0A3Q0IXN5_DIACI/317-435 AC A0A3Q0IXN5.1
#=GS A4B8Z2_9GAMM/51-159 AC A4B8Z2.1
#=GS A0A226DRD9_FOLCA/158-260 AC A0A226DRD9.1
#=GS K0RZE1_THAOC/304-449 AC K0RZE1.1
#=GS A0A8B8IS47_VANTA/377-525 AC A0A8B8IS47.1
#=GS A0A4Q5NNS8_9BACT/195-316 AC A0A4Q5NNS8.1
#=GS R4YZE0_9ACTN/382-454 AC R4YZE0.1
#=GS E2AEB8_CAMFO/250-399 AC E2AEB8.1
#=GS T1JDM1_STRMM/265-434 AC T1JDM1.1
#=GS A0A8B8GQE1_9HEMI/271-418 AC A0A8B8GQE1.1
#=GS A0A7M7JXV7_VARDE/475-626 AC A0A7M7JXV7.1
#=GS A0A834XKF2_9HYME/230-375 AC A0A834XKF2.1
#=GS A0A834IE72_RHYFE/2-50 AC A0A834IE72.1
#=GS A0A6J1RUH1_FRAOC/121-268 AC A0A6J1RUH1.1
#=GS A0A7K8RY47_9PASS/337-482 AC A0A7K8RY47.1
#=GS A0A1U9N6R3_9GAMM/51-161 AC A0A1U9N6R3.1
#=GS A0A5N5TE66_9CRUS/1-115 AC A0A5N5TE66.1
#=GS A0A1Z4R2K7_9CYAN/1546-1642 AC A0A1Z4R2K7.1
#=GS A0A6J1NRW4_BICAN/378-520 AC A0A6J1NRW4.1
#=GS A0A7D5QBV2_9EURY/50-174 AC A0A7D5QBV2.1
#=GS A0A261GNE7_9GAMM/45-173 AC A0A261GNE7.1
#=GS A0A4Q5T3D4_9ACTO/179-284 AC A0A4Q5T3D4.1
#=GS A0A853I9S0_9GAMM/48-172 AC A0A853I9S0.1
#=GS A0A4R6KTI1_9ACTN/193-290 AC A0A4R6KTI1.1
#=GS A0A1P8WQR4_9PLAN/95-220 AC A0A1P8WQR4.1
#=GS Q7MF03_VIBVY/44-191 AC Q7MF03.1
#=GS A0A026WD87_OOCBI/241-392 AC A0A026WD87.1
#=GS A0A6I8V4X2_DROPS/339-486 AC A0A6I8V4X2.1
#=GS A0A8W7IJD9_AEDAE/369-517 AC A0A8W7IJD9.1
#=GS B7Q492_IXOSC/3-105 AC B7Q492.1
#=GS T1J948_STRMM/229-359 AC T1J948.1
#=GS A0A0Q7Q759_9ACTN/215-295 AC A0A0Q7Q759.1
#=GS A0A7D5KFL2_9EURY/46-174 AC A0A7D5KFL2.1
#=GS A0A4R6PP94_9GAMM/199-327 AC A0A4R6PP94.1
#=GS A0A853IJ94_9GAMM/49-173 AC A0A853IJ94.1
#=GS D8R5G0_SELML/189-308 AC D8R5G0.1
#=GS A0A8R2R0V3_BOMMO/377-525 AC A0A8R2R0V3.1
#=GS A0A8B8IQE7_VANTA/377-525 AC A0A8B8IQE7.1
#=GS A0A7D5N2H6_9BACT/65-188 AC A0A7D5N2H6.1
#=GS A0A6I8VDK8_DROPS/339-487 AC A0A6I8VDK8.1
#=GS A0A257M171_9BACT/196-277 AC A0A257M171.1
#=GS A0A2P1PUG8_9GAMM/222-373 AC A0A2P1PUG8.1
#=GS G3I1N9_CRIGR/114-219 AC G3I1N9.1
#=GS A0A238UDS3_9FLAO/228-354 AC A0A238UDS3.1
#=GS A7SIU9_NEMVE/238-339 AC A7SIU9.1
#=GS A0A7Y6PRK2_9DELT/116-208 AC A0A7Y6PRK2.1
#=GS B8BPX1_THAPS/283-412 AC B8BPX1.1
#=GS A0A6A4VGZ7_AMPAM/297-445 AC A0A6A4VGZ7.1
#=GS A0A821TEB3_9NEOP/4-88 AC A0A821TEB3.1
#=GS A0A858RDK6_9BACT/294-372 AC A0A858RDK6.1
#=GS A0A853IGR4_9GAMM/55-198 AC A0A853IGR4.1
#=GS B0JJT5_MICAN/203-292 AC B0JJT5.1
#=GS A0A0B4KFG8_DROME/337-484 AC A0A0B4KFG8.1
#=GS A0A813ZFQ6_9BILA/45-182 AC A0A813ZFQ6.1
#=GS A0A0P9BW09_DROAN/334-481 AC A0A0P9BW09.1
#=GS A0A7Y9BL54_9ACTN/142-269 AC A0A7Y9BL54.1
#=GS A0A6J1QCP8_9HYME/262-410 AC A0A6J1QCP8.1
#=GS U4UCE8_DENPD/284-420 AC U4UCE8.1
#=GS A0A143PP17_LUTPR/59-163 AC A0A143PP17.1
#=GS A0A8J2J840_9HEXA/2-58 AC A0A8J2J840.1
#=GS A0A3S1BU27_ELYCH/435-559 AC A0A3S1BU27.1
#=GS A0A6A4X8B5_AMPAM/280-428 AC A0A6A4X8B5.1
#=GS A0A0P8Y920_DROAN/334-482 AC A0A0P8Y920.1
#=GS A3U7H6_CROAH/236-359 AC A3U7H6.1
#=GS A0A0F7ZYB9_9HYPO/73-201 AC A0A0F7ZYB9.1
#=GS A0A2A2KAJ8_9BILA/7-123 AC A0A2A2KAJ8.1
#=GS B4GBL4_DROPE/339-487 AC B4GBL4.1
#=GS A0A180FU82_9BACT/76-190 AC A0A180FU82.1
#=GS B7P5A5_IXOSC/1-54 AC B7P5A5.1
#=GS A0A1S3JI21_LINUN/277-422 AC A0A1S3JI21.1
#=GS A0A7J7FP01_DICBM/304-435 AC A0A7J7FP01.1
#=GS A0A7J8I2T9_MOLMO/4-92 AC A0A7J8I2T9.1
#=GS A0A820Y5A4_9BILA/105-224 AC A0A820Y5A4.1
#=GS A0A158N9V5_ATTCE/245-394 AC A0A158N9V5.1
#=GS B3PH79_CELJU/39-149 AC B3PH79.1
#=GS A0A8J6M6J2_9ALTE/199-325 AC A0A8J6M6J2.1
#=GS A0A850GLD4_9DELT/239-333 AC A0A850GLD4.1
#=GS A0A8B8GP91_9HEMI/271-419 AC A0A8B8GP91.1
#=GS A0A3B0J7P1_DROGU/333-480 AC A0A3B0J7P1.1
#=GS Q2MGN5_DROME/337-484 AC Q2MGN5.1
#=GS A4AN81_MARSH/219-345 AC A4AN81.1
#=GS A0A8J3Z5N7_9ACTN/44-166 AC A0A8J3Z5N7.1
#=GS A0A2P1PM15_9GAMM/268-390 AC A0A2P1PM15.1
#=GS A0A1I3FQP0_9ACTN/89-198 AC A0A1I3FQP0.1
#=GS A0A8J2JN68_9HEXA/281-429 AC A0A8J2JN68.1
#=GS Q2SL70_HAHCH/46-174 AC Q2SL70.1
#=GS A0A3L8PU61_9GAMM/44-172 AC A0A3L8PU61.1
#=GS A0A2X4PMJ4_9PORP/242-366 AC A0A2X4PMJ4.1
#=GS A3UB25_CROAH/237-358 AC A3UB25.1
#=GS D8T9D2_SELML/168-287 AC D8T9D2.1
#=GS A0A3N0DS55_9ACTN/138-256 AC A0A3N0DS55.1
#=GS A0A545UTB3_9HYPO/67-189 AC A0A545UTB3.1
#=GS A0A8R1W5L9_ACYPI/270-418 AC A0A8R1W5L9.1
#=GS A0A1S2VB81_9BACT/102-210 AC A0A1S2VB81.1
#=GS A0A834IFP7_RHYFE/316-461 AC A0A834IFP7.1
#=GS A0A668AMW0_9TELE/56-186 AC A0A668AMW0.1
#=GS B7Q2B9_IXOSC/243-330 AC B7Q2B9.1
#=GS E9PYF2_MOUSE/244-395 AC E9PYF2.1
#=GS A0A8B8IQD7_VANTA/377-524 AC A0A8B8IQD7.1
#=GS A0A6L2PNG3_COPFO/10-158 AC A0A6L2PNG3.1
#=GS A0A401PKZ3_SCYTO/4-133 AC A0A401PKZ3.1
#=GS A0A1M6SW63_9BACT/187-303 AC A0A1M6SW63.1
#=GS A0A1G9CMB4_9MICO/118-232 AC A0A1G9CMB4.1
#=GS A0A7H9BMA4_9NEIS/348-430 AC A0A7H9BMA4.1
#=GS A0A345P9K6_9GAMM/449-531 AC A0A345P9K6.1
#=GS A0A512M7S1_9BACT/303-388 AC A0A512M7S1.1
#=GS B0JJT8_MICAN/202-292 AC B0JJT8.1
#=GS A0A2T7PTH6_POMCA/222-331 AC A0A2T7PTH6.1
#=GS A0A2R8B8V4_9RHOB/85-204 AC A0A2R8B8V4.1
#=GS A0A8C4GXJ2_DICLA/229-369 AC A0A8C4GXJ2.2
#=GS A0A6P8Z931_THRPL/126-273 AC A0A6P8Z931.1
#=GS A0A232FA94_9HYME/650-784 AC A0A232FA94.1
#=GS A0A1Y1RNM9_9MICC/137-227 AC A0A1Y1RNM9.1
#=GS F2UNU0_SALR5/212-317 AC F2UNU0.1
#=GS A8FYH0_SHESH/167-297 AC A8FYH0.1
#=GS A0A6G0ZLY7_APHCR/312-460 AC A0A6G0ZLY7.1
#=GS A0A6J2JSM3_BOMMA/377-525 AC A0A6J2JSM3.1
#=GS E9FRL1_DAPPU/168-316 AC E9FRL1.1
#=GS Q5ZZG9_LEGPH/237-361 AC Q5ZZG9.1
#=GS A0A4P7JPZ3_9GAMM/242-367 AC A0A4P7JPZ3.1
#=GS A0A0N9I2D2_9PSEU/156-255 AC A0A0N9I2D2.1
#=GS A0A089L4G5_9BACL/47-156 AC A0A089L4G5.1
#=GS A0A813ZU80_9BILA/45-182 AC A0A813ZU80.1
#=GS A0A5C5VYM9_9BACT/99-194 AC A0A5C5VYM9.1
#=GS A0A0R3PXV7_ANGCS/1-69 AC A0A0R3PXV7.1
#=GS A0A8J7SL13_9BACT/303-393 AC A0A8J7SL13.1
#=GS A0A5C6DXL0_9BACT/73-207 AC A0A5C6DXL0.1
#=GS L8HA05_ACACA/179-301 AC L8HA05.1
#=GS A0A126T160_9GAMM/226-329 AC A0A126T160.1
#=GS A0A401Y8I5_9ACTN/163-255 AC A0A401Y8I5.1
#=GS A0A4P9VS47_9GAMM/51-179 AC A0A4P9VS47.1
#=GS A0A0Q7ZEW9_9ACTN/162-276 AC A0A0Q7ZEW9.1
#=GS A0A249SZE4_9BACT/203-298 AC A0A249SZE4.1
#=GS A0A6J8DDB2_MYTCO/218-327 AC A0A6J8DDB2.1
#=GS A0A6I9WT05_9HYME/262-410 AC A0A6I9WT05.1
#=GS A0A1Y3B8A4_EURMA/284-435 AC A0A1Y3B8A4.1
#=GS A0A0L0DLM4_THETB/356-442 AC A0A0L0DLM4.1
#=GS A0A5C4VQX4_9ACTN/152-266 AC A0A5C4VQX4.1
#=GS A0A6J3L3D6_9HYME/261-408 AC A0A6J3L3D6.1
#=GS A0A433T1U9_ELYCH/16-167 AC A0A433T1U9.1
#=GS B4I8T0_DROSE/604-672 AC B4I8T0.1
#=GS A0A453Z0T3_ANOGA/350-498 AC A0A453Z0T3.1
#=GS A0A672SI64_SINGR/72-217 AC A0A672SI64.1
#=GS A0A098S6X2_9BACT/78-204 AC A0A098S6X2.1
#=GS A0A345H3L6_9FLAO/238-360 AC A0A345H3L6.1
#=GS A0A5N4B159_PHOPY/314-461 AC A0A5N4B159.1
#=GS A0A443SQU4_9ACAR/279-430 AC A0A443SQU4.1
#=GS A0A8J2HGJ9_COTCN/190-340 AC A0A8J2HGJ9.1
#=GS A0A0F0HJH1_9ACTN/140-266 AC A0A0F0HJH1.1
#=GS A0A7M7H714_NASVI/289-437 AC A0A7M7H714.1
#=GS A0A098MCI4_9BACL/54-174 AC A0A098MCI4.1
#=GS A0A4P9VJC8_9GAMM/46-168 AC A0A4P9VJC8.1
#=GS K9PJ53_9CYAN/92-190 AC K9PJ53.1
#=GS B8CAS0_THAPS/411-523 AC B8CAS0.1
#=GS A0A833SDN1_9HYME/238-386 AC A0A833SDN1.1
#=GS A0A4V2A2H9_9ACTO/167-285 AC A0A4V2A2H9.1
#=GS A0A4R6UVG2_9GAMM/209-309 AC A0A4R6UVG2.1
#=GS A0A0Q5TL85_9BACT/9-130 AC A0A0Q5TL85.1
#=GS A0A1H9MGM2_9BACT/237-367 AC A0A1H9MGM2.1
#=GS A0A0C4Y5N2_9BURK/405-522 AC A0A0C4Y5N2.1
#=GS A0A7J7BSD9_9COLE/332-478 AC A0A7J7BSD9.1
#=GS A0A226DXS7_FOLCA/115-236 AC A0A226DXS7.1
#=GS A0A5C6DF96_9BACT/69-148 AC A0A5C6DF96.1
#=GS B7YZP6_DROME/337-485 AC B7YZP6.1
#=GS A0A2V0PML9_9CHLO/262-354 AC A0A2V0PML9.1
#=GS A0A7M7HC53_NASVI/289-437 AC A0A7M7HC53.1
#=GS A0A542SPL3_9MICO/131-259 AC A0A542SPL3.1
#=GS A0A5C8IG20_9MICO/239-365 AC A0A5C8IG20.1
#=GS Q3JD54_NITOC/242-366 AC Q3JD54.1
#=GS A0A7E5VIR0_TRINI/382-530 AC A0A7E5VIR0.1
#=GS A0A6J3C5W8_GALME/353-501 AC A0A6J3C5W8.1
#=GS F4X7S9_ACREC/263-411 AC F4X7S9.1
#=GS G2FBV7_9GAMM/26-147 AC G2FBV7.1
#=GS A0A6P8YFB9_DROAB/345-493 AC A0A6P8YFB9.1
#=GS A0A6P4YLM5_BRABE/276-411 AC A0A6P4YLM5.1
#=GS E1RHW1_METP4/251-391 AC E1RHW1.1
#=GS A0A0L0FJ31_9EUKA/245-371 AC A0A0L0FJ31.1
#=GS A0A835CV31_9HYME/240-389 AC A0A835CV31.1
#=GS K9QCL7_9NOSO/267-363 AC K9QCL7.1
#=GS A0A6P8WQT1_DROAB/345-493 AC A0A6P8WQT1.1
#=GS A0A4C1YAF4_EUMVA/12-127 AC A0A4C1YAF4.1
#=GS MEP72_PSEAE/45-175 AC Q9I060.1
#=GS A0A6I9XMC6_9HYME/262-409 AC A0A6I9XMC6.1
#=GS F5B3R2_9CAUD/122-214 AC F5B3R2.1
#=GS A0A3N0CGZ6_9ACTN/182-300 AC A0A3N0CGZ6.1
#=GS A0A2V4BQ82_9FLAO/3535-3665 AC A0A2V4BQ82.1
#=GS A0A834Y0E5_9HYME/280-414 AC A0A834Y0E5.1
#=GS A0A7M7QSG6_NASVI/275-422 AC A0A7M7QSG6.1
#=GS A0Z7P4_9GAMM/191-326 AC A0Z7P4.1
#=GS A0A0L8HWG1_OCTBM/112-251 AC A0A0L8HWG1.1
#=GS A0A0D9P162_METAN/84-205 AC A0A0D9P162.1
#=GS A0A2U3A477_9ACTN/15-129 AC A0A2U3A477.1
#=GS A0A2M9BUU5_9MICO/62-161 AC A0A2M9BUU5.1
#=GS A0A7Y9YG12_9ACTN/187-290 AC A0A7Y9YG12.1
#=GS A0A8J5TJX3_HOMAM/268-415 AC A0A8J5TJX3.1
#=GS A0A317F5A0_9PROT/201-291 AC A0A317F5A0.1
#=GS A0A023C0Z2_9FLAO/210-291 AC A0A023C0Z2.1
#=GS B8BUR0_THAPS/296-424 AC B8BUR0.1
#=GS A0A8H4VB96_9HYPO/72-211 AC A0A8H4VB96.1
#=GS A0A232F158_9HYME/323-470 AC A0A232F158.1
#=GS A0A2G3K2J5_9BURK/213-347 AC A0A2G3K2J5.1
#=GS A0A0A2LJF6_9FLAO/236-359 AC A0A0A2LJF6.1
#=GS A0A2J7PL26_9NEOP/102-249 AC A0A2J7PL26.1
#=GS A0A2T7PTM1_POMCA/234-352 AC A0A2T7PTM1.1
#=GS Q9W1J9_DROME/337-485 AC Q9W1J9.2
#=GS A0A1J1LWJ5_9CYAN/123-234 AC A0A1J1LWJ5.1
#=GS A0A3R7SY12_PENVA/454-588 AC A0A3R7SY12.1
#=GS A0A2C6AEM1_9HYPO/90-239 AC A0A2C6AEM1.1
#=GS A0A5N6MQC5_9MICC/183-303 AC A0A5N6MQC5.1
#=GS A0A2V1GY26_9GAMM/428-547 AC A0A2V1GY26.1
#=GS A0A8I6RAV1_CIMLE/235-383 AC A0A8I6RAV1.1
#=GS A0A6I9WUY4_9HYME/262-410 AC A0A6I9WUY4.1
#=GS A0A8B8CUU6_CRAVI/353-461 AC A0A8B8CUU6.1
#=GS A0A6I8TVZ5_AEDAE/369-516 AC A0A6I8TVZ5.1
#=GS A4EW16_9RHOB/150-265 AC A4EW16.1
#=GS T5APK0_OPHSC/107-235 AC T5APK0.1
#=GS A0A8B8IQD9_VANTA/377-525 AC A0A8B8IQD9.1
#=GS A0A447G6X6_9ARCH/195-334 AC A0A447G6X6.1
#=GS A0A4S8MZY2_9ACTN/170-263 AC A0A4S8MZY2.1
#=GS A0A1H4N1R6_9MICC/119-226 AC A0A1H4N1R6.1
#=GS A0A1V9XPV0_9ACAR/344-495 AC A0A1V9XPV0.1
#=GS A0A2N5Y5R4_9GAMM/195-290 AC A0A2N5Y5R4.1
#=GS A0A0S2F8E8_LYSAN/422-525 AC A0A0S2F8E8.1
#=GS B7QK26_IXOSC/2-108 AC B7QK26.1
#=GS A0A6J1QA22_9HYME/237-385 AC A0A6J1QA22.1
#=GS A0A0S9PZ04_9ACTN/220-343 AC A0A0S9PZ04.1
#=GS A0A5E4QBN2_9NEOP/340-488 AC A0A5E4QBN2.1
#=GS A0A0L0CQY7_LUCCU/4-89 AC A0A0L0CQY7.1
#=GS B8BUQ4_THAPS/341-469 AC B8BUQ4.1
#=GS A0A1R4H4X4_9GAMM/196-273 AC A0A1R4H4X4.1
#=GS Q7USV3_RHOBA/100-207 AC Q7USV3.1
#=GS A0A8R2D2V4_ACYPI/318-465 AC A0A8R2D2V4.1
#=GS A0A026WD78_OOCBI/210-358 AC A0A026WD78.1
#=GS A0A8J4Z9A5_9CHEL/276-427 AC A0A8J4Z9A5.1
#=GS A0A6P3XM04_DINQU/86-235 AC A0A6P3XM04.1
#=GS K7W9Y0_9NOST/64-193 AC K7W9Y0.1
#=GS U1MVG2_9EURY/58-163 AC U1MVG2.1
#=GS A0A2G1XP38_STRCJ/129-256 AC A0A2G1XP38.1
#=GS A0A4T0URV7_9ACTN/299-399 AC A0A4T0URV7.1
#=GS A0A8W8IWH2_CRAGI/44-141 AC A0A8W8IWH2.1
#=GS A0A834R210_SARSC/422-573 AC A0A834R210.1
#=GS A0A1Z4UNT2_9CYAN/88-190 AC A0A1Z4UNT2.1
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