#=GF ID   RnlA-toxin_DBD
#=GF AC   PF19034.4
#=GF DE   RNase LS, bacterial toxin DBD domain
#=GF PI   RnlA-toxin_C;
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF SE   C terminal of PF15935
#=GF GA   27.00 27.00;
#=GF TC   28.10 32.20;
#=GF NC   25.40 26.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0291
#=GF RN   [1]
#=GF RM   21927020
#=GF RT   Regulation of growth and death in Escherichia coli by
#=GF RT   toxin-antitoxin systems.
#=GF RA   Yamaguchi Y, Inouye M;
#=GF RL   Nat Rev Microbiol. 2011;9:779-790.
#=GF RN   [2]
#=GF RM   20980243
#=GF RT   Escherichia coli rnlA and rnlB compose a novel toxin-antitoxin
#=GF RT   system.
#=GF RA   Koga M, Otsuka Y, Lemire S, Yonesaki T;
#=GF RL   Genetics. 2011;187:123-130.
#=GF RN   [3]
#=GF RM   28085056
#=GF RT   RnlB Antitoxin of the Escherichia coli RnlA-RnlB Toxin-Antitoxin
#=GF RT   Module Requires  RNase HI for Inhibition of RnlA Toxin Activity.
#=GF RA   Naka K, Qi D, Yonesaki T, Otsuka Y;
#=GF RL   Toxins (Basel). 2017; [Epub ahead of print]
#=GF DR   INTERPRO; IPR043994;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   RnlA toxin is an RNase LS and a putative toxin of a bacterial
#=GF CC   toxin-antitoxin pair. Toxin-antitoxin systems consist of a
#=GF CC   stable toxin and an unstable antitoxin. In this case, a novel
#=GF CC   type II system, RnlA is the stable toxin that causes inhibition
#=GF CC   of cell growth and rapidly degrades T4 late mRNAs to prevent
#=GF CC   their expression, and this is neutralised by the activity of the
#=GF CC   unstable antitoxin RnlB [1, 2]. This entry represents the
#=GF CC   C-terminal DBD domain, responsible for the RNA cleavage activity
#=GF CC   and toxicity. Through interaction between DBDs, RnlA dimerises
#=GF CC   in solution. T4 Dmd binds to DBD for inhibition of RnlA toxicity
#=GF CC   and RnlB also inhibits the toxicity of DBD [3].
#=GF SQ   53
#=GS A0A410PU81_9FIRM/148-265  AC A0A410PU81.1
#=GS A0A842IX81_9FUSO/207-332  AC A0A842IX81.1
#=GS A0A1G8CD09_9VIBR/202-324  AC A0A1G8CD09.1
#=GS A0A1Y4EVM1_9FIRM/339-464  AC A0A1Y4EVM1.1
#=GS R7MKU9_9FIRM/284-417      AC R7MKU9.1
#=GS A0A081P3B2_9BACL/199-322  AC A0A081P3B2.1
#=GS T2RD92_PAES9/19-97        AC T2RD92.1
#=GS A0A1I0M210_9FIRM/204-329  AC A0A1I0M210.1
#=GS A0A1G4FJR5_9FIRM/313-434  AC A0A1G4FJR5.1
#=GS R1ASA3_9FIRM/200-333      AC R1ASA3.1
#=GS A0A1R3T3Z7_9BACT/219-342  AC A0A1R3T3Z7.1
#=GS B3PN28_META1/326-454      AC B3PN28.1
#=GS V2Q9F8_9BACT/318-436      AC V2Q9F8.1
#=GS R5HGM4_9MOLU/192-313      AC R5HGM4.1
#=GS A0A133YXK3_9FIRM/348-475  AC A0A133YXK3.1
#=GS A6TLN0_ALKMQ/1-97         AC A6TLN0.1
#=GS A0A2R5FX74_NOSCO/206-331  AC A0A2R5FX74.1
#=GS Q6LR54_PHOPR/203-326      AC Q6LR54.1
#=GS A0A420XHI8_9PAST/200-325  AC A0A420XHI8.1
#=GS A0A4Y6UV56_SACBS/203-335  AC A0A4Y6UV56.1
#=GS I5B0B2_9DELT/194-316      AC I5B0B2.1
#=GS R6HGE4_9FIRM/378-499      AC R6HGE4.1
#=GS A0A1D9P153_9FIRM/197-314  AC A0A1D9P153.1
#=GS A8H216_SHEPA/204-326      AC A8H216.1
#=GS A0A1Q2SMK9_9GAMM/199-320  AC A0A1Q2SMK9.1
#=GS I9LJM3_9FIRM/199-325      AC I9LJM3.1
#=GS A0A2Z4UAX4_9FIRM/27-152   AC A0A2Z4UAX4.1
#=GS A0A0K0G997_9FIRM/180-316  AC A0A0K0G997.1
#=GS A0A1S2LYS0_9BACI/412-539  AC A0A1S2LYS0.1
#=GS RNLA_ECOLI/203-325        AC P52129.2
#=GS Q5LEL8_BACFN/195-316      AC Q5LEL8.1
#=GS A0A068YT17_9BURK/190-313  AC A0A068YT17.1
#=GS F7Q2N3_9MOLU/335-462      AC F7Q2N3.1
#=GS A0A2K9EV90_9RHOB/197-320  AC A0A2K9EV90.1
#=GS A0A6B3W4C2_9BACI/412-535  AC A0A6B3W4C2.1
#=GS J4TIL4_9FIRM/333-460      AC J4TIL4.1
#=GS A0A5B8YI56_9FLAO/191-313  AC A0A5B8YI56.1
#=GS A0A7Y9HWN6_9SPHI/67-191   AC A0A7Y9HWN6.1
#=GS A0A484GDR0_9GAMM/26-154   AC A0A484GDR0.1
#=GS A0A1I4ZNX1_9CLOT/216-339  AC A0A1I4ZNX1.1
#=GS A0A0F5IPM6_9BACT/195-316  AC A0A0F5IPM6.1
#=GS A0A8H2QT99_9FIRM/330-457  AC A0A8H2QT99.1
#=GS Q6AIF3_DESPS/1-68         AC Q6AIF3.1
#=GS A0A410PKL7_9CLOT/319-445  AC A0A410PKL7.1
#=GS E6SSM9_BACT6/195-316      AC E6SSM9.1
#=GS A0A235F597_9BACI/207-331  AC A0A235F597.1
#=GS A0A845GNN9_9BURK/193-312  AC A0A845GNN9.1
#=GS A0A1G6W110_PEPNI/334-466  AC A0A1G6W110.1
#=GS LSOA_ECO57/191-312        AC O82881.1
#=GS A0A7U9TM69_9MOLU/1-73     AC A0A7U9TM69.1
#=GS A0A3R6ILL0_9BACT/195-316  AC A0A3R6ILL0.1
#=GS A0A7W2ENA5_9BURK/199-323  AC A0A7W2ENA5.1
#=GS E3GLT6_9FIRM/376-499      AC E3GLT6.1
A0A410PU81_9FIRM/148-265             .............k-TEDVRSEMETLLPR...SYGK.LDDMVL...KLLSPSIS.LRTV..KKLEEEYSY..YAFPALRALEGYM.......KYLFGI..---..-----.KGI..HI....G.YN....FL..EVF.D...KEL...........MR.E.ST.A.LK.I.A..DEN.YQkELERLYHYLMNSRHVVFY--kk....
A0A842IX81_9FUSO/207-332             ......kdinrisc---------------...-IEN.LQEDCK...IMINTYIN.LREIfkEKVLGDYSF..LCFYPLRVSEAVL.......RKALIE.nITI..PVGYElNSR..KF....V.LI....ND..EKH.Q...IVIf........neKK.E.IT.S.RI.VvN..TTY.IKdAIQDLYIHFNNNRHGLFH--ge....
A0A1G8CD09_9VIBR/202-324             ..............QQEVARTHLKAVLGD...AYEK.IHQSVE...KLLTSGLC.VKLA..APELPDYCL..LLYPELRSIEGAL.......KDKMKD..FGM..TVGKD.---..GF....G.EF....FE..HNN.G...KWE...........LN.TaSA.A.KF.P.N..IAT.TN.VIESAYNFYNRERHGLFHME......
A0A1Y4EVM1_9FIRM/339-464             ..............KENEIETRFELVLPH...YRHE.SKKHYT...NLL-SAVY.NTML..TGYMPDYTC..LVTPIFRAYEYYL.......HRILGD.iMGL..DTETD.KGT..NN....F.SF....FS..KNS.V...GLY..........eCN.N.RR.K.NL.L.S..QQQ.LD.YLNNLYTQYNSVRHPYSH--ws....
R7MKU9_9FIRM/284-417                 ...........svl---EARNILKERIPN...AYDK.LDEEIK...KILSPSIS.LSNS..NIEVEEYSC..YVFPVLKGLEALLlkl.llnKSILID..HAA..PKGSG.KYK..NF....G.AI....FE..KDN.N...SQIf.........kLR.S.NF.K.NI.I.S..DSV.YElCVEDIYNYIVGSRHVYFHAN......
A0A081P3B2_9BACL/199-322             ..............KKENIEQVYVGWFPN...SHDK.HSPKLK...KVLHQAIY.NLQL..EGDMFDYTY..LAFPALRALEGHL.......KTIMTN..HRI..ILEN-.--N..RF....S.MY....TK..VPS.T..gKYI...........LE.A.NFiT.TF.N.S..QAK.VQ.YVERAYNFYNSNRHSLFH--wg....
T2RD92_PAES9/19-97                   ............ea--SEIADEMKEQLED...SYAF.LGETLR...KVLSPAFV.LKKL..DIELEDYSS..FAYPALRTLEGYL.......KKILLN..NGI..EIKKS.---..--....-.--....--..---.-...---...........--.-.--.-.--.-.-..---.--.--------------------siflle
A0A1I0M210_9FIRM/204-329             ...........pkn---DIYEEMKSTLGN..dLYNF.LTTTQK...AILSSAFI.FNKI..DIDMDDYSS..LIIPAARALEGYI.......LKLISQ..SGV..IMDE-.--R..KL....G.NY....FY..YDD.C...KNQf.........lLK.EiYI.Q.KI.N.S..ENR.TK.SITTLYRLYHKRRHPYSH--st....
A0A1G4FJR5_9FIRM/313-434             .............e-QEQIDNQFILYLPN..aNKDL.IEEKRK...TVLSQSIF.NLSV..GGQMYDYAC..LAFPVLRVTEAYI.......KDIRDR..IAK..SIEP-.---..--....H.NL....FE..KSD.N...NVFk.........lKE.C.YK.K.KI.G.N..KEK.IS.HFNKLYNYYCQERHRLFHWD......
R1ASA3_9FIRM/200-333                 .............d-KENIENELKELLPN...SYHK.LHPTIL...DFLYDSLV.FSKL..QIPVKEYSS..YVFPALKALEGYI.......KILFGN..--N..EIRVE.NKL..GF....A.KI....VN..GKR.T...PYFitngtnkfkyrLN.K.SI.V.SI.N.C..PKT.CA.ALEECYNYFNKNRHSLFHTD......
A0A1R3T3Z7_9BACT/219-342             ............es--EILNSDLRQHIMY...NYDK.IEGKIE...MFLNTSLL.LINT..IIKLPDYSS..YCFSALKALEGII.......KKRFVD..---..EIGSN.-FE..KI....G.EF....FE..EKK.K...TKSf........ilKS.E.KE.A.LF.A.N..EST.CR.CLENAYSFFNKTRHPLFHAD......
B3PN28_META1/326-454                 ..............KEENLQTKFSNFLPN..fSINS.NDFKIK...NILLSAVC.GTLM..KGYLPDYTY..LVMPLFRSMEYYL.......HIILGD.kLGR.kTTRKN.GAN..DF....C.HF...sFN..KKT.N...EYE...........YN.H.ST.K.ER.L.N..NEQ.LQ.YLNKLYNMYNKLRHPYFHL-p.....
V2Q9F8_9BACT/318-436                 .......nfqskdi-------NLKFYLPK...SYNI.FPDMLF...SILQPSL-.LEQP..TYTLQDYSM..YAFPALRTLEGSI.......KYLLTS..YGI..EIDNK.GLK..CF....D.GY....--..--E.L...RDK...........Y-.R.VK.I.QN.K.N..NKL.AE.HIEKMYKYYKDNRHPLCHT-t.....
R5HGM4_9MOLU/192-313                 ...........sta---DIRETIKANLSN...SYTF.LDEALI...KSLSGSIT.SLKT..IKESEDYTC..CVTGAFKTLEGYL.......TKVLVN.kY--..SYKID.KKN..KF....S.MF....YK..DRG.N...SSK...........I-.-.EN.D.KL.I.S..NDE.KE.YLIKLNKIYSNKRNVFLHA-t.....
A0A133YXK3_9FIRM/348-475             .............e-KSEVENAFSAILPN..fPINE.QDTKLR...NTLLSAVF.NTLI..IGYMPDYTY..LVTPLFRVMEFYL.......HRILSD.rLGK..NTTTS.KGK..NK....F.GY....FK..PNK.S...TNR...........YEyN.SS.K.GN.L.N..NNQ.ID.YLNDLYNRYNKMRHPYSH--ws....
A6TLN0_ALKMQ/1-97                    ...........mgq---------------...----.------...--------.----..RIKIPDYGI..LIDSTCRAFEGYF.......KTLLKTidISKnrEMKKS.-DW..NS....G.NI....FD..GNR.NllsQYH...........HK.L.SF.D.DK.I.K..NEQ.LN.ILSEMYSLMKDLRNPISH--sg....
A0A2R5FX74_NOSCO/206-331             .............d-ENTIETELKALLPN...AYSS.LGEGIL...TMLRTSYT.LKDI..SIPLPDYSC..YVFPALRALEGVM.......RRLLFN..EGY..SIEDN.-NN..SF....G.GI....FY..GDS.R...KNYl.........vKN.D.FK.Q.EI.G.N..SKI.CN.ALEICYTYFVQQRHELFHAN......
Q6LR54_PHOPR/203-326                 ..............HEEVASIYIKKALPN...AFER.LDDTYR...SLLSSSYC.VKLA..SPSLSEYSM..LIYPDLRVLEGVI.......KEAMAK..-ND..LYTSS.EGI..DI....G.EY....FT..HGR.Q...TEL...........KT.E.YN.S.NF.Q.S..ESE.IR.CLEQCYAYFKAHRHSLFHMD......
A0A420XHI8_9PAST/200-325             ............rp--ETSESLLKMKLPK...SYDN.LPKEIK...NLLISSCC.IRAA..SPNLPEYSM..LTYCELKALEGII.......KSKLVE..-CQ..IVEIP.--N..NV....G.EL....FE..IPH.D...PKAi........tlKN.E.IL.Q.QY.K.E..LNQ.IKtPIEAAYKYYRARRHSLFHMQ......
A0A4Y6UV56_SACBS/203-335             .............i-EELADQYIKHNLPN...GFKY.LDPIMA...NFITDSFT.LVAA..GTNLRDYAA..WVMPTMRVLEHSIkriclnsSIYLED..KGG.fRYFNG.NGS..KT....S.PV....FQ..DHN.G...SQV...........VN.T.DL.Q.SR.L.D..SDR.VD.ILVRCYLYLKSNRHELFHT-t.....
I5B0B2_9DELT/194-316                 ..............KPDVVREELESRLFA...VYGR.FDEKIL...KVMTPALS.LMKI..DVELEDYSC..CIYPALRGLEGYI.......RMLLSE..FSK..EYKTV.--G..RL....G.SL....FD..ENK.S...YET...........ML.F.LK.D.DI.K.N..DVV.CK.SLQNAYFMYVKHRHPLFHTD......
R6HGE4_9FIRM/378-499                 ...........raf---EIERQLRKKLPD...AYDL.LGEQAR..iDFAIGVID.IDNS..TAVLYDYST..LLIPCFRGLERFI.......FDLQRA..---..--QGI.EVK..MI....G.QA....YE..KEN.G...SYV...........LK.S.GY.R.RK.I.P..FVVyAE.VMAALYTEYNSQRNFYAHS-d.....
A0A1D9P153_9FIRM/197-314             ...........ktg---DVHNELKAVLKN...SYDY.LEPAII...KMLSPAVA.MRNV..SIDLDDYSC..FVFPALRALEGYI.......KWLFQK..---..---K-.-GV..YV....G.NT....FN..GIF.S...GYS...........LC.P.AV.A.TQ.I.S..DSV.FQaEIENLFKYYKDNRHIHFHA-s.....
A8H216_SHEPA/204-326                 ..............QQEVARSYLQTVMGD...SYRH.LHKNVE...KLLVSGLC.VKLA..APQLPDYCM..LLYPELRSIEGAL.......KGKMAL..FGL..VVGRD.---..GF....G.GF....FE..KIP.G...KYQ...........LE.A.SHrA.HF.P.S..DVS.AN.IVEDAYTFYNKERHGLFHME......
A0A1Q2SMK9_9GAMM/199-320             .............r-EEMAEDYLKGFFHR...SYVH.LPEAVK...KLLISGCC.IKLA..APKLPDYCL..LLYPDLRSLEGVL.......KQEMTH..YMR..S----.VEN..GF....G.DF....FD..VKD.G...ACT...........LK.P.EH.A.EAvG.H..TKM.VD.AFNTGYSFFRKHRHTIFHME......
I9LJM3_9FIRM/199-325                 .............e-KEQVENQFNVYLPN...SYNK.HTDKLK...KSLLKAVY.--NL..NITSQEYTCteLTFEVLRALEGHI.......KLTLFN.dYGI..N--SP.--N..RF....G.TLemfkFN..NYT.D...KAY..........lLE.P.VR.S.IV.G.T..STK.IS.YYEKAYKHLVIYRHKIFHWD......
A0A2Z4UAX4_9FIRM/27-152              ............dk--DEVCSEFQFYMPN...SFDK.FSSKME...KALLQAVY.NLKL..NGKMFDGTF..LAHPAMRVVEAHL.......KILLVK..YEI..IPDAK.YIK..DN....GfNM....FD..KLG.A...KYK...........LK.M.DQ.H.GT.A.T..EDK.AK.YIGNLYTFYHNNRHVLFHWD......
A0A0K0G997_9FIRM/180-316             .............l-EDKVQQHLKMHFPK...GWDS.LEPTMQ...GFVKDCFT.LAEV..NTKLSDYAA..WVMPIMRVLEYRIkki.cldYNIMID..DAKgfKYYTN.IANprAT....A.WI....FI..IDF.S...NDY...........VK.G.VN.P.NI.K.NmpQEA.KD.IIVECYDFLRKNRHEMFHA-t.....
A0A1S2LYS0_9BACI/412-539             .............k-VEDTRTELQRLMPN...TYGK.IDDTLF...KILSPAIA.LKKI..GREVEDYSC..YAFPALRALEGYL.......MHTFSI..ENI..VIGHK.YGE..QC....G.SH....FKyvKRN.D...SHV...........LK.K.DT.V.DR.L.S..NHK.SKaVLEEVYNYLKKNRHTLFHS-e.....
RNLA_ECOLI/203-325                   ..............QQEVARTYLQTVMAD...AYPH.LHVTAE...KLLVSGLC.VKLA..APDLPDYCM..LLYPELRTIEGVL.......KSKMSG..LGM..PVQQP.--A..GF....G.TY....FD..KPA.A...HYI...........LK.P.QF.A.AT.L.R..PEQ.IN.IISTAYTFFNVERHSLFHME......
Q5LEL8_BACFN/195-316                 .............v-GCVIEKDLNKHFTK...TENI.EGSILE...DFLKTSIA.LANS..GVVVDDYGC..YTFGIMKALDGLI......sKRLLED..---..---AP.DFK..DY....G.TY....FE..RGK.D...GNYh.........fLE.N.VG.T.YN.G.N..PSL.KR.ALEKAYDFYNKNRHTTFHID......
A0A068YT17_9BURK/190-313             ............tl--ETARNDLIARVPN...VHDA.LAEEVR...MQLSSALS.MTKA..GVVLEDYAA..LAFPALKGLEGLC.......FQLLRE..ECQfsPV---.KKS..TL....S.DY....FD..MEG.L...GFK...........MR.V.PH.S.EG.V.P..IPV.QK.LLVQCYGMWYDQRHRLFHMD......
F7Q2N3_9MOLU/335-462                 ..........deie----VINKMKDLIPN..fPGNF.SDTKHY...NNVLSAVF.NTML..VGYMPDYTC..LLTPTFRAMEYYL.......HKILNG.kLGK..NTENT.NGR..NN....F.SF....FS..KDS.T...TEK..........yYY.N.SS.N.NG.L.D..KTK.ID.YLNDLYNYYNKIRHPYSH--ws....
A0A2K9EV90_9RHOB/197-320             .............r-KEMAEDYLKTFFPN...SYVN.IPDDIK...KLLISSCC.VKLA..APNLPDYCL..LLYPDLRSLEGIL.......KLKMAK..HNM..SVQDA.-EN..GF....G.DF....FD..VAS.G...KCT...........LK.L.EH.Q.GK.V.S..KKI.AE.SLSNGYTFYRKHRHAIFHME......
A0A6B3W4C2_9BACI/412-535             .............k-VEDTRTELQKLMPN...AYGN.IDDTLF...KILSPAIS.LKKV..NVEMEDYSC..YAFPALRALEGYL.......KYLFSI..--E..EIEIG.--H..SY....G.YH....FG..HDT.R...TDAf........hlKR.H.VV.Q.EL.K.N..PKV.EA.PLVETYNYINKNRHTLFHTE......
J4TIL4_9FIRM/333-460                 .............e-KEEVENAFSLILPD..fSIKN.KDIKLR...NTLLSAVF.NTLV..VGYMPDYTC..LVTPLFRAMEFYL.......HRILSD.kLGN.nTTRSN.GSN..NF....-.SY....FS..KDStS...GEY...........KY.N.SS.T.QS.L.R..GDQ.ID.YLNELYNKYNKLRHPYSH--ws....
A0A5B8YI56_9FLAO/191-313             ..........ssdd----IIGELENRLPV...AGKY.IDDKIK...SVISPSLA.LRKT..DLALKDYSV..FAFPILRGIEGVM.......KQLFAS..KGK..LVTKD.---..GF....G.EL....FE..NNG.I...SVT...........FS.Q.VT.KsDI.K.S..KNY.EK.ALCDLYSFYSSHRHSLFHMD......
A0A7Y9HWN6_9SPHI/67-191              ...........ttd---EVLIQLKHILPN...AYSY.LGETLI...AILSPSIA.LKSL..SINLTDYSA..FAFPVLRGLEGYL.......KKLMSD..NGI..TIESN.--A..NM....G.SF....IE..TQS.D...KTVk.........vHE.K.IT.Q.QI.N.N..KDV.ID.AVEESYLYYKDKRHALFHID......
A0A484GDR0_9GAMM/26-154              ..........nikm----AEFHLKSKIGE..dIFER.FPKNIK...SLLLSSFC.VKFS..SPPLPDYCM..LLYPEFRSLEGMI.......KEKLSN..YNL.vASEHD.DIE..SF....G.CF....FL..KTQ.N...GSFi.........iKQ.K.YQ.S.NI.L.D..KVI.QN.RLSDAYSFFNKHRNRLFHMD......
A0A1I4ZNX1_9CLOT/216-339             ..........dssk----LETELYEYIPKldrLVEK.QRLGIR...NNLHTAIY.MLKC..NIDLPDRTF..LIFNALRGLESII.......KLIAAK..---..-YEIN.-YI..DK....L.TM....FN..VDN.G...HVK...........LS.K.EC.E.EK.L.G..SSV.KTgLYKRMYTAYRKERNVYFHWD......
A0A0F5IPM6_9BACT/195-316             .............v-GCVIEKDLNKHFTK...TENI.EGSILE...DFLKTSIA.LANS..GVVVDDYGC..YTFGIMKALDGLI......sKRLLED..---..---AP.DFK..DY....G.TY....FE..RGK.D...GNYh.........fLE.N.VG.T.YN.G.N..PSL.KR.ALEKAYDFYNKNRHTTFHID......
A0A8H2QT99_9FIRM/330-457             ...........eks---DLENAFSQIMPD...FPDSiENSKIR...NTLLTAVF.NTKM..VMDIPDYTF..LVTPVFRAMEYYL.......HRILHD.yLGK..ETETD.KGK..NN....F.AY....FG..KDD.V...TKE..........yFY.N.SS.N.ES.L.S..SSQ.ID.YLNKLYNEYSKIRHPYSH--ws....
Q6AIF3_DESPS/1-68                    mkqllfkyyqddfc---------------...----.------...--------.----..---------..-------------.......------..---..-----.-AK..RI....G.KI....FE..TKD.G...GSTy........slNY.G.IS.A.GI.G.R..KEV.IV.ALEESYKFWNVYRHPYFHVD......
A0A410PKL7_9CLOT/319-445             .............d-KDIIESEFESYFPN...SYNL.IPCELN...NYLHQAVY.NLHI..MGNVYAADF..LAEPAIRSLEPVL.......KIALKD..NGI..PIRKD.-GN..DY....D.SFf..vFE..RQG.N...RYV..........lKD.E.YK.K.ER.H.S..KEL.LH.YISECYTFLRENRHTLFHWD......
E6SSM9_BACT6/195-316                 .............v-GCVIEKDLNKHFTK...TENI.EGSILE...DFLKTSIA.LANS..GVVVDDYGC..YTFGIMKALDGLI......sKRLLED..---..---AP.DFK..DY....G.TY....FE..RGK.D...GNYh.........fLE.N.VG.T.YN.G.N..PSL.KR.ALEKAYDFYNKNRHTTFHID......
A0A235F597_9BACI/207-331             .............t-KETIVNELDIYLPD...AIEK.ISEKLK...RLSYQALM.NLKV..NDDMFDYAF..LAYPSFRLIEGHL.......KYVMHE..KTI..PLESG.NFS..MF....T.KL....IP..GHL.S...RYT...........LQ.P.TY.D.VK.F.T..SQQ.KK.SVEDAYNFYKYNRNPLFHWD......
A0A845GNN9_9BURK/193-312             ..........kakd----LLEELKQWTPS...AVEI.LGDAGA...AIIAPSLA.LMKL..NVELTDYSA..FAYPALKGLEAYM.......KALMAE..HGM..PIKNV.--V..GF....G.SS....FN..GPK.L...K--...........-S.G.VC.A.KI.N.C..QHT.VA.AVEKSYDLYNRHRHSLFHAD......
A0A1G6W110_PEPNI/334-466             .............e-KLEVENAFSTLLPN..fPIDD.KDTKLR...NTLLSSVF.NTLI..TGYMPDYTC..LVTPLFRAMEFYL.......HRILHD.kLGK.nTTRTG.KDG..KFkrnnF.AF....FD..ENE.T...TGN...........FE.Y.NSsA.VG.L.S..SNQ.ID.YLNQLYSSYNKMRHPYSH--ws....
LSOA_ECO57/191-312                   ..............KKETIESELHSKLPK...SIDK.IHEDIK...KQLSCSLI.MKKI..DVEMEDYST..YCFSALRAIEGFI.......YQILND..VCN..P-SSS.--K..NL....G.EY....FT..ENK.P...KYI...........IR.E.IH.Q.ET.I.N..GEI.AE.VLCECYTYWHENRHGLFHMK......
A0A7U9TM69_9MOLU/1-73                ..............---------------...----.------...--------.----..---------..--MPIMRVLEGVL.......RKILVD..SGI..TIKDK.--Q..YP....F.SC....FS..NPT.G...VYL...........LN.K.QG.-.-S.L.S..SDK.KA.KVERAYDFYRDQRHSVSH--sg....
A0A3R6ILL0_9BACT/195-316             .............v-GCVIEKDLNKHFTK...TENI.EGSILE...DFLKTSIA.LANS..GVVVDDYGC..YTFGIMKALDGLI......sKRLLED..---..---AP.DFK..DY....G.TY....FE..RGK.D...GNYh.........fLE.N.VG.T.YN.G.N..PSL.KR.ALEKAYDFYNKNRHTTFHID......
A0A7W2ENA5_9BURK/199-323             .............r-REMAEDYLKGFFPR...SYGY.LPEAVK...KLLISSCC.VKLA..APKLPDYCL..LLYPDLRSLEGVL.......KQEMSG..YLM..SVADT.-TD..GF....G.EY....FD..VKH.G...VCT...........LK.PqYE.A.AV.G.H..AAM.VD.ALNKGYSFFRKHRHTIFHME......
E3GLT6_9FIRM/376-499                 .............e-KESINEVIRKKIPY...TIRI.LKDQADqfiNLISPSFVlLNDA..SIELTDYSP..MVFSVYRGVELYL.......KY-LAD..LSG..IDLAN.--Q..PV....G.KI....FK..TVG.R...Q--...........-K.H.QY.L.QM.I.N..DSM.KGeMLQSIFENFGSYRNALFHAN......
#=GC seq_cons                        ................p.lcsplpthlPs...shsh.lspplc...phL.suls.hpph..sspl.DYoh..hsaPshRuLEGhl.......Kplhsc...sh...hpss...p..sh....G.sh....Fp..psp.s...p.h...........hp.p..p.p.ph.h.s..ssh.hc.hlpchYsaapcpRHslFHhp......
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