#=GF ID RnlA_toxin_N
#=GF AC PF19417.3
#=GF DE RNase LS, bacterial toxin N-terminal
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF SE N-terminal of PF15935
#=GF GA 24.00 24.00;
#=GF TC 24.00 24.80;
#=GF NC 23.00 23.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 21927020
#=GF RT Regulation of growth and death in Escherichia coli by
#=GF RT toxin-antitoxin systems.
#=GF RA Yamaguchi Y, Inouye M;
#=GF RL Nat Rev Microbiol. 2011;9:779-790.
#=GF RN [2]
#=GF RM 20980243
#=GF RT Escherichia coli rnlA and rnlB compose a novel toxin-antitoxin
#=GF RT system.
#=GF RA Koga M, Otsuka Y, Lemire S, Yonesaki T;
#=GF RL Genetics. 2011;187:123-130.
#=GF RN [3]
#=GF RM 28085056
#=GF RT RnlB Antitoxin of the Escherichia coli RnlA-RnlB Toxin-Antitoxin
#=GF RT Module Requires RNase HI for Inhibition of RnlA Toxin Activity.
#=GF RA Naka K, Qi D, Yonesaki T, Otsuka Y;
#=GF RL Toxins (Basel). 2017; [Epub ahead of print]
#=GF RN [4]
#=GF RM 24112600
#=GF RT Structure-function studies of Escherichia coli RnlA reveal a
#=GF RT novel toxin structure involved in bacteriophage resistance.
#=GF RA Wei Y, Gao ZQ, Otsuka Y, Naka K, Yonesaki T, Zhang H, Dong YH;
#=GF RL Mol Microbiol. 2013;90:956-965.
#=GF DR INTERPRO; IPR045837;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC RnlA_toxin is an RNase LS and a putative toxin of a bacterial
#=GF CC toxin-antitoxin pair. Toxin-antitoxin systems consist of a
#=GF CC stable toxin and an unstable antitoxin. In this case, a novel
#=GF CC type II system, RnlA is the stable toxin that causes inhibition
#=GF CC of cell growth and rapidly degrades T4 late mRNAs to prevent
#=GF CC their expression, and this is neutralised by the activity of the
#=GF CC unstable antitoxin RnlB [1, 2]. This entry represents the
#=GF CC N-terminal domain composed of four-stranded twisted antiparallel
#=GF CC beta-sheet and two alpha-helices [3,4].
#=GF SQ 38
#=GS A0A420XHI8_9PAST/4-83 AC A0A420XHI8.1
#=GS A0A1Q2SMK9_9GAMM/4-84 AC A0A1Q2SMK9.1
#=GS A0A081P3B2_9BACL/1-82 AC A0A081P3B2.1
#=GS A0A235F597_9BACI/7-88 AC A0A235F597.1
#=GS A0A259UAF6_9FIRM/1-78 AC A0A259UAF6.1
#=GS A0A0K0G997_9FIRM/2-78 AC A0A0K0G997.1
#=GS A0A6B3W4C2_9BACI/225-299 AC A0A6B3W4C2.1
#=GS R7MKU9_9FIRM/89-169 AC R7MKU9.1
#=GS A0A2K9EV90_9RHOB/4-84 AC A0A2K9EV90.1
#=GS A0A2R5FX74_NOSCO/5-84 AC A0A2R5FX74.1
#=GS RNLA_ECOLI/6-88 AC P52129.2
#=GS A0A4Y6UV56_SACBS/17-94 AC A0A4Y6UV56.1
#=GS A0A1B6BF20_9FIRM/5-86 AC A0A1B6BF20.1
#=GS A0A3R6ILL0_9BACT/2-82 AC A0A3R6ILL0.1
#=GS A0A5B8YI56_9FLAO/3-81 AC A0A5B8YI56.1
#=GS I9LJM3_9FIRM/2-82 AC I9LJM3.1
#=GS A0A1U7MEM7_9FIRM/2-83 AC A0A1U7MEM7.1
#=GS I5B0B2_9DELT/3-81 AC I5B0B2.1
#=GS Q5LEL8_BACFN/2-82 AC Q5LEL8.1
#=GS A0A3E2NW29_9SPHI/3-80 AC A0A3E2NW29.1
#=GS A0A4R1Q097_9FIRM/2-83 AC A0A4R1Q097.1
#=GS A0A1G8CD09_9VIBR/5-87 AC A0A1G8CD09.1
#=GS A0A1R3T3Z7_9BACT/17-107 AC A0A1R3T3Z7.1
#=GS A0A075KGH2_9FIRM/2-83 AC A0A075KGH2.1
#=GS A0A3G9MDX4_RHOOP/1-46 AC A0A3G9MDX4.1
#=GS A0A154BR99_ANASB/2-83 AC A0A154BR99.1
#=GS E6SSM9_BACT6/2-82 AC E6SSM9.1
#=GS LSOA_ECO57/6-80 AC O82881.1
#=GS A0A7W2ENA5_9BURK/4-84 AC A0A7W2ENA5.1
#=GS A0A0F5IPM6_9BACT/2-82 AC A0A0F5IPM6.1
#=GS Q6LR54_PHOPR/3-83 AC Q6LR54.1
#=GS R1ASA3_9FIRM/6-90 AC R1ASA3.1
#=GS A0A1W2DQS0_9FIRM/1-78 AC A0A1W2DQS0.1
#=GS A0A517DV41_9FIRM/2-83 AC A0A517DV41.1
#=GS A0A402BX84_9FIRM/2-83 AC A0A402BX84.1
#=GS A0A1S2LYS0_9BACI/222-301 AC A0A1S2LYS0.1
#=GS A8H216_SHEPA/7-89 AC A8H216.1
#=GS A0A1D9P153_9FIRM/4-82 AC A0A1D9P153.1
A0A420XHI8_9PAST/4-83 ........FTDLNLDR..........EKLKNCLEQFCK..KNEFHLEFVEDKP---.NKKTFKIIKSGLEpARLVFHLK...KSGATTIQINEGKN.KKLNCEIAEYI.............
A0A1Q2SMK9_9GAMM/4-84 ........YKDLNLNR..........EILDADIQSFLE..SNGYTLH--GGIQPLG.KRKRVVFGVAGAEfATVDLHLN...GTGTTTVQWKIGKN.QPVGEQLAVYL.............
A0A081P3B2_9BACL/1-82 ........MKNLNLNR..........DNLIQSIQQYYS..LNGKEATISDFLHKGG.TRQRVDIVTEDGS.VYIDFHFN...KNGSTTIDISGGGH.HKIKEEISRYI.............
A0A235F597_9BACI/7-88 ........YGQLHLYR..........DQIETTVIAFLS..SKEEEFTCSELNNVNG.NRHRIEFTYGFDA.NKVDFHYN...MDGTTTIDLTPGGV.NEIKEEMAEFI.............
A0A259UAF6_9FIRM/1-78 ........----MLNR..........ELIVPTIKKICS..ANYKEFTVSELIHKGG.HRHRVEIEADGSD.FFVDFHFR...ANGSTSIDISSGHH.IAKKKQIKEAI.............
A0A0K0G997_9FIRM/2-78 .......a-KGLFINR..........DQLERVINAN--..---CTLKLIELKKKEQ.GFYRYHVEKEDKE.FSIDVYYT...KKKGTTVLATCENG.QELEQAIINS-i............
A0A6B3W4C2_9BACI/225-299 ....vnpt--------..........-ELEDIIKNTGT..QMWDDFRFISLEERG-.KVNKCNFTVNGKL.CSLNFHSK...NNGTTTMSPT-GKN.TELSLALKE--ri...........
R7MKU9_9FIRM/89-169 ......ki--SVYMDK..........DNLNSLIEECGT.eLWKESFKMIDYSTVG-.QAERLTYSVSGTQ.LKIDFFFR...KDGSVTIKSVGSQN.-ITSKRLIEKI.............
A0A2K9EV90_9RHOB/4-84 ........YKDLNIDR..........ETLDEHIQRFIE..SAGYSID--GEIETSD.KRKRLVFGRPGAQfATVDLHLN...KTGTTTIQWKMGKN.QPIGEELAVHL.............
A0A2R5FX74_NOSCO/5-84 ........FKELNLDR..........TRLKECVEEFWR..INNFQEGI--YSEEQN.SRHRVKYIQDGCD.VMVELLLR...QNGTTTIHTKIGKY.PDKGEQLALYL.............
RNLA_ECOLI/6-88 ........YKNLNLVR..........ANIETESRQFIE..NKNYSIQSIGPMPGSR.AGLRVVFTRPGVNlATVDIFYN...GDGSTTIQYLTGAN.RSLGQELADHL.............
A0A4Y6UV56_SACBS/17-94 ....nkgy----FLNK..........IGLESVVNNFCN..-----IEKSECLNPAN.QQTRYFLEKEDKK.FSIDVFFR...KDNTITITPLPNQ-.-----------efigiatelhgli
A0A1B6BF20_9FIRM/5-86 ........FKKLHINQ..........DLILSKIEQFLK..ENTITYEAPSLIPKDS.KRHRAHIKYKDIE.FYLDFFFN...NDQTTTIDVTGGQN.QHLKLILAYYL.............
A0A3R6ILL0_9BACT/2-82 .......a-KKHSLSV..........ENIDQVAIDFIA.tKPSYSIKITDCQEG--.KLKKIAITHNKET.GILNCFIN...-GGQVSYSTQGKAHlKGICEECWNVI.............
A0A5B8YI56_9FLAO/3-81 ........YKKLNLNR..........SIIKTTIET---..TVGTSVE-IETSKKAE.GFHIYKFTKTGFNpASLNIYYN...NDGTTTLQPNTGKN.QEWSKDIAGA-i............
I9LJM3_9FIRM/2-82 ........FKDLKLNR..........DNLEIALMNYAK..DNYSTYSLSKTTNNQ-.FNIRYNLVLDGKA.LFLDFFFN...NKGGTTIQTTNGKE.QDVKLKIAEYI.............
A0A1U7MEM7_9FIRM/2-83 .......s-REKMLNR..........ELIVPKIKEFCA..EFYREFTVSDLIHKGG.HRHRVEIEADGSK.FFVDFHFR...ANGSTSIDISSGHH.LDKKQQIKTAI.............
I5B0B2_9DELT/3-81 ........YKNLNIDQ..........KRLNELLKD---..KIFFDLSEPPIVKKTKgASSNITIEKQGIQ.ASITIYFN...NNGTVSFSII-GKN.PELSEDYIKFL.............
Q5LEL8_BACFN/2-82 .......a-KKHSLSV..........ENIDQVAIDFIA.tKPSYSIKITDCQEG--.KLKKIAITHNKET.GILNCFIN...-GGQVSYSTQGKAHlKGICEECWNVI.............
A0A3E2NW29_9SPHI/3-80 ........YKGLQLNK..........AKINNTIQEYNP..-----DAVITITEKSP.VFHQYHIELDGEPkAQLDIYYT...VNGKVTLNPVSTKN.VDLADKIAQHV.............
A0A4R1Q097_9FIRM/2-83 .......s-REKMLNR..........ELLVAAVEKFCS..ENYKKFAVSGLIHKGG.HRHRVEIEADGMN.FYVDFHFK...VNGSTSIDVSSGQH.QDKKKQIMAA-i............
A0A1G8CD09_9VIBR/5-87 ........YKNLNLDR..........AAIEELTQKMIA..ERGYTLESFDDVPGTQ.AGKRVVFGHAGKNfATVDILFI...KGGVSTIKYLTGAN.RELGKELADYL.............
A0A1R3T3Z7_9BACT/17-107 .......c-GNLSLQImanpvyslipDEIEPAAKDFVS..NLGEDYKFTHISETD-.TKKRIEISKGKDK.GILFYYIK...-RGQISFSIAGKKNlYTVCENCQNYI.............
A0A075KGH2_9FIRM/2-83 .......s-REKMLNR..........EIIVSTIKKFCT..VNYQEFTVSNMIHKGG.YRHRVEIEADGSH.FYVDFHFR...ENGSTSIDISSGHH.MDKKKQIKDAI.............
A0A3G9MDX4_RHOOP/1-46 ......gl--------..........------------..----------------.---RVVFTRPGVNlATVDIFYN...GDGSTTIQYLTGAN.RSLGQELADHL.............
A0A154BR99_ANASB/2-83 .......s-REKMLNR..........EIIVSTIKKFCS..VNYKEFNVSDLIHKGG.HRHRVEIEADGSS.FYVDFHFK...ENGSTSIDISSGHH.VDKKKQIKDAI.............
E6SSM9_BACT6/2-82 .......a-KKHSLSV..........ENIDQVAIDFIA.tKPSYSIKITDCQEG--.KLKKIAITHNKET.GILNCFIN...-GGQVSYSTQGKAHlKGICEECWNVI.............
LSOA_ECO57/6-80 ........FKALNINI..........DKIESALTQ---..--------NGVTNYSSnVKNERETHISGTY.KGIDFLIKlmpSGGNTTIGRASGQN.NTYFDEIALII.............
A0A7W2ENA5_9BURK/4-84 ........YKDLNLNR..........ETLDANIQSFMV..--SYSYTLDGGIQSIE.KRKRVVFGAAGSEyATVDLHLN...GTGTTTVQWKMGKN.QPVGEQLAAYL.............
A0A0F5IPM6_9BACT/2-82 .......a-KKHSLSV..........ENIDQVAIDFIA.tKPSYSIKITDCQEG--.KLKKIAITHNKET.GILNCFIN...-GGQVSYSTQGKAHlKGICEECWNVI.............
Q6LR54_PHOPR/3-83 .......n-NGLAMQT..........EKLSTYVDEFLT.vHNAISMEARDITQ---.SKQTFKFIKTGQDvATVIVYIK...QGGLVTITYKTGKN.HALGKVFHDFL.............
R1ASA3_9FIRM/6-90 ........FKKLSLDK..........SKINDIIIEFCQinFNQFKLKEKKEINTAT.GQTRYYIEGDGIE.FTTDFYFR...NDNKTSLQPIGSGEaYNNSLK-----lcefi........
A0A1W2DQS0_9FIRM/1-78 ........----MLNR..........EKIVSTTKRFCS..ENYKEFTVSDLIHKGG.HRHRVEIEADGSG.FFVDFHFR...ANGSTSIDISSGHH.IDKKKQIKDAI.............
A0A517DV41_9FIRM/2-83 .......s-REKMLNR..........EILVPAIKKFCS..VHYKDVTVSDLLHKGG.HRHRVEIEADGMA.FYVDFHFK...ANGSTSIDISSGHH.IDKKKQIKEAI.............
A0A402BX84_9FIRM/2-83 .......s-REKMLNR..........EMIIPAIKKFCS..ENYRQYTVSDFIHKGD.YRHRVEIEADGAN.FFVDFHFR...GNGSTSIDISSGLH.MDKKKQIKDVV.............
A0A1S2LYS0_9BACI/222-301 giyvdptd--------..........--LIELIKTAGT..QEWDDFHFISLEEKG-.NVNKCDFTVNDKP.CSLNFHSK...NNGTTTMSPT-GKN.TEFSSVLKE--riie.........
A8H216_SHEPA/7-89 ........YKNLNLVR..........ANIEDVVNTFMD..QHGFTLESIGDMPGAQ.NGKRVVYGQAGSLyATVDIFFN...NTGTSTVQFKTGRN.QLLGKRLADCL.............
A0A1D9P153_9FIRM/4-82 .......s-KGLYVDR..........STLIEQIKEICD..EMWSECKISDMYPVG-.NMNRIDICADGKK.AILNFFFK...EDG-TTIQAA-GAN.KDIAQLIK---akl..........
#=GC seq_cons .........+phtLs+..........-plpsslppFhs..p.hhphphschhptst.pp+RlplptsGpp.shlDhaap...tsGoTTIshpsGpp.pslscpltphl.............
//
