#=GF ID   Rota_Capsid_VP6
#=GF AC   PF00980.21
#=GF DE   Rotavirus major capsid protein VP6
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_1047 (release 3.0)
#=GF GA   25.00 25.00;
#=GF TC   356.40 356.20;
#=GF NC   24.40 21.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9266993
#=GF RT   Deletion mapping of functional domains in the rotavirus capsid
#=GF RT   protein VP6. 
#=GF RA   Affranchino JL, Gonzalez SA; 
#=GF RL   J Gen Virol 1997;78:1949-1955.
#=GF RN   [2]
#=GF RM   8057471
#=GF RT   Characterization of virus-like particles produced by the
#=GF RT   expression of rotavirus capsid proteins in insect cells. 
#=GF RA   Crawford SE, Labbe M, Cohen J, Burroughs MH, Zhou YJ, Estes MK; 
#=GF RL   J Virol 1994;68:5945-5952.
#=GF DR   INTERPRO; IPR001385;
#=GF DR   SCOP; 1qhd; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Rotaviruses consist of three concentric protein shells.  The
#=GF CC   intermediate (middle) protein layer consists 260 trimers of VP6.
#=GF CC    VP6 in the most  abundant protein in the virion.  VP6 is also
#=GF CC   involved in virion assembly, and possesses the ability to
#=GF CC   interact with VP2, VP4 and VP7 [1,2].
#=GF SQ   17
#=GS VP6_ROTHC/1-395         AC P69481.1
#=GS I6VRE1_9VIRU/1-396      AC I6VRE1.1
#=GS A0A125RLH3_9VIRU/1-396  AC A0A125RLH3.1
#=GS E2EBU4_9VIRU/1-397      AC E2EBU4.1
#=GS A0A1B4XK09_9VIRU/1-396  AC A0A1B4XK09.1
#=GS S5QCF3_9VIRU/1-396      AC S5QCF3.1
#=GS VP6_ROTS1/1-396         AC P03531.2
#=GS F2X9B9_9VIRU/1-395      AC F2X9B9.1
#=GS K9L5A7_9VIRU/1-396      AC K9L5A7.1
#=GS E7D6P6_9VIRU/1-376      AC E7D6P6.1
#=GS D0TZ87_9VIRU/1-396      AC D0TZ87.1
#=GS D7NN21_9VIRU/1-396      AC D7NN21.1
#=GS A0A222NY35_9VIRU/1-385  AC A0A222NY35.1
#=GS L0CRY4_9VIRU/1-396      AC L0CRY4.1
#=GS VP6_ROTSH/1-396         AC A2T3T0.1
#=GS A0A0K0LAS1_9VIRU/2-398  AC A0A0K0LAS1.1
#=GS Q32WR3_9VIRU/1-395      AC Q32WR3.1
VP6_ROTHC/1-395                    MDVLFSIAKTVSDLKKKVVVGTIYTNVEDVVQQTNELIRTLNGNIFHTGGIGTQPQKEWNFQLPQLGTTLLNLDDNYVQSTRGIIDFLSSFIEAVCDDEIVREASRNGMQPQSPALILLSSS.KFKTINFNNSSQSIKNWNAQSRRENPVYEYKNPMLFEYKNSYILQRANPQFGSVMGLRYYTTSNTCQIAAFDSTLAENAPNNTQRFVYNGRLKRPISNVLMKIEAGAPNISNPTILPDPNNQTTWLFNPVQL..MNGTFTIEFYNNGQLIDMVR-NMGIVTVRTFDSYRITIDMIRPAAMTQYVQRIFPQGGPY.HFQATYMLTLSILDATTESVLCDSHSVEYSIVANVRRDSAMPAGTVFQPGFPWEHTLSNYTVAQEDNLERLLLIASVKRMVM..
I6VRE1_9VIRU/1-396                 MDVLYSLSKTLKDARDKIVEGTLYSNVSDLIQQFNQMMITMNGNEFQTGGIGNLPIRNWNFDFGLLGTTLLNLDANYVETARNTIDYFVDFVDNVCMDEMVRESQRNGIAPQSDSLRKLSGI.KFKRINFDNSSEYIENWNLQNRRQRTGFTFHKPNIFPYSASFTLNRSQPAHDNLMGTMWLNAGSEIQVAGFDYSCAINAPANTQQFEHIVQLRRVLTTATITLLPDAERFSFPRVINSADGATTWYFNPVIL..RPNNVEVEFLLNGQIINTYQARFGTIVARNFDTIRLSFQLMRPPNMTPAVAALFPNAQPF.EHHATVGLTLRIESAVCESVLADASETMLANVTSVRQEYAIPVGPVFPPGMNWTDLITNYSPSREDNLQRVFTVASIRSMLV..
A0A125RLH3_9VIRU/1-396             MDVLYSLAKTLKDARARIVEGTLYTNVADIVQQINQVINSINGSTFQTGGIGNLPVRNWTFDFGTLGTTLLNLDANYVENARTTIDYFIDFVDSVCVDEIVRESQRNGIAPQSDSLRQLSNA.KYKRINYDNESEYIENWNLQNRRQRTGYLLHKPNILPYNNSFTLTRSQPAHDNVCGTIWLNNGSEIEIAGFDSECALNAPGNIQEFEHVVPMRRVLNNATVSLLPYAPRLTQRAVIPTADGLNTWLFNPIIL..RPNNVQVEFLLNGQVITNYQARYGTLAARNFDSIRISFQLVRPPNMTPGVAALFPLAAPF.PNHATVGLTLKIESASCESVLSDANEPYLSIVTGLRQEYAIPVGPVFPAGMNWTELLNNYSASREDNLQRIFTAASIRSMII..
E2EBU4_9VIRU/1-397                 MEALSSIALTVREAREKIINGTIYSNVSDVIQQFNQMVRVLNGSTFTTGGLATMPLREWTFDLPQLGTTLLNIDANYVESMTPTLDMLTEFVIAVCETELLVDNNRNGAYPQSEALRLLSNN.KYVFLNMDLGSKYISEWHYRLSARDPMFSNHVPYIFPYDMAIAYDRVTAAYDNVSGTRFASLNNAIHFAAFDQDFVRGQPANARQFEYLYNLRTPVSNATIVIHPISDILSVPSMIRNQAATHYWPYNPYNIptFRDDIRVEFQLAGQVIYVA-ANLGMHTIPQFDAVNIILTMRRLPLLA-DLQNIFPAGNPSaTHQAVISTKIEVLNATTETTVPSINEHLYALIVGTRGRYQMQAGPVFPPGMRWDDILNRYTPARQSNMHRLMTTASILDL--vs
A0A1B4XK09_9VIRU/1-396             MDVLYSLSKTLKDARDKIVEGTLYSNVSDLIQQFNQMIITMNGNEFQTGGIGNLPIRNWNFDFGLLGTTLLNLDANYVETARNTIDYFVDFVDNVCMDEMVRESQRNGIAPQSDSLRKLSGI.KFKRINFDNSSEYIENWNLQNRRQRTGFTFHKPNIFPYSASFTLNRSQPAHDNLMGTMWLNAGSEIQVAGFDYSCAINAPANTQQFEHIVQLRRVLTTATITLLPDAERFSFPRVINSADGATTWYFNPVIL..RPNNVEVEFLLNGQIINTYQARFGTIIARNFDTIRLSFQLMRPPNMTPAVAALFPNAQPF.EHHATVGLTLRIESAVCESVLADASETMLANVTSVRQEYAIPVGPVFPPGMNWTDLITNYSPSREDNLQRVFTVASIRSMLV..
S5QCF3_9VIRU/1-396                 MEVLYSLSKTLKDARDKIVEGTLYSNVSDLIQQFNQMIVTMNGNDFQTGGIGNLPIRNWTFDFGLLGTTLLNLDANYVENARTTIEYFIDFIDNVCMDEIARESQRNGIAPQSEALRKLSGI.KFKRINFDNSSEYIENWNLQNRRQRTGFVFHKPNILPYSASFTLNRSQPAHDNLMGTMWINAGSEIQVAGFDYSCAFNAPANIQQFEHVVPLRRALTTATITLLPDAERFSFPRVINSADGTTTWYFNPVIL..RPSNVEVEFLLNGQTINTYQARFGTIVARNFDTIRLSFQLVRPPNMTPAVANLFPQAPPF.IFHATVGLTLRIESAVCESVLADASETLLANVTSVRQEYAIPVGPVFPPGMNWTELITNYSPSREDNLQRVFTVASIRSMLI..
VP6_ROTS1/1-396                    MDVLYSLSKTLKDARDKIVEGTLYSNVSDLIQQFNQMIITMNGNEFQTGGIGNLPIRNWNFNFGLLGTTLLNLDANYVETARNTIDYFVDFVDNVCMDEMVRESQRNGIAPQSDSLRKLSAI.KFKRINFDNSSEYIENWNLQNRRQRTGFTFHKPNIFPYSASFTLNRSQPAHDNLMGTMWLNAGSEIQVAGFDYSCAINAPANIQQFEHIVPLRRVLTTATITLLPDAERFSFPRVINSADGATTWFFNPVIL..RPNNVEVEFLLNGQIINTYQARFGTIVARNFDTIRLSFQLMRPPNMTPAVAVLFPNAQPF.EHHATVGLTLRIESAVCESVLADASETLLANVTSVRQEYAIPVGPVFPPGMNWTDLITNYSPSREDNLQRVFTVASIRSMLI..
F2X9B9_9VIRU/1-395                 MEAIYSIARTIADAEEKIVVGTLFSNVQQIVMQMNEVIKVMNGSQFLTGGVGNMGVTQWTFNHGQLGVAPLYVDENYREELMQTINYYKRFVHAVCETEMCLESQRGGATMQSAAMQALQTV.KFKNLSYDYSENYIKQWALQKVRVRTAYSSRNPYVVPELNTITYRRSQAAMDNVAGTRVMAIGDTIKFAVFDQDFARTEPGQMWESNFEYNMPVPISDATIQVGTDASGLLNDQVLITNTYNTTWLYVPFQV..PLTRFTIEFYNTGNLVYQIV-APGMHCVPTFNSIIFRLRIVRPAVLSQQLQQYFPAQNPG.NVHATVVISLQIKSCVTDVVLADPDSTHYARITNVRTLYGIPVGPVFPPNMAWDTIVRDYSASRQDNMQRLMTIAAIDCML-s.
K9L5A7_9VIRU/1-396                 MDVLYSISRTLKDARDKIVEGTLYSNVSDLIQQFNQMLVTMNGNEFQTGGIGNLPFRNWNFDFGLLGTTLLNLDANYVESARTTIDYFVDFIDNVCMDEMVRESQRNGIAPQSDALRKLSGV.KFRRINFNNSSEYIENWNLQNRRQRTGFTFHKPNIFPYSASFTLNRSQPQHDNLMGTMWLNAGSEIQVAGFDYSCAINAPANIQQFEHIVQLRRVLTTATITLLPDAERFSFPRVINSADGATTWYFNPVIL..RPNNVEVEFLLNGQIINTYQARFGTIVARNFDTIRLSFQLMRPPNMTPAVAALFPNAQPF.EHHATVGLTLRIDSAICESVLADASETMLANVTSVRQEYAIPVGPVFPPGMNWTDLITNYSPSREDNLQRVFTVASIRSMLV..
E7D6P6_9VIRU/1-376                 --------------------GTLYSNVSDLIQQFNQMIVTMNGNDFQTGGIGNLPIRNWTFDFGLLGTTLLNLDANYVETARTTIEYFIDFIDNVCMDEMARESQRNGVAPQSEALRKLAGI.KFKRINFNNSSEYIENWNLQNRRQRTGFVFHKPNIFPYSASFTLNRSQPMHDNLMGTMWLNAGSEIQVAGFDYSCALNAPANIQQFEHIVQLRRALTTATITLLPDAERFSFPRVINSADGATTWFFNPIIL..RPNNVEVEFLLNGQIINTYQARFGTIVARNFDTIRLSFQLMRPPNMTPAVNALFPQAQPF.QHHATVGLTLRIESAVCESVLADATETLLANVTAVRQEYAIPVGPVFPPGMNWTELITNYSPSREDNLQRVFTVASIRSMLI..
D0TZ87_9VIRU/1-396                 MEVLYSLSKTLKDARDKIVEGTLYSNVSDLIQQFNQMIVTMNGNDFQTGGIGNLPIRNWTFDFGLLGTTLLNLDANYVENARTTIEYFIDFIDNVCMDEMARESQRNGVAPQSEALRKLAGI.KFKRINFDNSSEYIENWNLQNRRQRTGFVFHKPNIFPYSASFTLNRSQPIHDNLMGTMWLNAGSEIQVAGFDYSCAINAPANIQQFEHIVQLRRALTTATITLLPDAERFSFPRVINSADGATTWFFNPVIL..RPNNVEVEFLLNGQIINTYQARFGTIIARNFDTIRLSFQLMRPPNMTPAVNALFPQAQPF.QHHATVGLTLRIESAVCESVLADANDTLLANVTAVRQEYAIPVGPVFPPGMNWTELITNYSPSREDNLQRVFTVASIRSMLI..
D7NN21_9VIRU/1-396                 MDVLYSLSKTLKDARDKIVEGTLYSNVSDLIQQFNQMIITMNGNEFQTGGIGNLPIRNWNFDFGLLGTTLLNLDANYVETARNTIDYFVDFVDNVCMDEMVRESQRNGIAPQSDSLRKLSGI.KFKRINFDNSSEYIENWNLQNRRQRTGFTFHKPNIFPYSASFTLNRSQPAHDNLMGTMWLNAGSEIQVAGFDYSCAINAPANTQQFEHIVQLRRVLTTATITLLPDAERFSFPRVINSADGATTWYFNPVIL..RPNNVEVEFLLNGQIINTYQARFGTIIARNFDTIRLSFQLMRPPNMTPAVAALFPNAQPF.EHHATVGLTLRIESAVCESVLADASETMLANVTSVRQEYAIPVGPVFPPGMNWTDLITNYSPSREDNLQRVFTVASIRSMLV..
A0A222NY35_9VIRU/1-385             ------------DARDKIVEGTLYSNVSDLIQQFNQMIVTMIGRDFQTGGIGNLPIRNWTFDFGLLGITLINLDANYVETARTTIEYFIDFIDNVCMDEMARESQRNGVAPQSEALRKLAGIlKFKRINFNNPSEYIENWNLQNRRQRTGFVFHKPNIFPYSASFTLNRSQPMHDNLMGTMWLNAGSEIQVAGFDYSCALNAPANIQQFEHIVQLRRALTTATITLLPDAERFSFPRVINSADGATTWFFNPIIL..RPNNVEVEFLLNGQIINTYQTRFGTIVARNFDTIRLSFQLMRPPNMTPAVNALFPQAQPF.QHHATVGLTLRIESAVCESVLADANETLLANVTAVRQEYAIPVGPVFPPGMNWTELITNYSPSREDNLQRVFTVASIRSMLI..
L0CRY4_9VIRU/1-396                 MDVLYSLAKTLKDARARIVEGTLYTNVADIVQQVNQVINSINGSTFQTGGIGNLPIRNWTFDFGTLGTTLLNLDANYVENARTTIDYFIDFVDSVCVDEIVRESQRNGIAPQSDSLRQLSNA.KYKRINYDNESEYIENWNLQNRRQRTGYLLHKPNILPYNNSFTLTRSQPAHDNVCGTIWLNNGSEIEIAGFDSECALNAPGNIQEFEHVVPMRRVLNNATVSLLPYAPRLTQRAVIPTADGLNTWLFNPIIL..RPNNVQLEFLLNGQVITNYQARYGTLAARNFDSIRISFQLVRPPNMTPGVAALFPLAAPF.PNHATVGLTLKIESASCESVLSDANEPYLSIVTGLRQEYAIPVGPVFPAGMNWTELLNNYSASREDNLQRIFTAASIRSMII..
VP6_ROTSH/1-396                    MDVLYSLSKTLKDARDKIVEGTLYSNVSDLIQQFNQMIITMNGNEFQTGGIGNLPIRNWNFNFGLLGTTLLNLDANYVETARNTIDYFVDFVDNVCMDEMVRESQRNGIAPQSDSLRKLSAI.KFKRINFDNSSEYIENWNLQNRRQRTGFTFHKPNIFPYSASFTLNRSQPAHDNLMGTMWLNAGSEIQVAGFDYSCAINAPANIQQFEHIVPLRRVLTTATITLLPDAERFSFPRVINSADGATTWFFNPVIL..RPNNVEVEFLLNGQIINTYQARFGTIVARNFDTIRLSFQLMRPPNMTPAVAVLFPNAQPF.EHHATVGLTLRIESAVCESVLADASETLLANVTSVRQEYAIPVGPVFPPGMNWTDLITNYSPSREDNLQRVFTVASIRSMLI..
A0A0K0LAS1_9VIRU/2-398             MEALSSIALTVREAREKIINGTIYSNVSDVIQQFNQMVRVLNGSTFTTGGLATMPLREWTFDLPQLGTTLLNIDANYVESMTPTLDMLTEFVIAVCETELLVDNNRNGAYPQSEALRLLSNN.KYVFLNMDLGSKYISEWHYRLSARDPMFSNHVPYIFPYDMAIAYDRVTAAYDNVSGTRFASLNNAIHFAAFDQDFVRGQPANARQFEYLYNLRTPVSNATIVIHPISDILSVPSMIRNQAATHYWPYNPYNIptFRDDIRVEFQLAGQVIYVA-ANLGMHTIPQFDAVNIILTMRRLPLLA-DLQNIFPAGNPSaTHQAVISTKIEVLNATTETTVPSIDEHLYALIVGTRGRYQMQAGPVFPPGMRWDDILNRYTPARQSNMQRLMTTASILDL--vs
Q32WR3_9VIRU/1-395                 MDVLFSIAKTVSDLKKKVVVGTIYTNVEDVVQQTNELIRTLNGNIFHTGGIGTQPQKEWNFQLPQLGTTLLNLDDNYVQSTRGIIDFLSSFIEAVCDDEIVREASRNGMQPQSPALILLSSS.KFKTINFNNSSQSIKNWNAQSRRENPVYEYKNPMLFEYKNSYILQRANPQFGSVMGLRYYTTSNTCQIAAFDSTLAENAPNNTQRFVYNGRLKRPISNVLMKIEAGAPNISNPTILPDPNNQTTWLFNPVQL..MNGTFTIEFYNNGQLIDMVR-NMGIVTVRTFDSYRITIDMIRPAAMTQYVQRIFPQGGPY.HFQATYMLTLSILDATTESVLCDSHSVEYSIVANVRRDSAMPAGTVFQPGFPWEHTLSNYTVAQEDNLERLLLIASVKRMVM..
#=GC seq_cons                      M-VLYSluKTl+DAR-KIVEGTLYSNVSDlIQQFNQMIhTMNGNpFQTGGIGNLPlRNWsFDFGhLGTTLLNLDANYVEoARsTIDYFlDFlDsVChDEhlRESQRNGlAPQS-uLRpLSul.KFKRINFDNSSEYIENWNLQNRRQRTGFsaHKPNIFPYssSFTLsRSQPAHDNlMGThWLNsGSEIQlAGFD.oCAlNAPANhQQFEHlVpLRRsLosATIoLLPDA-RhShPpVIsoADGsTTWhFNPlIL..RPNNVcVEFLLNGQlIssYQARaGTlsARNFDoIRlSFQLhRPPNMTPuVssLFPpApPF.pHHATVGLTL+IESAlCESVLADAsEThLApVTuVRQEYAIPVGPVFPPGMNWT-LloNYSPSREDNLQRlFTlASIRSMLl..
//