#=GF ID   Rotavirus_VP7
#=GF AC   PF05868.15
#=GF DE   Rotavirus major outer capsid protein VP7
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_9690 (release 8.0)
#=GF GA   24.00 24.00;
#=GF TC   25.00 73.20;
#=GF NC   23.50 23.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0217
#=GF RN   [1]
#=GF RM   12050377
#=GF RT   Antibodies to rotavirus outer capsid glycoprotein VP7 neutralize
#=GF RT   infectivity by inhibiting virion decapsidation. 
#=GF RA   Ludert JE, Ruiz MC, Hidalgo C, Liprandi F; 
#=GF RL   J Virol 2002;76:6643-6651.
#=GF DR   INTERPRO; IPR008818;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several Rotavirus major outer capsid
#=GF CC   protein VP7 sequences. The rotavirus capsid is composed of three
#=GF CC   concentric protein layers. Proteins VP4 and VP7 comprise the
#=GF CC   outer layer. VP4 forms spikes and is the viral attachment
#=GF CC   protein. VP7 is a glycoprotein and the major constituent of the
#=GF CC   outer protein layer [1].
#=GF SQ   8
#=GS D6NGF9_ROTGA/1-249      AC D6NGF9.1
#=GS A0A0F6QPL1_9VIRU/1-248  AC A0A0F6QPL1.1
#=GS U3QY93_9VIRU/1-247      AC U3QY93.1
#=GS A0A024CFJ0_9VIRU/1-247  AC A0A024CFJ0.1
#=GS VP7_ROTJ1/1-251         AC Q45UF2.1
#=GS Q6KF86_9VIRU/1-247      AC Q6KF86.1
#=GS A0A1L6BXL9_9VIRU/2-245  AC A0A1L6BXL9.1
#=GS A0A0E3GNI1_9VIRU/1-262  AC A0A0E3GNI1.1
D6NGF9_ROTGA/1-249                 ....MASLPLLVLAAAVNAQLNIVPSVHPEVCVLYA.DDHQSDANKFNGNFTQIFHSYNSITLSFMSYS.SSSYDVIDI..MSRYDLSSC...S...ILAIDVF...DASMDFNVFLQSTNNCSKYNANKIHYI.KLPRGEEWFSYSK.NLKFCPLSDSLIGMYCDTQLSDTYFEISTG......GTYEVTDVPEFTQMGYTFHS.SEDFYLCHRISSE..AWLNYHLFY..RDYDVS...GVISKQINWGNVWSGFKTFAQVLYKILDLFFNSKRNVEPRA....
A0A0F6QPL1_9VIRU/1-248             ....MAFTLLLVLAACVNAQLNIVPSIHPEICVLYS.DDL-TDAKKYFGNFTKIFENYNHVTISLTNYS.NSDYDVIDI..LSKHNYEAC...D...VLAIYVK...YAYMDFATFLQSENNCTKFAGRKIHYV.QLPKNQEWFVYSR.DLKFCPLSDDLIGMFCDTQLEGTYFEVAPD......RRYYITDIPEFTTRGYTLYS.NNPFYVCQRITER..PWINVHYFY..NDNEPS...GTVSQRISWGNVWTNVTTFAQMLYKILDIFFNNNRSAEPRA....
U3QY93_9VIRU/1-247                 ...m-FMLTLLSLAAVGSSQLIIEPVIKNSVCLAYP.NEE--PISELNGNFTNIFSSYSGVHFQLINYSlGADKDVIQV..IRNLDVESC...P...TLAVYIT...DASLDFVTFLSAENRCQRFKQGLTHYI.KLPVENEYFTYSK.TLKFCPLSNDLIGIYCDSQLKDTYHTVIDQ......ATYDIVDIPEFTEMGYLFYS.DSDFYICERLATN..EYMDVYYFY..KDQPAA...GTVTKAIDWNRVWTNFKKVAQVAYKILDIFFG-KKTVEPRA....
A0A024CFJ0_9VIRU/1-247             ....--MMLLLFLATCVSAQLTMKPITERNICLLYP.QGQ--TITDYSGNLTKVFSSYNGVYMVMTEYNlATDKNVLEI..ARANDISGC...D...LVAIHIA...ESGADFVTFFSSENDCTEYAPNKIHYV.QLPRDKEFFTYSK.ELKFCALDDSLVGIYCDSQLESTYFQVVDKs....qSYYEVTDFPEFNEKGVLFYS.TAKFYVCERTGSI..ESNKIYYFY..VNDDNT...GTIRLKPNWGNVWKNFKKVAQVIYKILDIFYGQQ-RVQPR-q...
VP7_ROTJ1/1-251                    ....--MLLFIILSVGVDAISYIQNDRSNDLCIVYEmTSFGTSFNNANDSLVKLHK-HMGLKYEVCKIE.SNANALTQMqkCNCIYDDTP...Q...IVVFTNF...KK-SSLKTLIGTENKCELLPQTTIYTP.TVDIESEYFIYGN.DVKICYLDKNLLGIGCDATDTTSWLDLDAG.....lPTNHALDIPEITSDGFKLFAkYSDSFLCQRLMDE..PKKQIQFYAevDNVPSN...DVIESSRSWASVWKVVKTVLHFTYHILDLFYGNRRA-----tarm
Q6KF86_9VIRU/1-247                 ....MPLPLLLVLAACAKAQLIITPISNPEICVLHA.NDR--NVNTFGENFTNIFESYNSVTLSFYNYD.SNNYDVIDI..LSKKDYSLC...Q...ILAIDVI...RPEMDFITFLQSNNECSKYSRQKIHYQ.KLTTGDEWFVYSK.NLKFCPLSDNLIGLYCDTQVNGTYFPLSNN......ERYDVTDLPEFTEMGYVFYS.DDDFYICKRVTEE..KWINYHLFY..REYSAS...GTVARAISWDNVWTGFKTFAQVVYKILDIFFNNRRNFEPRA....
A0A1L6BXL9_9VIRU/2-245             lsma---LFLLALLSITEARINV-GFVSPDVCIVAE.RQT-SDADKINNLL-D-FYSFRGFTYEICQFN.-QDADAIDA..ISKCSCLYG...NntqIVA-YAD...TVKSDLATLLGNDNDCTVFTKKTKKWIpQYDRDREYFLYAK.NVRICYISESLLGMGCDSTKEWTWQNIT-S......TDYAIADIPEMTLDGFWLFT.TETAYLCVRKDSSqpKPIYFFNLI..GNKPPE...DQIGQTRSLATAWKAVNSILHFVYKVLDIFYRER-------lr..
A0A0E3GNI1_9VIRU/1-262             .mwf------LLLLPIVSSTVVIQEYKPVDVCIFVY.ASSGDNSSAYYAFHTWMQRLQPVLATTYHVCG.VQAVDSVDV..IKAVAECSClndK...LTDVNIVysdEPQSTLATFIGNQNTCTKLQVRKAAYI.HLNKSEEFFIYGKrDLKLCFLSSSYLGLDCDSANPTTWPTIDYNiqsiihEKPIIYDIPEITYAVGIYPE.ADPTYICKRVDD-..NGINPTYFF..AGDNSIqwgDQMAREINWGNVWNKVVSVSQALYKILDLFFNEKERIEQ--qpr.
#=GC seq_cons                      ......hhhLLlLAusVsAQLsIpPhhps-lCllYs.ssp.sssscasuNaTplFcSYsulshshpsYs.usshDVIDl..lsphshsuC...s...llAlplh...csphDFsTFLuo-NcCo+astpKIHYl.pLs+scEaFlYSK.sLKFCsLS-sLlGlaCDoQlpsTYaslsss......spYclsDIPEFTptGahaaS.sscFYlCcRlssp..phlshaaFY..sspsss...GsluppIsWuNVWsshKolAQslYKILDIFFsp++shEPR.....
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