#=GF ID Roughex
#=GF AC PF06020.15
#=GF DE Drosophila roughex protein
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF SE Pfam-B_7712 (release 9.0)
#=GF GA 25.00 25.00;
#=GF TC 120.40 25.40;
#=GF NC 22.60 22.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 11027291
#=GF RT Roughex mediates G(1) arrest through a physical association with
#=GF RT cyclin A.
#=GF RA Avedisov SN, Krasnoselskaya I, Mortin M, Thomas BJ;
#=GF RL Mol Cell Biol 2000;20:8220-8229.
#=GF RN [2]
#=GF RM 11231149
#=GF RT The cyclin-dependent kinase inhibitor Roughex is involved in
#=GF RT mitotic exit in Drosophila.
#=GF RA Foley E, Sprenger F;
#=GF RL Curr Biol 2001;11:151-160.
#=GF DR INTERPRO; IPR009259;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family consists of several roughex (RUX) proteins specific
#=GF CC to Drosophila species. Roughex can influence the intracellular
#=GF CC distribution of cyclin A and is therefore defined as a distinct
#=GF CC and specialised cell cycle inhibitor for cyclin A-dependent
#=GF CC kinase activity [1]. Rux is though to regulate the metaphase to
#=GF CC anaphase transition during development [2].
#=GF SQ 23
#=GS B4MTD5_DROWI/27-277 AC B4MTD5.1
#=GS A0A0Q9XFP4_DROMO/16-286 AC A0A0Q9XFP4.1
#=GS Q95WF1_DROSE/10-349 AC Q95WF1.1
#=GS A0A6I8UFV9_DROPS/14-301 AC A0A6I8UFV9.1
#=GS B4MB29_DROVI/15-281 AC B4MB29.1
#=GS A0A484B5L5_DRONA/11-274 AC A0A484B5L5.1
#=GS A0A6P4EQK0_DRORH/18-207 AC A0A6P4EQK0.1
#=GS A0A0M4ELE3_DROBS/7-254 AC A0A0M4ELE3.1
#=GS A0A6J2U1H9_DROLE/22-283 AC A0A6J2U1H9.1
#=GS M9NDP7_DROME/10-335 AC M9NDP7.1
#=GS B4L757_DROMO/12-285 AC B4L757.1
#=GS A0A3B0JVL3_DROGU/19-302 AC A0A3B0JVL3.1
#=GS B4JX75_DROGR/11-121 AC B4JX75.1
#=GS B4R5B7_DROSI/10-344 AC B4R5B7.1
#=GS A0A6P4IN36_DROKI/32-292 AC A0A6P4IN36.1
#=GS A0A6P4EUY7_DRORH/40-229 AC A0A6P4EUY7.1
#=GS A0A6P4IN36_DROKI/279-345 AC A0A6P4IN36.1
#=GS B4JX75_DROGR/129-289 AC B4JX75.1
#=GS B3MY94_DROAN/41-405 AC B3MY94.1
#=GS A0A6P4EUB4_DRORH/10-333 AC A0A6P4EUB4.1
#=GS RUX_DROME/10-335 AC P50445.2
#=GS A0A6P8X9S7_DROAB/12-273 AC A0A6P8X9S7.1
#=GS B4H099_DROPE/14-307 AC B4H099.1
B4MTD5_DROWI/27-277 ..............TPSSIIQRFIQSVNDGTVRTELAEDCILNFFGRHITGIDSVTGYMRTQLMDRFRHAGFSEAQPCDPADEVILRERFARTFDRTRRRLHQQ....KER.VRA.TT.LHLL....A.ESDD.dE.....E...VgrgS.T....Q.....VPS.HLVTPPRP..S.TH.NT..ELLTYIQAKGMLDPI.HDS..D-DGGIDL.GDSRQVQLTLGYRRE-------HSDEIYLALYEKF.RQLRQKSTLAPP----TPRAIQWRRHGA------------DTEEQAT..I...P-EPRSVRRTLFASGSDDL-----.---------------.------------------------------------------------------------------------------------------------------eagdgkvlvspqvvk.................
A0A0Q9XFP4_DROMO/16-286 ..........ssql-----FRRFLQCMEDGQIRRELSDDCILSFLGRCVKGAGPVSSYMRAQLVGRYNHMEFLDARQCNESEESALKERFRRSFQLLRSRFK-Q....PDV.L-P.TS.MHLR....A.ESDE..EveeeeE...T...A.S....A.....ICVkQLVTPPRC..ApAD.GI..ELMHCITASGSLQA-.SHK..HSDGGIEL.SGNCQMSLTLGYRGNTLGHKDDTSSDICLIVYEKV.RLR-------TP-TVQ---RHSRMRSAR----NVLTDD-----EGEV..P...A--PRSVRRTLFS--NTDDCDEDA.---VQPAIDDNSPLL.LPRKRQH-----------------------------------------------------------------------------------------------kgdssarktkr.....................
Q95WF1_DROSE/10-349 ..............TPLEVIHEFINDVDDGSIRRDLGEDCILSFYSRNVRGAKAVTGFLRNQLTMRYKHEGFEEAAQIEWGDELLLKARFGRSFDLERRRIYEE....KER.T-G.TT.LHVH....P.ESDD..E.....E...V...N.K....E.....FSS.TLITPPRP..S.SY.NL..NSLKYVEACGLLNK-.RNE..HVYGGLDM.GESCAVHLTLGYRSTLLPGGKVSGFEICLAVYDRG.LKNLKRSTLTSP-----LCSFSFARRAS-ARCNPTTDDEGDTEEDLP..P...PTARRCVRRTLFT-EENTQKEEDP.DSIPLEEQQPA----.-PQQQTAPQQ---QTALQQQAAPQQQTAPQQVEETGEVV-----DLSTPLKTTN-----------------LCSYTSRKRQQTIHCNEVERKRVTGPRRMRF................................
A0A6I8UFV9_DROPS/14-301 ............sa--SEIVQNFIVGVDTGLVRADLADDCMLSLFGRQIRGVVAVTGFIRTQIFNRFKHIGFEDARPCTPSKEVFIKEWFGPTFERVRRRMHEQ....KER.ERA.IS.EGRRiavgD.SEGE..E.....E...V...Q.S....R.....SSP.HLATPPRP..A.IRpAM..DMLQYVEARGVMEDV.EGN..RNDGGIQL.YDTQHVLLTLGYRQTATASISLRDIEVCLAIYEDY.R----------P------FPRQRQRGSVAISSNPLTDDEAEEPASSH..P...LSHLRSVRRTLFARAESEEPEQNPlEDSVEPVPV---EPSpSSSQSQCESQDQVP----------------------------------------------------------------------------------------rippppvrd.......................
B4MB29_DROVI/15-281 .............s-PSQVMRRFVQCMDDDDVRRELTDDCILSVLGRSIKGVSAVTGYVRTQLTGRYKHVGFRAASHCSEAQKSLIMERYARSFHVLRSRRKVA....KPM.P--.SS.LHMR....P.ESDD..D.....E...D...G.EpdaiQ.....CPN.QLVTPPRS..S.AH.AQspQLLHYIESSGVLEA-.AHE..HDDGGIDL.GESCQVRLMLGYRCSSLAYTNECAVEISLVIYEK-.---LKPRSLQHPARIRTSSGVQRQSRMR-SSRNVHTDD-----EGEL..P...AT--RSVRRTLFTSADCEESEES-.---------------.------------------------------------------------------------------------------------------------------lvrmlpedspakppp.................
A0A484B5L5_DRONA/11-274 ..........assq----LFRRFLQCMEDGQIRRELSDDCILSFPGRCLKGAGPVSSYLRAQLVGRYNHIEFLNARQCNESEESALKDRFRRSFQSQRDRFK-A....PEV.L-P.TS.MHLR....A.ESDE..E.....V...E...E.E....EtasgsCAN.QLITPPRScvS.AD.TI..EVMHCITASGSLQA-.SHD..HSDGGIEL.SENCQMSLTLGYRDTTLVDKDHTSTDICLIVYEKV.NS------MTPV-----VQRHSRMRRAR----NVLTDD-----EGEV..P...A--PRSVRRTLFSNT-SDDCDEDA.---------------.------------------------------------------------------------------------------------------------------vqpaidhspllprkrqhkgds...........
A0A6P4EQK0_DRORH/18-207 ..............TPLSVIHGFVKAVENGSICKELAQECILYVFGHNIQGVSKATRYLSAEIKNVFEHEHFEEACFLREGLEIIMKERFARTFDIERRK----....---.---.-T.SHLC....M.DRNV..Y.....N...V...P.-....-.....-GD.ILVTPPRP..A.NF.DM..DKLQFIEATGTLKRL.RDS..ESGYTFGI.GHSAAIHLTLGYRHH----G--QGIEIYLAVYEKYyPISVNMSSL--------------------------------------..-...------------------------.---------------.------------------------------------------------------------------------------------------------------pynppngndt......................
A0A0M4ELE3_DROBS/7-254 ..............TPIEVVKQVVASVEAGDVRSLLAEICVFNFLGRNVCSATEVTGWVRTQVTNRFKHQQFESATLCDLRQEVHLKERFGSSFGRQQYRPKLK....HEL.PSS.LK.LHID....T.DDDD..Ds...dEigaV...V.D....P.....LAL.VLKTPPRGgdA.SS.SH..VLVQYVMATGVLKA-.CHK..ADDGGICV.GPLIPVELTVGYRNNP--------LEVCLIVYDKH.DRYLGAA-LKR-------------RGARSHRRHANTDD-EAG-EDEQ..P...PP--RTVRRTLFINEVDLDDD---.---------------.------------------------------------------------------------------------------------------------------lglrpimes.......................
A0A6J2U1H9_DROLE/22-283 ............st--HAIMQNYLQDVESGAIRSTLAPEVILNVFGRSVKGASSVTGFMRTQITNRYKHVGFDEATNCHQDVAAEMNSRFGRALHTVR-RLREQ....KAR.EKMpSS.LRLR....A.DSDE..E.....D...L...SiI....E.....LSS.RLATPPRN..E.--.--..-SLNYVEGIGRLEA-.THS..NDDGGIDI.GDSQPTRLTLGHRASPRS----TTHEICLVVYEKV.PPG---SPVTGTRTSTSAGPAAARRQRPWPVGNEHTDD-ESVEAPETliR...RQPRSSVRRTLFT-STDLDQH---.---------------.------------------------------------------------------------------------------------------------------nqplsaepsvslssp.................
M9NDP7_DROME/10-335 ..............TPLEVIHEFINGVDDGTIRRDLGEDCILSFYSRNVRGAKAITGFLRNQLTMRYKHEGFEEAAQIEWGDELLLKARFGRSFDSERRRIYEE....KER.T-G.TT.LHVR....P.ESDD..E.....E...V...N.E....K.....FSS.TLITPPRP..S.SY.NL..NSLKYVEACGLLNK-.RNE..HIYGGLDM.GESCAVHLTLGYRSTFLPGGQVSGFEICLAVYDRG.LTSLKRSTLIPP-----LCSISFARRAS-ARCNPTTDDEEDTEEDST..P...PTARRCVRRTLFT-------EENT.---------------.----QKEEDADFIPVVEQEQPAPQEQPAPQQAEETGEVVIPV--DISTALKTTN-----------------FSSCTPRKRQQATNGNEVVRKRATGPRRMRF................................
B4L757_DROMO/12-285 ..........sssq----LFRRFLQCMEDGQIRRELSDDCILSFLGRCVKGAGPVSSYMRAQLVGRYNHMEFLDARQCNESEESALKERFRRSFQLLRSRFK-Q....PDV.L-P.TS.MHLR....A.ESDE..EveeeeE...T...A.S....A.....ICVkQLVTPPRC..ApAD.GI..ELMHCITASGSLQA-.SHK..HSDGGIEL.SGNCQMSLTLGYRGNTLGHKDDTSSDICLIVYEKV.RLR-------TP-TVQ---RHSRMRSAR----NVLTDD-----EGEV..P...A--PRSVRRTLFS--NTDDCDEDA.---VQPAIDDNSPLL.LPRKRQH-----------------------------------------------------------------------------------------------kgdssarktkrsn...................
A0A3B0JVL3_DROGU/19-302 .............s-PSEIVQNFIVGVDTGLVRADLADDCILSLFGRHIRGVVAVTGFIRTQIFNRFKHIGFEEARPCTPSKEVAIKERFGRSFDRVRRRIHEQ....KER.ERA.NAdVGVR....RlAVDDmeE.....D...V...D.Al..pR.....SSP.HLVTPPRP..T.RH.VM..DMLQYIEARGVMEDV.EGN..SNDGGIQL.GDSQHVLLTLGYRHTQTASLSLRDIEICLAVYEDY.RT-------FPR---------QRARASAAITSNPLTDDE--AEEPAV..SgllRGHLRSVRRTLFARAESEEPEQNP.---LE----------.------------------------------------------------------------------------------------------------------dsaepvptepspsssqsqcesqgpvpvpp...
B4JX75_DROGR/11-121 ...........sas---QVMRQFVQYISEDGIRRELADECILTLIGRTVKGASAVTSF----LTGRYKHVGFVDAHPCDAARVSLLKDRYARSFEVLRRHQREA....KPNiQLP.HT.LRPR....A.ESID..D.....-...-...-.-....-.....---.--------..-.--.--..---------------.---..--------.-----------------------------------.-----------------------------------------------..-...------------------------.---------------.------------------------------------------------------------------------------------------------------paaadd..........................
B4R5B7_DROSI/10-344 ..............TPLEVIHEFINGVDDGSIRRDLGEDCILSFYSRNVRGAKAVTGFLRNQLTTRDKHEGFEEAAQIEWGDELLLKARFGRSFDLERRRIYEE....KER.T-G.TT.LHVH....P.ESDD..E.....E...V...N.K....E.....FSS.TLITPPRP..S.SY.NL..NSLKYVEACGLLNK-.RNE..HVYGGLDM.GESCAVHLTLGYRSTLLPGGKVSGFEICLAVYDRG.LKNLKRSTLTSP-----LCSFSFARRAS-ARCNPTTDDEGDTEEDLP..P...PTARRCVRRTLFT-------EENT.---------------.----QKEEDPDSIPLEEQEQPAPQQQPAPQQQAA------PQ---QQTAPQQVE-ETGEVVDLSTPLKTTNLCSYTSRKRQQTIHCNEVERKRATGPRRMRF................................
A0A6P4IN36_DROKI/32-292 ..............TPLEVVQEFVAAANSGSIGRELADDCVISFFGRHSRGSAVSAGYFRVFISSRYQHEGFEKATFVSPAKVENLKLRFMRSFSWARRRMVEEqkvqKVQ.QRA.TS.LHLR....A.ESDD..E.....D...EqppP.S....R.....CTA.ELVTPPRP..V.SQ.GL..DQVKFVAAKGVLKSL.SAD..YSDNGLDF.GHTRTIRLTLGYRQVPLAFGQGRHIDICLAVYEKY.SSASSSSVAVP-------------RRGSAARCNPPTDD--EAEDDS-..-...-DHRNGARRTLFAEADNEDNAEA-.---------------.------------------------------------------------------------------------------------------------------eqdepepaleh.....................
A0A6P4EUY7_DRORH/40-229 ..............TPLSVIHGFVKAVENGSICKELAQECILYVFGHNIQGVSKATRYLSAEIKNVFEHEHFEEACFLREGLEIIMKERFARTFDIERRK----....---.---.-T.SHLC....M.DRNV..Y.....N...V...P.-....-.....-GD.ILVTPPRP..A.NF.DM..DKLQFIEATGTLKRL.RDS..ESGYTFGI.GHSAAIHLTLGYRHH----G--QGIEIYLAVYEKYyPISVNMSSL--------------------------------------..-...------------------------.---------------.------------------------------------------------------------------------------------------------------pynppngndt......................
A0A6P4IN36_DROKI/279-345 .aeaeqdepepale------------------------------------------------------------------------------------------....---.---.--.----....-.----..-.....-...-...-.-....-.....---.--------..-.--.--..---------------.---..--------.-----------------------------------.-----------------------------------------------..-...------------------------.---------------.---------------------------------------------HTPARVEVNTQEESALEETPPPS---ISSCTPRKRHIASSGGEVKPKRTPRLNRLRF................................
B4JX75_DROGR/129-289 vvqssisrvgaeiv------------------------------------------------------------------------------------------....---.---.--.----....-.--DQ..V.....N...V...D.V....S.....YSE.QLATPPRT..R.TH.--..--LHYIESVGVIEPC.HQA..DDGGGFDQsTDALEVTLTLGYQHC---SGEGS-AEICLIVYKKF.RPT-ARTT---PTATGHLRTHSRMRTTL--THNVHTDD----EGDVV..P...A--PQTVRRTLFTSADSDDPDND-.---------------.------------------------------------------------------------------------------------------------------iaivslrsqt......................
B3MY94_DROAN/41-405 ..............TPHDIVIQFVTSVDTGSIRSELAEDCIFSFFGRHVRGVNAIMGYVRTQLLGRFQHERFDRAQIVSQSHELILKERFGRSFDVVRRRIYEQ....KER.ERA.TT.LHLR....A.ESDD..E.....E...V...P.S....R.....YPV.QLVTPPRA..S.SH.SM..DQLTFVEACGVLESL.RDS..NFSGGLDL.GDLVPMHLTLGYRLTPVVLGNLRAIEICLAIYEKY.PLKLNRSTLVPPPTVEEIFGIGRLRNTTLAPANPQTDD----EGEEV..P...QARSLSVRRILFADGADEDGDEDT.DGSVEEKKDDASEPD.LPDQNQEEDKD-----EPEQQGEQEEQQQQQPEEA-----PASSSSSTAQEETNPPAEPIVGERNPPEKSIICSLTPRKRTQTTNVCEVEPKRTPLRTRMRF................................
A0A6P4EUB4_DRORH/10-333 ..............TPLEVIHEFVAGVDNGTVRRDLAEDCILSFCSRNVRGDSAITGFLRTQVTNRYMHERFDEAAAPSIATEIILRERFGRSFDRARRRLYEQ....KER.ERS.TT.MHLR....P.ESDD..D.....E...V...V.E....R....mFPV.LLVTPPRA..S.SY.AL..HTLKYVEAIGLLKSRsHNT..HSDGGLDL.GESCTVHLTLGYRRTQLPGRNVRSIEICLVVYDRG.PTSLNRSSLLPQPS------RIPARQRVIGRCNPTTDD---EAEEAP..P...PTTRRGVRRTLFT-------EENT.---------------.----EEEEAEDEVSQVAQEQPPQPAEEAPQEEANV-DAVVPV-----LPLLDT----------------PTCSNYTPRKRHQTANGNEVTPKRTPGQQRLRF................................
RUX_DROME/10-335 ..............TPLEVIHEFINGVDDGTIRRDLGEDCILSFYSRNVRGAKAITGFLRNQLTMRYKHEGFEEAAQIEWGDELLLKARFGRSFDSERRRIYEE....KER.T-G.TT.LHVR....P.ESDD..E.....E...V...N.E....K.....FSS.TLITPPRP..S.SY.NL..NSLKYVEACGLLNK-.RNE..HIYGGLDM.GESCAVHLTLGYRSTFLPGGQVSGFEICLAVYDRG.LTSLKRSTLIPP-----LCSISFARRAS-ARCNPTTDDEEDTEEDST..P...PTARRCVRRTLFT-------EENT.---------------.----QKEEDADFIPVVEQEQPAPQEQPAPQQAEETGEVVIPV--DISTALKTTN-----------------FSSCTPRKRQQATNGNEVVRKRATGPRRMRF................................
A0A6P8X9S7_DROAB/12-273 ..............TPAEILHQYVECINDGDVKRTVTEDCILNLFARSVQGGDAVARFLRIQLSGRYNHTDFGIPSCCAISQQELLTERYARRFERHWRRKRAA....EEP.RVD.SD.DDVE....D.ANDD..Q.....S...P...N.K....-.....---.RQVTPPRS..S.-K.VT..TKLQYIEANGVLKTL.RDNadDSDGGLDF.GDCRQVRLVLGFRHTSA-------PQVCLIVYEKL.QA---RSSRLPI-------ELQRSRNHR----NVHTDD-----EGET..P...--APLNVRRTLFGSG-NDDGDEDP.---------------.------------------------------------------------------------------------------------------------------vilavevspkprplsrkrphardeqqqkatkn
B4H099_DROPE/14-307 ............sa--SEIVQNFIVGVDTGLVRADLADDCMLSLFGRQIRGVVAVTGFIRTQIFNRFKHIGFEDARPCTPSKEVFIKEWFGPTFERVRRRMHEQ....KER.ERA.IS.EGRRiavgD.SEGE..E.....E...A...L.S....R.....SSP.HLATPPRP..A.IRpAM..DMLQYVEARGVMEDV.EGN..RNDGGIQL.YDTQHVLLTLGYRQTATASISLRDIEVCLAIYEDY.RT-------FPR---------QRQRGSVAISSNPLTDDEAEEPASSH..P...LSHLRSVRRTLFARAESEEPEQNPlEDSVEPVPV---EPSpSSSQSQCESQDQVPR---------------------------------------------------------------------------------------ippppardgtgemp..................
#=GC seq_cons ...............P.pll+pFlpsV-sGslR+-Lu-DCILShaGRsl+GssuVTGalRsQlssRacH.tF--Ap.ss.ucEhhLK-RFuRSF-h.RRRhhtp....K-h...s.oo.hHlR....s.-SD-..E.....-...l...s.p....p.....hss.pLlTPPRs..u.sh.sh..p.LpYlEAsGlLcs..csp..cssGGl-l.G-optlpLTLGYRps.hs.tp.pshEICLsVYE+h..h....sshhs.........hph.Rpst...tNshTDD.....-sts..P.......RsVRRTLFs...s.p.-ps............................................................................................................................s...........................
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