#=GF ID SAM_DrpA
#=GF AC PF18255.5
#=GF DE DNA processing protein A sterile alpha motif domain
#=GF PI DrpA_SAM;
#=GF AU Smart A;0000-0002-6965-5633
#=GF SE ECOD:EUF04873
#=GF GA 26.20 26.20;
#=GF TC 26.30 28.30;
#=GF NC 26.10 24.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF CL CL0003
#=GF RN [1]
#=GF RM 22904190
#=GF RT Structure-function analysis of pneumococcal DprA protein reveals
#=GF RT that dimerization is crucial for loading RecA recombinase onto
#=GF RT DNA during transformation.
#=GF RA Quevillon-Cheruel S, Campo N, Mirouze N, Mortier-Barriere I,
#=GF RA Brooks MA, Boudes M, Durand D, Soulet AL, Lisboa J, Noirot P,
#=GF RA Martin B, van Tilbeurgh H, Noirot-Gros MF, Claverys JP, Polard
#=GF RA P;
#=GF RL Proc Natl Acad Sci U S A. 2012;109:E2466-E2475.
#=GF DR INTERPRO; IPR041104;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This is the N-terminal domain found in DNA processing protein A
#=GF CC (DprA) present in Streptococcus pneumoniae. DprA has recently
#=GF CC been discovered to be a transformation-dedicated RecA loader.
#=GF CC Transformation is believed to play a major role in genetic
#=GF CC plasticity. This domain is known as the sterile alpha motif
#=GF CC (SAM) domain. DprAs are able to form a type of dimer through
#=GF CC SAM-SAM interactions, also known as N/N interactions [1].
#=GF SQ 45
#=GS A3CN35_STRSV/1-62 AC A3CN35.1
#=GS A0A1G6CC08_9STRE/1-62 AC A0A1G6CC08.1
#=GS F9VDX8_LACGL/2-63 AC F9VDX8.1
#=GS A0A2A5RJC4_9LACT/2-63 AC A0A2A5RJC4.1
#=GS A0A1E8GS26_9LACT/4-60 AC A0A1E8GS26.1
#=GS A5M7M0_STREE/3-64 AC A5M7M0.1
#=GS A0A1Q8E9J9_9STRE/1-62 AC A0A1Q8E9J9.1
#=GS Q8DZU1_STRA5/1-63 AC Q8DZU1.1
#=GS A0A2X3VYZ8_9STRE/1-62 AC A0A2X3VYZ8.1
#=GS A0A3P1VFR9_9STRE/1-62 AC A0A3P1VFR9.1
#=GS F5X6H9_STRPX/1-62 AC F5X6H9.1
#=GS A0A0E4H474_9STRE/1-62 AC A0A0E4H474.1
#=GS A0A380KX97_9STRE/1-62 AC A0A380KX97.1
#=GS A0A2L0D4I4_9STRE/1-62 AC A0A2L0D4I4.1
#=GS A0A139NJU5_9STRE/1-62 AC A0A139NJU5.1
#=GS G5JMZ9_STRCG/1-62 AC G5JMZ9.1
#=GS A0A4Y9FLK9_9STRE/1-62 AC A0A4Y9FLK9.1
#=GS Q8DUD4_STRMU/1-62 AC Q8DUD4.1
#=GS A0A7X2D163_9LACT/3-64 AC A0A7X2D163.1
#=GS Q5M4N4_STRT2/1-62 AC Q5M4N4.1
#=GS A0A139NKT1_9STRE/1-62 AC A0A139NKT1.1
#=GS A4VV15_STRSY/30-91 AC A4VV15.1
#=GS A0A2R5HKQ8_9LACT/2-63 AC A0A2R5HKQ8.1
#=GS F9PVG6_9STRE/5-66 AC F9PVG6.1
#=GS A0A3L9DV38_9STRE/1-62 AC A0A3L9DV38.1
#=GS J0UZG3_STREE/1-49 AC J0UZG3.1
#=GS DPRA_STRR6/3-64 AC Q8DPI7.2
#=GS A0A380KBA3_9STRE/1-62 AC A0A380KBA3.1
#=GS A0A5C5TGL2_9STRE/1-62 AC A0A5C5TGL2.1
#=GS T1ZFA2_STRIT/1-62 AC T1ZFA2.1
#=GS G6ENW1_STRTR/1-62 AC G6ENW1.1
#=GS A8AXH5_STRGC/1-62 AC A8AXH5.1
#=GS B9DS67_STRU0/1-64 AC B9DS67.1
#=GS A0A7X6S1R8_9STRE/1-61 AC A0A7X6S1R8.1
#=GS A0A2A5S1T9_9LACT/1-69 AC A0A2A5S1T9.1
#=GS A0A387BH02_9LACT/2-63 AC A0A387BH02.1
#=GS A0A139NRW2_9STRE/1-62 AC A0A139NRW2.1
#=GS A0A224X0N9_9LACT/1-65 AC A0A224X0N9.1
#=GS A0A172Q7E2_9STRE/1-62 AC A0A172Q7E2.1
#=GS G5KFZ9_9STRE/1-62 AC G5KFZ9.1
#=GS A0A1J0MYY1_STRIN/1-62 AC A0A1J0MYY1.1
#=GS A0A239SSK8_9STRE/1-62 AC A0A239SSK8.1
#=GS A0A6A0BCB4_9LACT/1-67 AC A0A6A0BCB4.1
#=GS A0A6A0B3H5_9LACT/1-73 AC A0A6A0B3H5.1
#=GS Q99ZM5_STRP1/1-62 AC Q99ZM5.1
A3CN35_STRSV/1-62 .MNNFEIYKMKKAGLTNHQVLNVLRYAE.SKD.....G...........K...LSLRDKAVVSECRNPALFIEKYKRLDLPA-l...
A0A1G6CC08_9STRE/1-62 .MNNFELFKLKKAGLSNLNILNILDYQK.RVG.....K...........S...LSLRDMAIVSKTKNPVLFMEAYKNLDIKEL....
F9VDX8_LACGL/2-63 .IRNFEILRLKKAGMSNLGILKLIDYQE.RHE.....A...........K...LTLRQLARIAEVKAVPNFIESYKSQDVKRL....
A0A2A5RJC4_9LACT/2-63 y-TNFDLFRLKDAGMTNLGLNKLLRFAE.TNP.....V...........K...LSLRKMAQISGTKSIPDFIERYKSQDCKIL....
A0A1E8GS26_9LACT/4-60 s-NGFDIYKLKRAGMTNLSILRVLENNE.NQ-.....-...........-...-SLSQIAQLAGIKNQEIFIEKYKSLDIK--n...
A5M7M0_STREE/3-64 .ITNYEIYKLKKSGLTNQQILKVLEYGE.NVD.....Q...........E...LLLGDIADISGCRNPAVFMERYFQIDDAHL....
A0A1Q8E9J9_9STRE/1-62 .MNNFELFKLKKAGLTNLHIHKVLAHQE.RAG.....K...........S...LSIKSIALVSTCPNPVLFIEQYKQLDIKA-c...
Q8DZU1_STRA5/1-63 .MNHFELFKLKKAGLTNLNIHNIINYLK.KNS....lT...........S...LSVRNMAVVSKCKNPTFFIENYKQLDLKKL....
A0A2X3VYZ8_9STRE/1-62 .MNHFDIYKLKKAGLNNLNVINILNYQE.KHQ.....K...........S...LSLRDIAVVSDCKNPLQFIENYKNLDSKTL....
A0A3P1VFR9_9STRE/1-62 .MNNFEIFKLKKAGLTNLQVNKVLAYRK.QTG.....K...........S...LSLRNIAVASETSNPTFFMEQYKALDVKA-c...
F5X6H9_STRPX/1-62 .MNNFELFKLKKAGLTNLNILAILDYQE.KQE.....K...........S...LSLRNMAVVSKCKNPILFMEKYKALDIKEL....
A0A0E4H474_9STRE/1-62 .MNNFEIFKLKKAGLSNLQVHKVLTYRE.KTG.....K...........S...LSLRTVALVSETTKASLFMENYKALDIK--tc..
A0A380KX97_9STRE/1-62 .MENFEIYKLKKAGLSNQQVLNALEYEK.RKG.....K...........K...LSLRDIAVVSETVKPAIFMENYNQLDTDKL....
A0A2L0D4I4_9STRE/1-62 .MNNFELYKLKKAGLSNQHILNILDYEA.KYQ.....K...........S...LSLRDRAVVSKCSNPVVFMEHYKNLDSKTL....
A0A139NJU5_9STRE/1-62 .MDNFDIYKLKKAGLSNKHILNILHHVK.STK.....E...........K...LSLRNLAIISECRNPAIFIENYRQLDE---dvm.
G5JMZ9_STRCG/1-62 .MNNFELFKLKKAGLTNLQILNILDYQK.KVG.....K...........S...LSLRDMAVVSQTSKAGHFMESYKHLDLKAL....
A0A4Y9FLK9_9STRE/1-62 .MKRFDIFYLRKLGLTNIQIQKIIDYEV.EKG.....E...........E...EILRNRLVISGCKEPFDRLQKAKKWDQEAL....
Q8DUD4_STRMU/1-62 .MDNFQLFKLKKAGLTNLNILNIIDYEE.RTQ.....K...........S...LSLRDMAVVSKNKKPLIFMEHYKNLDSKAL....
A0A7X2D163_9LACT/3-64 .ISNFTIYRWKNAGMTNLNVYRLLKYLK.KNP.....E...........Q...ISLRTMAKIGQVKSIPDFIERFKSQDVQTL....
Q5M4N4_STRT2/1-62 .MNNFELFKLKAAGLTNLNILNILDYQK.NQD.....K...........K...LSLRDMAVVSKSKNAVLFMEKYKNLDVKQL....
A0A139NKT1_9STRE/1-62 .MNTFELFKLKEAGLSNLNINHLLAYQE.REK.....R...........H...LSLRDMAVVSRVKNPSLFIQSYKQLDLAEL....
A4VV15_STRSY/30-91 .MNNFELFKWKKAGLTYLNVNKVLAYQE.KHG.....K...........K...LTLRNVAVVSECKNPVLFMENYKNLDTKA-c...
A0A2R5HKQ8_9LACT/2-63 t-NNFDIFRWKMAGLSNRSVNRILDFLA.ESP.....Q...........K...LPLRRLAEIGQPKSTVNFIEGYKSQDVKDL....
F9PVG6_9STRE/5-66 .IDNFEIYKLKQAGLSNQQVLKVLQYGE.IYD.....Q...........E...LSLETIAEASECRNPVVFMERYHKLT----fesm
A0A3L9DV38_9STRE/1-62 .MNNFDLYKLRKAGLTNLNILNILDYQK.RVG.....K...........S...LSLRDMAVVSQCKNPVLFIETFKNLNSKEL....
J0UZG3_STREE/1-49 .-------------MTNQQILKVLEYGE.NVD.....Q...........E...LLLGDIADISGCRNPAVFMERYFQIDDAHL....
DPRA_STRR6/3-64 .ITNYEIYKLKKSGLTNQQILKVLEYGE.NVD.....Q...........E...LLLGDIADISGCRNPAVFMERYFQIDDAHL....
A0A380KBA3_9STRE/1-62 .MNNFELFKLKKAGLTNLNIINILDYQE.RVG.....K...........S...LSLRDMAVVSKCKNPVAFIENYRALDSKTL....
A0A5C5TGL2_9STRE/1-62 .MNNFELYKLKKAGLSNLNILNILAYQK.NLN.....K...........S...LSLRDMAVVAKCKQPIQFIEAYKTLESKSL....
T1ZFA2_STRIT/1-62 .MNNFDIYKLKEAGLTNQQVINVLEYAE.IHE.....K...........D...LSAKGMAVVSECRNPALFIEKYLQLDDD--ll..
G6ENW1_STRTR/1-62 .MNNFELFKLKAAGLTNLNILNILDYQK.NQD.....K...........K...LSLRDMAVVSKSKNAVLFMEKYKNLDVKQL....
A8AXH5_STRGC/1-62 .MKNYDIYKMKHAGLTNGQVLNVLRYVE.NKE.....K...........E...LSLRDIAVVSECRNPALFMERYKQIDDD--fl..
B9DS67_STRU0/1-64 .MNNFDIFKLKCAGLKNHHILNIIAYMK.HST.....Qs.........lS...LSLRNMAVVSKCSDPITFIENYKALKSKEL....
A0A7X6S1R8_9STRE/1-61 .MKRFELFKWRQAGLSNLQLNRILAYQA.KTG.....K...........T...LSARDCVVVSEVKNPAVILEHYRQLDE---ea..
A0A2A5S1T9_9LACT/1-69 .MTNFDLFRLKQAGMSNLFINRFLVFIL.VNK.....Tefs....senlL...LLLPKFIRQANMRHKALFWEKFRQLDLKH-t...
A0A387BH02_9LACT/2-63 .ITNFDLFRWKNAGMTNLGVNKLLKFYR.RYE.....K...........K...ISLRQMGQVAQIKSIPNFIESYKNQNVKEL....
A0A139NRW2_9STRE/1-62 .MNNFELYKLQRAGLQNHQILKVIHYAK.MHK.....K...........S...LSLRDVAVVSECRKPVLFMENYRSLDLLA-l...
A0A224X0N9_9LACT/1-65 .MINFDIYRLKKAGMSNLMINQFLTLTR.DSQ.....E...........KnplVYLPAFVRQTRMKQPALFWEKFRSFDLKVL....
A0A172Q7E2_9STRE/1-62 .MNNFELFKLKQAGLSNLNVINILTYQK.QKQ.....K...........S...LSLRDMAVVSQCKDPLLFIEAYKNLNSKEL....
G5KFZ9_9STRE/1-62 .MNNFELYKLKKSGLANKAILNVLSYQE.KNQ.....K...........S...LSIRDIAVVSQTKDPVSFIENYKKIDSKEL....
A0A1J0MYY1_STRIN/1-62 .MNNFELYKLKKAGLKNHHILNIIHYSQ.QTK.....K...........S...LSLRNMAVVSGTSKPCLFLENYKLLNIKEL....
A0A239SSK8_9STRE/1-62 .MKAYDIFKWKQAGLTNLQINRILDYEQ.KAG.....K...........K...LSDRDIVIVSEVKNPAVILEHYRNLDEAQ-c...
A0A6A0BCB4_9LACT/1-67 .MTNFDLYRLKKAGMTTLMINKFLAFIA.ESDfdeknK...........M...LLLPSFVTASTMKNKALFWEKFRQIDVKEL....
A0A6A0B3H5_9LACT/1-73 .MTNFELYRLKLAGMTNLMLNKFLSFIDeRNS.....EndlndsqtgndL...LQLPEFIKRSDMKQKALFWEKFRQIDAK--v...
Q99ZM5_STRP1/1-62 .MNHFELYKLKKAGLTNKNILNILDYQK.HQE.....K...........S...LSLRDMAVVSGCKHPSHFIEAYKQLDIQNL....
#=GC seq_cons .MsNFElaKLK+AGLoNLpIlplLcYpc.cps.....K...........p...LSLRchAlVScsKsPslFhEpYKpLD.KpL....
//
