#=GF ID   SGBP_BT4661-like
#=GF AC   PF16319.9
#=GF DE   Surface glycan binding protein BT4661-like
#=GF PI   DUF4958;
#=GF AU   Chang Y;0000-0002-2418-3433
#=GF SE   Jackhmmer BT_4661 (NP_813572.1)
#=GF GA   28.80 28.80;
#=GF TC   28.90 47.00;
#=GF NC   28.70 27.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   28630303
#=GF RT   How members of the human gut microbiota overcome the sulfation
#=GF RT   problem posed by glycosaminoglycans.
#=GF RA   Cartmell A, Lowe EC, Basle A, Firbank SJ, Ndeh DA, Murray H,
#=GF RA   Terrapon N, Lombard V, Henrissat B, Turnbull JE, Czjzek M,
#=GF RA   Gilbert HJ, Bolam DN;
#=GF RL   Proc Natl Acad Sci U S A. 2017;114:7037-7042.
#=GF DR   INTERPRO; IPR032529;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This protein family, mainly found in Bacteroides, includes the
#=GF CC   putative surface glycan binding protein (SGBP) BT4661 from
#=GF CC   Bacteroides thetaiotaomicron (Swiss:Q89YS0). BT4661 appears to
#=GF CC   play a role in the bacterial degrading apparatus of the host
#=GF CC   glycosaminoglycans heparin (Hep) and heparan sulfate (HS). It
#=GF CC   shows six discrete domains that adopt an Ig-like fold arranged
#=GF CC   in an extended, curved conformation [1]. 
#=GF SQ   23
#=GS D1PVS0_9BACT/12-714       AC D1PVS0.1
#=GS W4UW69_9BACE/1-667        AC W4UW69.1
#=GS A0A1W2D9B0_9SPHI/10-707   AC A0A1W2D9B0.1
#=GS A0A099BWA8_9BACT/7-715    AC A0A099BWA8.1
#=GS A0A368VD70_9BACT/203-417  AC A0A368VD70.1
#=GS A0A1H4FLB0_9BACT/4-716    AC A0A1H4FLB0.1
#=GS Q89YS0_BACTN/7-726        AC Q89YS0.1
#=GS I9S9N2_9BACE/5-711        AC I9S9N2.1
#=GS A0A4Q8RYX0_9BACT/210-434  AC A0A4Q8RYX0.1
#=GS E5C4B4_9BACE/7-713        AC E5C4B4.1
#=GS A0A1Y3VIE2_9BACT/2-723    AC A0A1Y3VIE2.1
#=GS A0A840CMS9_9BACT/5-719    AC A0A840CMS9.1
#=GS A0A1G9N0I3_9SPHI/7-705    AC A0A1G9N0I3.1
#=GS A0A108T7U4_BACSE/6-799    AC A0A108T7U4.1
#=GS R6CKD4_9BACE/6-750        AC R6CKD4.1
#=GS A0A6M1N8Z4_9SPHI/4-702    AC A0A6M1N8Z4.1
#=GS A0A173WBI2_9BACE/6-777    AC A0A173WBI2.1
#=GS A0A425XZ56_9BACT/176-489  AC A0A425XZ56.1
#=GS A0A3L7Z1G5_9BACE/8-734    AC A0A3L7Z1G5.1
#=GS W4P3W4_9BACE/5-714        AC W4P3W4.1
#=GS A0A2V3ZZI9_9BACT/183-425  AC A0A2V3ZZI9.1
#=GS F5J3D8_9BACT/3-122        AC F5J3D8.1
#=GS R6E3I2_9BACE/5-760        AC R6E3I2.1
D1PVS0_9BACT/12-714                  .....atnaflcl-------------LCCFVGV..SCSD-DTTDDTAFQLFYSDVTDIGPSMTMRLYEPTYIGPKPSDFSIVGIKLDDSNV.EAS..SFNI.DPETGAIIIENTGKLAIGNYALSVACKAGGKGYTFNDIVHVNMMRTVPEGIVATPNKIEVSYEDVMSK-SGEALPSSQITTDGN.HIHINKYVIANV...........RHeGEQVA---NEDRFTV.SGKGVVGF.GSK.HTD..LNPG.KYVIDLKLTTAVVDEQSEEGLF..ANAVEFDITSKPLTLTYEPDNSK.VEFN----P.TAPVKSVVPVMVGS.RDGLKFEISKKTPA.....DAP..ITIDPATGELSMGAN-TLAVGTE.CKVSVKVSNPYGS.S...--DFDEAYTFTIVPF.IH.PI.K..T..FAYPAAAEMMEG.....TAF.IQKV..S...NMDGDEVKYSFKE.LPSA......LQNQLTINAQTGEISAAKGNTIARG.....QYTVTVVAENTKGS....KT....AT..FTLNVVKNKYMFSYVSWGNNLN....................LTPVEK..YASQYRRTESGSFTM-..---KVV..SSDIE....KGVSA-V--YAI.DKGNSSTGAKI....DAHSGEITFDSW...K.......-DG..........RVFVVVVKTTTGKGT.PgE...VTIKTPVFVHCSAPV.......-KGVTVNY....TPFVFQVNPRKGGS.S.VAPKII....................-GADPSKFLMDYRR...SFNYYNI..GGPesHVTGQLKA----G.......QTTTFMYKMWQSYygnAAVNA.....G.....A......RKPVSYY.D---...NKASLNTALCYV..........D.AT.K....gCAITVNPGKW.....-QAD-QE.FANGVFIGQMTFV...TD..GNPSK.V.AKGS...Q.VF...PVAIWFNTDF.......................................................................
W4UW69_9BACE/1-667                   .........mnfn--------------------..------------------------------LDGPTYIGNTPSDFAITRITVNGEVY.STD..CFAI.DSDKGSITIANTSDLPVGLYSLSISCYSSGKYYEFKDILTINMMKSVPDGITVEPNKIEVEYGDIIDEESTEILPTAQVKTDGN.HISIRKYIIANV...........RK.DGALIE--NKDFFAI.SATGEISV.VKG.QTG..IQPG.KYVLDLKLTTAVVDEEAEEGIF..ANALEIDITSKPLSLVYTPNSVR.TE------V.GTGNVSVSPEFIGS.VDDLVYSIKSKSPS.....TAP..ISIDPTTGVLTLDANNSLAIDDK.CEVTVTATNKFGT.A...--DFENVYTINIVAF.IH.PI.D..N..FSYNNTEDFIQA.....TAF.EHSV..A...VIDGDEVSYSFVN.LPEE......LS-ALTIDSHSGKITATKGNSIPVG.....SHTVTVLAKNSKNE....KQ....AS..FKLNVAKNPYYFTYIHWGNNLN....................LAPAKA..YASQHRVNSKAELLA-..LSIPVA..ETDLPn..dVKVIWEVATESF.SGGS----TQI....D-EHGTLTFTGG...W.......IDA..........KCFVVVVSATTGKGT.A.G..eITVKTPVFVDCSAAI.......K-GITVSY....TPFAFQVNPRTGGN.S.VAPVIT....................GAADQSQFLMDYRR...TFNFYNI..NGPasHLDGQPTV-----.......-KTSFMYSIWAAY...FNAIG.....S.....SsvntgaRAPLSYY.DNIG...K---TSIPAAFV..........N.NT.D.....LSVVVNPDKW.....--KDDAG.FANGVMIGQMTYA...TN..GNPSS.I.GGGE...K.IF...PLAIWFDTKF.......................................................................
A0A1W2D9B0_9SPHI/10-707              ......lkrylsw-------------VFALLLItgGCKKEEVTDNTSFAIYYTGMTDIGPSMSGVIASPTFIGAKPNSFEILSISLDGATY.SGN..SFEI.NKDNGSISIKETTGIPVGLYKITVSCYSNGTRYEFKNAIEINMMKPVPDGITVEPNKLTVNYSDIIDPQSTAELPTAQVTTNKN.HVSIRKYEIAKS...........--.-------DFSKYFAI.SATGVISI.VRG.DAT..LLPG.KYVLSLKLTTGA--SKEDEGIF..QNAIEIDIISKPLSLIYTPSLGK.IEEESALSG.KTSFKSNVPAYKGS.MNDLAYSIKSISPA.....TNK..ITIDPQTGVISVPENHGFAAGQQ.YKVTVNAKNVYDQ.A...GVDFNDVFVLDVVKF.IE.PI.Q..L..FAYQNKNATQAV.....AFN.VNPD..A...GFKGDEVRFEFIE.LPAA......LQGKLSLS-AQGAISAVKGNTIPLG.....AYTIKVKATNPKNE....SI....AS..FTLTVGTNPNYFTYVRYGNNLG....................LAPAEN..YANQFRIAVGAALSTV..KPTPA-..ATDAK....VSLTYEI-----.--RNIQGSGTI....NAGTGQITLTTV...N.......-AA..........SCGVFMVTATAGKGTpE.E...YAVQTPVFIHNSQAV.......NAAV-VEY....SPFVFQVNPNTGGR.S.TRPAIT....................GVADKTKFTMDYRR...TFNYYNF..FGT..QLSGQPTV-----.......-ENSFIRGLFDKY...AESKG.....T.....Npn.ygsRDPLSYY.A---...NQANLTLPLAYL..........D.AS.T.....LELVVNPNKW.....IYNG--E.AANGAMVGQITFG...ID..GK--D.P.QGGS...G.LF...PIVLWFDTKF.......................................................................
A0A099BWA8_9BACT/7-715               ..........cmt---ETFLCTLIVLLSGMMVV..SCSE-ETVDSGKFQLYYSDVTDIGPSMSMTLYAPTYIGAKPYDFEITRVMLDGAAV.QTE..SFGI.DKETGAIIIANTSQLAIGNYALSVACKSAGKHYAFEDIVHVNMMRTVPEGIVATPNKIDVKYEDVLSK-SISDLPTSAITTDGN.HIHITKYVVANV...........RH.EGELVEN--DELFAV.SDAGVVSF.GNK.HQN..LKPG.KYVIDMKLTTAVVDAESTEGLF..ANAIEVNVASKPLSLAYDPNFSK.VEQGTEEPT.KT----VTPVMVGS.REGLKYSVKSVVPA.....NTP..VSIDATTGELTLAK-NNLAMGTE.CKVAVTVTNAYGS.-...-TDFAQAYTFTIVPL.IH.AI.T..K..FAYEPTVELIEG.....AAL.TQKV..K...AIAGDEVKYSFKD.LPTA......LVGKLNINAQTGEITADKGNGIAQG.....NYTINVVAENPKGS....MT....AT..FTLKVIKNKYLFTYVHWGNNIG....................LSPVRN..YASQYRIKSAAPLV--..MKVQS-..-TDIQ....SGVEAEY-SIDT.K-NSSTTDVTI....DSHTGEITFNKW...Q.......-GG..........KVFMVLVVTTTGKGT.S.A..eVTVKTPVFVHCSKAV.......K-GVSVDY....TPFVLQVNPRTGGI.S.NAPTVS....................GG-KPGKFLMDYRR...SFNYYNI..GGPasHVTGVLKA----G.......VTNTFMYAMWKNYygsAAVNA.....G.....A......RKPVSYY.DNQG...---ALNTTLCYV..........D.ATkD.....CAVQVNANKW.....-IVD-QE.YANGVFIGQMTFT...ND..GNVGS.V.AKGS...Q.IF...PLAIWFDTNF.......................................................................
A0A368VD70_9BACT/203-417             .......vtneag--------------------..--------------------------------------------------------.---..----.------------------------------------------------------------------------------------.------------...........--.---------------.--------.---.---..----.------------------TVTF..ENAVAIQLETTPYNLVYEPNQINgIETEP----.---SQSGIPGVEGT.SNEENPIVFSLADN....ySGN..FSIDESNGRISLMNDHTLAAG-T.YALDVIAANKHGE.-...-TLFEGAITFDIIEL.VElPA.S..N..LLYNPDAYTVFEg...yGFT.SAQP..T...VEGTTPITYSL--.--AD......DFGALTIDSETGIITLADGHSLTAG.....TYSIDVVATNTVD-....--....--..----------------------....................------..----------------..------..-----....------------.-----------....------------...-.......---..........---------------.-.-...---------------.......--------....--------------.-.------....................--------------...-------..---..-------------.......-------------...-----.....-.....-......-------.----...------------..........-.--.-.....----------.....-------.-------------...--..-----.-.----...-.--...----------aitftgaatlevkaavie.....................................................
A0A1H4FLB0_9BACT/4-716               lfrnvcfaaltal--------------CAVVLA..ACEDD-DTKSGDLQLFYPTVVDIGPSMNFVSGTPTYYGPAPSNFSIAGITLDDKSV.ATE..CFSI.GADTGMVSISNTDDLEPGTYKLTIACQAGGGVYRFTDIFVVRMVPAAPEAIEVSEPALVIPYAELETTKASV-----TVTPVGE.SVSILGYALVQT...........--.-------EGEEYFAI.SGKGVVTL.NAN.FSG.eIMPG.DYPLPIRITTYA-----GAAVY..ENLLTARITSEPLEIRYPSVSGR.MEY------.NMAFQSPAPTLKGS.PDEVVWAIKKVTPAegfetTDK..IRIDPATGVISVDADSELPIDAS.YTLDLTVSNSFGS.-...-TDFEGAYTLTVIEY.IA.PI.EpeT..FSYAPVEVVEGT.....NFK.APKT..D...GFVGDEASFSLGD.VPAA......LAGQLTVDEATGEVSSLRGITAAPG.....VYQVPVRASNMKSE....TP....VEvmLTLTVIQNPNMFTTFSYGNNLG....................LDWKTN..-ADQHVFDMQGDAKGD..TTVDIP..VAQEDf.agREVTFKMTYV--.HNNPFRTAAAKsyvtDDGTLHLTFRND...R.......-AG..........QIGVIKVDATIGTGE.T.-...-AITRSTYLFTKTQT.......AVDKVVVY....KPLVFRVNPRTGGY.S.EAPTID....................A--DKSNFMISLKR...NIFYYNL..NGPssHVSGQLNA-----.......TSTTFIYRMWGSY..fGSTVN.....A....gS......REPMSYY.ELTSg.sVAANLTAKIGYI..........DcGT.D.....FKMYIPANKW.....-MLD-GA.YANGVLIFQAPYT...TT..GTFAD.LdASGT...KnFI...YMAVWFDENF.......................................................................
Q89YS0_BACTN/7-726                   .............NITSRLLGVLIVIAVTIVNS..SCSDTETTDSTKFTIYYTGMTDIGPSMTGVISSPTYKGGTPYDFAITRITLDGEPF.SDS..IFAI.DSETGKITLNSTSNTPVGLYKLSVACYSNNNRYEYTDIVEINMMKPVPDGIKTDPEKLQVEYADIIDTESSNELPTSQIRTEGN.HISISNYTIASA...........-M.WNGVAVESPEDYFAV.SDKGEISI.IKG.NQN..IQPG.KYILSFKLTTAATGEDPEKGIF..ENALEINVTSRPLSLIYTPDEGK.IEEEGERSP.ETTFQSNIPALKGS.AEGLVYSISSVSPN.....TDK..ITIDPTTGVLSVAAHHGFKDGEK.YQISVKAINEFSP.E...GVVFENVFTLNTVEF.IE.PI.A..N..FGYADVNDVQAV.....EID.INKN..E...NFKGDEVKYEFVN.LPTD......LQGELALD-LDGNIAIKKGNKIPVG.....QYTVQVMATNTKGS....ET....AT..FTLTITANPNYFTYFRYGNNLG....................LTPIEN..YADQFRIEAGGKLNSV..KPVPT-..ATDAKd.glSSLKWEV---EL.KHNPNNTKATI....NESTGQITITGL...K.......-QG..........QCGMVMVTATAGEGK.T.A...VSVKQPVFFHFSMIS.......DSNVQLEY....TPFVFQVNPARGGE.S.IAPSLG....................AGIDKSTFRLDYRR...DFFYYNI..AGPdsHISGALAQ-----.......KVDNFLSEMWNSY...DATAG.....T.....S......RKPMSYF.E---...NTTNLSKALGYI..........D.QT.D.....FKVHINPNLW.....RNKD--G.YANGAMIGQITYD..vTG..KDPQA.A.TSGA...R.VS...PIFIWFDTKF.......................................................................
I9S9N2_9BACE/5-711                   ............k-LTSGFLAILTVTSLILTGT..SCSDTETTDSTPFAIYYSGMTDIGPSMNAKISAPTYIGATPTDFTITKIILENESV.NTE..SFVI.DATTGEIEIKNSDNLAVGLYHLSISCVSNGKTYNFTDAVSINMMRPVPEGITVEPNLLTIDYADVKTSDA-----KAQVKTEGE.HVSISKYSIAES...........--.-------GFKDYFTV.NASGEISI.NKN.YEG.dILPG.IYKVALKLQTEA-----GEGIF..ADAVTFNITSKPLALTYTPNKGK.MEEATE--G.PTSYTTNVPTLKGS.LEGVVYRIANITPA.....TDK..IKIDASTGVISVVEGHGFKAGET.YVIDVNVKNIYNT.TeeaDKVFESVFTLEVVGF.IA.PI.E..D..FTYENVTKTQAT.....PFT.IAHT..D...AFKGDEVTFELGE.LTAE......LQGQLNIDATTGTITAKKGNTIPVG.....THTVAVKAKNVKGE....QT....TT..FTLVIEKNKNFFTTITYGNNLG....................LPEGS-..-AFQYRYNSAEELAK-..AVIPAP..KTDIPe..gVTVTWKV---QN.KLNMSNGKVGK....DGALNLAN-ITW...K.......-DA..........TCGMIMVTATAGEGD.E.A...VSVSVPVFFHFAAPV.......K-DVTINY....TPFVLQVNPKTGGR.S.VAPTVT....................-GADKSKVLMDYRR...NFSYYNI..NGSesHISGQMKNDGTTD.......--DFFMNQVWRNF...YTAIGvkpnyG.....A......RKPMSYY.DNAG...SET---TTLAYV..........D.PA.D.....KSVVINPGKW.....IGED-KT.YANGVMSGQITFV...TN..GASAG.L.GSGN...Q.IY...PILVWFDEKF.......................................................................
A0A4Q8RYX0_9BACT/210-434             ....gnniadsvm--------------------..--------------------------------------------------------.---..----.------------------------------------------------------------------------------------.------------...........--.---------------.--------.---.---..----.--------------------TF..NNALTVNVVSKPYKLVYEP---K.IQTNVQEFA.--ARSSQEPTVTASnTADVTYTLA--DGT.....SEY..FTIDEKSGAVSLKAMHSFKAGQT.VYVSVIATNDYGA.-...-QLFEEAVGFEIVPQePV.PP.T..E..FNYSAGNEGTVMe..tmAFA.SAVP..Y...VEGAYPISFAI--.KAGN......EAGQFSIDATTGQVTLPKGHTLAEG.....NYPLEIEATNAFGS....AP....LN..YTVHVTT---------------....................------..----------------..------..-----....------------.-----------....------------...-.......---..........---------------.-.-...---------------.......--------....--------------.-.------....................--------------...-------..---..-------------.......-------------...-----.....-.....-......-------.----...------------..........-.--.-.....----------.....-------.-------------...--..-----.-.----...-.--...----------lmksvifdadfn...........................................................
E5C4B4_9BACE/7-713                   .............NLTSRFFAILMTIGLCITGI..SCTDPETTDSTKFAIYYAGVTDIGPSMNFNMSGPTYIGGTPSDFAITRVTLNGEVY.ETS..SFQIsDPSTGAIKLTDTDNLPVGTYCISISCISNGKYYEFKDVITVNMLAPVPDGISVDPSEVTVDFADIYKESA-----SAQVKTEEGtHVHISKYEI---...........--.----IQEEGKEYFAI.SKTGKITV.NDKyEGE..ILPG.KYVLNLKLTTEA-----GAGIY..ENAVTFKIISSPLTLTYNPSSVK.VEKD-----.-EAFTSSVPTLKGS.TDGLTYKIKSISPE.....TSA..ITIDEQTGVITLAGNNGLEIDNS.YSVVVTATNQYGS.K...D-FDETPFVINIVAF.IN.PI.T..K..LQYANQEKVQGV.....AFE.FTPE..D...V-DGDELTYSFVD.LDSR......LTDKLNIDPVTGAISAKKGNSIEVA.....TYTITVKAKNNKSE....QT....AT..FTLNITKNPNSFTFIRYGNNLG....................LTPEEN..YADQFDYDKKATLLAA..KLTPKT..DIPEG....RPVKWEV---KI.QNTTALSGTTI....-SETGELSFSEN...Kw.....nSNY..........GVSVLFVTATVGEGE.E.A...VSKTVPVFIRQ-NKD.......KNDIFVEY....TPFAVKMNPAKGGT.T.PAPVVKls................gsPYTDYTKFLMDYRR...DFYYYSF..IGD..HVDGIQST-----.......-VGSFMYGLWTTY...YNTIGktpnyS.....A......RGPMSYY.D---...NSQNTNQALGYV..........N.NK.D.....LSVVINPGKW.....--KDTEGvYANGVFIGRMSFV...TD..GTQNDlA.NDGTtknQ.IF...PLAIWFDESF.......................................................................
A0A1Y3VIE2_9BACT/2-723               .....nkssilhn--------LLLIVALCASGL.wSCTEDETA--SPVTLHFQSVGDIGPGMPYRGVAPTYSGAAPSDFAIESITLDGVSF.TDEvpCFAL.DPQSGFLTISDSRDLPLGTYRFTVSCLAAGSRHIFPDAFSVRMVAATPEQIIVTPNLIEALYD-----EERVAWPTAQVAPADE.AVSFNGYAL---...........--.----VQEKGKEYFQI.SSSGVISVnLKY.EGT..IPPG.VYKPVLRLTTKAGSAD-----Y..ADAVTIRVNSEPLGVTYARNPG-.-----TAEI.GTAFRSDVPELLGS.TDEVHYAILSVSPS.....TDQ..FAIDPATGVISLAEGHTLPANSS.YEFSLAVSNKFSNgE...AVALRGVYAVEVVPF.IT.PI.DpsT..FSYAPATMTEAC.....KFE.TEKA..E...GFVGDVVTFSLGE.LPEE......LQGWVVIDSQTGRITIPRGNGIPQG.....SYEIPVVVTNPKSDpeapTT....AT..LSLTVEANPNMFYKFGYGNNLG....................L-PAEE..HFDQFRWDGDGSTNVD..KVIPLSggYNDFN...gRTPTFKVEVIHD.WAMQNAGTTTT....VDTNGDLHLKMR...G......nRWG..........QIGYVRVTATLGEGE.T.S...VSRSTIVFVMLRNPS.......NSN-QIEY....TPFVFRINSRAGGY.SgVPPTYG....................SGVDASKVMMRWRQ...NCFFYEGlgTGE..TKSGGKLEAGQTE.......RTIYKIWATYFSN...GIADV.....S.....N......SMPFSWY.NTTGvkdSNENMSRKLGYF..........D.PD.N....gNQLYIAPNKW.....LNAG--Q.PVNGVLTFQASYS...VT..ANNED.L.GKTT...N.LI...GVAVWLDENF.......................................................................
A0A840CMS9_9BACT/5-719               .....ntqlrllf-------FLLIVLLSFGVFT..ACDDTETVDKTDFAIYYTGMTDIGPSMTGIISSPSYIGGTPYDFEIVRTTLNDETY.SGE..SFEI.DKENGNITISKTAGIPVGHYKLTIKCFSNGKMYEFRDIVEVNMMKPVPDGITVEPNKLKADYADVIDASSEIELPTAQVNTDGN.HVSIRKYEIAKS...........--.-------DFSKYFEI.SSTGLISI.VRG.DAG..LLPG.KYILSLKLTTGAS--AEDEGIF..ENAVEIDITSRPLALEYTPSSGK.IEEESVQSG.STTFESNAPVLKGS.PDDLTYSIKSVTPA.....TNK..IEINPQTGILSVKEKHGFTAGQK.YSVNVTVKNAYSE.S...GVDFNNVFELEVVEY.IE.PI.Q..N..FSYENLEAIQAV.....AFE.NSPA..A...EFKGDEVRFEFID.LPAA......LQGKISID-HEGKVSGLKGNTIPLG.....SYTVKIKATNPKSD....PElpsiAS..FSLIVKENPNYFTYVRYGNNLG....................LTPESN..YANQFRIAVGGSHSDV..SPVPQ-..-TDAK....VGLTYEIRSI--.---HQSAGTTI....DSNSGKITLAGL...A.......-KK..........QCAIVMVTAIAGKGT.P.A..eYSVQTPVFFHYSDLVspa.snaAENVLIEY....TPFVLQVNPNSGGR.S.TKPTVT....................GVNNIALFTMDYRR...TFNYYNF..FGT..HQDGQPNA-----.......-AGSFLQNLWNNY...AESTG.....T.....Npn.ygsRNPLSYY.A---...NTGNIDKTLAYV..........D.PN.S.....YELVVNPNKW.....IYNG--E.PANGAMIGQITFE...TN..G--KD.P.QSGG...Q.VF...PIVLWFGTNF.......................................................................
A0A1G9N0I3_9SPHI/7-705               ...kqklkgylsw-----------VFALLLLTA..ACKKEEVVDSTTFTIHYTGMTDIGPSMSGVIAAPSYIGSQPNSFEIVSITLDGTAY.SGN..SFEI.NKEDGTVSIKETAGIPVGHYKLTISCVSNGKRYEFKDAIDINMMKPVPDGITVVPNKLTVNYADVINLQSTVELPTAQVTTDKN.HVSITKYEIAKS...........--.-------DFSKYFAI.SNTGVISV.VKG.DAT..LLPG.KYVLSLKLTTGASGQ--DEGIF..QDAVTIDVISKPLGLTYTPSLGK.IEEESALSG.KTSFTSNVPVLKGS.LNELVYAIKSITPA.....TNK..ITINPQTGVISVAENHGLTAGQQ.YKITVNAKNVYDQ.V...GVDFNDVFVLNVVQF.IE.PI.Q..S..FTYQNKNATQAV.....AFT.VTPS..A...GFKGDEVKFEFVD.LPAA......LQGKVTLN-AQGGISAVKGNTIALG.....SYTIKVKATNPKGE....SV....AT..FTLTVGANPNFFTYVRYGNNLG....................LAPAQN..YANQYRISAANPIATI..KPTPT-..-TDAN....VSLTYEIAIIHQ.G-----AGTTI....NASTGQISFAGI...N.......-TP..........QSAVFMVTATAGKGTpE.E...YAVQTPVFVQNS---.......--NALVDY....SPFVLQVNPNTGGR.S.VKPLIT....................GVADKSKFTLDYRR...TFNYYNF..FGT..QVNGVPAA-----.......--GTFLGRLFDKY...AENTS.....TspnygS......RNPLSYY.W--G..nPKGILSQALAYV..........D.AT.T.....FELVVNPNKW.....TYNG--E.AANGVFIGQMTYM...TD..G--TD.P.QNGT...T.VL...PIILWFDTKF.......................................................................
A0A108T7U4_BACSE/6-799               .........lstf---S-MLRFFIVAALTVFCV..SCDKTETTDSTGFILHYLGVTDIGPGMSYTLQAPTYKGSAPYDFTITKVTLNEETF.SNN.dNFVI.NAETGEITIQNTDGMTSGMYSISVGCYSNGKFFDFKDAVQVNMLLAVPEGVTVEPAEVLVNQ----DEEN-WAEASAQVSTEADkHVSITGYAIAQD...........ET.KPYL----SYFTFDP.NTKGKIII.RES.EKD.kLVAGeSYTLNLKLTTKA-----GEHMY..NNAVTFKVVSKPRDLFY-IETEA.LPDLFE--T.GTENKSVIPTIAGA.KEELKFAIKSVTPE.....TTA..FTINETTGQISVPEGNSLEISETpYVFTITASNAYGS.N...--DFEGIYSVKVVAF.IE.PI.QpeT..FKYTAINQLYQL.....GGK.AEDN..AivpGFVGGAPTFTFDA.NNSDeikaqiDQKFITLNSANGTIDITDKQTLSTG.....KHEIKVRVTNKKNE....EGv..vSA..LEVNVIPNPNNFEYVSWGTNIEneiptntngnktnpistettEETKEE..NRNLFRFIQGRDVRELplQRIKMI..NENAN....TTFTYKVLENNFiGHEKIVKGAKV....KE-DGTIYFTNLtakKnfadgssNAK..........GCVFQIAVTAKGNNA.P.A...VTKNIPIFISTPKPTvirypniVDKDKINYvllcTPFVIKVNPKEPKIpS.IKTQMHiigaqdidgvqtnyslysgiLDDYHSKFIWDYRD...DFSYCNF..DDN..TGHGTGDN----K.......SAGNLLNQIWSNI...GVATT.....T.....-......NTPFRYY.DHKT..gQIDKQNTKAAYI..........E.PT.Sn...gHQLIINPNVW.....QAAD-GK.YPYGAMLGNMRFT...LE..NKPEN.L.EAGT...L.CAsqySFIIWFDETY.......................................................................
R6CKD4_9BACE/6-750                   .............NILSRFLGVLTVMVFALLGI.tSCSETETTDKTDFILYYTSMTDIGPGMSSDIAQPSYKGATPSDFTITGVTLDGQAY.TGN..LFEI.NPTSGTVHIESDETTPVGVYKISVSCVAGGSTFTYNDIISVNFLKRVPEGITVTPEALVADFADIIDANSTVELPTAQVTTEQN.HISITGYSISSV...........RL.GETIVDNKKNPMFAV.SSDGTISI.VRG.SNA..IEPG.LYTIDLKLNTAVSGSDSEEGLF..ANALTVNVTSKPLALTY--ATGK.LEEATEESG.NTSFVSQVPTFKGS.TDGIAYSIESVSPA.....SDK..FVIDAKTGVISVAEGHGLKSGEK.YVVSVRVKNDYST.E...GVVFNNVFTLNVVEY.IE.PI.S..N..FAYEMTPVTEQV.....EFE.IPVK..D...GFKGAEPVFVFES.ISAE......DKNIVSLDGKTGTISAKKGHKLTLG.....EHKFTVKASNDKNS....ET....AE..LIINVTENPNKFTYIRYGNNLG....................LTPAEN..YANQFRLADKEEFNGN..AEFSTP..ETDSK....KTLTWSVSGIDV.GGTSTWNKVKI....DSKTGKLTLNAL...P.......NEQ..........KCVVVLVKATAGSGK.K.A...YSITVPVFFHNSNAD.......KTNGKIEY....TPFVLQVNPKKGGR.S.VTPTIT....................NTIDMSKFVLDFRR...DPIYYNI..NGE..YQDGTPLESGGTQkhtkgyyKQSPFMEALWVQC...GAGLG.....A.....-......KAPMAYF.DVKGn.iRENHTDKTLGYV..........D.NA.Dgd.kkFSVVINANQWcqraeDSQDILA.WANGVVIMSMTYS...--..DNVTN.V.NKGT...E.VG...PIVIWLDTNF.......................................................................
A0A6M1N8Z4_9SPHI/4-702               ........glill----------------FVTT..ACKKTEVVDSADFTLYYTGMTDIGPSMTGIISSPSFIGGTPSDFKIVRITLDDVAY.SGG..GFEI.DPEKGEISVRETAGMPVGLYKLTISCSANGIQHEFADIVEVNMMKPVPDGIAVVPNKLTVDYGDVIDATSEVELPTAQVTTDGD.HVSIRKYEIAQS...........--.-------DFSKYFDI.SSTGLISI.VRG.DNT..LVPG.KYVLSLKLTTGASGED--EGIF..ENAIEINITSKPLALTYAPASGK.IEEETALSG.KTTYTSTVPVLKGS.PDDLVYTLKSVTPA.....TDK..IKIDPQTGVISVAQDHGLVAGEE.FQVSVNVKNIYSA.E...GVDFENVFLLQVVEF.IE.PI.Q..G..FAYPNVQAIQAV.....PFD.NDLN..P...GFKGDEVRFEFVD.LPAA......LQGNISID-LQGKISAERGNTIPIG.....SYTVRVKATNPKSE....EAnptiAS..FTLTVSANPNFFTFVRYGNNLG....................LTPAEN..YANQFRIAAGTSTAGF..SS-GVA..ETDAT....VSLVYEISQVH-.----QAGGASI....NSTTGEITLGGS...N......pKTS..........QCAIIMVTATAGKGTpS.E...YSVKTPIFFHNSEPV.......N-SVLVEY....SPFVFQVNPNSGGH.S.ANPVIT....................GVSDMSNFFMDYRR...TFNYYNF..FGT..HMDGQPSVE----.......--GSLMRQLFKNY...ADSKG.....T.....Npn.ygsKDALSYY.S---...NTGNLSLPLAYV..........D.PN.T.....YSVVVNPNRW.....-IAD-GE.PANGTMIGQITFS...--..SDLTT.I.NNGS...Q.IF...PIVLWFDTKF.......................................................................
A0A173WBI2_9BACE/6-777               ...........lt--FS-FLAILIVTVSPLFYV..SCSDTETTDSSNFALYYTGLTNIAPSMTGTISKPTYKGSAPSDFTITGITLNNEVY.TGN..CFLI.DSETGVISVQNTENAAKGRYKISISCVSGGTRYEYKDIVIVKLLASAPKNVIVTPKLIQADYGDIINKNSEIDMPIAKITTTGEeHISISSYTVSDVfkitnenteeePI.YELVTTEGVKECFSI.SQEGEFTI.VQD.EKSgiLEPGtLYAVSILLSTRT-----DEYLLdeKNSINIKVTSKPLNFSYDPAEGE.LEEESTATPeGTTFESVLPTYQGA.TDGLKYSIYAIEPA.....IEQeiIKINENTGKLYVEAGHGLQKGTT.YKISVCARNMYNE.EgevGTVIENAYSLKIVAF.IA.KF.D..Q..FYYENETNTIERmelspSYT.IEPT..I...VGGGENIKYTLIE.CEPE......LQKNIEFNATTGAITMKEGNKLVINdegkdSYTMKVKVANSKYE....KE....AN..ITFKLTQNEDRITYIHCGNNLDtn................gnALPGIQ..YENQFRFNSEDDMNRT..FTIKTN..A----....----YSTAKITF.KYEKLSTSVTA....NITNNEITFSGW...K......gDAA..........TSNIGIITATVNDKT.E.-...--LKVPVFFHFNNWTk....ynQDNVKIEY....YPFVLHVNPHKGGI.S.TSPKIIlkgk...........sdselSGDVRKKFLLDYRR...NFNYYNF..GGN..HTNGVPYDQKNPD.......KISPFMAHLWETC...GQKNN.....A.....N......KPPMAFF.TNSG...YKDNSSQSLGYVinynpntieyK.NH.E.....HSVNIIKDMW.....--KDSEG.YANGFIAAEMTFC...TD..GIIGN.V.NSGG...K.VT...PLIIWFDENY.......................................................................
A0A425XZ56_9BACT/176-489             .......vtfals--------------------..--------------------------------------------------------.---..----.------------------------------------------------------------------------------------.------------...........--.--------KNSDFVIdTKTGEISL.AID.SQ-..IDAG.EYRLSVV-ATNVTGE----QTF..EEVVRIDVQTLPYDLVY-STNAY.LGVQQTQA-.---KQSVEPAINGT.-GPVTYSL---KNN.....FNA..FTIDPLTGVVSLPEAHTLA-IDT.YNLTVVATNEHGS.-...-VDFVDALSFEIIAI.QA.II.A.tD..LTYVNVSYSVNQ.....AFA.FTSD..I..pTVSGSTPTYSLLE.S---......-FGEFGIDPVTGVISLTEGNTLAIG.....NYPMTVVASNLAGD....AI....FT..DVISVTVK--------------....................------..----------------..------..-----....------------.-----------....------------...-.......---..........---------------.-.-...---------------.......--------....--------------.-.------....................--------------...-------..---..-------------.......-------------...-----.....-.....-......-------.----...------------..........-.--.-.....----------.....-------.-------------...--..-----.-.----...-.--...----------aavvelifedgwdeltpavgetrlgnmieysakeapkqatnnkwtrgwgnwsvidqdgvtvrgavmipekt
A0A3L7Z1G5_9BACE/8-734               ....insfawrfa----------TICLLAVLGV..ACSDSETTDTTRFTLYYTGLTDIGPSMSGTIASPTYKGSTPYDFVITNVTLNGEQYnTTE..IFEI.DSNTGAITLTSAKDTPVGLFKISVSCYSDGKRYDYADAIEVNMMKPVPDGIIVEPNWLETDYENIINNDDALQLPTAHVKTDGN.HISITGYKIASV...........-M.YNNVAIDQPNKYFTI.SNSGEFSI.VKG.NTA..IKPG.VYTISLRLITAAVDEEEEEGIF..ENAIQVNITSKPLSLVYTPNEGK.IEEETAQSG.QTTFTSSVPEFVGS.LEEIQYSISKITPA.....TEK..IQIDATTGVLTVATGHQFAAGEN.YVVNVKVANKFAP.E...GVEFEECFTLSTVEY.IN.PV.A..N..FTYSATKATQAI.....AFS.VEKA..A...NFIGDEVWYEFVN.LPEE......LKEQINIGERDGIISAVQGNTIKPG.....TYSIQVKASNTKNE....EI....AT..LVLTVEENPNYFTYIRYGNNLG....................LTPVEN..YANQFRVASGEELTAL..K--LTP..ETDLKp..gVSVKWEITS---.--LHQSGNIKI....NDE-GVITTASK...D......yKAG..........NCGIALIEATAGNGP.T.A...VTVKTPIFFRYSSVV.......-SGVTIEY....TPFVLQANPRKQTR.S.VVPVVT....................GTDDLSKIYLDYRR...TFNYYNI..NGA..TSDGVAHG-SGVI.......TSNTFLQYLWDKC...EADYS.....T.....-......KFPISYYsDTKGt.iKNDLTNNTLAYV..........D.NT.DnssnrLSVVVNANQW.....-EHD--G.WANGCFIAQMTFV...TN..GNVAS.I.NSGS...Q.IF...PLVIWLDTKF.......................................................................
W4P3W4_9BACE/5-714                   ...........ql--SSSLLAFLTVILVSVAGV..SCSDTETTDETGFIIYYSGMTDIGPSMSGVIGSPTYKGNAPSDFSITGVTLNGETV.NGE..QFSI.DPATGAISVSSKKDTPIGIYSLSISCVSNGKTYQFKDIVQVNMMKAVPDGITVEPNKLQAEYADVADPNSETALPTAQVKTDGN.HVSIRKYEIAQS...........--.-------EYSDCFAI.SQTGEISI.LKG.NPK..LVPG.IYVLALKLTTGATGED--EGIF..ENAVEINITSKPLELKYYPDNGK.IEEETPQSG.QTTFTSNAPTLKGS.PEGIAYSIKSIMPA.....TDK..ITIDSKSGVLSVAASHGFKAKEK.FVVSVHVVNDYDK.E...GVDFTDVFTLEVVDF.IA.PI.T..D..FGYPDTECVQAV.....ETE.IKPN..A...GFKGDEVKFEFVE.PDPK......LKSALTLE-VDGTIRVKHGNDIPLG.....NYTIKVKATNPKSD....PEhpavAT..FTLSVKENPNFFTYFRYGNNIG....................LTPEEK..YADQFRVEAGGKLSSV..HPKPV-..KTDAK....VKLVWSITPIH-.----QAAGTTI....DPETGEITLAGL...K.......-AS..........QTGAVLVTATAGEGK.A.A...VSVTQPVFFNFAQ-E.......LSGILVEY....TPFVIQANPKQKTV.S.VAPTVK....................GTTVTPDFVMDYRR...SFNYYPI..KGS..HKKGQPKD-----.......-KDSFLFKLWSNYfngDESKT.....G.....S......KDPLSYF.T---...NKSDLTKPLAYV..........D.NS.N....nFTIVVNPEKW.....-TAD-GE.YANGLLFGQIPFS...TKgiKDCDD.S.KNPN...K.HF...PVVIWLDTKF.......................................................................
A0A2V3ZZI9_9BACT/183-425             ....eesnfvida--------------------..--------------------------------------------------------.---..----.------------------------------------------------------------------------------------.------------...........--.---------------.-ATGEISL.PVD.S-D..LEAG.NYKLSVKVSNIA--GD---TEF..SEVVMVNLETKPYSLVYTPQQ-Y.LDVQQKQ--.--AKKSAAPTVKGT.G-PFTY---ALKDN.....YGE..FTIDENTGVISLPENHALEI-ND.YPLTVVVTNTHG-.-...SVEFENAVSFQIVEI.KA.VLpS..D..LQYSTTSYIVNE.....GFA.FESTqpT...VVGTTPITYALV-.---D......DKGAFAIDAATGVISLAKDNTLAVG.....DYTLSVKATNVKGE....VT....FA..DVITVT----------------....................------..----------------..------..-----....------------.-----------....------------...-.......---..........---------------.-.-...---------------.......--------....--------------.-.------....................--------------...-------..---..-------------.......-------------...-----.....-.....-......-------.----...------------..........-.--.-.....----------.....-------.-------------...--..-----.-.----...-.--...----------iqvatpe................................................................
F5J3D8_9BACT/3-122                   ........iiisk---SKLLLILSIVLSLIFFA..ACDDTETTDETDFALYYTGMTDIGPSMTGVISTPSYIGGKPSGFEIFKVTLDGESY.SSS..SFVI.NEDEGAITISET--AGMYQYQKSLGNQN--------------------------------------------------------.------------...........--.---------------.--------.---.---..----.----------------------..-----------------------.---------.--------------.--------------.....---..-----------------------.-------------.-...---------------.--.--.-..-..------------.....---.----..-...-------------.----......-------------------------.....--------------....--....--..----------------------....................------..----------------..------..-----....------------.-----------....------------...-.......---..........---------------.-.-...---------------.......--------....--------------.-.------....................--------------...-------..---..-------------.......-------------...-----.....-.....-......-------.----...------------..........-.--.-.....----------.....-------.-------------...--..-----.-.----...-.--...----------nghlfglky..............................................................
R6E3I2_9BACE/5-760                   ..........dlf---TKCLMFLAISLLGHLAV..SCTDTEETDSSNFALYYYGVTDIGPSMNFELKEPSYIGGAPYDFAITNITLKDESY.STE..SFVI.NESTGAITIQNTENLSTGLYKISVSCYSNGKYYEFKDIVQVNILLAAPEGITVIPSDVIVNLD-----EEKWEESSAQVTTEKDtHISIIGYDIAAD...........--.----GNKDYLDYFTV.SETGKITI.VSK.YKD.rLEPGkQYTLSLKLTTRV-----DEYIY..ADAVTFSVVAKPYNLEYSPKNVN.VEYNVELTS.GD------MSIQGS.PEEMAFRIKSISPT.....TDA..FKIDPSTGKITLKENNGLEVGSI.FKLDITVSNKYGE.R...D--FPEAYTVNIIDF.MD.PV.D..EntFKYKATNIYEGQ.....ELKpLSYE..E...GLIGDDLTFSLATdNSDE......ILKLFKVEEKTGEISMVKANTLKANd..ntPYEIKVTASNYKSN....AT....TT..FKLTVMTNPNMFTFVSYGTNLEntwevg........qktshkYTKEKNptNRNLFRYINKGNIPLE..-PLTIL..DSDLPngsnFIVEYSIDERYT.STTGGFKYTEI....NSSTGEINLDPT...Tts...esDKNrggniftgkfEGGVLLIKVTVSNTD.P.EippVTKRIPLFFNTPKKT.......GNNLILTY....TPFVVKANPRTGIC.S.QSKCEVvnwn...........sqkinSFEDMSKVILDFRGgnlEYLFYRF..NDN..ENHGSSAA----G.......NASSLINNVFANY...ASSQK.....I.....-......-NMMSYY.L---...ESDRLGAKPAYI..........Q.PG.D.....FQIKINPGKW.....IGSD-NE.YANGVVIAKVRGAlsgTQ..SDLDS.D.GTSI...P.VF...PVFIWLDENF.......................................................................
#=GC seq_cons                        ...........hh...........h.h.hhhhs..uCs-sEssDposFtlaYsuhTDIGPSMshhlssPoYhGusP.DFtIsplTLsspsa.ssp..sFtI.s.psGtIolpsTpshslGhYploluChusGphYpFpDhlplNMhtsVP-GIhVpPstlpspYs-lhs.put.t.soAQVpT-ts.HlSIptYtIups.....................t.pchFsl.SssG.ISl.sps.pts..l.PG.pYslsLKLTTts.....tEulF..pNAlplslsSKPLsLsYsPspu+.lEppst..s.tTshpSssPslpGS.s-slsYuIpSloPu.....Tsp..lsIDspTGVlSlspsHuLtsGpp.YploVsssNtYus.t...sssFcssaolplVta.Ip.PI.s..s..FsYsssstspss.....sFp.hp.s..s...shtGDElpashhp.lssp......Lpuplsl-ttoGpIoht+GNolshG.....sYolpVcAoNsKu-....ps....Ao..hoLsVtpNPNhFTalpaGNNLs....................LsPtpp..aAsQaRhtstsphst.....h.h....sDht....htlpapl............stspl....sspsGplohssh...p........ts..........psshhhVsATsGpGp.t.t...holphPlFhp.st.s.........shhlpY....oPFVhplNPppGGh.S.ssPslt....................ss.chopFhhDYRR...sF.YYNh...Gs..phsG..ts..............ssFh.thatsh...sts.s.....s.....s......+tPhSYY.s......ppsthstsLuYl..........-.ss.s.....hplhlNsspW.......tD..t.hANGshluphoas...sp..up.ts...tsGs...p.lh...PlhlWhDppF.......................................................................
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