#=GF ID   SH3_11
#=GF AC   PF18103.5
#=GF DE   Retroviral integrase C-terminal SH3 domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF00899
#=GF GA   25.00 25.00;
#=GF TC   40.50 39.10;
#=GF NC   24.90 23.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF WK   Integrase
#=GF WK   SH3_domain
#=GF CL   CL0010
#=GF RN   [1]
#=GF RM   20118915
#=GF RT   Retroviral intasome assembly and inhibition of DNA strand
#=GF RT   transfer.
#=GF RA   Hare S, Gupta SS, Valkov E, Engelman A, Cherepanov P;
#=GF RL   Nature. 2010;464:232-236.
#=GF DR   INTERPRO; IPR040903;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the carboxy-terminal domain (CTD) found in retroviral
#=GF CC   integrase, an essential retroviral enzyme that binds both
#=GF CC   termini of linear viral DNA and inserts them into a host cell
#=GF CC   chromosome. The CTD adopts an SH3-like fold. Each CTD makes
#=GF CC   contact with the phosphodiester backbone of both viral DNA
#=GF CC   molecules, essentially crosslinking the structure [1].
#=GF SQ   15
#=GS POL_FOAMV/1064-1126         AC P14350.2
#=GS Q7SIS6_9RETR/1063-1125      AC Q7SIS6.1
#=GS O41894_9RETR/1072-1133      AC O41894.1
#=GS A0A077JIG0_9RETR/1063-1125  AC A0A077JIG0.1
#=GS A0A8D0BAC1_SALMN/1364-1425  AC A0A8D0BAC1.1
#=GS D5JWU6_9RETR/1064-1125      AC D5JWU6.1
#=GS POL_FFV/1064-1126           AC O93209.1
#=GS K7YNA8_9RETR/1063-1125      AC K7YNA8.1
#=GS D5JWV1_9RETR/1063-1125      AC D5JWV1.1
#=GS A8HC78_9RETR/1060-1122      AC A8HC78.1
#=GS A0A0G3Y3B8_9RETR/1063-1125  AC A0A0G3Y3B8.1
#=GS L7RZJ2_9RETR/1064-1126      AC L7RZJ2.1
#=GS POL_SFV3L/1063-1125         AC P27401.2
#=GS Q9J4C7_9RETR/1065-1127      AC Q9J4C7.1
#=GS POL_SFVCP/1064-1126         AC Q87040.1
POL_FOAMV/1064-1126                    ..RSWSPVVGQLVQER.VARPASLRPRWHKPSTVLKVLNPRTVVILDHLGNNRTVSIDNLKPTSHQ...
Q7SIS6_9RETR/1063-1125                 ..RSWTPAVGLLVQER.VARPASLRPRWHKPVKILEVLNPRTVVILDHLGNNRTVSVDNLKLTANQ...
O41894_9RETR/1072-1133                 ..RSWTPSPGLLVQER.VARPAQLRPKWRKPTPIKKVLNERTV-IIDHLGQDKVVSIDNLKPAAHQ...
A0A077JIG0_9RETR/1063-1125             ..RSWSPSVGQLVQER.VARPASLRPRWHRPTTVLEVVNPRTVIILDHLGNRRTVSVDNLKLTAHQ...
A0A8D0BAC1_SALMN/1364-1425             sv--WIPEVGQLIMQRmVSKNPKSRRKRRKPKAITKVLNPQTVVVLEQKGQEKIVSIDDCK-----kwe
D5JWU6_9RETR/1064-1125                 .k-TWTPSVGLLVQER.VYRPSQLRPKWKKPTPILEVLNERTVVI-DNNGQRRTVSVDNLKYTPHQ...
POL_FFV/1064-1126                      .s-GWSPYVGQLVQER.VYRPSQLRPKWRKPTKVLEILNPRTVIIVDHLGQRKSVSIDNLKPTAHQ...
K7YNA8_9RETR/1063-1125                 ..RSWSPSIGQLVQER.VARPASLRPRWHKPTEILEVLNPRTVVILDHLGNRRTVSVDNLKLTAYQ...
D5JWV1_9RETR/1063-1125                 ..RAWLPSVGLLVQER.VARPSQLRPKWKKPTPILEVVNDRTVVILDNQGQRRTVSIDNLKLTPHQ...
A8HC78_9RETR/1060-1122                 ..RSWRPSVGLLVQER.VARPSQLRPKWKKPVIICELINDRTVVIVDKAGNKRTVSIDNLKLTPHQ...
A0A0G3Y3B8_9RETR/1063-1125             ..RSWLPSVGLLVQER.VARPSQLRPKWRKPTPILEVVNDRTVVILDNQGQRRTVSIDNLKLTPHQ...
L7RZJ2_9RETR/1064-1126                 .s-GWSPYVGQLVQER.VYRPSQLRPKWRKPTKVLEILNPRTVIIVDHLGQRKPVSIDNLKPTAHQ...
POL_SFV3L/1063-1125                    ..RAWSPSVGQLVQER.VARPASLRPRWHKPTPVLEVINPRAVVILDHLGNRRTVSVDNLKLTAYQ...
Q9J4C7_9RETR/1065-1127                 pk--WTPCPGLLVQER.VNRPAQLRPKWKKPTPILKVLNPKTVVIAGPGGQERIVSIDNLKKTPH-h..
POL_SFVCP/1064-1126                    ..RSWSPVVGQLVQER.VARPASLRPRWHKPSTVLEVLNPRTVVILDHLGNNRTVSIDNLKPTSHQ...
#=GC seq_cons                          ..RoWoPuVG.LVQER.VARPupLRPKW+KPTsILEVLNPRTVVILDHLGp+RTVSIDNLKhTuHQ...
//