#=GF ID SLATT_6
#=GF AC PF18169.5
#=GF DE SMODS and SLOG-associating 2TM effector domain 6
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Burroughs AM;0000-0002-2229-8771
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE Laks
#=GF GA 27.10 27.10;
#=GF TC 28.80 115.70;
#=GF NC 26.80 26.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0676
#=GF RN [1]
#=GF RM 26590262
#=GF RT Comparative genomic analyses reveal a vast, novel network of
#=GF RT nucleotide-centric systems in biological conflicts, immunity and
#=GF RT signaling.
#=GF RA Burroughs AM, Zhang D, Schaffer DE, Iyer LM, Aravind L;
#=GF RL Nucleic Acids Res. 2015;43:10633-10654.
#=GF DR INTERPRO; IPR041119;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The SLATT domain contains two transmembrane helices. SLATT
#=GF CC domains are generally predicted to function as pore-forming
#=GF CC effectors in a class of conflict systems which are reliant on
#=GF CC the production of second messenger nucleotide or nucleotide
#=GF CC derivatives. SLATT domains are predicted to initiate cell
#=GF CC suicide responses upon their activation. This SLATT family
#=GF CC associates with a SMODS nucleotide synthetase domain fused to
#=GF CC the predicted AGS-C sensor domain. It is sometimes further
#=GF CC coupled to R-M systems [1].
#=GF SQ 31
#=GS A0A1T5IQ77_9BACT/32-208 AC A0A1T5IQ77.1
#=GS E3BGI2_9VIBR/1-176 AC E3BGI2.1
#=GS A0A0B8YCW9_9SPHI/1-178 AC A0A0B8YCW9.1
#=GS A0A1N7SE25_9BURK/1-178 AC A0A1N7SE25.1
#=GS A0A2W7MUB8_9BACI/4-181 AC A0A2W7MUB8.1
#=GS A6DSC2_9BACT/1-177 AC A6DSC2.1
#=GS A0A126T1I1_9GAMM/1-177 AC A0A126T1I1.1
#=GS D0YVS7_PHODD/1-176 AC D0YVS7.1
#=GS F6B744_DESCC/1-181 AC F6B744.1
#=GS A0A1N7KYJ3_9GAMM/1-178 AC A0A1N7KYJ3.1
#=GS C4ZPI0_THASP/2-179 AC C4ZPI0.1
#=GS A0A8J7IZ28_9CYAN/1-177 AC A0A8J7IZ28.1
#=GS A0A840F543_9SPHN/1-172 AC A0A840F543.1
#=GS A0A1Q8ISW5_9BURK/1-189 AC A0A1Q8ISW5.1
#=GS A0A4Q1KPG1_9SPHN/1-172 AC A0A4Q1KPG1.1
#=GS A0A420E850_9ALTE/1-176 AC A0A420E850.1
#=GS A0A562RJB4_9BURK/1-129 AC A0A562RJB4.1
#=GS Q6ARQ5_DESPS/15-191 AC Q6ARQ5.1
#=GS K8DWQ3_9FIRM/1-181 AC K8DWQ3.1
#=GS A0A0Q7EEV5_9CAUL/1-174 AC A0A0Q7EEV5.1
#=GS A0A1Y4CRK6_9DELT/2-172 AC A0A1Y4CRK6.1
#=GS A0A0P8Y8B6_9GAMM/1-176 AC A0A0P8Y8B6.1
#=GS A0A5E7YMT9_9SPHN/1-173 AC A0A5E7YMT9.1
#=GS A0A2I8Q2E0_9ENTR/1-177 AC A0A2I8Q2E0.1
#=GS A0A494W205_9SPHN/1-178 AC A0A494W205.1
#=GS D2TSW9_CITRI/1-176 AC D2TSW9.1
#=GS I4VNH1_9GAMM/18-195 AC I4VNH1.1
#=GS A0A239DIN8_9BURK/1-178 AC A0A239DIN8.1
#=GS Q62NB9_BACLD/1-180 AC Q62NB9.1
#=GS A0A8A8D1T7_9BURK/1-178 AC A0A8A8D1T7.1
#=GS A0A5J5GBH3_9BACL/1-178 AC A0A5J5GBH3.1
A0A1T5IQ77_9BACT/32-208 ...k-TREDLLKRIAQRGFEVGYAANLNFATHDIADKVPVVISFVSMAVGILALV..APVFQ...LTGVAVCLTLLGILTLYIEKYPA--HEYGERGKRTMDMLHDLETLYCKVKNnaDPNATFREEED...ELSTLTIEFIASTNPRQILFATWYANFKFFAEKDYDWIDEQLHFRFwRDKVPANLRIL-l.............
E3BGI2_9VIBR/1-176 ....MSEQTTKKQIAREYYNVIYGAKLNLASLDICEKLPSIISLLSLSLGILGLS..FETFN...NKSLASFLLIAGLIGLMLKPREIQKDKYCKAGGELTDISKRLELLHSEIEP..SEPESEASGRV...ELRKLQTEHKEVYQPSPVFLASWYAHYKLFSEHNNKWFCIELGLTW.KDKIPLSLRSTV..............
A0A0B8YCW9_9SPHI/1-178 ....MDKTNFLKTLAQKGYDIGFGAKKNFASFDIINKLPTWVGFISLAIGIIQIA..YENMP..fNKELSILLILVGIAIIYIDVFKNSAQLYEKEGVRLTKLFNKMRDLYYSVQS..DNNYSYSKYES...EYLNILSDFYSTTISKQVFMSQWFAHFKFFYEMQIDWINIELKFNFfRDKIPNSLKTT-f.............
A0A1N7SE25_9BURK/1-178 ....MKKEDLLRMVAESGYNVGFGAKLHFATLDIVEKAPGWVNVIGFVVGVYSLI..FPALA...VAGISATLVIASSLTLYINFYNSDKEKYDKAGIALTRAYHALQQLYAEVKA.qPGSADMSAFAK...RRIDIVDGASGVSLSKQIFLAPWYAHMKFFWEHQVDWVNEELKLSFwRDKVPLG-----awltl.........
A0A2W7MUB8_9BACI/4-181 ....MDKDALLKQLADYGYRIGFGAKKHFATYDIVSKVPSGISLIGLFIGVGQLA..YPNYN..ySTMISTILILASIIGLTMNSYNAEKEIYSQIGQELTQLFNEVQALYFKVRN..SSEQTFTTEVQ...QLNEILTKYYQISRSQQIFGADWFAHYKFFWQMEKKWIEEQRPFSFlRDMIPLSLVFF-l.............
A6DSC2_9BACT/1-177 ....MDRNDLLKHIAETGYNVGFGAKKHFATFDIVNKAPGVISFLSMAVGILALV..CKNFS...TNWVSAALIILGIIGLYISMRSRDNNKYEATGNKLIKMFNELKTLYFKVKE..ASPESLENHNV...TLNSIEAKYCDSCISDQVLFSGWWAHYKFFWEHQIGWIEEQKKFKFfRDKVPLTLTVTM..............
A0A126T1I1_9GAMM/1-177 ....MDKNDLLKHIAETGYNVGFGAKKHFATYDIVDKLPGLIGFVSTAVGIFSLF..IDVLT...DNYLSATFIVLGICGLYISFYDATKIDYETSAKEITKIFNDLKRLYYKAKS..AKPDDLAAIET...ELMALENKYYQVAISKQILFSDWYAHYKFFWQHQIGWIEEQKTFSFlRDKIPLSFSFFV..............
D0YVS7_PHODD/1-176 ....MTEQTIKKQVAREYYNVLYSAKLHFASFDICEKLPTMISVISLSFGVLGLA..FAEFN...SKALAALLLIIGIIGITLKPRELQKGQYEATGVSLTDISKKLEHIYCEIDV..QDTESVAKARA...DLAQAQADHRAVGTMPPVLMSSWYAHYKVFSEHNSDWMSKELELGF.NDKVPLSLRAV-i.............
F6B744_DESCC/1-181 ....MDKYSLLKSLAEKGYNIGFGARKTFLSYGIYSKIPRFLSLCTVFVGVYQMTtrYKNLNpgtQEIVSVIIICIGILALILDAGSKDKEHYNQVGKQLASLYNELQTMYNTVKN.mDDHADFSPFEK...RMKEIEAEVHRIAISTKCHLPIFLPTFT-FSMVAPKLIGLMSSYTS.PSRINFHFYTT-k.............
A0A1N7KYJ3_9GAMM/1-178 ....MTKNDLLRSIAQKGYDVGFGAKKHFASYDIIEKAPGLISFLSMAFGIISLA..VENSP...TKLISSGFVVLGIIGLYVSMCDHEKLKYEQCGVALTKLFNELKALYLNVQT.tDEQADFSDLAA...KLSELESKYYDSCMSKQILFSNWYAHYKFFWEHQIDWIDEQLKFRFfRDKVPLSLWFF-l.............
C4ZPI0_THASP/2-179 ....MNKENLLKVIADSGYNIGFGAKKNFATFDIVEKAPGWLGFLSLIVGIYALF..VPELA...TNHISAAMVVFGITTLYISFYLPDKERYEKAGIELTGGFHRLRALYYEVRS.lPDGADFTKQVA...EHDAIVRASLNSTVSKQIFLSDWYAHFKFFWQQQTDWLDEQKHFKLlRDKLPLSFSLTV..............
A0A8J7IZ28_9CYAN/1-177 ....MSKDNVLKLIAETAYNVGFGAKKHMATFDIVVKAPGLIRFFSITVGIYSLA..FDGLS...SKTLSASLLILGIIGLYISLYDSQKDRYEKVGIELIQLFNDLKKLYYYAKE..ADDEALNEILK...QLTEVEAKYYQLSISKQILFSDWYTHYKFFWQYQIDWVDEQKHFGLfRDKVPLSFLATV..............
A0A840F543_9SPHN/1-172 ....MDKDLLLRTIAEKGYDVGFGAKKTFATYDIIGKGPGWVGLISGAVGIFALI..FEPLS...AKVPSAILLIAGFASVYLSFYRA--EDYEKAANKLLSQYNRLKALYRSVQS..--GQDTVAAKA...ELDVIDAEYYATTIGRQVFLSGWYAHYKLFAESQIGWMDEQLHFTW.KDKWPVSARIT-i.............
A0A1Q8ISW5_9BURK/1-189 ....MQKDNLLKNIATTGYNVGFGAKKHFATYDIVEKTPGWIGFLSTAFGIYALI..FDGLS...TKFLSATFVIIGIVGLYITFYDSKKSAYETAGIELTKQFNSLRNLYRTVQG..SNETDLTQYMQ...QLSAIEQAYFGACISKQIAFSDWYAHYKFFWQHQIDWIDEQKQFKLwRDKLPLSFIA--silsviviiiylvm
A0A4Q1KPG1_9SPHN/1-172 ....MDKDRLLRLIAEKGYDVLFGVKKTFATYDIVSKGPGWIGFISLAVGVFALI..YDPLS...AKLPSAILVIAGIASLYISFYRA--EEYERSANSQLSIYNKLKSLYLSVQS..--GSDPVAAKT...EYDAIDANYYSTTMSKQIFLSGWYAHYKLFAETQIDWLEEQRQFTW.KDKWPVSARIT-i.............
A0A420E850_9ALTE/1-176 ....MTKQTIKKQVAREYYNVLYSAKLHFASLDICEKLPTIISITSLSFGVLGLA..FAEFN...SKALAALLLIIGIIGIILKPRELLKEQYEATGDSLTDISKKLEHIYCEVNE..QDAASVTKARA...DLSQIQTEHRSVKTISPVLMSSWYAHYKVFSEHNSDWMSAELALSW.RDKVPLSLRLVV..............
A0A562RJB4_9BURK/1-129 ...m------------------------------------------------ALV..FPMLS...EKVPSAMLIIFSVASLYMGFYD--KNVYMKAGEKLTQSFQDLRSLYSRVKS.mPPGSDFNAVEL...EYDRIRSEANGAGISRQIFLSDTAAHYKFFWQQQIGWIEEQITFRFwRDKIPLST----lvac..........
Q6ARQ5_DESPS/15-191 ....MNKEDLLKHIAETGYNVGFGAKKHFATYDIVEKTPGFISFFSMAFGIYALA..FEGLS...TKFLSASFVVLGIVGLYISLYDHKKTAYESYGIKLTQLYNDLAKLYRKTKN..SDGSDIEILEN...QLSQLQGEYYSSCQSKQILFSDWYAHYKFFWQHQIDWVDEQKHFSFlRDKIPLTFSLFV..............
K8DWQ3_9FIRM/1-181 ....MDKYSLLKSLAEKGYNIGFGARKTFLSYGIYSKIPRFLSLCTVFVGVYQMTtrYKNLNpgtQEIVSVIIICIGILALILDAGSKDKEHYNQVGKQLASLYNELQTMYNTVKN.mDDHADFSPFEK...RMKEIEAEVHRIAISTKCHLPIFLPTFT-FSMVAPKLIGLMSSYTS.PSRINFHFYTT-k.............
A0A0Q7EEV5_9CAUL/1-174 ....MTKDGLLKSIAETGYNVGFGAKKHFATYDIVEKAPGWIGFISLAVGILSLV..FEGLS...AKLPSACLTIAGVVALYIAFYDRDKGKYERAGKEMTQLFNQLRDLYRQVQA..--DADLKVSAG...SLGLIEGRFYEVAISKQILFSDWYAHYKFFAQHQIEWIDEQKHFTW.RDQVPLSFRAC-l.............
A0A1Y4CRK6_9DELT/2-172 pdsn------LRFIVDLAYNVGFGAKKHFATYDIVTKIPAWLSFILISFGIISLV..YETFS...AKEFSAITLILSIFSFSIQLA-YDPEVYRAKGTRLIELYNELRLLYIKAKE..--QGYGEELEH...KLNKISDEYYQISIPKQILFSDTFAHYKFFFQTNIDWIENERRFTL.TDKTPKSLYIF-i.............
A0A0P8Y8B6_9GAMM/1-176 ....MEKDYLLKHIAETGYNVGYTAKLHFASYEMIEKAPGLISIISMAFGIYALA..YDGLS...TKFISSTLLVLGIIGLYVSIRNGDKGDYQTKGIELTNIFNKLKHLINDVKH..-ETGDLTPLSA...QLKDIETEYNNNCAPQHIMFATWFAHYKFFWEQQTGWIEEYRKLGFfRDKIPLTFWV--sl............
A0A5E7YMT9_9SPHN/1-173 ....MTRDDLKRSIAETAYNVGFGAKKHFATFDMVEKMPGWIGWASFAVSIFALF..TDWLA...DKTPSAILIIVGVGLIYIANYRS--GEYEVAGKSLTKLFNQLRALYRSVDA..--GKPVQDAKT...ELDAIEAEYYNISISRQIFLSDWWAHLKFFGQHQVDWIVDELKLTFwRDKVPTTLKLL-v.............
A0A2I8Q2E0_9ENTR/1-177 ....MLKNDLLNHIASAGYNVGFGAKKTFATFDIVSKLPGWIGIISLAVSVLGLY..MDEMS...SKNISAIFIILSIGSLYINFYDGDKSKYEEAGKRQTDIFRKIERLYYDAKS..ESQPDSAKYIQ...ELEVLMQDFDNSTITKQICGSNWYAHYKFYSELEKRWIEEQLSLTFwKDKFPNTLKIF-l.............
A0A494W205_9SPHN/1-178 ....MNREGLLRSIAETGYNVGFGAKKNFATHDVVQKAPGLIGFLSLAVGVFALI..YEPLN...SKWIAATLVVLGIASLYVTHYDHNKVAYCEEGERLTALFYRLRDLYRDVQA.tGEDDDLAVYRE...RLDDLQSEVFGSNQSKQILFSDWYAHYKFFWQHQIEWIDEQKQFTFwRDKMPLSLSLT-l.............
D2TSW9_CITRI/1-176 ....MTQSEMLKLIARHGYNVGFGAKKNFATYDLICKASGWISFISLAVGVFALF..IPELA...TNVISAILIIFGVATMYIQFYDSEKQSYESAGIEQTKIFNELEVIYRNVKS..DANFDYQRTQQ...SIDAIMSRFYGTVISKQIFGSNWYAHYKFYCEFEKAWVEEELNLTL.KDKIPLSLCFL-a.............
I4VNH1_9GAMM/18-195 ....MERPYFLKELAQTGYNIGYAAKKHLATYDIVEKAPGWISLVTLGFGVFALV..IPAME...NHILAAVLLLIGIAAFYFNSYQDQRARYENVGSRLTTLFTELRGLYYEAKG.rHEGDDLADLEA...RYRETLAESQSIGISKQIFLSDWYAHYKFFWQAQTDWLDEQLHFKFwRDKIPLSLSVTV..............
A0A239DIN8_9BURK/1-178 ....MDKQALLKLIAESSYNIGFGAKKHFATFDIVEKVPGWIGLASLTAGVLALF..IKELE...EKYVTAAFTILGIAALTFNSYNEKKDQYNQTGIALTGKFHELRSLYQTVKS.lTATVGLTPYLA...EHSRIQQEALQFGMSKHIFLSDWYAHIKFFGQSQTDWMDEQLHFGFiKDKIPFSAKV--lf............
Q62NB9_BACLD/1-180 ....MERNLFLRQLAENGYNVIYGAKKHFSTYDTVVKMPGRIAFITLAIGIWQIY..KPSFP..yNSEISLLLIIASIIALTISQYNSEKDRYREVGNRLIQIHNELREIYYQAKS..SEQENFSNESNeaiRMNELLNEFYQISISKQIFLSDWVAHYKLFFQSQYEWIDEQKKFTW.KDKIPISFRIA-v.............
A0A8A8D1T7_9BURK/1-178 ....MKKEDLLRMVAESGYNIGFGAKLHFATLDIVEKAPGWVNVIGFAVGVYSLI..FPALA...LAGISATLVIASSLTLYINFYNSDKEKYDKAGVALTSAYHELRQLYAEIQT.qPAGADMGPFSA...RRMTIVSGASSISISKQIFLASWYAHIKFFWEHQVDWINDELKLSFvRDKVPFG-----awatl.........
A0A5J5GBH3_9BACL/1-178 ....MDKDRLLYALAENGYNVVFGARKHFATYDIIEKIPGIFAFFGLIIGVWQIY..YPTFK..yNTEVSLVLIFLSIIALYIDPYKSSKEGYKDRGEKLIQLHNQLRQLYYSVKS.kSVNDSFIQEES...EMNQILTQYNTGNIANQILFSDWYAHYKLFAKSQYDWIDEQKHFKF.RDKFPLSFRFF-a.............
#=GC seq_cons ....MsKpsLLKpIA-pGYNVGFGAKKHFATaDIlpKhPGhIuhlSlulGlhuLh..acshs...s+hlSAhLlllGIhuLYlshYstpKpcY-psGtcLTplaNcL+pLYhpV+s..ssssshsshps...clspIpscahssslS+QIhhSsWYAHYKFFhppQh-WI-EQhcFsahRDKlPLShphh.h.............
//
