#=GF ID   SPECT1
#=GF AC   PF18680.5
#=GF DE   Plasmodium host cell traversal SPECT1
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF08137
#=GF GA   38.40 38.40;
#=GF TC   42.40 42.30;
#=GF NC   33.10 33.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   25479287
#=GF RT   Structure of the essential Plasmodium host cell traversal
#=GF RT   protein SPECT1.
#=GF RA   Hamaoka BY, Ghosh P;
#=GF RL   PLoS One. 2014;9:e114685.
#=GF DR   INTERPRO; IPR040897;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found in SPECT1 (sporozoite microneme protein
#=GF CC   essential for cell traversal). It is formed of a four
#=GF CC   alpha-helix bundle with a 'hook'-like feature at one end. These
#=GF CC   helices in parallel or antiparallel alignment [1].
#=GF SQ   22
#=GS Q7R8B6_PLAYO/8-44        AC Q7R8B6.1
#=GS A0A024VNH0_PLAFA/1-150   AC A0A024VNH0.1
#=GS A0A0L7KAU3_PLAFX/60-240  AC A0A0L7KAU3.1
#=GS A0A1J1HDK8_PLARL/58-237  AC A0A1J1HDK8.1
#=GS A0A1A8W1R6_9APIC/37-216  AC A0A1A8W1R6.1
#=GS W7J6G8_PLAFA/1-119       AC W7J6G8.1
#=GS A0A1D3SP01_PLAMA/58-237  AC A0A1D3SP01.1
#=GS K6UVQ8_PLACD/58-237      AC K6UVQ8.1
#=GS A0A024WKG6_PLAFA/60-240  AC A0A024WKG6.1
#=GS A0A1D3TK37_9APIC/58-232  AC A0A1D3TK37.1
#=GS A5K863_PLAVS/28-173      AC A5K863.1
#=GS A0A0L1I885_PLAFA/60-240  AC A0A0L1I885.1
#=GS Q8IDR4_PLAF7/60-240      AC Q8IDR4.1
#=GS A0A024W275_PLAFA/60-240  AC A0A024W275.1
#=GS W4IZW3_PLAFP/60-240      AC W4IZW3.1
#=GS A0A509APC6_PLABA/57-236  AC A0A509APC6.1
#=GS A0A653HB20_9APIC/1-118   AC A0A653HB20.1
#=GS A0A679L6C8_PLAKH/58-237  AC A0A679L6C8.1
#=GS A0A024X1U3_PLAFC/60-240  AC A0A024X1U3.1
#=GS A0A1A8Z8T0_9APIC/42-221  AC A0A1A8Z8T0.1
#=GS A0A0L7LZU4_PLAF4/45-111  AC A0A0L7LZU4.1
#=GS A0A1Y1JIV0_PLAGO/58-237  AC A0A1Y1JIV0.1
Q7R8B6_PLAYO/8-44                   .....ISDDFSDDINTTKQTIKDLFLDIEGSFEDTSDDVVK----------------------------------------------------------------------------------------------------------.--------------------------------------l....
A0A024VNH0_PLAFA/1-150              mdnsi------------------------------------FISKYSLTIEEKLNLFDGLLEEFIENNKGLISNLSKRQQKLKGDKIKKVCDLILKKLKKLENVNKLIKYKIILKYGNKDNKKEMIQTLKNEEGLSDDFKNNLSNYEtEQNNDDIKEIELVNFISTNYDKFVVNLEDLNKELLKDL.....
A0A0L7KAU3_PLAFX/60-240             ...mv--DDFSDDIGFVKTSMREVLLDTEASLEEVSDHVVQSISKYSLTIEEKLNLFDGLLEEFIENNKGLISNLSKRQQKLKGDKIKKVCDLILKKLKKLENVNKLIKYKIILKYGNKDNKKEMIQTLKNEEGLSDDFKNNLSNYEtEQNNDDIKEIELVNFISTNYDKFVVNLEDLNKELLKDL.....
A0A1J1HDK8_PLARL/58-237             ....i-IEEFSNDVNTAKMIIRETFLDTESSFKEISDDVVKIISKYSFVTDEKLNIINGLFQEFIENNKSTIFNLSEEHTIKKKDKIKEVSDSILCKLKKLIELNIFNKYHAILKFGNKNIKNEALEALKIEKNISDKLKEKLLNYK.TSENEDIKELESTDFLNYHYDKFTAKLDELINELNKE-l....
A0A1A8W1R6_9APIC/37-216             ....i-LEDFSNDINTTKDTIKNLFLDVEASFEEVSDDIAKSVSKYSFSAEEKLNILDGITRQFVENNRSFIYNSSESKKIVEREAFKKVCDLILNKLKILVQLNTINNYHILLKFGRGNVKKETLETVKNDSNISDELRKEFLKYN.RMKNQDVKVTELINFMTPIYDKLTSQLNHLIRELSMDL.....
W7J6G8_PLAFA/1-119                  ....n---------------------------------------------------------------KGLISNLSKRQQKLKGDKIKKVCDLILKKLKKLENVNKLIKYKIILKYGNKDNKKEMIQTLKNEEGLSDDFKNNLSNYEtEQNNDDIKEIELVNFISTNYDKFVVNLEDLNKELLKDL.....
A0A1D3SP01_PLAMA/58-237             .....ITEDFSNDINTTKVIVKNLFLDIEASFEDVSDDIAKSVSKYSYSVEEKLNKIEGLVREFIENNKGIMFNSSESKEKVEKEKIKKVFNLILSKLKKLIHLSTMINYHTLLKFGNSDVKKETLEAVKNDDNISDELKKELIKYE.GKENQDIKATELINFISPLYDNFTNKLNMLINELPTDL.....
K6UVQ8_PLACD/58-237                 .....IAADFTDDINTAKEALQNMFLDIEASFEELSDDVAKSVSQYSYDTEEKLNILVGLVNEFVENNKGVIFKSSEEKKKVEEHKFKKMCDLILEKVKTVVELSTINNYRIILKFGKGDRKSDILDKVKNDDSISDALKSELLKYE.DVESKNANVSSLVNFISPIYESFKQKLNALIREVSSDL.....
A0A024WKG6_PLAFA/60-240             ...mv--DDFSDDIGFVKTSMREVLLDTEASLEEVSDHVVQSISKYSLTIEEKLNLFDGLLEEFIENNKGLISNLSKRQQKLKGDKIKKVCDLILKKLKKLENVNKLIKYKIILKYGNKDNKKEMIQTLKNEEGLSDDFKNNLSNYEtEQNNDDIKEIELVNFISTNYDKFVVNLEDLNKELLKDL.....
A0A1D3TK37_9APIC/58-232             ....i-LEDFSNDINTTKDTIKNLFLDVEASFEEVSDDIAKSFS-----AEEKLNILDGITRQFVENNRSFIYNSSESKKIVEREAFKKVCDLILNKLKILVQLNTINNYHILLKFGRGNVKKETLETVKNDSNISDELRKEFLKYN.RMKNQDVKVTELINFMTPIYDKLTSQLNHLIRELSMDL.....
A5K863_PLAVS/28-173                 ...fl------------------------------------SVSQYSYDAEEKLNILEGLVNEFVENSKGVIFNSPEEKKKMEKHKFKKMCDIILEKVKTVVELSTINNYRIILKFGKGERKSEVIDKVKNDDNISDELKSELLKYE.DVESKDANVSGLINFISPIYDSFEQKLNALIREVSADL.....
A0A0L1I885_PLAFA/60-240             ...mv--DDFSDDIGFVKTSMREVLLDTEASLEEVSDHVVQSISKYSLTIEEKLNLFDGLLEEFIENNKGLISNLSKRQQKLKEDKIKKVCDLILKKLKKLENVNKLIKYKIILKYGNKDNKKEMIQTLKNEEGLSDDFKNNLSNYEtEQNNDDIKEIELVNFISTNYDKFVVNLEDLNKELLKDL.....
Q8IDR4_PLAF7/60-240                 ...mv--DDFSDDIGFVKTSMREVLLDTEASLEEVSDHVVQNISKYSLTIEEKLNLFDGLLEEFIENNKGLISNLSKRQQKLKGDKIKKVCDLILKKLKKLENVNKLIKYKIILKYGNKDNKKEMIQTLKNEEGLSDDFKNNLSNYEtEQNNDDIKEIELVNFISTNYDKFVVNLEDLNKELLKDL.....
A0A024W275_PLAFA/60-240             ...mv--DDFSDDIGFVKTSMREVLLDTEASLEEVSDHVVQIISKYSLTIEEKLNLFDGLLEEFIENNKGLISNLSKRQQKLKGDKIKKVCDLILKKLKKLENVNKLIKYTIILKYGNKDNKKEMIQTLKNEEGLSDDFKNNLSNYEtEQNNDDIKEIELVNFISTNYDKFVVNLEDLNKELLKDL.....
W4IZW3_PLAFP/60-240                 ...mv--DDFSDDIGFVKTSMREVLLDTEASLEEVSDHVVQSISKYSLTIEEKLNLFDGLLEEFIENNKGLISNLSKRQQKLKGDKIKKVCDLILKKLKKLENVNKLIKYKIILKYGNKDNKKEMIQTLKNEEGLSDDFKNNLSNYEtEQNNDDIKEIELVNFISTNYDKFVVNLEDLNKELLKDL.....
A0A509APC6_PLABA/57-236             ...ls--DDFSNDINATKQTIKDLFLDIEASFEDTSDDVVKLLSKYSFVPEEKLNIIDGILRSFIENNKTHVINSSNAYIYIQKEKIKNVCNFILKKLNSLIQINELNKSHIILKYGKGEAKKGVLESIKNNDDISKNLKSELLKYE.NVNNQNIRVSELINFITPIYDDFIKNLTDLINDLQI--kl...
A0A653HB20_9APIC/1-118              ....n---------------------------------------------------------------KNRIYTSTKLEENNDKKGIKKECDLALNKLKDVVEYIRLNKFYTFLKYGEGDVKKEALEYVKNNDNINKELKDELLKYE.KNEGENKNVSKLINHVTPIFNKVIEKLVELRSELSKDL.....
A0A679L6C8_PLAKH/58-237             .....IAADFSDDINATKEALQNMFLDVEASFEDLSDDVAKSVSKYSYDTEEKLNILQGLLSEFVENSKGVIFNSPEEKKKEEKHKFKKMCDLILQKVKTLVELGAIDKYRIILKFGKGERKSDILDKVKNDNSISNELKEELLKYE.EVEGKDANVSSLINFISPIYDNFLQKINAIIGELSADL.....
A0A024X1U3_PLAFC/60-240             ...mv--DDFSDDIGFVKTSMREVLLDTEASLEEVSDHVVQSISKYSLTIEEKLNLFDGLLEEFIENNKGLISNLSKRQQKLKGDKIKKVCDLILKKLKKLENVNKLIKYKIILKYGNKDNKKEMIQTLKNEEGLSDDFKNNLSNYEtEQNNDDIKEIELVNFISTNYDKFVVNLEDLNKELLKDL.....
A0A1A8Z8T0_9APIC/42-221             ....i-LEDFSNDINTTKDTIKNLFLDVEASFEEVSDDIAKSVSKYSFSAEEKLNILGGITRQFVENNRSFIYNSSESKRVLEREAFKKVCDLILNKLKNLVQLNTINNYHILLKFGRGNVKKETLETVKNDSNISDELRKEFLKYN.RMKNQDVKVTELINFMTPIYDKLISQLNQLIRELSIDL.....
A0A0L7LZU4_PLAF4/45-111             ...mv--DDFSDDIGFVKTSMREVLLDTEASLEEVSDHVVQSISKYSLTIEEKLNLFDGLLEEFIES--------------------------------------------------------------------------------.--------------------------------------kiqff
A0A1Y1JIV0_PLAGO/58-237             .....IALDFSDDINSTKEVVKNLFLDIEASFEELSDDVAKNVSMYNYGTEEKLNVLDGLINEFIENNKGIIFNSSDEEKKIAKKKFKKMCDLILGKLKVAVELCVINNYRILLKYGKGDRKKEALDRVKNDDNISDELKKELLKYE.NLENKDANVSELINFITPIYESFMNKLNALIREVSVDI.....
#=GC seq_cons                       ....l..-DFSsDIshsKpsh+plhLDhEAShEElSDcVspslSKYShshEEKLNlh-GLlcEFlENNKGlI.N.SccppKlct-KhKKVCDLILpKLKpL.plNpl.pY+IILKaGpt-sKKEhlpslKN--slSD-hKppL.pYE.c.pNcDlK.hELlNFIos.YDKFhspLpcL.+EL.tDL.....
//