#=GF ID SPOUT_MTase_2
#=GF AC PF14419.10
#=GF DE AF2226-like SPOUT RNA Methylase fused to THUMP
#=GF PI SPOUT_MTase_11;
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF SE Manual
#=GF GA 28.40 28.40;
#=GF TC 28.80 29.40;
#=GF NC 28.30 27.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Family
#=GF CL CL0098
#=GF RN [1]
#=GF RM 11763972
#=GF RT SPOUT: a class of methyltransferases that includes spoU and trmD
#=GF RT RNA methylase superfamilies, and novel superfamilies of
#=GF RT predicted prokaryotic RNA methylases.
#=GF RA Anantharaman V, Koonin EV, Aravind L;
#=GF RL J Mol Microbiol Biotechnol. 2002;4:71-75.
#=GF DR INTERPRO; IPR025849;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC SPOUT superfamily RNA methylase fused to RNA binding THUMP
#=GF CC domain [1].
#=GF SQ 26
#=GS A2BJY2_HYPBU/183-354 AC A2BJY2.1
#=GS E3GWV1_METFV/168-341 AC E3GWV1.1
#=GS A0A0F7DC08_9EURY/167-340 AC A0A0F7DC08.1
#=GS F6BCN2_METIK/168-341 AC F6BCN2.1
#=GS A8AC59_IGNH4/171-342 AC A8AC59.1
#=GS A0A0V8RTD0_PYROC/180-351 AC A0A0V8RTD0.1
#=GS A0A0U2U5L3_9CREN/173-344 AC A0A0U2U5L3.1
#=GS Q5JGM1_THEKO/169-342 AC Q5JGM1.1
#=GS Q8TZR0_PYRFU/172-345 AC Q8TZR0.1
#=GS F2KQY0_ARCVS/173-344 AC F2KQY0.1
#=GS A0A7L9FKM2_9CREN/178-351 AC A0A7L9FKM2.1
#=GS E0SSC1_IGNAA/177-352 AC E0SSC1.1
#=GS Q8ZTN2_PYRAE/175-345 AC Q8ZTN2.1
#=GS A0A328PCC9_9EURY/169-342 AC A0A328PCC9.1
#=GS A0A133V5S6_9EURY/161-332 AC A0A133V5S6.1
#=GS D2RFH8_ARCPA/167-340 AC D2RFH8.1
#=GS S6A4T2_9CREN/180-356 AC S6A4T2.1
#=GS Q8TVD0_METKA/167-338 AC Q8TVD0.1
#=GS Y421_METJA/168-341 AC Q57864.1
#=GS Q9YCV6_AERPE/169-340 AC Q9YCV6.2
#=GS G0EGB5_PYRF1/179-351 AC G0EGB5.1
#=GS A1S137_THEPD/177-353 AC A1S137.1
#=GS D3S2R7_FERPA/167-340 AC D3S2R7.1
#=GS A0A2H5V2T1_9ARCH/179-350 AC A0A2H5V2T1.1
#=GS F0LM29_THEBM/169-342 AC F0LM29.1
#=GS O28057_ARCFU/168-341 AC O28057.1
A2BJY2_HYPBU/183-354 ..........................RIAIVQMPYLG.PLDACKTMGVRIGREVQNFEVGELVIAPIGLVDALQLKTFLEGVFEGIESRYQVQVKSYGRQVYKVPVYVQDLYQLVR.SRF.N-.EPIIVFEPEGDPVSKRA.KDLYELL.....RSGRRVN.MLFGSREGIPEGVYRFANLVLDFAPGVTLSTEYAAAAAVIAVVSVVHD..............................
E3GWV1_METFV/168-341 ..........................KITIVQLPYWG.DYKVCRKMGEKIGRAAQAFEIKELIISPKEKMDAYELMEFIRGVKKGQRSRYLIQKDAYPWDVRKIPVSVWDLYQVIRdKRR.KN.RTIIITDPLGDIVSNVK.NKLKKDL.....KFSKEII.VFIGSREGIPRGLFDLADYVLDLTPHMTFATEQGIPAILILLWHLYE-s.............................
A0A0F7DC08_9EURY/167-340 ..........................KVSFVQMPYLE.NPKGAREIGERIGRSAQSFEIKELIIAPYGYVDADELYEFLRGLRRGKESRLKIQRRSYARDVREVRVLVHDLYQTFRdKRR.KR.SVLISTDPTGKQLSEIR.EELKRAF.....ERADEIV.IFAGSRTGLPKGILRLSDFVIDLTPYITFPTEIAIPASLIALLDVYEE..............................
F6BCN2_METIK/168-341 ..........................KVTIVQMPYWG.ELKVCRKFGEQIGRAAQAFEVKELIIAPKGKIDAYELLEFLKGVQIGQKSRYLVQKEAYPWEVKKVPVSVHELYQVVRdKRR.NN.RLLIVTDPKGNTLNQVK.DKLKKDL.....KFAKEVI.IFIGSREGIPRGIFRFADYVIDLAPYMTFATEHGIPGALIGLWTIYDE..............................
A8AC59_IGNH4/171-342 ..........................KVVVVQEPYLG.PLEGVKEVSKRVGRVLQSFGVGTYYAALTEEADGDQLAEFLRGVREGAESRRRQREKSEGK-ANRLQIKVFDMYHLVA.SRG.KK.DLVVVFEPEGKSFEEVM.EDLGRAL.....RKARRVY.LVLGSRKGVPMGLYKFADFVVDVAPGAVLSTETAVAAALEAVVIAF--la............................
A0A0V8RTD0_PYROC/180-351 ..........................RLSVVQMPYLG.PLDACRTMGVRVGREVQNFEVGELVVSPIGLVDALQLKTFLDGVFEGIESRYQVQRKSYGRDVHRVPVYVQDLYQLVR.SRY.D-.EPVIVFEPEGDPISKRA.RDILELV.....RKGRRVN.LLFGSREGIPEGVYRFADLVLDVAPGITLSTEYAAAAALIAIGSVIH-d.............................
A0A0U2U5L3_9CREN/173-344 ..........................RLSVIQEPYLG.PPKSIEELGKRIGRILQSYGVGEYYIGLIEETDALQLAQFIESVRDGMEARRKQEEKVEGK-ALSTKLKVFDVYHLAL.SKS.KK.ELMVVFEPEGKSFEEVE.EELAKAL.....RKAKRVK.AFLGSRKGVPMGIYKLADFVIDVAPGRTLSTETALAAALEALLIAY--lr............................
Q5JGM1_THEKO/169-342 ..........................KVTLVQMPYWG.DYKACRKFGEKIGRAAQAFEVKELIIAPKEKMDAYELMEFLRGIKIGQESRYQIQREAYPWKVEKVPVSVWDLYQVVRdKRR.NK.RLLIITDPKGPTLAEVK.EKLAKDM.....HYAKEVV.IFIGSREGIPRGLFRFADYVVDLAPYMTFATEHGIPATLVSLWEVYEE..............................
Q8TZR0_PYRFU/172-345 ..........................KLTIVQMPYWG.DYKTARAFGEKIGRAAQAFEVKELIIAPKEKMNAYELMAFIRGVKEGQESRYQIQKEAYPWEVEKVPVSVWDLYQVIRdKRR.SR.RLIIITDPKGPTLNEVK.DKLAKDM.....YYAKEVV.VFIGSREGIPVGLFRFADYVVDLAPYMTFATEHGIPATLVALWTIYEE..............................
F2KQY0_ARCVS/173-344 ..........................KISIVQLPYLE.--KGAFELGERIGRAVQAFEIKELIIAPFGYANAYELEQFIKGVRKGQIARFEVQKRAYDRDVRKVPVLLQDLYQTARdKRK.KR.NLLIVTDPTGKQIKNVK.DELGRKM.....FYADEIV.VFVGSRVGIPKGVFKFADYVIDLAPYITFATEQAIPSALVALIAVFEE..............................
A0A7L9FKM2_9CREN/178-351 ..........................RIVVGQVPYIA.EGDASYKVGVRIGRSVQSFEIRELVVTPYTPTEASPLARFIIGLLEGIESRYRIQVKTYGRSVHRTPVSLFDLYQLVRdYRE.RG.VPILATSTRGRYIGEVR.DVLRNVF.....RRSERVL.VLVGSREGLPTGVLRLSDLVIDVMPGITLATDIAATSILTAISNVLV-e.............................
E0SSC1_IGNAA/177-352 ..........................RFVVVHEPYLG.PEDASYTMGVRIGREVQTYEVGELVVAPIGSVDAYSMYHFLRGLFEGIESRYDIQRKSYGREVHRVRVSIQDMYQFIR.SHM.G-.EPIIVFEPEGEPISKLA.NEVSEFIvk.svKAGKKIY.MMIGAREGIPTGLFRYASYVLDIAPGIVISTDYALASALIAITTVLHE..............................
Q8ZTN2_PYRAE/175-345 ..........................KVALGQFVYEG.DEEAVRKMGERIGRAVQTFEVGELTILLHKPVQGRALRAFIQAVEEGIESRYQIQVKSYGRAVWKVPVYVYELYQYVR.ARE.G-.EPIVVTDPKGDYITHVK.ERLAELF.....-ARDRVN.ILIGAREGVPPGVFRFASLVVDLVPEVTIATDFVVPSLAIALISALEE..............................
A0A328PCC9_9EURY/169-342 ..........................KTTIIQMPYWG.KPQIVRKFGEKIGRAAQAYEIKELIIAPKEKMDAQQLAEFIQGIKKGQKSRYMIQKEAYPWPTKKVPISLWDLYQAIRdKKR.KN.RTIIITDPKGKTINTIK.ENLKKDL.....RKSKEII.ILIGSREGIPRGLFKFADYIIDLTPYITFATEHAIPATLTTLYQIYT-k.............................
A0A133V5S6_9EURY/161-332 ..........................KIHLVQLVYRGkDRRGIERIGVSLGRSAQAFETKKVTIVFDSPTDADKLQAFLNGIDEGIDSRFRIQKRVYERSMSRVPVDVYELYQFLR.KIDgEE.DLVIMTDPRGEVLQNSR.NNLKEDL.....KSAETVY.LFNGSNKGIPTGCFERADHVLDLAPHITYATDQAITASVIALLN----l.............................
D2RFH8_ARCPA/167-340 ..........................KISLVQMPYLE.DISAAKEMGEKIGRSAQAFEVKELVIAPFGYVNAYELEAFIRGVRRGQFSRLEIQKKAYAREVREVPVYVQDLYQTARdKRR.KN.NILIVTDPVGKQIKDVK.DDLKRDL.....KYADEVV.VFMGSRQGIPKGIFRLADYVIDLAPYITFATEHAIPASIIALISVYEE..............................
S6A4T2_9CREN/180-356 ..........................RMVVTHEPYLG.PPDASYVMGTRIGREIQCFEVGKLVVAPVGAVEAEALQRFLRGVIDGQKSRLGIQKKSYGREVHRTEILVQDMYQFVR.SWH.G-.KPLIIFEPEGEPVSRVG.GELADFIiekvfREKKELG.VMVGAREGIPSGLFRYADFVLDVAPGVVISTDLALTSGLIAIGTAVH-d.............................
Q8TVD0_METKA/167-338 ..........................KLELAQIPYLG.DPRAAYSMGERIGRAVQGFELKSYIVTPYEPVNAVELLHFLRGLRDGVKSRMDVQRESYGREFRRTELLLYDLYQLIRlKRD.A-.-LIIGTDPKGDPYTEIR.KTLGEAL.....READEVV.VLAGSRVGLPRGVLRACDFVVDLCPGVTFATEHVVPSVVTALVDSYLE..............................
Y421_METJA/168-341 ..........................KVVIVQMPYLG.EKIVCKRFGEAIGRAAQGFEVKELIIAPKEKVDAYELMEFIKGVKIGQHSRYEIQKRAYPFEIKLVPVTVQDLYQVVRdKRR.DN.RLLIITDPKGDELSKIK.DKLAYDL.....RKKREII.VFCGSREGIPRGLFRFADYIVDLAPHMTFATEHAIPAALIALWGVYS-g.............................
Q9YCV6_AERPE/169-340 ..........................RVAVVQMPYLG.PLDACRNMGVRIGREVQNFEVRELVVAPTGLVDARQLAEFLQGVFEGVESRFEVQRKSYHRRARRVPVYLQDLHQLVR.DRR.G-.EPIIVMEPEGEHISRVA.DRLWEMF.....RGSRRVN.VLVGSREGIPLGVYRYADLVVDIAPGITLSTDYAAASALVAIATVLYE..............................
G0EGB5_PYRF1/179-351 ..........................KISLVQMPYLG.PLDACRNMGVRIGREVQNFEVAELVIAPDGPVDALQLKTFIEGVLEGIESRYEVQRKSYGREARRVPVLVQDIYQLVR.ERH.GR.EPIIVLEPEGEPVTRAA.WKLYEMF.....RNARRVS.VLVGSRRGIPLGIYRFADLVIDIAPGITLSTDYAAAAALIAIGTVVHD..............................
A1S137_THEPD/177-353 ..........................KLVVAHEPYLG.PPDASYVMGTRIGREVQVFEVGKLYVTPVGAVDAYSLYSFLRGAFEGQRSRFELQKRSYGREVVKTEVYVQDMYQFAR.SRL.G-.KPLIIFEPEGEPVSRVA.GEVADFIirkvfKEKEEVA.IMVGAREGVPTGLFRFADFVLDVAPGVVISTEYALSSGLIALATILHE..............................
D3S2R7_FERPA/167-340 ..........................KISFVQMPYLE.DLRGAKQIGERIGRAAQSFEIKELIIAPYNYVNAYELLEFLKGVRRGQTARLKIQRKSYAREVREVPVYVHDLYQTVRdKRR.RR.NVLIVTDPTGKQLSDIK.EELKKAF.....RRADEIV.VFAGSRVGLPKGIFRFADFVIDLTPYITFATEHTIPTTLIALLDVYEE..............................
A0A2H5V2T1_9ARCH/179-350 ..........................KISVVQMPYIG.PPKSCREMGARIGRAVQAFEVGEVVVAPAEPVEARSLAEFILGILEGQESRLEVQSRAYARRPRRVEVLVQDLYQLVR.ARR.G-.EPIIVFEPEGVELSRAS.ERLSELY.....RSARRVN.FLFGAREGIPKGVYRVADLVVDLAPAMTLPTELAAPTALLAVYTAL--rv............................
F0LM29_THEBM/169-342 ..........................KVSIVQMPYWG.DYKACRNFGEKIGRAAQAFEVKELIIAPKEKIDGYELMEFLRGVKIGQESRYQIQREAYPWKIEKVPVYVWDLYQVIRdKRR.NK.RLLIITDPKGHTLAEVK.DELAKDM.....YYAKEVV.VFIGSREGIPRGLFRFADYVVDLAPYMTFATEHGIPGALIALWTIYEE..............................
O28057_ARCFU/168-341 ..........................KISFVQMPYLE.DTKAALEIGERIGRAAQAFEIKELIIAPHDYVNAFELEYFIKGVRRGQIARYKIQERAYAREVRKVPVFVRDLYQTARdKRR.KR.NVLIITDPTGRQISDVK.EELVRRI.....RFADEVV.IFAGSRVGIPKGLFRLADFVIDLAPYITFATEQTIPVTLSALLTVYEE..............................
#=GC seq_cons ..........................KlslVQhPYLG.shcus+phGcRIGRusQuFEV+ELlIAPhthlDAhpLhpFl+GVccGtcSRaclQ++uYuRcV++VPVhV.DLYQhlR.cR+.pp.chlIlT-PcGc.lscl+.-cLtcth.....+tu+cVs.lhlGSREGIPpGlFRaADaVlDLAPtlThuTEaAlsuuLlALhslhc-..............................
//
