#=GF ID STK_08120-like
#=GF AC PF11485.12
#=GF DE STK_08120-like
#=GF PI DUF3211;
#=GF AU Pollington J;0000-0002-8158-8998
#=GF SE pdb_2ejx
#=GF GA 21.60 21.60;
#=GF TC 21.60 21.80;
#=GF NC 21.50 20.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF CL CL0209
#=GF RN [1]
#=GF RM 23836863
#=GF RT A thermoacidophile-specific protein family, DUF3211, functions
#=GF RT as a fatty acid carrier with novel binding mode.
#=GF RA Miyakawa T, Sawano Y, Miyazono K, Miyauchi Y, Hatano K, Tanokura
#=GF RA M;
#=GF RL J Bacteriol. 2013;195:4005-4012.
#=GF DR INTERPRO; IPR021578;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family of proteins specific to thermoacidophile archaea
#=GF CC includes STK_08120 from Sulfurisphaera tokodaii. This protein
#=GF CC shows three alpha-helices and a seven-stranded beta-sheet. It
#=GF CC may function as a carrier of fatty acids in their biosynthesis,
#=GF CC metabolism, and/or intracellular transport processes [1].
#=GF SQ 43
#=GS A0A031LNU7_9CREN/11-135 AC A0A031LNU7.1
#=GS A4YE61_METS5/2-137 AC A4YE61.1
#=GS F4B421_ACIHW/1-134 AC F4B421.1
#=GS A4YHZ4_METS5/1-156 AC A4YHZ4.1
#=GS A0A650CRV6_9CREN/10-75 AC A0A650CRV6.1
#=GS A0A550D2J2_9CREN/1-137 AC A0A550D2J2.1
#=GS A0A2T9WT45_9CREN/4-137 AC A0A2T9WT45.1
#=GS A0A2T9WKA3_9CREN/1-134 AC A0A2T9WKA3.1
#=GS A0A2U9IHZ0_9CREN/1-137 AC A0A2U9IHZ0.1
#=GS A0A2U9IHB4_9CREN/1-132 AC A0A2U9IHB4.1
#=GS F4B4J6_ACIHW/1-139 AC F4B4J6.1
#=GS Q97V09_SACS2/1-138 AC Q97V09.1
#=GS W7KVW9_9CREN/11-73 AC W7KVW9.1
#=GS A4YE84_METS5/1-136 AC A4YE84.1
#=GS A0A2U9II11_9CREN/3-159 AC A0A2U9II11.1
#=GS A0A348B1L9_9CREN/1-136 AC A0A348B1L9.1
#=GS F4B7M1_ACIHW/1-132 AC F4B7M1.1
#=GS T0RA00_9PROT/272-356 AC T0RA00.1
#=GS A0A348B6M4_9CREN/3-146 AC A0A348B6M4.1
#=GS A4YG62_METS5/1-135 AC A4YG62.1
#=GS A0A2U9II12_9CREN/1-136 AC A0A2U9II12.1
#=GS A0A2U9IIX3_9CREN/2-136 AC A0A2U9IIX3.1
#=GS A0A348B5T4_9CREN/1-129 AC A0A348B5T4.1
#=GS Q973T5_SULTO/2-136 AC Q973T5.1
#=GS A0A650CPE7_9CREN/1-137 AC A0A650CPE7.1
#=GS H2C7A4_9CREN/1-136 AC H2C7A4.1
#=GS A0A031LV79_9CREN/1-135 AC A0A031LV79.1
#=GS Q97VV4_SACS2/1-134 AC Q97VV4.1
#=GS A0A550D1I1_9CREN/1-117 AC A0A550D1I1.1
#=GS A4YE85_METS5/1-136 AC A4YE85.1
#=GS W7L4X4_9CREN/1-139 AC W7L4X4.1
#=GS H2C1D9_9CREN/1-136 AC H2C1D9.1
#=GS A0A031LS80_9CREN/1-139 AC A0A031LS80.1
#=GS A0A510DYZ1_9CREN/1-134 AC A0A510DYZ1.1
#=GS W7KJY3_9CREN/1-137 AC W7KJY3.1
#=GS A0A650CMU3_9CREN/2-136 AC A0A650CMU3.1
#=GS A0A031LTB3_9CREN/1-133 AC A0A031LTB3.1
#=GS Q96ZH2_SULTO/1-148 AC Q96ZH2.1
#=GS A0A348B4G4_9CREN/1-137 AC A0A348B4G4.1
#=GS W7L871_9CREN/2-103 AC W7L871.1
#=GS Q976U2_SULTO/1-155 AC Q976U2.1
#=GS A0A510E1Y7_9CREN/1-136 AC A0A510E1Y7.1
#=GS A4YFA8_METS5/1-136 AC A4YFA8.1
A0A031LNU7_9CREN/11-135 ........lygne----------.------IKIFADPEFLLPNLLGG-EMVKVDGKE.FTAQIP.....MrGGG.AMIAFG.SIMVSSNS.VTYFIDIAGY.................GKGKGGK.IKLT....LNSS....IIRIEIDMKLPI.E.......ILNA.GV....IKGKVKDFKTKIEEL.LRQERIRRKL..........................................................
A4YE61_METS5/2-137 ...........li--ISRNIPTS.HTPEAVRVILSDPGFVIPKLFPTIKRLEVSGKS.FSGMAR.....Y.MFF.DHEIKG.NVFVSNTE.VTYPYTVSHG.................NDVGTGR.LIFS....IGQG....EVRIRLEYEGWM.E.......HFSA.PL....LEKWLSGFLKGLEED.LRLERIKRKI..........................................................
F4B421_ACIHW/1-134 .............MRISVEIQTK.HESNALLVVLSDPSFVLPNLLPPIKEVKISEGK.YTCKGK.....F.LGM.PFEIVG.NYYLSTEGrIKYVFTINKG.................---GTGN.LEFL....IEQG....KVTLIFDYDGWF.E.......KISR.LF....ISRWINDFKKNFEEK.VRLKRIESKI..........................................................
A4YHZ4_METS5/1-156 .............MKISIQISSK.HEPNVILSLFSDPKFFFETLLQF-KIMDFENQNtFFVYGElt.slF.SLV.DIEAKV.TRYISNTG.VIYVLNVAPGlvklppgkeldrsfkptPPKGNGK.ITIT....RTAS....SINVEFDYEGER.E.......KMIV.NS....LSKRFKSI-RNLDDI.IWKERVSRHL..........................................................
A0A650CRV6_9CREN/10-75 .........veyv----NQVKNP.HGT-VVIELLSDPHFTFKNVLGADK-VETQNGK.IKAEI-.....-.---.------.--------.----------.................-------.----....----....------------.-.......----.--....---------------.----------plkglviwkpvnqfrklhyf......................................
A0A550D2J2_9CREN/1-137 .............MEKSVTIHLP.YSNSQLYSVLSDPEFVLPRLFPPIKEVEVTGDS.FNAYGR.....F.MGM.RFHIYG.ILNKG-EQ.ITYKIYLTAG.................TGKGEGK.LVIR....VADS....QVELRFEYEGWM.E.......RFSGiLF....MDRWFDQFVKRLKEEgVFQKAIER--sv........................................................
A0A2T9WT45_9CREN/4-137 ............v-KIEKIIKVN.HEIDVVLQIMSDPTFLIPRLFPSISEIKVNGDE.FYFKGK.....V.AFI.PYEGKG.RVFVGAEG.VRIVYETSRG.................----SGI.VLLQ...kFNDN....SVKITLQHDNEL.Y.......GNMGkLA....INSNLSKLEKNINED.IRLERIKRKI..........................................................
A0A2T9WKA3_9CREN/1-134 .............MKIEKIIKVN.HEIDVVLQIMSDPTFLIPRLFPSISEIKVNGDE.FYFKGK.....V.AFI.PYEGKG.RVFVGAEG.VRIVYETSRG.................----SGI.VLLQ...kFNDN....SVKITLQHDNEL.Y.......GNMGkLA....INSNLNKLEKNINED.IRLERIKRKI..........................................................
A0A2U9IHZ0_9CREN/1-137 .............MLVEKDVRIS.HEWNAIIEILSDPYFTLPRLFPPIKKVNRNGES.FECEGK.....F.VGM.RFTMRG.NIYRSTDL.ITFIFSLRAG.................GGLGNGK.LMIN....SESE....VLKLIFSYEGWM.N.......RFSKtFF....MSKWFDNFAKNLNEE.IRLERIRRKI..........................................................
A0A2U9IHB4_9CREN/1-132 ...........mk---EVSLNVS.HELDVVLSLFSDPEFSLPRIMPGYE--SHTGKDnFQVIGV.....V.GMF.PYIMEG.RIFRG-SS.IKYVFRMIDG.................-LKGAGN.IDIS....GIES....KLKFIIDYDGDA.K.......SQFE.SS....FEKGIKKISKSINED.IRLERIKRKI..........................................................
F4B4J6_ACIHW/1-139 .............MKLTSEIKNE.HGT-SVLTILSDPFFLFPAMLKATNVEKIDNKYkVEIPIKg..vfY.LPF.NLITYV.TRYISINS.VNYVVNIADF.................AEHRWGN.IKID....VEDK....KVKLDLNIPLPL.D.......SINS.KI....LGKRIKEFEKNFNEL.IRVERIKRKI..........................................................
Q97V09_SACS2/1-138 .............MEWRKIIMTN.HDIDAVIKILSDPEFFIPLVLPVTKFLLNSDSRlYRCEGD.....I.GKL.PVVFQG.REYVGSYN.ITHIIEFERP.................-PNVSGK.INIQ....AIEN....KIVITILLQNLY.I.......IYLPlRV...hISNRLNQLEKTFEEK.IRLERIKRKL..........................................................
W7KVW9_9CREN/11-73 ..alpqgvglssl----------.---------------------------------.------.....-.---.------.--------.----------.................-------.VMFK....VREG....AVDMEVEVEVPL.N.......FVTS.RI....LRKRVERFAESFNEA.VRLYRIEKKI..........................................................
A4YE84_METS5/1-136 .............MNKSITINTS.HDRQSLLIILSDPKFVLPKLFPPIKEVEVENDS.FNAHGR.....F.MAM.SFNMHG.NVLRG-AD.LVYAFYLSAG.................GGMGQGK.LTMR....IKER....EINLEFEYDGWM.E.......RMSGiFF....MDRWFSGFARRLDED.VRMERIKRKI..........................................................
A0A2U9II11_9CREN/3-159 ...........vq--AKVTISSP.FEKDIILKLFSDQKFFFANFTPFTIINEESENV.FYVYGEfy.slF.SAF.DVEARV.RKYISSYV.ITYILIVQPGliqgsydnlidrsfkgvSPKGNGK.IVIS....MSQG....SIEITIDYEGDK.E.......KAIV.NF....IVKRMNKQIKNFDKI.IQLERIKRHI..........................................................
A0A348B1L9_9CREN/1-136 .........mrei----YSFPTK.QEASPIKVICADPKFLLPKVIRALKDVTIKEEG.YVGWGF.....Y.FGT.NFTIRG.HVYSPEDG.VVYPFELEGR.................-GKGGGK.VTLL....VHEN....QVTVEFQYEGWKfT.......PLMG.TV....IRGWLKKFGEEFDEQ.VTLERIKRKI..........................................................
F4B7M1_ACIHW/1-132 ...........mk---EVQLNVK.HEVEVVLELFSDPDFALPRIIPGYE--SHTGKDtFQVIGV.....L.GLY.PYIMEG.RVFKGSV-.IKYVFRMIDG.................-LKGAGN.IEIS....SIEN....SIKFLVDYEGDS.K.......SMFE.SS....FEKGIKKLSKSINED.IRLERIKRKI..........................................................
T0RA00_9PROT/272-356 cvitllnneitpi----------.----------------------------ILENK.FNEFGE.....F.LKS.KYKLLD.TIIVSFVP.VEYPFYMPRK.................LSDRDVN.VTLD....VNEN....KIEYTVKYCKQM.D.......DIFK.--....---------------.----------k.........................................................
A0A348B6M4_9CREN/3-146 ..........ivw----HEIKNS.HDPEVVYSIVSDPEFFLTRVIEVDGLQRVGEDT.YSGK--.....V.--T.GMKVRI.TVYRGAEN.TTFIFYMEPTgfa...........rftKGKVVRK.FVVR....KGES....SVLVEFEKQLAV.DavwdqdaALLK.TT....LDRAVEELQRNGDEI.IRMERVKRKI..........................................................
A4YG62_METS5/1-135 .............MEITRSIKLD.HEWEAVSTILSDPEFVIPRLFPPVKSITVNGSS.FRGSGK.....Y.AMR.DFEISG.TVFKG-TE.IRYVFQVKSG.................-GIGTGR.LTFA....PRDD....ELILKFEYEGVF.K.......RVFSlTA....RDRWIGGFLEKLNEE.IRLERIRRKI..........................................................
A0A2U9II12_9CREN/1-136 .............MKYHTEINTS.HTMDSLKILLSDPNFVLPRIFKSIKDLKVNGSS.FYGKAK.....Y.MGI.EHELNG.NVYSSLNE.ISCIFTLRHG.................KDFGSGK.LMFT....LQSN....KVSIFLEYEGWM.E.......RVSF.SL....INRWINDFLKNFEED.IRMERIRRKI..........................................................
A0A2U9IIX3_9CREN/2-136 ............l-RIVKSIKTK.HDRNSLIIILSDPSFILPRIFPPIKSVENNNSS.FIAKGK.....F.LFT.DFCLRG.NVYSSIDN.IRYIFTLKSG.................NKTGNGK.LEFQ....FTE-....NINISFEYDGWR.D.......LMAR.NF....MSKWVNDFLDKLDED.IRMERIRRKI..........................................................
A0A348B5T4_9CREN/1-129 ............m-RVSRSIDLHpSGKDPLWRALSDPNYVFPRLFPPVKQVHQVGGS.FRGDGK.....F.IGS.SFVLNI.YREVRGDE.VAYHFVLTTG.................GKEGSGE.LLIK....FADR....RVLLEFQYSGWM.E.......NVSGiFF....VRRWFDGFL------.----------gkvvsds...................................................
Q973T5_SULTO/2-136 .............MKVEKEIKTN.QDIDVVMTIFSDPAFTIPQIFPGIASIKCIEPEiFEAEGK.....F.LAF.SYKVKG.RVYKGVDE.VRIIYDSDRG.................----NGI.LYIR...kKDNN....TLQIILEHDNKL.T.......AFLGkPY....VSSNLDRLAENIDEI.IRLERIKRKI..........................................................
A0A650CPE7_9CREN/1-137 .............MRLEYSVTTT.HTPDALREILSDPNFVLPKIFRSIKEIRSEGSS.FSGTAN.....Y.LGI.KHYFQG.NVYSSYNK.VTYVFQIRRD.................KDSASGK.LTFN...iNADG....RLDISLEYSGFM.E.......KGAT.IL....LKKWIGSFISNINEE.IRLERIRRKI..........................................................
H2C7A4_9CREN/1-136 .............MIKSVEFDTS.HDSNSLSTILSDPDFVLPRLFPPIKQVTKSGTS.FDARGR.....F.MGM.KFNMHG.NVLKG-TE.IIYAFHLGAG.................GGEGEGR.LTIR....LLPG....KVALRFEYEGWM.E.......RVSGiFF....MQRWFENFGKSLEEE.VRMERIKRKL..........................................................
A0A031LV79_9CREN/1-135 .............MIVKEQIENH.FEPNVIVKILLDPVFVFKNMFEA-TTVNLENDS.FTANIK.....I.GLT.EYIVYG.RVITGTYK.VRYILNLAGY.................GNDKTGV.LLFD....ITDR....VIDISLEMKIPL.E.......FLSS.RN....LKKRISKFKENFDEL.VRLERINKKI..........................................................
Q97VV4_SACS2/1-134 ............m---EITFSTQ.HNIQALAKILSDPIFTLYKILGA-ETVSVNGNE.FDALIS.....L.GVT.SLILHG.TVYVGNNK.VSYKFY-SVG.................TQKGEGGvLEFD...lFKEG....EIRLIVEFEGRF.A.......SFIK.FS....LRRKIEKNIKRFDEE.VRLERIKRKI..........................................................
A0A550D1I1_9CREN/1-117 .............MELEKEIKVN.HEITSLFKILSDPCFIIPKIFPSIKHIECKGDE.FKGNGN.....L.SILgEYDFRG.RVYVGDSR.IKYIYNTTKG.................----NGT.LEIE...kVNVG....IIKLKLEHDNGL.S.......SYFIrFL....FSSNL----------.----------rk........................................................
A4YE85_METS5/1-136 .............MERSITITTT.YDKRSLISILSDPTFVLPRLFPPIKSVSRGENS.FDGEGR.....F.MTT.KFHMHG.TVIVR-DD.IVYGFYLSAG.................GSQGNGR.LIFT....FNNN....EINLKLEYQGKM.E.......KLSGlFF....IDRWFSDFASKLNEE.IKAEVIKRRL..........................................................
W7L4X4_9CREN/1-139 .............MKIRRQIEHD.HGDSAIF-ALSDPFFVFKNMFEA--NVEKWDTR.YKVEIPlkglfY.LPF.NLVVYVtSVLRSTHS.VNYVINVADF.................AEHRWGI.VMFK....VRED....EVDMEVEVEVPL.N.......IVTS.RI....LRKRVERFAENFNEA.VRLYRIEKKI..........................................................
H2C1D9_9CREN/1-136 .............MKYIAEIGTE.HPQESIRALLSDPHFVIPRVFKSVKEFRVEGSS.FRGVAR.....Y.FGF.EHEVLG.NVYSSVNE.VSYPFTLRHG.................VDVGTGR.LTFL....IQPG....SVRVILEYEGWM.E.......RFSR.GI....LKGWVRDFLTDFEEV.VRMERIKRRL..........................................................
A0A031LS80_9CREN/1-139 .............MQVEKEILYP.HEFEPLKTILSDPTFVLPRVFPPIKNTRFKEGS.FESNGK.....F.MGM.QFNIEG.NYYIGSES.VTYTFILKAG.................RWKGNGK.LVIEl..kPQQR....KINVKFSYEGWM.D.......TLSKtFF....MSKWFNDFASKLDEE.VRLERIRRKI..........................................................
A0A510DYZ1_9CREN/1-134 .............MDVNYTIETD.YSKDVVLALLSDPEFTIKTFLPVKEIKKESENL.YSVTLP.....G.TLG.NVKMST.RYVNNGDT.ITLIVNLIRP.................--KGVGK.MMIK....PEDK....RIDIKGTSSIWT.D.......PILA.IS....MNRKVSKLKKEINEI.LRLERIRRKI..........................................................
W7KJY3_9CREN/1-137 .............MIIEVVFRLT.HETDAFLKVVSDPSFLIPKVIPPVYSVEVNGSR.FVAYGK.....Y.MVV.PFTISG.NVFTGENS.ATYAFTLSAK.................GGKGSGR.LTVS....ALGE....SGSIKLDFEGFM.H.......RLAGtFL....IRKWLENFAKNLNEE.VRLERIKRKI..........................................................
A0A650CMU3_9CREN/2-136 .............MKLEKEIKVS.HQVDVVLQILADPGFTIPRIFPNINRIKVDGEK.FEADGK.....V.VLS.SYHLTG.RVFPGYNE.VKYVFDYDND.................---KGGV.LKIS...kVNEN....VIRITLEYDSSL.I.......ARIGtFI....LNSNLNKLEKNINED.IRLERIKRKI..........................................................
A0A031LTB3_9CREN/1-133 .............MKIILEFPTK.HEEEVLTIILSDPTFVLPFLFPVIKKVENENTK.FKALGR.....F.GIT.NFEMNG.NVYRRYNG.VEYIFTMTPK.................---GSAN.LKFI....LDRN....KVRIEFDYEGWL.D.......SFTT.LF....IKRWFNIASKDFEER.IRLRRIEKKI..........................................................
Q96ZH2_SULTO/1-148 .............MELEYNFETN.TPKDVILEYISNPENLLKYV-PAFKSLKRLDENsWELEVK.....W.L-F.TIKLKV.KRIIGTDE.VTYTIEKTEGli............kisASLRYVI.LTPK....NRNT....ILKIIFSYEGPF.E.......SIAK.KQteeyYRRGVEIFKRDLE--.----------kleekhlniqrvttkf..........................................
A0A348B4G4_9CREN/1-137 .............MHVVREYGTS.HEPEALVKVLGDPKFVLPRLFPPVKEVETRGTS.FQAKGR.....F.LGS.SFSMSG.EVYVSVDA.VTYPFVLLAG.................SGKGDGR.LTAR....FSPG....SLVLAFDYDGWM.N.......RLSGtFF....MGRWFSNFGKGLEEE.VRLERVRRKV..........................................................
W7L871_9CREN/2-103 ...........sl--ISKEFKTS.HECDAVLSIMKDPKFLLKNLFPSVREVELRERGgLVATGK.....F.MLQ.GFKMSG.NVYSSPTS.ITYVLTMNDK.................-KDSGGK.LVIS....CFNG....EVKIDFEYEG--.-.......----.--....---------------.----------..........................................................
Q976U2_SULTO/1-155 .............MRVNIKFETS.HEREVVFHILSDHTFFFKNFTPFKFIFPSDEENvFYIYGEls.slF.SVF.PAEAKV.RKFVSPVK.ISYVMLFQPKliklpkekeldmmymgtEPNGSGK.IEIN....---E....FLEVLIEYEGEK.E.......KAIV.SA....IKKTIEKSKREFDEI.IRKERIARHI..........................................................
A0A510E1Y7_9CREN/1-136 .............MKYYTEINTS.HTADALSILLSDPRFVLPRMFKSIKDLQVDGSS.YHGRAN.....Y.MGL.WHEING.NVYSSMNE.ISYVFSLRYG.................RSLGLGK.LVFS....LGLN....KVSLSLKYEGWM.E.......RTSS.VI....INMWIKDFLKNFEED.VRLERIKRKI..........................................................
A4YFA8_METS5/1-136 .............MILELSVGTS.HDVESLRIILSDPYFVLPAIFPSIKELKILGGS.FQGYAN.....Y.LGI.EHEVSG.NIYISKNE.VTYPFTLSKG.................KNLGAGK.LTFY....LTPG....RVLIRLEYEGWM.E.......RLAG.GL....LRGWVKKFSNDLEEK.VRMERIKRKI..........................................................
#=GC seq_cons .............Mphphplpss.H-hcslhplLSDPpFllPplhPslcplchpsss.FpupGc.....a.hhh.saphpG.plahu.sp.lsYsaplpsG..................t.GsGc.Lhhp....hpps....plplph-Y-Ghh.c.......ph.s.hh....lp+hlpphtcshpEt.lRhERI+RKI..........................................................
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