#=GF ID   SUa-2TM
#=GF AC   PF18179.5
#=GF DE   SMODS- and Ubiquitin system-associated 2TM effector domain
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Burroughs AM;0000-0002-2229-8771
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   Laks
#=GF GA   25.00 25.00;
#=GF TC   25.70 53.20;
#=GF NC   24.60 24.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   26590262
#=GF RT   Comparative genomic analyses reveal a vast, novel network of
#=GF RT   nucleotide-centric systems in biological conflicts, immunity and
#=GF RT   signaling.
#=GF RA   Burroughs AM, Zhang D, Schaffer DE, Iyer LM, Aravind L;
#=GF RL   Nucleic Acids Res. 2015;43:10633-10654.
#=GF DR   INTERPRO; IPR041502;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Predicted pore-forming effector domain observed exclusively in
#=GF CC   conserved genome contexts with the SMODS nucleotide synthetases
#=GF CC   and the bacterial Ubiquitin conjugation systems [1].
#=GF SQ   17
#=GS A0A844LNY6_9BACI/11-165  AC A0A844LNY6.1
#=GS A0A0U1QPG8_9BACL/7-287   AC A0A0U1QPG8.1
#=GS B1C2T6_9FIRM/3-278       AC B1C2T6.1
#=GS A0A3E3I464_9FIRM/1-274   AC A0A3E3I464.1
#=GS A0A1H3VI33_9FIRM/1-194   AC A0A1H3VI33.1
#=GS F0GWA5_9FIRM/2-272       AC F0GWA5.1
#=GS A0A1Y3W7Y3_9FIRM/11-287  AC A0A1Y3W7Y3.1
#=GS A0A2T0B5Y2_9CLOT/1-273   AC A0A2T0B5Y2.1
#=GS K0DER7_LEUCJ/2-280       AC K0DER7.1
#=GS W4QLG9_9BACI/1-265       AC W4QLG9.1
#=GS A0A0R1UTE6_9LACO/18-299  AC A0A0R1UTE6.1
#=GS A0A415RAE0_9FIRM/2-276   AC A0A415RAE0.1
#=GS A0A416JUU2_9FIRM/1-273   AC A0A416JUU2.1
#=GS A0A0R1SCA2_9LACO/4-275   AC A0A0R1SCA2.1
#=GS U2VJ39_9ACTN/1-281       AC U2VJ39.1
#=GS A0A143X720_9FIRM/1-208   AC A0A143X720.1
#=GS A0A844LVK1_9BACI/2-121   AC A0A844LVK1.1
A0A844LNY6_9BACI/11-165             ................nasd--------------..---------------------..----..-----..---.-...-------------.--...---------------------...----------------------------------------LQYKLLL.MDIFPEVIVD.SDVEEK...AQSI--NVIEK.NMD..YPS...NELNLILVDTYEIT.DSQIPTNKAHLPTIFIK..SGN.EIDSN.RSLNPEYIKEIRRKTNVYHKI.YKKLNVFCTTNTNHNQLIINKCF..KNGNRTGFENIVVYQASRSNF--VFNRGHKVL............
A0A0U1QPG8_9BACL/7-287              ....................KYRKNMC-WNYWNLfvKTIVPVLLLIFFPLLPLFFLT..KIES..HYLYM..GLM.P...NKYYRVVLESVMR.RMdvsLSFILGILIFVSLMYFIRKNN...KDAIYNGKGTIYYEYPYIFFWINSKILGYNKIQLAGIPIYLQFKLVL.NNTFHTIIPD.AGKQFQ...EEETTTETLCE.NFN..QST...STLNLILEDTYQIS.LQSLPDELRGLPRITVR..TSQ.DIQGK.RYKNPEFISEIRKIVSKYNTK.YETVNIFSTANPANNIEIINSSF..RQFGRIGFKKVYVYQMDTPSCK--YIKHHRIL............
B1C2T6_9FIRM/3-278                  ....................KLIKIIKNKIVDSG..REYLQILLLFISFMFPLFVNM..SEII..RTILG..GQK.P...NFDNAKYYYLMLS.G-...NNVIGLLFVLYVLFNFIRKVN...KETILN-KGNVYHNHTYAWYWFCSKILGYDKCNLVLVPIQMQFKLVV.RDTFKEYPF-.FENMFP...NEDCCQVQVTKkSVD..NHC...NEFTLIIEDTYPIK.EKQIPEKYLNIPLIKLT..RSC.NTVGK.RVYNEKFIDAIVQEIRLLPED.-SIINIFATTNPKNTYEIAKKGL..FLAERSNIIMVNVFQQEGSGERLFKDKPYTVI............
A0A3E3I464_9FIRM/1-274              ..............mrhffk--------KVKENS..RSIAEIIVLVVAVFIPSKIDA..TGLI..GLCFK..NTL.I...DFDNIKYLFLLNA.G-...-NWVIGLIFMLYLLLKIRGYN...KGKMFN-TQNVYHNYPYLWYWFCAKILGYEKCNLKLVPIFAQFKLVL.NDTFPEYYVG.ADEDYP...VIENEHIDIQKkNYN..QVS...EEVNLILADTYPIDiRQQIPINKRRLSMIIIE..-RD.RTDVS.RYYSPQFVAKIVDEVRRLPSN.VKDINVYATTNPKHTLKIVRDAF..KLAERGNIEKLVVFQQEKNGNRKF--------grkgkvi.....
A0A1H3VI33_9FIRM/1-194              ...................m--------------..---------------------..----..-----..---.-...-------------.--...--------------------N...KEAVINPDNNIYHEHSYIAYCICSKFLDYKQCRLQGVPIPMQIKLVT.NGAFEKFIIDdGIHAAP...KKDKARVT---.NPK..NYT...STVNLLISDTYKVT.VQQLPRTVLQFSTVEIN..RSS.D-DYM.RYNSEELIKTVISIIRNLPKT.VMELNLFMTTNSTNTYRIAKEAL..ATAGRDRISHIYVFQQEREEPRNFEAK-----glkif.......
F0GWA5_9FIRM/2-272                  .......keiirkfkdcktq--------------..------LCQFFFIFLALFLPK.iSNIE..SVINT..KPKdI...SFDIIDIIYYFLS.KL...GNLGIGIFFAGIAIFTIRKMN...KNKILN-NGNIYHDHSYLWFLLCSKILGYEKCNLVLVPIYMQFKLVI.NDVFSEFIV-.-TNNIS...EEKTSSKIIYI.NCD..NKD..sLEYNLILEDTYSIN.DFQIPPEKKQLPTIKVI..NSKtKSEGV.RKYNPKFVEFVVKEIRALPKG.-VLINIFATTHAQHNYEIVEQSL..KLADRGNIAEVFVYQQDRQSYR-NFSERYKVI............
A0A1Y3W7Y3_9FIRM/11-287             .............neyennk--------KIKANS..VQILEVLMLITVIFLPYILDI..PSWF..EDYLR..DHK.P...EPEISNFLPYYIL.KA...GNVAISLGLLFAVLIVIRRYN...KEFVMN-NDNVYHDYPFIWYWFCAKVLGIKKCNLILVPIYMQFKLVI.KNIFKDYPLD.-EMDFP...VIEAEPECIIE.KKN..MRAd.lSEINLILEDTYVIE.SNQIPFRKKSLPTVKIS..RNT.DNSHT.RHFSPKFINSVSEEVRKFLTV.-SRVNIYATTNPMNTLRIARSAF..KMADRGNIEHLFVYQQKREGLRKFEQEGHRI-y...........
A0A2T0B5Y2_9CLOT/1-273              ...................m--KKFVG-KIIDNG..RAIIQILLLVFCFLFPKHVNL..SEII..RTLFG..GQS.P...DFSTAKYYYLMQS.G-...NCTMGILLATIVLFKFIRKSN...EEKILL-KGNIYHDYSYIWFWICSKILGYNSCNLILVPIAMQYKLVI.RGTFEKYPI-.PEESFP...ERDMNVIVKYE.NKD..AEN..aNEINLILEDTYPIT.KSQIPELKKPLRTIIIK..HDR.KDDVS.RIYNNKFVKEICKEVRALPEK.-TIVNIYSTTNPRHNYEIAKQAF..SLANRGNIKELYIYQQERGNTR-KFTKRKK--iy..........
K0DER7_LEUCJ/2-280                  ...............rmkti------KHYIISYP..LAIFGSLLVVLFSVCIIFNIV..KINP..VTLVN..ELT.KamfSFDLLSIFSSFPP.YF...LKVLAITLIFLGFMIFSRRHY...SHKIYH-EDNNYYNSDPFFFFYIAGIFGFQKINPVNIPIWIQAKIIL.RTNLKFIEQI.LDNNNE...EGKVVKYNIVP.--N..SNI...KEFNFIIEDTYKIR.NDDLSQKKLQFPTVKVQ..RGH.FSSGY.HLYNEWLIEQCSKEIDNIITRgGNRINFFCSTNPKHTFLIFNNLL..PRLERESNITIYVYQSEHKDGHFVYDEPHKI-y...........
W4QLG9_9BACI/1-265                  .................mnk--------------..-VLFQCLLILLPAIVSIFYPL..QDLA..YGILSlfGID.A...TNFHEVIKNFFNNeRV...ISIIAGVVSSIVIYIWRTKTN...KNKIFN-TGNKYNDYPIWVYWMASKILGYGKVSLVRVPMYLQYKLLL.KDIFPEVIVD.SDVEEK...AQ---SINVTErNMD..YPS...NELNLILVDTYEIT.DSQIPTNKAHLPTIFIK..SGN.EIDSN.RSLNPEYIKEIRRRTNVYHKI.YKKLNVFCTTNTNHNQLIINKCF..KNGSRTGFENIVVYQASRSNY--MFNRGYKVL............
A0A0R1UTE6_9LACO/18-299             ....................RNKRFRATQMFFRE..LLTWPFLLTIIISCGLYYLYFykRNIF..HALIP..KLI.A...NNSCAAMLSVLTN.QY...FSTVILIIFPIAIYLFFRKISm.eHLNKLIIPRDKYVMFSYNSFKFFVLLTGRNRIYAQSIPVPLIAQLCTkKDKFDVIINDiAEETYP...VKTI-------.KIN..GENnnnTTANIIISSTYCVT.EDKIPQTLLKYDLYHVS..--D.WFEGVnRHYNEELIYEVKKLKNKLLSEgISQINLLLYIPPKVIEKLMVDVFdrTLPSEEQFEDVYIYDSSSSNG-FMFKNRHHIV............
A0A415RAE0_9FIRM/2-276              .................dck----KIINFISDNK..RIVIEILMFIIALILVYSVDL..PESFgeRWLNP..KDL.P...DS----IFYIIIT.AF..pAIPVLKIMLLGFILYKIRSCN...KEYILN-MDNYYHDYSYFWYRFCSSIMGISKCNLILVPIHMQFSLVI.HQVFHEFPL-.QDESFP...ESDADEKVIVK.DFN..NLHg.gLEYNIIIEDTYLIS.MEQLPLDKKELPSFKIS..RNN.KGKSD.RHFNRQFINEIVRVLRDLPDK.-VTVNIYTTTNPKHTFYIAQDAL..KLSDRGNIEHVFVYQQERDNGR-HFKKFYKV-y...........
A0A416JUU2_9FIRM/1-273              ..............mksffr--------KIAVNV..RPAFQIIGLILVGFLPSLLNV..SEIV..TEQPQ..ITA.S...QKWFDYVFYFVWT.RG...DEAIGLLLLIIALFA-VRKVN...KGYIFN-KGDVYKNYPYIWYWVCAKILGYSECNLILVPIFMQFKLVI.QDTFDKYHC-.--GTFN...KKDNDTISVNKkNMS..SAS...DEVNLIIADTYPLE.AKQIPVSKRVNPTILIS..RDN.SVDHN.RYDSPKLVQTVVNEVRNLPSN.IKKVNVYATTNPQNTMNIASNAF..KLGERGNLDEVTVFQQRRTGNPRKFEKK----gkvv........
A0A0R1SCA2_9LACO/4-275              ......lmirfkfgpkgkai--------------..-------ILIITFIIITTLLF..K--F..SFIRS..KYI.S...NEILEMFYNSLPP.KI...FRCVFSSLVITLGYLLTRFVGnkiLSDTLNPNETKYIRNSINWIYIACFFGGAKEFKLKNMPIWISFKIILtWPRLEGIVDS.LET--D...NSKI----LCK.MVNtgNNN...DEVNIIVDDTYETL.SKIDPSDFVSRETWYLKkiKSN.NYSGSyKSYNARLLSDFSSKIGELSKC.YTTVNLFLSTSPYMTKKIIDTCF..EMDRRDGFKHLCVYESSSEHN-FKFVKKHKI-f...........
U2VJ39_9ACTN/1-281                  ...................m--IKRICEWLADSW..EQCIELILIFILPWLPFKFDF..QAAI..EVGKP..DKL.N...DFASLLTYYAMAH.G-...NASISIVLVLFGVIA-AHKIN...AGRILN-RGNHFHRHTMLWYWICSKVLGYNKCKLMLVPIYSQFKLVL.ADTFAEYDYG.ADDYYEvvgEEEVALNTKPA.RED..TDCstpQTVNIVISDTYPLT.EKLLPPSCLKHETITLQ..RKT.NEQTKaRCYSPTLVKAVVDTVRTLPNG.-CRVNVFPTTNPKNTYMIVYKAF..KTGGRDNIGSLYVYKQPNNE------------sywhfaekgvri
A0A143X720_9FIRM/1-208              ....................--------------..---------------------..----..-----..---.-...-------------.--...------MFVLYVLFNFIRKVN...KETILN-KGNFYHNHTYAWYWFCSKILGYDKCSLVLVPIQMQFKLVV.RDTFKEYPF-.FENMFP...NEDCCQVQVTKkSVD..NHC...NEFTLIIEDTYPIK.EKQIPEKYLNMPLIKLT..RSF.NTFGK.RDYNEKFVDTIVQEIRLLPED.-SIINIFATTNPKHTYEIAKKGL..FLAERSNIIMVNVFQQEGNGERLFKDKPYTVI............
A0A844LVK1_9BACI/2-121              lpaivsifypiqeiaygils--------------..---------------------..----..--LIG..IDT.S...NFDEMIKNIINNE.RV...ISIIGGVILSIIIYIWRTKAN...KDKLFN-TGNKYNEYPIWIYWLASKILGYGKVSLVRVPMYLQSLALQ.ENKI------.------...-----------.---..---...--------------.-----------------..---.-----.---------------------.-----------------------..--------------------------------kksrnii.....
#=GC seq_cons                       ......................................hh..lhhhhh.hh.hhh.h..p.....thhh...t.h.s...s.....hh.hh.t.t.....phlhhlhhhhhlhhhhR+hN...KpplhN.psNhYapasahaaahsuKILGYpKssLhhVPIahQaKLVl.pssFcch.h...-pphs...ppcht..sl.c.shs..sts...sEhNLIlpDTY.Ip.ppQlP.phhphsolhlp..pss.p.psp.RhaN.chlpplscclctLspp..pplNlasTTNPppshpIhppuh..phupRsshpplhVYQpcpss...hhpc.apl.............
//