#=GF ID SWC7
#=GF AC PF17330.6
#=GF DE SWR1 chromatin-remodelling complex, sub-unit Swc7
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE PRODOM:PD072365
#=GF GA 25.00 25.00;
#=GF TC 25.70 25.10;
#=GF NC 23.70 22.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 19234524
#=GF RT YEATS domain proteins: a diverse family with many links to
#=GF RT chromatin modification and transcription.
#=GF RA Schulze JM, Wang AY, Kobor MS;
#=GF RL Biochem Cell Biol. 2009;87:65-75.
#=GF RN [2]
#=GF RM 19424290
#=GF RT Chromatin remodelling beyond transcription: the INO80 and SWR1
#=GF RT complexes.
#=GF RA Morrison AJ, Shen X;
#=GF RL Nat Rev Mol Cell Biol. 2009;10:373-384.
#=GF RN [3]
#=GF RM 16299513
#=GF RT Swc2 is a widely conserved H2AZ-binding module essential for
#=GF RT ATP-dependent histone exchange.
#=GF RA Wu WH, Alami S, Luk E, Wu CH, Sen S, Mizuguchi G, Wei D, Wu C;
#=GF RL Nat Struct Mol Biol. 2005;12:1064-1071.
#=GF RN [4]
#=GF RM 19088068
#=GF RT N terminus of Swr1 binds to histone H2AZ and provides a platform
#=GF RT for subunit assembly in the chromatin remodeling complex.
#=GF RA Wu WH, Wu CH, Ladurner A, Mizuguchi G, Wei D, Xiao H, Luk E,
#=GF RA Ranjan A, Wu C;
#=GF RL J Biol Chem. 2009;284:6200-6207.
#=GF DR INTERPRO; IPR020195;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC The SWR1 complex is involved in chromatin-remodeling by
#=GF CC promoting the the ATP-dependent exchange of histone H2A for the
#=GF CC H2A variant HZT1 in Saccharomyces cerevisiae or H2AZ in mammals.
#=GF CC The SWR1 chromatin-remodeling complex is composed of at least 14
#=GF CC subunits and has a molecular mass of about 1.2 to 1.5 MDa. In S.
#=GF CC cerevisiae there are core conserved subunits (ATPase;
#=GF CC Swr1,RuvB-like; Rvb1 and Rvb2, Actin; Act1, Actin-related: Arp4
#=GF CC and Arp6, YEATS protein; [1]) and non-conserved subunits (Vps71
#=GF CC (Swc6), Vps72 (Swc2), Swc3, Swc4, Swc5, Swc7, Bdf1 [2]). Seven
#=GF CC of the SWR1 subunits are involved in maintaining complex
#=GF CC integrity and H2AZ histone replacement activity: Swr1, Swc2,
#=GF CC Swc3, Arp6, Swc5, Yaf9 and Swc6. Arp4 is required for the
#=GF CC association of Bdf1, Yaf9, and Swc4 and Arp4 is also required
#=GF CC for SWR1 H2AZ histone replacement activity in vitro. Furthermore
#=GF CC the N-terminal region of the ATPase Swr1 provides the platform
#=GF CC upon which Bdf1, Swc7, Arp4, Act1, Yaf9 and Swc4 associate [3].
#=GF CC It also contains an additional H2AZ-H2B specific binding site,
#=GF CC distinct from the binding site of the Swc2 subunit [4]. In
#=GF CC eukaryotes the deposition of variant histones into nucleosomes
#=GF CC by the chromatin-remodeling complexes such as the SWR1 and INO80
#=GF CC complexes have many crucial functions including the control of
#=GF CC gene regulation and expression, checkpoint regulation, DNA
#=GF CC replication and repair, telomere maintenance and chromosomal
#=GF CC segregation and as such represent critical components of
#=GF CC pathways that maintain genomic integrity. This entry represents
#=GF CC the subunit Swc7; the smallest subunit of the SWR1 complex. Swc7
#=GF CC is not required for H2AZ binding. It associates with the N
#=GF CC terminus of Swr1, and the association of Bdf1 requires Swc7,
#=GF CC Yaf9, and Arp4 [3].
#=GF SQ 28
#=GS J8TY86_SACK1/26-128 AC J8TY86.1
#=GS SWC7_CANGA/29-125 AC Q6FRX6.1
#=GS SWC7_ASHGO/26-123 AC Q757G5.1
#=GS SWC7_KLULA/27-120 AC Q6CPF9.1
#=GS A0A4C2E3E1_9SACH/26-125 AC A0A4C2E3E1.1
#=GS G8BPH0_TETPH/32-130 AC G8BPH0.1
#=GS A0A1G4MDE8_LACFM/26-121 AC A0A1G4MDE8.1
#=GS G0WH34_NAUDC/26-131 AC G0WH34.1
#=GS A0A1S7HZ57_9SACH/48-147 AC A0A1S7HZ57.1
#=GS A0A7H9HSV4_9SACH/26-125 AC A0A7H9HSV4.1
#=GS A0A7H9AYU8_ZYGMR/26-125 AC A0A7H9AYU8.1
#=GS SWC7_YEAST/26-128 AC Q06707.1
#=GS I2GWU7_TETBL/28-146 AC I2GWU7.1
#=GS G8ZUS9_TORDC/26-123 AC G8ZUS9.1
#=GS A7TGG0_VANPO/27-124 AC A7TGG0.1
#=GS A0A1E5RHW8_9ASCO/33-151 AC A0A1E5RHW8.1
#=GS A0A0C7MY84_9SACH/26-121 AC A0A0C7MY84.1
#=GS G0VKT2_NAUCC/27-122 AC G0VKT2.1
#=GS A0A1V2L3F8_CYBFA/21-109 AC A0A1V2L3F8.1
#=GS A0A376B128_9ASCO/42-148 AC A0A376B128.1
#=GS A0A1G4IN71_9SACH/26-121 AC A0A1G4IN71.1
#=GS A0A1X7RAH5_9SACH/26-127 AC A0A1X7RAH5.1
#=GS C5DFD2_LACTC/26-121 AC C5DFD2.1
#=GS H2ANT7_KAZAF/26-125 AC H2ANT7.1
#=GS A0A1G4JF22_9SACH/26-121 AC A0A1G4JF22.1
#=GS G8JRK2_ERECY/26-123 AC G8JRK2.1
#=GS J7RHL5_KAZNA/27-123 AC J7RHL5.1
#=GS A0A1S7HKZ2_9SACH/26-125 AC A0A1S7HKZ2.1
J8TY86_SACK1/26-128 .............DKTLNLQELLMEPIIDNDILTEFKTHKLVQLY............G.......PQYY....rDISLRGLKTMVTDIFAEEIPKAEqs..................seTDEPTTVVTLANHYYAQRIDELQKTEIPQLKELLLKK-l....
SWC7_CANGA/29-125 .............NKDLDIKKLLVEPVIDIEVMNNCQSNTFLKLN............A.......PTVS.....KLTVRNLRFLVEEWLSEGIPNV-......................PKEETTIITLANYYYSKRINELEEKELPTIRSEAKEL-f....
SWC7_ASHGO/26-123 .............DKTLSQISLLREPVVDTAVLERFSAHRVVRLY............A.......PELC.....GLRLEELQAVVREVFARGLAGSA......................EDTPVTLITLANHYYRLRVQELELQELPKLKELMES--aa...
SWC7_KLULA/27-120 .............DSSLSLDELLVEPIVDNTVVEKFTSHSMVQIY............A.......PELA.....PLNIRSIKGLISDLFTNT----N......................IQEPKNLITLANHYYSERLNYLQEEKIPELIQQMKDE-y....
A0A4C2E3E1_9SACH/26-125 .............DKSISLPQLLKEPIVDRESLQEFQSHKLVRMY............S.......PELC.....TIPLRTFKSIVNKLFEEGLSCKTd....................gLDEPITIIKLAEYYYSERIQEIQEVQLPGLKEQMLEQ-l....
G8BPH0_TETPH/32-130 ............a-NKEKYEKLLERPIIDQEILSRFVTDKLVIMY............A.......PELC.....EMQLRSLKTLVLDIFNKGIEGED.....................kESILVNVITLANYYYYKRIKDIEETRLPELRSQMKI--il...
A0A1G4MDE8_LACFM/26-121 .............DKSLDSDTLMTDPIIDDAILHKFRNHKLVELH............A.......ADLS.....GIRLRILKNLVKELFEKGLPD--......................DEGPVNVVSLANFYYSQRIRELESEELPKIRNELI---rdl..
G0WH34_NAUDC/26-131 .............DKSLNLQTLLQDPIIDNEVLQQFNSHKLVKLY............C.......PELS.....SMTRRTLQAMVHDIFQSGFGATSsspl..............eeqyANIPITVASLANFYYDKRLNEIQQEELPKLEQQLKDQ-y....
A0A1S7HZ57_9SACH/48-147 .............DKSLELTELLREPIVDKEALQQFQSHKLVRMY............C.......SELC.....AVSTRTLKSLVSELFQIGIPVQAe....................tPHDPVTLITLAEYYYSQRIEEIESQQMPELRQHMLH--hl...
A0A7H9HSV4_9SACH/26-125 .............NKSLDLAQLLRDPIVDKEVLDQFQNHKLVKMY............S.......PELS.....NLHLRALKGLVTDLFTYGIPSAEs....................pQGQETNVITLANHYYNKRIGELTLIELPELRQEIKNL-l....
A0A7H9AYU8_ZYGMR/26-125 .............DKSLSLESLLMEPIIDRALLVEFQNHTLVKMY............A.......PELQ.....TLQLRSLKSLVNEVFELGTPDVKs....................tDETPVTVVTLANYYYTKRIEELQNYQLPMLRQNIMEH-l....
SWC7_YEAST/26-128 .............DKSVDLQTLLKDPVIDNDVLVEFKTHKLVQLY............G.......PQYC....rDISLRGLKTMVTDIFANGIPKNAqs..................sgNDQPVTVVDLANYYYMQRINELQNTELPQLKEALLT--rl...
I2GWU7_TETBL/28-146 .............NKKLRLPNLLVDPIIDEAILNEFKNHTLVKVY............A.......PELC.....KIQLRSLRMLVKEIFSVGFNIEEnedningnvkqenvsysdsnqkQDTIINVITLANFYYDKRITEIEK-RLPEIRDEMQET-l....
G8ZUS9_TORDC/26-123 .............DKSLDLAALLKEPIVDKEVLTQFQNHKLVKMY............A.......PELC.....NVHLRLLKSLVADIFMTGTPGDE......................THDDTTVITLANYYYNQRIEELTQDQLPRIRHEIAEL-l....
A7TGG0_VANPO/27-124 .............DKKKDYNLLLVEPVIDTEVLKEFQNHKLVKLH............A.......PDMC.....NIQLRSLRLLVNEIFEKGIPEVE......................GNIPVNIVSLANYYYAKRIKQIEDVELPRLRNEMKSN-l....
A0A1E5RHW8_9ASCO/33-151 ...........dg--KNDITEFLTDPVIDDFVLNEFKSHKMFEVYkldgtlqgvsfdT.......PKKKnqnhxKLTLRDLRTIVATLYKTPISTPVne..................nlTKNRPTLITLCDRYYALRIEQLSTDMLPKLREELKA--ak...
A0A0C7MY84_9SACH/26-121 ..........ekg---GKLNELLVDPVVDEVVLDRFTNHRIVKLY............A.......PELE.....KVRLRTMKKEVADLFSAGLPD--......................KNLPVTVITLANHFYYTRINELEKDQIPKINRQMV---nfv..
G0VKT2_NAUCC/27-122 .............DKNLHMETLIKDPIIDDEILNQFISHKLIKIY............T.......PDLS.....HMTKRSLKTMVNELFVEGLST--......................SQDPVTIVTLANYYYERRVKELETELIPQLKSQLQAQ-l....
A0A1V2L3F8_CYBFA/21-109 qlleqygpsdlet------------------IHSEFIKHPAFHLS............H.......NELNqd.elSITQRQLQQIIDDLVAEY-----......................--PDMTIIQLCEHFYAKRIAELEK-EISETQQK-----fseva
A0A376B128_9ASCO/42-148 ............d-SNLSEVECAKNPVIDDFIFNTFINHKLVKYY............NimskntrNSVVp...tDLTLEELKQIVRSIYSRGLPQNE......................NNDPNTLVALCNYYYFKRIDELENNILPKIKKQLQQQ-q....
A0A1G4IN71_9SACH/26-121 .............DNSVKLDELMLEPVVDESVLTRFRNHKLIRLY............N.......PDQC.....GVQLRTLKGIVRDIFELGLPE--......................ESADVTVISLANHYYAQRIKELEEKELPQLQMQMRR--av...
A0A1X7RAH5_9SACH/26-127 .............NKKFKLEDLMTEPLVDSVVLKKFVEHPLVHLY............A.......PETE.....NITLRGLKSIVRDIFDQGLDGTTdn.................ndkGSTPVTVVTLANHYYAKRIRELED-ILPNMKDQIQQE-l....
C5DFD2_LACTC/26-121 .............DKTLDNDQLLADPVLDEMILSKFANHRLVRMY............A.......PELS.....GIQLRTLKGIVRELFEQGLPD--......................DDVPVTVVTLANHFYYTRVQELEREQIPELKAKVQEL-q....
H2ANT7_KAZAF/26-125 ............d-VGLNMEDLRKDPIIDNEILHAFQSHKLTRLY............A.......PDIE.....AMTLRGLKSLAADVFSEGIPSEDe...................ehSKETVDILDLANYYYNLRIEELEN-QLPKLKEELLQK-l....
A0A1G4JF22_9SACH/26-121 ............g-KDLKLDDLLVEPVVDESILTKFSTHRLVKLY............V.......PELR.....GLQLRTLRVLVNDLFKKGLPD--......................KSLPVTVVTLANHYYFVRVTELEQEEIPNLKGELAK--vl...
G8JRK2_ERECY/26-123 .............NRALDYERLLMNPTVDEEVLKRFTRHKLVRLY............C.......PYIC.....DIQLRGMKSIVQDIFTKGLKDNK......................GNVPVTLVTLANHYYRQRIQQLEKEELPKLKELIQSN-l....
J7RHL5_KAZNA/27-123 .............DKSLQLKSLLKEPIVDAQVLEQFTSHKLVKLY............S.......PELQ.....DVTLRTLRAMVGQLFVEGAEE-L......................SDQQITVITLANSYYNKRIQQLETQLLPQLKQELVQL-l....
A0A1S7HKZ2_9SACH/26-125 .............DKSLELTELLREPIVDKEALQQFQSHKLVRMY............C.......SELC.....AVSTRTLKSLISELFQIGIPVQAe....................tPQDPVTLITLAEYYYSQRIEEIETQQMPELRQHMLH--hl...
#=GC seq_cons .............sKsLclppLLt-PllDpplLpcFpsHKLV+lY............u.......PELs.....slpLRsLKslVs-lFppGlss.t......................sspPlTllTLANaYYspRIpELEpppLPcL+pphtp..h....
//
