#=GF ID Sec31
#=GF AC PF11549.12
#=GF DE Protein transport protein SEC31
#=GF AU Pollington J;0000-0002-8158-8998
#=GF SE pdb_2qtv
#=GF GA 25.00 25.00;
#=GF TC 25.60 35.70;
#=GF NC 24.30 20.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 17981133
#=GF RT Insights into COPII coat nucleation from the structure of
#=GF RT Sec23.Sar1 complexed with the active fragment of Sec31.
#=GF RA Bi X, Mancias JD, Goldberg J;
#=GF RL Dev Cell. 2007;13:635-645.
#=GF DR INTERPRO; IPR021614;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Sec31 is involved in COPII coat formation as it forms through
#=GF CC the sequential binding of three cytoplasmic proteins: Sar1,
#=GF CC Sec23/24 and Sec13/31. Sec13/31 is recruited by the pre-budding
#=GF CC complex and polymerisation of Sec13/31 occurs to form an
#=GF CC octahedral cage that is the outer shell of the COPII coat [1].
#=GF CC Sec13/31 is a hetero-tetramer which is organised as a linear
#=GF CC array of alpha-solenoid and beta-propeller domains to form a rod
#=GF CC in which twenty-four copies assemble to form the COPII
#=GF CC cub-octahedron [1].
#=GF SQ 31
#=GS J8PQM3_SACAR/903-950 AC J8PQM3.1
#=GS A0A1E5RBI5_9ASCO/970-1021 AC A0A1E5RBI5.1
#=GS SEC31_KLULA/875-924 AC Q6CL75.1
#=GS A0A7H9HPK6_9SACH/882-929 AC A0A7H9HPK6.1
#=GS G0VG26_NAUCC/900-953 AC G0VG26.1
#=GS A7TPC2_VANPO/907-954 AC A7TPC2.1
#=GS SEC31_CANGA/892-941 AC Q6FNU4.1
#=GS H2B291_KAZAF/874-923 AC H2B291.1
#=GS A0A1E5RJY6_HANUV/959-1008 AC A0A1E5RJY6.1
#=GS A0A1X7R2N2_9SACH/896-945 AC A0A1X7R2N2.1
#=GS A0A0C7MRM6_9SACH/939-987 AC A0A0C7MRM6.1
#=GS G0W3Q7_NAUDC/933-980 AC G0W3Q7.1
#=GS A0A4C2E790_9SACH/888-935 AC A0A4C2E790.1
#=GS A0A1G4JPS8_9SACH/907-953 AC A0A1G4JPS8.1
#=GS G8BNB0_TETPH/940-987 AC G8BNB0.1
#=GS G8ZRI3_TORDC/891-938 AC G8ZRI3.1
#=GS A0A1G4M7V9_LACFM/904-950 AC A0A1G4M7V9.1
#=GS A0A1S7HPX1_9SACH/882-929 AC A0A1S7HPX1.1
#=GS A0A1S7HC86_9SACH/882-929 AC A0A1S7HC86.1
#=GS A0A376BAC2_9ASCO/981-1028 AC A0A376BAC2.1
#=GS I2H5V4_TETBL/937-989 AC I2H5V4.1
#=GS SEC31_YEAST/899-946 AC P38968.3
#=GS SEC31_ASHGO/892-941 AC Q75A30.2
#=GS G8BS07_TETPH/941-989 AC G8BS07.1
#=GS A7TGU4_VANPO/893-940 AC A7TGU4.1
#=GS A0A7H9B416_ZYGMR/884-930 AC A0A7H9B416.1
#=GS G8JWY3_ERECY/885-932 AC G8JWY3.1
#=GS J7RV07_KAZNA/914-964 AC J7RV07.1
#=GS A0A1G4JN98_9SACH/926-974 AC A0A1G4JN98.1
#=GS C5E249_LACTC/929-977 AC C5E249.1
#=GS A0A1B7TBK8_9ASCO/985-1034 AC A0A1B7TBK8.1
J8PQM3_SACAR/903-950 .....ssq---PPMNV--...VSGQTPHLNRKANDGWNDLPL..KVKE...RPSRAKAVSVAPPN-i..
A0A1E5RBI5_9ASCO/970-1021 .....spv---PSSTMNGsypRSGQTPSLNKKANEGWNDLDL..PMKD...KIVRAKPVLTKPV--g..
SEC31_KLULA/875-924 ........APPPISGASG...YSGQTPHLHDKPIDGWNDLPS..VSKE...KPTRAKAVNTAPIG-m..
A0A7H9HPK6_9SACH/882-929 .....aav--PPL--PSM...ASGQTPYLNKKANDGWNDLPL..PVAE...KPSRAKAGSVAP---pi.
G0VG26_NAUCC/900-953 ...pspal----MTAAHP...LSGQAPHLNRNANDGWNDLSL..QMAEketKPSRAKPIAIGSI--ns.
A7TPC2_VANPO/907-954 ........PPPPITNV--...KSGQTPHLNKDANDGWNDLPL..KSKE...KPSRAKPVAVSPAA-s..
SEC31_CANGA/892-941 .......s-APPVKSPSV...YSGQTPHLNKKANDGWNDLAL..PVKE...KPQRAKPVTVAPSP-i..
H2B291_KAZAF/874-923 ........PSAPPMNRGM...QSGQKPHLNKKANDGWNDLPL..KVKE...KTSRAKAVSVAPVAV...
A0A1E5RJY6_HANUV/959-1008 ......es--PNKAPSDM...VSGQKPVGNKHANAGWNDFAL..PLPG...TASRAKAIGVKK---eps
A0A1X7R2N2_9SACH/896-945 ........PPPPQNMNGM...RSGQTPHLNRKANDGWNDLPL..KVEK...DKGRAKAVSVAPP--pm.
A0A0C7MRM6_9SACH/939-987 ........PPPPITGV--...SSGQTPHLNKKANDGWNDLPL.kNVSD...KPTRAKAVSVAPASV...
G0W3Q7_NAUDC/933-980 ........PPPVPSHM--...HSGQSPHLNRKANDGWNDLPI..KIEA...KPSRAKAVSVAKTG-v..
A0A4C2E790_9SACH/888-935 .......a-NPPPTNI--...KFGQAPHLNRKANDGWNDLPL..NVKE...KPQRAKAPSVAPVNI...
A0A1G4JPS8_9SACH/907-953 ...mtrpp--------SE...PSGQSPHLNKKANDGWNDLPL..SVKE...KSTRAKAVSVAPVSI...
G8BNB0_TETPH/940-987 .......l-PPPPINM--...RSGQIPHLTKEANDGWNDLPL..KSKD...KPSRAKAVAVAPVA-p..
G8ZRI3_TORDC/891-938 ......tg-PPPPT---V...ASGQTPSLNRKANDGWNDLPL..PVKE...KPSRAKAGSVAPVKI...
A0A1G4M7V9_LACFM/904-950 .......l--PPISPS--...TSGQTPHLNRKANDGWNDLPL..DVKE...KPTRAKAVSVAPVSV...
A0A1S7HPX1_9SACH/882-929 ......tn-PPPP-TM--...KSGQAPHLNKKANDGWNDLPL..NVKE...KPQRAKAPSVAPINI...
A0A1S7HC86_9SACH/882-929 ......an-PPPP-TM--...KSGQAPHLNKKANDGWNDLPL..NVKE...KPQRAKAPSVAPINI...
A0A376BAC2_9ASCO/981-1028 spslsqpl---------P...LSSQDPRINKKANEGWNDLAL..PVKD...KQVRAKAVSTQPS--t..
I2H5V4_TETBL/937-989 ........APPPQNGKSG...ASGQTPHLNKKANFGWNDLPIgkDATQ..aKPSRAKAVSIQPSN-s..
SEC31_YEAST/899-946 .....psq--PPI-NA--...VSGQTPHLNRKANDGWNDLPL..KVKE...KPSRAKAVSVAPPN-i..
SEC31_ASHGO/892-941 ........PPVNPAATNV...LSGQSPHLNRKANNGWNDLPE..IVKE...KKSRAKPVSTAPVAV...
G8BS07_TETPH/941-989 ......sa--APQ-KPAM...TSGQAPRNNLQSNKGWNDLPM..NIAE...KVTRAKAVQVMPI--qp.
A7TGU4_VANPO/893-940 .......r-NPVPGNV--...ISGQVPHANKKANDGWNDLPL..DVRE...KTIRAKPVSVAPVS-s..
A0A7H9B416_ZYGMR/884-930 ......ia---PPS--SV...ASGQTPSLNKKANDGWNDLPL..DVKE...RPQRAKAGNIAPAS-i..
G8JWY3_ERECY/885-932 ...sldpn-------SRV...LSGQKPYLNKSANNGWNDLPE..IVKE...KNTRAKAVSTAPMNV...
J7RV07_KAZNA/914-964 ........PPPPTMGAGG...LSGQAPHLNRKANDGWNDLPL..KVRE..kKPARAKPVSVAPM--vn.
A0A1G4JN98_9SACH/926-974 .......vAPPPING---...ASGQTPHLNKKANDGWNDLPL.kKVAD...KPTRAKAVSVAPAS-l..
C5E249_LACTC/929-977 ......pl-APPASNA--...ASGQTPHLNKNANDGWNDLPL..NVKE...KPTRAKAVSVAPVSV...
A0A1B7TBK8_9ASCO/985-1034 .....est---NNSQASL...VSGQKPVGNIHANAGWNDFAL..PIPG...KVSRAKPIGVKK---esv
#=GC seq_cons ..........PP.tsh.....hSGQsPHLN+KANDGWNDLPL..sVKE...KPoRAKAVSVAPss....
//
