#=GF ID Shigella_OspC
#=GF AC PF06128.15
#=GF DE Shigella flexneri OspC protein
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF SE Pfam-B_10333 (release 9.0)
#=GF GA 25.60 25.60;
#=GF TC 25.60 73.10;
#=GF NC 25.50 22.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 12142411
#=GF RT MxiE regulates intracellular expression of factors secreted by
#=GF RT the Shigella flexneri 2a type III secretion system.
#=GF RA Kane CD, Schuch R, Day WA Jr, Maurelli AT;
#=GF RL J Bacteriol 2002;184:4409-4419.
#=GF DR INTERPRO; IPR010366;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family consists of the Shigella flexneri specific protein
#=GF CC OspC. The function of this family is unknown but it is thought
#=GF CC that Osp proteins may be involved in post invasion events
#=GF CC related to virulence. Since bacterial pathogens adapt to
#=GF CC multiple environments during the course of infecting a host, it
#=GF CC has been proposed that Shigella evolved a mechanism to take
#=GF CC advantage of a unique intracellular cue, which is mediated
#=GF CC through MxiE, to express proteins when the organism reaches the
#=GF CC eukaryotic cytosol [1].
#=GF SQ 14
#=GS OSPC2_SHIFL/191-482 AC Q8VSL8.1
#=GS A0A3R9EG56_9VIBR/163-445 AC A0A3R9EG56.1
#=GS OSPC3_SHIFL/191-482 AC A0A0H2US87.1
#=GS A0A1I5A0D3_9GAMM/1-115 AC A0A1I5A0D3.1
#=GS A0A4V2W4P5_9GAMM/189-480 AC A0A4V2W4P5.1
#=GS A0A014NPM8_9GAMM/1-248 AC A0A014NPM8.1
#=GS OSPC4_SHIFL/133-422 AC A0A0H2USP8.1
#=GS Q327C5_SHIDS/191-482 AC Q327C5.1
#=GS OSPC1_SHIFL/186-469 AC Q8VSJ7.1
#=GS A0A0M2K6X2_9GAMM/187-431 AC A0A0M2K6X2.1
#=GS Q327E0_SHIDS/186-469 AC Q327E0.1
#=GS COPC_CHRVO/186-473 AC Q7NWF2.1
#=GS Q326U4_SHIDS/191-482 AC Q326U4.1
#=GS A0A1I4ZZX8_9GAMM/2-73 AC A0A1I4ZZX8.1
OSPC2_SHIFL/191-482 .......VEISNHQETLPLNKTHHTVDFGANAYIIDHDSP...YGYMTLTDHFDNAIPPVFYHEHQSFFLDNFKEVVDEVSRYVHGNQGKTDVPIFNTKDMRLGIGLHLIDFIRKSKDQRFREFCYNKNIDP.VSLDRIINFVFQLEYHIPRMLSTDNFKKIRLRDISLEDAIKASNYEEINNKVTDKKMAHQALAYSLGNAKS..........DMALYLLSKFNFTKQDIAEMEKMNNNMYCELY..DVEYLLSED.SANYKVLEYFISNGLVDVNKRFQKANSGDTMLDNAMKSKDSKTIDFLLKNGAVSGKRF............................
#=GR OSPC2_SHIFL/191-482 pAS ..................................................................................................................................................*.....................................................................................................................................................................................................
A0A3R9EG56_9VIBR/163-445 .......VEFSDDEAQLPLNTRHTTVDFGGNAYIVDGQFP...HGYLTLTDHFDNTVPPAYTHEHQE-FIAQFSRVNREIFRKVHGDKGRIDIPIFSSKDMKLGLGLHLIDFLRNSEDTEFKEFALDENLDA.KNLDRILNFVFQPEFHVPRMVSTDHFTEVKLRDISLKEAVKASNFEAISVYLKNKDDAYEVMEHAITYAKK..........DVVDLLFSKFSFTRQDVMKMST--------FY..DIQYNLSNY.SADEKILKEFLERGLVDPNHVFIKVNSGDTMLDNAFKYDKKEMIAILLEYGAVRG---snn.........................
#=GR A0A3R9EG56_9VIBR/163-445 pAS ..................................................................................................................................................*.....................................................................................................................................................................................................
OSPC3_SHIFL/191-482 .......VEISNHQETLPLNKTHHTVDFGANAYIIDHDSP...YGYMTLTDHFDNAIPPVFYHEHQSFFLDNFKEVVDEVSRYVHGNQGKTDVPIFNTKDMRLGIGLHLIDFIRKSKDQRFREFCYNKNIDP.VSLDRIINFVFQLEYHIPRMLSTDNFKKIKLRDISLEDAIKASNYEEINNKVTDKKMAHQALAYSLGNKKA..........DIALYLLSKFNFTKQDVAEMEKMKNNRYCNLY..DVEYLLSKD.GANYKVLEYFINNGLVDVNKKFQKVNSGDTMLDNAMKSKDSKMIDFLLKNGAILGKRF............................
#=GR OSPC3_SHIFL/191-482 pAS ..................................................................................................................................................*.....................................................................................................................................................................................................
A0A1I5A0D3_9GAMM/1-115 ......m---------------------------------...-------------------HEHKE-FIAQFSEVRNEIYRRVHGDKGTKDTPIFNSKDMKLALGLHLIDFLRNSNDTEFKRFAMNKELDD.KNLDKILNFVFQPEFHVPRMVSTYIFKEVKLREISARDAVKASNF--------------------------..........--------------------------------..---------.----------------------------------------------------------............................
#=GR A0A1I5A0D3_9GAMM/1-115 pAS ..................................................................................................................................................*.....................................................................................................................................................................................................
A0A4V2W4P5_9GAMM/189-480 .kppgnn--------RLIANTTHNGTDFGAIAYLIDEHHPgarYGYMTLTDHLDSALPLSRYHEHQE-MVYCFPICALERDRAMC-EVDEQEVAIYTPADMKQALSLSTVLFLRRSADTAFKNFAYAALANS.IELDRILNFLFQSEFHIPRMVSTDRYQKYRFRLPALEEIARFPHPMLVDEHIRDKADALRLIIVAIHAHNT..........KTVLHLLDKYDFTADDFLPDNPILDDPRLHLYgsEIPYALTRSpGYDLFVLTTLLERKLIDPNYQFRQKRAGKTMLANAIDCRSIRLVMLLLEHGA------ditl........................
#=GR A0A4V2W4P5_9GAMM/189-480 pAS ..................................................................................................................................................*.....................................................................................................................................................................................................
A0A014NPM8_9GAMM/1-248 .......---------------------------------...---MTLTDHLYNDVPHASRHEHQE-FIAQFSGVKKEVFRLVHGNKGTTDIPVFNTKDMRLGLGLHLIDFLRNSNDTEFKNFALNKNLNG.KNLDRILNFVFQPEFHVPRMVSTDNFKEVKLREMSAEEAVRAYNFAALSAHMKNKDDACKVMGIAINNARK..........DVIDLLFSKFSFTREDLIKKTN-------MYY..DIEYSLSDS.DADEKILKDFLERGLVEPNHVFRKINSGDTMLDNAINNDNKKMINILLEYGAMTGE--ei..........................
#=GR A0A014NPM8_9GAMM/1-248 pAS ..................................................................................................................................................*.....................................................................................................................................................................................................
OSPC4_SHIFL/133-422 .......VEISNHQEKLPLNKTHHTVDFGANAYIIDHDSP...YGYMTLTDHFDNAIPPVFYHEHQSFFLDNFKEVVDEVSRYVHGNQGKTDVPIFNTKDMRLGIGLHLIDFIRKSKDQGFREFCYNKNIDP.VSLDRIINFVFQLEYHIPRMLSTDNFKKIKLRDISLEDAIKASNYEEINNKVTDKKMAHQALAYSLGNKKA..........DIALYLLSKFNFTKQDVAEMEKMKNNRYCNLY..DVEYLLSKD.GANYKVLEYFINNGLVDVNKKFQKANSGDTMLDNAMKSKDSKMIDFFIKK--------wsgirq......................
#=GR OSPC4_SHIFL/133-422 pAS ..................................................................................................................................................*.....................................................................................................................................................................................................
Q327C5_SHIDS/191-482 .......VEISNHQETLPLNKTHHTVDFGANAYIIDHDSP...YGYMTLTDHFDNAIPPVFYHEHQSFFLDNFKEVVDEVSRYVHGNQGKTDVPIFNTKDMRLGIGLHLIDFIRKSKDQRFREFCYNKNIDP.VSLDRIINFVFQPEYHIPRMLSTDNFKKIRLRDISLEDAIKASNYEEINNKVTDKKMAHQALAYSLGNAKS..........DMALYLLSKFNFTKQDVAEMEKMNNNMYCELY..DVEYLLSED.SANYKVLEYFINNGLVDVNKRFQKANSGDTMLDNAMKSKDSKTIDFLLKNGAVSGKRF............................
#=GR Q327C5_SHIDS/191-482 pAS ..................................................................................................................................................*.....................................................................................................................................................................................................
OSPC1_SHIFL/186-469 .......VEISNHQKKHPLNTKHHTVDFGANAYIIDHDSP...YGYMTLTDHFDNAIPPVFYHEHQS-FLDKFSEVNKEVSRYVHGSKGIIDVPIFNTKDMKLGLGLYLIDFIRKSEDQSFKEFCYGKNLAP.VDLDRIINFVFQPEYHIPRMVSTENFKKVKIREISLEEAVTASNYEEINKQVTNKKIALQALFLSITNQKE..........DVALYILSNFEITRQDVISIKH-------ELY..DIEYLLSAH.NSSCKVLEYFINKGLVDVNTKFKKTNSGDCMLDNAIKYENAEMIKLLLKYGATSDNKY............................
#=GR OSPC1_SHIFL/186-469 pAS ..................................................................................................................................................*.....................................................................................................................................................................................................
A0A0M2K6X2_9GAMM/187-431 .......VEFSDKNTIHPINTKYKGWDFGSNAYIVKDEFK...HAYVTLDHHYGGYITSDFEHEQKE-FTSQFEIAEKEISSIYTSNKKNNDIAMYSTKSMKLAIGLNLIKFIQNTSDMKLKEFALSGQLST.LDIDRLINFIFQPECHLPRMISTKKFQEIRLADISLKDAIMAANLTRIDELVKDKKDAYNAIKLVLFLHKEresmttliakKIISYILDKCSFTKE-----------------..---------.----------------------------------------------------------lreslesdvikimkgnvknnvlskvnff
#=GR A0A0M2K6X2_9GAMM/187-431 pAS ..................................................................................................................................................*.....................................................................................................................................................................................................
Q327E0_SHIDS/186-469 .......VEISSHQKKHPLNTKHHTVDFGANAYMIEHSSP...YGYMTLTDHFDNVIPFAQYHEHQS-FLDKFSEVNEEVSRYVHGSKGIIDVPIFNTKDMKLGLGLYLIDFIRKSEDQSFKEFCYEKNLSP.VDLDRIINFVFQPEYHIPRMVSTENFKKVKIREISLEEAVTASNYEEINKQVTNKKIALQALFFSITNKKE..........DVALYILSNFEITKQDVISIKH-------ELY..DIEYLLSAH.NSSCKVLEYFINKGLVDVNTKFKKTNSGDCMLDNAIKYENAEMIKLLLKYGATSDNKY............................
#=GR Q327E0_SHIDS/186-469 pAS ..................................................................................................................................................*.....................................................................................................................................................................................................
COPC_CHRVO/186-473 vefsgrg------KQDKPLNHKHSTMDFGANAYVVPDTLPacrHGYLTLTDHFFNRVPGGREAEHQD-FVGSFPQMGAETGRWIHEGKYRQNAPIFNYRDMKAAVALHLIEFLRDSKDAAFKAYVFDQAMQSgQALDRVLNSVFQAEFHIPRLMATTDYAKHPLRPMLLKEAVDSVNLPALSGLVSSKGDAVTAMWHAIDKGKD..........AVAAHLLGNWRFEAGDFASAPP---GF---YH..ELNYALSEH.GASVYILDQFLSRGWAAVNAPFEHVNSGETMLDNAVKYGNREMAAALIKHGAD-----rnl.........................
#=GR COPC_CHRVO/186-473 AS ..................................................................................................................................................*.....................................................................................................................................................................................................
Q326U4_SHIDS/191-482 .......VEISNHQEKLPLNKTHHTVDFGANAYIIDHDSP...YGYMTLTDHFDNAIPPVFYHEHQSFFLDNFKEVVDEVSRYVHGNQGKTDVPIFNTKDMRLGIGLHLIDFIRKSKDQGFREFCYNKNIDP.VSLDRIINFVFQLEYHIPRMLSTDNFKKIKLRDISLEDAIKASNYEEINNKVTDKKMAHQALAYSLGNKKA..........DIALYLLSKFNFTKQDVAEMEKMNNNRYCNLY..DVEYLLSKD.GANYKVLEYFINNGLVDVNKKFQKVNSGDTMLDNAMKSKDSKMIDFLLKNGAILGKRF............................
#=GR Q326U4_SHIDS/191-482 pAS ..................................................................................................................................................*.....................................................................................................................................................................................................
A0A1I4ZZX8_9GAMM/2-73 ...stsy---------------------------------...-----------------------------------------------------------------------------------------.-----------------------------------------------------------------------..........-------------------------------E..DIEYSLSDH.SADEKILKDFLERGLVEPNHAFRSVNSGDTMLDNAIKYNKKEMIGILLEYGAVRGK--ei..........................
#=GC seq_cons .......VEhSscppphPLNppHpTsDFGANAYll-cp.P...aGYMTLTDHFDNslPsshhHEHQp.FlspFpcVscEluRhVHGspGppDlPIFNTKDM+LGlGLHLIDFlRcScDppF+EFsasKNlss.lsLDRIlNFVFQsEaHIPRMlST-sFKKl+LR-ISLE-Al+ASNaptIsppVpsKc.AhpAlhhulsstKp..........DlshaLLSKFsFT+pDlhphpp........hY..DlEYhLScc.uAshKlLc.FlppGLVDsNptFpKsNSGDTMLDNAhK.cspcMIshLLc.GAh.s...............................
//
