#=GF ID   Sial-lect-inser
#=GF AC   PF09264.14
#=GF DE   Vibrio cholerae sialidase, lectin insertion
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1w0p
#=GF GA   25.80 25.80;
#=GF TC   26.00 28.20;
#=GF NC   23.30 25.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0004
#=GF RN   [1]
#=GF RM   15226294
#=GF RT   Sialic acid recognition by Vibrio cholerae neuraminidase. 
#=GF RA   Moustafa I, Connaris H, Taylor M, Zaitsev V, Wilson JC, Kiefel
#=GF RA   MJ, von Itzstein M, Taylor G; 
#=GF RL   J Biol Chem. 2004;279:40819-40826.
#=GF DR   INTERPRO; IPR015344;
#=GF DR   SCOP; 1w0p; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Members of this family are predominantly found in Vibrio
#=GF CC   cholerae sialidase, and adopt a beta sandwich structure
#=GF CC   consisting of 12-14 strands arranged in two beta-sheets. They
#=GF CC   bind to lectins with high affinity helping to target the protein
#=GF CC   to sialic acid-rich environments, thereby enhancing the
#=GF CC   catalytic efficiency of the enzyme [1].
#=GF SQ   15
#=GS A0A081KGM9_9GAMM/80-239     AC A0A081KGM9.1
#=GS A0A518DGD4_9BACT/70-235     AC A0A518DGD4.1
#=GS A0A081KGM9_9GAMM/380-576    AC A0A081KGM9.1
#=GS A0A0Q0H4Q4_9GAMM/235-396    AC A0A0Q0H4Q4.1
#=GS NANH_VIBCH/347-543          AC P0C6E9.1
#=GS A0A518AMX0_9BACT/103-259    AC A0A518AMX0.1
#=GS A8H2Q3_SHEPA/57-230         AC A8H2Q3.1
#=GS D0Z2P3_PHODD/345-542        AC D0Z2P3.1
#=GS A0A1T4UZL6_9GAMM/55-223     AC A0A1T4UZL6.1
#=GS A0A6B3LE32_9BACT/1632-1805  AC A0A6B3LE32.1
#=GS Q4C0X8_CROWT/46-149         AC Q4C0X8.1
#=GS A8H2Q3_SHEPA/428-587        AC A8H2Q3.1
#=GS NANH_VIBCH/64-222           AC P0C6E9.1
#=GS A0A1T4UZL6_9GAMM/345-542    AC A0A1T4UZL6.1
#=GS D0Z2P3_PHODD/57-245         AC D0Z2P3.1
A0A081KGM9_9GAMM/80-239                ..............................ttvl---------AWYVNGLEGIAEWka..tpEGEFNAMASQNGWTMAFTMRVES.....GSYLTNYYGN.GVKRFLPVLKLDGNN-L..VVELEGDQ.AYTLVEGD.LEAAMGYHNYVISFDP.A.TGKATYQFDDKIIT.sDWQGSE...SAHNV.V.AWGNGSSSTSGAseAFYQSFTF--------------------.---------------------------dipgyeft.....................
A0A518DGD4_9BACT/70-235                aggsghnawqvtdsstsvvnpyyfvnlspsyalq----------------------......-------AGSQGWRLQTEASVVDay.rdGPAMGLLSYF.NNLRYGAAVGLDPLGRL..VAELYGQG.QTHVLAPA.GASATATHAFELRYRP.E.TGKVSFLFDGGEVS..SWSGVPligAHPDS.F.LWGSTGVNQRGV..M---------------------------.---------------------------rfhtveaaig...................
A0A081KGM9_9GAMM/380-576               ..................................DITAQVRERAWDARGWSGKAAWsf..diTDALQTPAAG-NWSLVTDRKAIQ.....GQ-ITDYLVT.GEAILLPTVTVTEANNL..VVNLNGTG.GGDFTLLE.DVGPAEFHTSEIRYDP.V.TKTASYLFDGEVIA.sNWSGAP...NSAKK.V.VFGNDLTNDEGR..ATYKSANFTIGETTVIDYSASATP----.AAEATPVAQGWTAELAEKGRGILGWKS.............................
A0A0Q0H4Q4_9GAMM/235-396               ............................ddngdt---------VWQADGSAGKAEWevipdsQTNLDATNYG--WSMSSTVKVLS.....GSYITNYYAN.GNKRYLVNLKIDSSGAL..VADVEGD-.-AQYTLVS.QQGSDQYHDYEVNYDA.S.SQQATFWFDGEKVT..SWSGSA...SNQNV.I.VFGNGSSGTSGV..ANYKNVRFEVTDS---------------.---------------------------tqpials......................
NANH_VIBCH/347-543                     ..................................DVTDQVKERSFQIAGWGGSELY......RRNT-SLNSQQDWQSNAKIRIVD.....GAANQIQVAD.GSRKYVVTLSIDESGGL..VANLNGVS.APIILQSE.HAKVHSFHDYELQYSA.L.NHTTTLFVDGQQIT..TWAGEV...SQENN.I.QFGNADAQIDGR..LHVQKIVLTQQGHNLVEFDAFYLAQQTP.EVEKDLEKLGWTKIKTGNTMSLYGNAS.............................
A0A518AMX0_9BACT/103-259               ...................ltlfegspnlanare----------------------......----------RGWSFSTTAQFVDt..msGSANQGLSAYfDDQLYQVMIDLDTAGQLrgNVYLSPIE.TATFVLAS.AEQRNEYHDYELRYDS.A.NQQASFYFDDHRIT..SWPGYA...DQHET.IfRFGSVTASGAGQ..MNYREVNMSI------------------.---------------------------iptpaeqgdfnsdg...............
A8H2Q3_SHEPA/57-230                    ................................sv--AQDLNAASWKSTGSSGRAQWnm..vpTTELNNEASLKGWRMSWTSRVES.....GGYITDYYAN.GALRFLPILSISASGDL..VVNLVG--.GGEHTLVS.GTGADSYHQYVVEYDP.L.TQLASFSFDGVIID.pAWVGEA...SNQNM.I.AWGNGSSNINGV..AYYRAVTFETLSETV-------------.---------------------------peeakiiaawdss................
D0Z2P3_PHODD/345-542                   ..................................NVSSHVKEKTLQIVGWSGSEFY......SKSLDEISSQNSWSLQSKLKIYN.....GKDNDLVVAN.GTKQYKISFAVNENG-L..VAYLDDQN.SAKLIRTT.IQNIAGFINVAMDFDP.V.TQTAQLTIDDAVVG..TLSGIP...SADKH.I.LFGQTNAAHDGR..LHIANINLNVNGQRVIDYDAETLTDINPnEMNNTPESQGWSKHKSGRAYSFYGVAS.............................
A0A1T4UZL6_9GAMM/55-223                .........................eaikkkkrv---------EWYVNGEDGRANWki..tpTSDINTQAENFGWTLSTEMRVTE.....GGYLTNYYAN.GEYRFLPIVSLDGNQ-L..VVEFEGSE.EKT-VLAT.GREARKYHSYDIVFHPgV.NPTASFFFDGQLIK.aNWEPTP...STQNM.V.TWGNGSSHVDGE..AYYRSVNFTISGDSV-------------.---------------------------fsspdri......................
A0A6B3LE32_9BACT/1632-1805             .................agsqwaqyrkapsdaei----------------------......-----ALGNTNGWMLETKLRFVDdfnaeGS-TQVEYGN.GSKRFLVFYDLDDNDDL..TAKLFGTG.GGTYTLTSgGTGTQNFHDIVVLYDP.A.TQTASFVVDGVRFDggSWSGQG...SGAKG.V.EWGNESSGGQGS..AAFHTVK---------------------.---------------------------wsyfdmpitlgsgavvsynsgevnfdp..
Q4C0X8_CROWT/46-149                    ..................gvfvasgtqilsiaig----------------------......-----------------------.....----------.-----------------..---LNDIAmRRDIVSLN.HIDKSEFHDYRLEGSF.V.TGTADVYIDDIFIR..TISATN...NPNKNsL.IIGDPTQTRNAK..AELRSLTFTQGNHAV-------------.---------------------------pep..........................
A8H2Q3_SHEPA/428-587                   .........................gslvneqgq--------AAWQARGINGRAEWei..qpSVQVNRDATTLGWKMTTTSRIVS.....GSAISDYYAN.GNKRFLALLSINGNGDL..VAALEGGS.SHTLVPMT.--GADKYHTYEVTYDV.E.TSLATFYFDGIAIE..TWAGSA...TSQNV.I.VWGNGSSGTNGV..ANYRYVNFET------------------.---------------------------fgsg.........................
NANH_VIBCH/64-222                      .................................p---------AWLVQGIGGRAQWty..slSTNQHAQASSFGWRMTTEMKVLS.....GGMITNYYAN.GTQRVLPIISLDSSGNL..VVEFEGQT.GRTVLATG.-TAATEYHKFELVFLPgS.NPSASFYFDGKLIR.dNIQPTA...SKQNM.I.VWGNGSSNTDGV..AAYRDIKFEIQGDV--------------.---------------------------ifrgp........................
A0A1T4UZL6_9GAMM/345-542               ..................................DVTEEIKERTFQIIGWSGSEYY......TQDV-NVSAADQWDLNTQLRIHG.....GSANDLSVSN.GEKLFKVSFAINAENHL..VAFVDGSD.TPIVVREK.ADNVSGFIDVSLRYDP.E.SKHANLYIDDDFTA..GVTGTA...ASTTQ.V.LFGQTDHDVNGR..MHVSNITFISNGETVIDFDAKALSLINPaEQNTLPEAIGWAKHHTGRAYNFYGVAS.............................
D0Z2P3_PHODD/57-245                    ..........................vvnqgvde----------WYVNGNDGRANWti..tpTTELNNQATRYGWTLSTEMRVVS.....GGYITNYYAN.GQHRFLPIISLQN-GNL..VAEFEGRS.GATILASG.D-DVHGYHKYDIVFHP.GpNPTASFFFDGVLIK.sDWQGHP...SSQNM.I.AWGNGSSSQAGE..AYYRSITFTISGDPV-------------.---------------------------fstpdripslvtssqtpgtvaifaekrmg
#=GC seq_cons                          ...........................................sa.htG.sGpt.a......ppphps.usp.GWphsTph+lls.....GuhhsshhAN.GspRaLshlulsssGpL..VspLpGps.ussllhss.tpssspaHsY-lpYDP.s.oppAoFaFDGthIs..sWsGss...Sspsh.l.haGNsoosssGp..AtY+slsFphtsp........................................................................
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