#=GF ID SidC_N
#=GF AC PF18219.5
#=GF DE SidC N-terminal domain
#=GF AU Smart A;0000-0002-6965-5633
#=GF SE ECOD:EUF03080
#=GF GA 25.00 25.00;
#=GF TC 86.90 86.60;
#=GF NC 19.70 19.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 24556577
#=GF RT The structure of the N-terminal domain of the Legionella protein
#=GF RT SidC.
#=GF RA Gazdag EM, Schobel S, Shkumatov AV, Goody RS, Itzen A;
#=GF RL J Struct Biol. 2014;186:188-194.
#=GF DR INTERPRO; IPR041264;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This is the N-terminal domain of SidC present in Legionella
#=GF CC pneumophilia. SidC appears to be involved in modulating
#=GF CC mammalian trafficking by promoting the communication between
#=GF CC ER-derived vesicles and the Legionella containing vacuole. The
#=GF CC N-terminal domain (SidC-N) has a novel fold with 4 potential
#=GF CC subdomains. SidC-N does not show structural similarity to any
#=GF CC known protein domain in the protein data bank [1].
#=GF SQ 11
#=GS A0A098GF45_TATMI/3-200 AC A0A098GF45.1
#=GS A0A098GG82_TATMI/3-467 AC A0A098GG82.1
#=GS A0A098G530_9GAMM/3-466 AC A0A098G530.1
#=GS A0A6F8T7U5_9GAMM/2-497 AC A0A6F8T7U5.1
#=GS A0A222P336_9GAMM/3-99 AC A0A222P336.1
#=GS A0A0W0Y4Z1_9GAMM/3-463 AC A0A0W0Y4Z1.1
#=GS A0A098GDP3_TATMI/2-242 AC A0A098GDP3.1
#=GS Q5ZSK7_LEGPH/8-506 AC Q5ZSK7.1
#=GS A0A0W0ZUP3_9GAMM/3-466 AC A0A0W0ZUP3.1
#=GS A0A098G8K4_9GAMM/3-466 AC A0A098G8K4.1
#=GS Q5ZSK6_LEGPH/9-510 AC Q5ZSK6.1
A0A098GF45_TATMI/3-200 ...IPLTEPVSPRYIHINPkTNQVHLMVPVVGGQEISTDNTCKATVALREFFDG.GA--------LRELNAYKEALTFDIGLLEAG.NA........QRAGKEERLAQIEAYIEAVSAMRY....----.--------SYSGAMTAFLGRP--SNLYSVQLRPRAQDSQSRVV--NPVFNVNRTNNAE--...GTPL.......SPLYNAMHGTF..PTTVVATTDPRTRLTTTVLSAL......P---ASASFAD........IQRV----------------------.....-----------------------------------.-...........-----------........------------------------------------------------------------------------------------------------------...-----------------...----------------------.--------------------------------lse
A0A098GG82_TATMI/3-467 ...LPLKEPLSAKYLYISP.ENIVHVFMPIVSGTNIGLDNTCKAVYSLQEFFGK.GNNSNKKSTIKGELLAYKEALESDISLLGAD.AL........LTQSKQERLTQIKAYLKVVRHLEN....HPEL.DCLNQGFPSYPRPMEELMQDRTTSNLYSMVLRPAEEDGFLRSEAAKPVFSVAHKSVARQI...EHAV.......SPLQQELTQAY..TPLIFEAKDLKSQVIQQTLARL......VPPKMPVDFER........LRQILQETVKALLNVEIDFTKTQQGS.....SINQQYIDKAMGFNPQTTNPNEYMEALFGYCAGDL.F...........DTLIESPFNRL........TQVEHWSIATQFLLGITNIYCVSQGKISPDTNFGRILDAHPNLNIHFAQTLAQAQQSNSSIEEACLLWMNDHAKELDLTHPLTQEDIKSTTETFVKRYAEIK...DSPHFDEFFILDTQKKG...DFVIHQGSICTSFAKFVSSPLL.DVPQELNQPLEEARSHVGSLSVEIPHKNPLVQ...
A0A098G530_9GAMM/3-466 ...LPLKEPLFGKYLYISE.DNIIHVLMPVVSGTSIGLDNTCKAVLSLQEFFGK.GSNSNQKATLKGELLKYKGALENDLSLLNKD.AL........LTKQKQERLTQINAYLKVITALEH....HKEL.ECLNQGFPSYPRPLEELMQNRETSNLYSMVLRPTEEDGYLRSEAANPIFSVAHKSVARDI...KESV.......SPLQQALIKAY..KPLTYKARDLKSQVIETALAPL......KPLELPVDFKK........LRAILQKTVQDLLNVSIDFTKTKQDA.....ALEQKDIDEAMLFDVE-TTPKEYIDALLAYCAPDL.F...........KTVLESPFNSL........TQAEDWSIATQFLLGITNIYCVSQDKVSKDTNFGKILDNNPELNKDLAQTLAKAQKAHKRIEKTLLSWINEHAKELMLKKNVTQEEVKLITERFTVLYAQIK...DSPHFDEFFICDSQKKG...DFVIHQGSIGTSFAQFACSDLF.ELSKELIEPLQKARKEARKLNTEIPHKSPIVQ...
A0A6F8T7U5_9GAMM/2-497 ..i-VFDEPEDCDYIFIDN.DNRVHLLLPIIGGQEIAIDNTCESARELQTFFGT.NSNS-----AENILRRYKDRLLNDISAIQSQ.KGisrcayqdLMREKKQRLEQIEKYINLIGEIKDn..yNTGInRLFTVGIPELPSTIHKIIKSAN--NAFVVRLSPHHPDPFTKFY--DPLFSLMRNRSRYAIwgfKA-Ltk..glgARLRSAFQPED.sTPLLINRKSPKEQVIQKVLSAI......EDKNMNVPVEArek.klndLKIIIQNELVKIIPEITSLEKNRSGQ.....TMDLNFME-LMGINEH-DVIEEWINTLIDSSLDPItWenpelceillgVENKGSVFYDPadkgispeQLAELMSIRVQYLLAEINIYCKKNEL--SKANFGKFFDKEPH-ATQISRLVKEGLAQGQDIEPIIYGYVNNHLAALGLKTSLAVTQQAHITKKFTDNYRVIR...DSPHFDEFLVIDPDKKG...AIFSYKSRISCHFLDFFTLQTKgKYPLGDFENHAEALKSGT--SNRLHHKNHIV-s..
A0A222P336_9GAMM/3-99 ...IPLSEPISPRYLYINPtTNRVHLLVPIVSGQEISTDNTCKATTTLKEFFDG.GAL--------NVLNAYKDALTFDIRLLRAG.SL........EASLKQDRLTQVHTYIEALQ----....----.------------------------------------------------------------...----.......-----------..----------------------......-----------........--------------------------.....-----------------------------------.-...........-----------........------------------------------------------------------------------------------------------------------...-----------------...----------------------.--------------------------------p..
A0A0W0Y4Z1_9GAMM/3-463 ..i-LFNEPTSARWFFVNPvTNIIHLLVPAVGGERAGTDNTCQTMMAMKTFFGK.--NSGEHAGALQEMELYRRALQQDIASISPQ.DQer....rsIREQKQSRLQQIEKIIAALRLIQN....TPEI.NQLNHVYPDYPPSVARLME---GSNLYSMLMP-PVTDGYLYTK--NRVFTVDRTRND---...----.......-RFYGAMMVGF..NNLVFGSQSPKEQVIRAAIRQLea..laRQQNRQPSFEQ........IQSILTAAMKAQTGLDVNFAENSAGT.....PITEQLLKDIHMED--NPSFRDTVEAWLDSCALEL.W...........STLPISPFQSVnnpnltagKKKETLAIMLQFLLAEVNIYARSKDL--SQRNFGQILDENSSLRNTLITSVYNTLAQGGSIEQTVLEFINHNRQAFGLNRELNTADQKEIVDYFRSDWATIK...DSPHFDEFTIW-VDKPG...KFVVHQGAICVDFAEVIHSGFRnTVSQTDLAYFDQARADYQSVNGKLNHTNP---st.
A0A098GDP3_TATMI/2-242 fgl----------------.----------------------------------.-------------------------------.--........------------------------....----.------------------------------------------------------------...----.......-----------..----------------------......-----------........---------------AIDFTQRTDGT.....PATKEAIDTLMGFGAD-ATRDDYIDALLGACAVDV.W...........ETLPTPPFYSIpaa.tpedERTERLSILTQFFLANLNVYCKARGI--STQNFGAILDASPDLSNSLVSLVSTALTNGEDVERAICNFCNVNSDAFHLLRAINADDLTAIRQTFERTYRTVTataENPHMDDFMILDHGATGgtaKFVTHQGSICVNFAEIIDPVAA.SSNPDYFAS---IRTDFAAHPTEIPHRNES--vl.
Q5ZSK7_LEGPH/8-506 ...IKFKEPERCEYLHIAK.DNKVHILLPIVGGDEIGLDNTCETTGELLTFFYG.KTHGGTKYSAEHHLNEYKKNLEDDIKAIGVQrKIspn.ayedLLKEKKERLEQIEKYIDLIKVLKEkfdeQREIdKLRTEGIPQLPSGVKEVIKSSE--NAFALRLSPDRPDSFTRFD--DPLFSLKRNRSQYEAggyQRATdg...lgARLRSELLPPDkdTPIVFNKKSLKDKIVDSVLVQLdkdfntKDGDRGQKFED........IKKLVLEEYKK-IDSELQVDEDTYHQ.....PLNLDYLENIACTLDDNSTAKDWVYGIIGATTEAD.Ywpkk...esesGTEKVSVFYEKqke.ikfeSDTNTMSIKVQYLLAEINFYCKTNKL--SDANFGEFFDKEPH-ATEVAKRVKEGLVQGAEIEPIIYNYINSHHAELGLTSELSSKQQEEITEKFTQRYHIIE...NSPHFDEFFVADPDKKG...NIFSHQGRMSCHFLDFFARQTKgKYPLGDLAGHQEALQAGT--SNRLHHKNEVVA...
A0A0W0ZUP3_9GAMM/3-466 ...LPLKEPLSARYLYLSP.ENIVYIFMPIVSGTAIGLDNTCKAVYALQEFFDK.GSNSNKKASLKVELLAYKEALESDMSLLGAT.SP........LMQQKQERLTQIDAYLTLLASVEK....HPEL.NCLNTGFPSYPRPLEGMMQDRATSNLYSMVLHPSEQDGYLRTEGTNPVFRVAHKSVSRNI...EHAE.......SNLQKALIKAY..SPLIFTVQNVKAEVRHQVLAQF......KAQNMPCSVDI........IASLLQETIQRQMHVTVDFSKTAKGE.....PITQDFIAKAMLFDKE-TSPEEYVDALLGFCANDL.F...........TTVPISPFKYL........TNFESWSIATQFLLGLTNIYAVVQGKTSQDTNFGEILDKRPDLSTELAQILAKAQQDNANIEEACLLWINKRTHELKLMTAFTPEDLKTIKQNFAQQYVQIK...DSPHFDEFFVLDTEKEG...AFVMHQGSICTSFAKFVSSPLL.DVPQELIQPFEKVQQQASRLGVNIPHKNTLMQ...
A0A098G8K4_9GAMM/3-466 ...LPLKEPLFARYLYVSP.ENIVHVFMPIVSGTNIGLDNTCKAVYALQEFFGK.GSNSNKKASLKTELLAYKEALESDINLLGAE.SS........LTQQKQERLVQIDAYLKVLVSVEN....HPEL.SCLNAGFPSYPRPLEELMQDRDTSNLYSMILRPTAEDGFLRSEATNPIFSVAHKSVSKQI...HTSK.......SALQHALIQAY..TPLTFEAKNLKSRVIKQVAQLM......-PPNKPIDFEH........LRAVLKKTTQTLLNVDVDFTKTQQGT.....LIHQQEINKAMGFNPQTTSAEEYMEALFGYCAGGL.F...........DSLIESPFKCL........TQAEDWSIATQFLLGITNIYCLAQGIISPSTNFGQILDAHSSLSVHLAQTLAQAHQSNRSIEEACLLWINEHVNELALTRLLTQADINNIQETFVTRYSEIK...DSPHFDEFFVLDTQKKG...DFVRHQGFICTSFAEFVHSPLL.DVPQEVTQALEKARSGAQSLGVNIPHKNPLVQ...
Q5ZSK6_LEGPH/9-510 ...IKFKEPERCDYLYVDE.NNKVHILLPIVGGDEIGLDNTCQTAVELITFFYGsAHSGVTKYSAEHQLSEYKRQLEEDIKAINSQ.KKisphayddLLKEKIERLQQIEKYIELIQVLKKqydeQNDIrQLRTGGIPQLPSGVKEIIKSSE--NAFAVRLSPYDNDKFTRFD--DPLFNVKRNISKYDTpsrQAPIpiyeglgYRLRSTLFPED.kTPTPINKKSLRDKVKSTVLSHY......-KDEDRIDGEKkdeklnelITNLQNELVKELVKSDPQYSKLSLSKdprgkEINYDYLVNSLMLVDNDSEIGDWIDTILDATVDSTvW...........VAQASSPFYDGake.issdRDADKISIRVQYLLAEANIYCKTNKL--SDANFGEFFDKEPH-ATEIAKRVKEGFTQGADIEPIIYDYINSNHAELGLKSPLTGKQQQEITDKFTKHYNTIK...ESPHFDEFFVADPDKKG...NIFSHQGRISCHFLDFFTRQTKgKHPLGDLASHQEALQEGT--SNRLHHKNEVVA...
#=GC seq_cons ...lshcEPhps+YLalss.sNhVHlhhPIVuGppIGlDNTCcushsLppFFst.ussusp+.shcpcL.tYKcALppDIshlsup.sh........LhppKpERLpQI-tYlcllp.lcp....p.-l.phhstGhPphPpslcclhpstt..NhauhhLpPttpDuahR.c..sPlFsVt+ppsthth...ptsh.......u.Lppshh.s...sPlhhptps.KspVhppsLsth.........phshsh-p........lptllppthpt.ht.plsascsptup.....sls.phlpphhhhs.p.ss.c-al-ullshssssl.a...........so...SPF.ph........ppsEphSItsQaLLu.hNIYChspth..sssNFGphhDtpPp.sspluphltpu.tpstsIE.hhh.alNpptttLtLpp.lstpp.ppIpcpFsppYtpI+...-SPHFDEFhlhDspKcG...shh.HQGpIsspFhcFhsp.hh.chs.t.htshpcAhppsp..sscl.HKN.lh....
//
