#=GF ID   SidE_DUB
#=GF AC   PF19049.4
#=GF DE   SidE DUB domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   [1]
#=GF GA   24.20 24.20;
#=GF TC   24.70 253.00;
#=GF NC   22.80 21.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0125
#=GF RN   [1]
#=GF RM   26598703
#=GF RT   Structural basis of substrate recognition by a bacterial
#=GF RT   deubiquitinase important for dynamics of phagosome
#=GF RT   ubiquitination.
#=GF RA   Sheedlo MJ, Qiu J, Tan Y, Paul LN, Luo ZQ, Das C;
#=GF RL   Proc Natl Acad Sci U S A. 2015;112:15090-15095.
#=GF DR   INTERPRO; IPR043934;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This entry represents the N-terminal deubiquitinating domain
#=GF CC   from the SidE protein [1]. The SidE protein is a bacterial
#=GF CC   effector protein that can ubiquitinate and presumably
#=GF CC   deubiquitinate host proteins.
#=GF SQ   6
#=GS Q5ZTK8_LEGPH/1-173          AC Q5ZTK8.1
#=GS SIDE_LEGPH/1-172            AC Q5ZYX7.2
#=GS SDEA_LEGPH/1-173            AC Q5ZTK4.2
#=GS A0A378LV35_9GAMM/1000-1172  AC A0A378LV35.1
#=GS A0A0W0VZ27_9GAMM/1032-1207  AC A0A0W0VZ27.1
#=GS Q5ZTK5_LEGPH/6-178          AC Q5ZTK5.1
Q5ZTK8_LEGPH/1-173                     ...MPKYVEGVELTQEGMHAIFARMGHGDITSGSIYNGVPTIDTEALNRQGFMPVLTGVGPRRDSGHWIMLIKGPGNQYFLFDPLGKTSGEGYKNTLLAQLPIASTLSVIPNEPGLNKGLCGYWVASVGLKARSELSKDNP....PNLETLGQITTDAMKDELTDNGYLKITGWLKAVAD.
#=GR Q5ZTK8_LEGPH/1-173          pAS   ..................................................................*...............*.....................................*............................................................
SIDE_LEGPH/1-172                       ...MPKYVEGIELTQEGMHAIFERMGHPNITSGTIYNGEPTIDKGALDRQGFMPVLTGVSPRQDSGHWIMLIKGQGNQYFLFDPLGESSGKYYQNILAKKLP-GATLSVIPNNAGLNMGLCGYWVASVGLRAHAALTQPIP....PSLRNLGQTITQEMRDELTQDGSEKITQWLRAVGN.
#=GR SIDE_LEGPH/1-172            pAS   ..................................................................*...............*.....................................*............................................................
SDEA_LEGPH/1-173                       ...MPKYVEGVELTQEGMHAIFARMGYGDITSGSIYNGVPTIDTGALNRQGFMPVLTGVGPHRDSGHWIMLIKGPGNQYYLFDPLGKTSGEGYQNILAAQLPMGSTLSVIPNGSGLNMGLCGYWVASAGLRAHQALNQHNP....PTLLNVGQTITNEMRNELDHDGYRKITGWLRAVAD.
#=GR SDEA_LEGPH/1-173            AS    ..................................................................*...............*.....................................*............................................................
A0A378LV35_9GAMM/1000-1172             ael---YVEDMELTQSGMHALFARMGYPGIISGSIYNGNPTIDIEALNHQGFMPVLTDVGQSNVSGHWIMLMRGCNNEYFIFDPMGQASGKNYVDDLASQLPRGSRLSVIPTEAGLNRGLCGYWVASTGLRIHSALNQPTP....ISISILGKVFSEEMRDELANNGFMKIITWLQSVT-s
#=GR A0A378LV35_9GAMM/1000-1172  pAS   ..................................................................*...............*.....................................*............................................................
A0A0W0VZ27_9GAMM/1032-1207             .el---HVEDLELTQSGMHALFARMGYPGITSGSVYNGMPTIDIEALNRQGFMPVLTNVGQRNVTGHWIMLIHGRGNQYYLFDPLGQVSGMSNHDILAPQLPRDAALSIIPNGEGLNGGLCGYWIASVGLRVYTAINRAAAartlPDLVKLGQTITDDMQAELADNGYVRIINWLQSVA-a
#=GR A0A0W0VZ27_9GAMM/1032-1207  pAS   ..................................................................*...............*.....................................*............................................................
Q5ZTK5_LEGPH/6-178                     ...MPKYVEGVELTQEGMHAIFARMGHPEIKSGTIYNGVPTIDQEALDKQGFMPVLTGVGPKRDSGHWIMLIKGSGNQYHLFDPMGKISGEGYQDILATQLPKGSTLSVIPNEPGLNKGLCGYWVASVGLKACSALNKDNP....PNLETLGQITTDAMKDELTDNGYLKITGWLKAVAD.
#=GR Q5ZTK5_LEGPH/6-178          pAS   ..................................................................*...............*.....................................*............................................................
#=GC seq_cons                          ...MPKYVEGlELTQEGMHAIFARMGaPsITSGSIYNGsPTIDpEALNRQGFMPVLTGVGP+pDSGHWIMLIKGsGNQYaLFDPLGcsSGcuYpsILAsQLPhGSTLSVIPNpsGLNtGLCGYWVASVGLRA+oALNpssP....PsLpsLGQshT--M+DELscNGYhKITsWL+AVAs.
//