#=GF ID   SidF
#=GF AC   PF20988.1
#=GF DE   Phosphoinositide phosphatase
#=GF AU   Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   ECOD:2007.2.4
#=GF GA   27.10 27.10;
#=GF TC   27.10 27.10;
#=GF NC   23.30 23.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RC   Paper describing PDB structure 4fye
#=GF RN   [1]
#=GF RM   22872863
#=GF RT   Structural basis for substrate recognition by a unique
#=GF RT   Legionella phosphoinositide phosphatase.
#=GF RA   Hsu F, Zhu W, Brennan L, Tao L, Luo ZQ, Mao Y;
#=GF RL   Proc Natl Acad Sci U S A. 2012;109:13567-13572.
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Legionella pneumophila modulates the host metabolism of
#=GF CC   phosphoinositides (PIs) to impair membrane trafficking and
#=GF CC   establish the Legionella-containing vacuole (LCV) for its own
#=GF CC   replication. The virulence factor SidF is a unique PI
#=GF CC   phosphatase that specifically hydrolyses PI(3,4)P2 and
#=GF CC   PI(3,4,5)P3. This protein shows a large single domain that
#=GF CC   resembles a cowboy hat, which consists of 19 alpha-helices
#=GF CC   located around a 10-pleated beta-sheet core [1].
#=GF SQ   3
#=GS A0A0Q9YU24_9COXI/94-236  AC A0A0Q9YU24.1
#=GS A0A078KN81_9GAMM/75-898  AC A0A078KN81.1
#=GS Q5ZSD5_LEGPH/79-910      AC Q5ZSD5.1
A0A0Q9YU24_9COXI/94-236             griwnsgknlfsgrkmksnv-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSLGLGAVAVTGMVALCVLFPPAGATAAALGgaltLGVVGATAALAVGTAIATVVAGAL---------------------------------------------------------------------------------------------------afkvgesvaskiftdekfelnqdtaskfkkefamdeqtvslmnryllnriktvkselyqqdlkn
A0A078KN81_9GAMM/75-898             ....................DNLAAAAKALIDKDNPKDKELRKKAIDNLAENFKKTIQDNIDPRKATGNLFKSKKQTVNKDFLDELDTAQEILSDYTQALGKLTGHKLKELDEAGHQLRSQNRATLIHRFQAPNAKEGEEQFIMYIPCGRYTKRQQTLMGKGESP-NRDHDTTSHNRANLVLGNSSMARMVAGTRHADGTVTILHDSFTGPGARMPYSDFKSADSYKKLAIKAVTLINQEEIIQTLAQRQIDRMSNDELREKIPVEHLPARLPEDEKEARKTLIELYLA-SPDYQLSVTECYTQVVTAGQKVAAENQHEQFQYVREVMDAFDGTKVKVTIQTGEDSEAEAKVNYQARMGSWGVNWFR--GKHNPLADNSITQEQNARFINQMTRDVLENLKQVKGELQDFDRIDALYRLLNNSKTREDEKAIAQLENGHLIPLRSLYRKALFEYFNEYSKGEENWNRDELDRLKGQVELYEGQIKIQERRIYRIHKRIDDRRKSDFLDNRDEILRVLGDLKQQIEPALTSEETSPELKAKLQHFYNTCAYLTHAQELYYKDTWYKDKNNFNLQALMASLAEELDYANTKGCKSNNDRGQRLAQKIVGNALWTKMSDSGLYTRQFLDRKRTHREEVSPIEALDRKLTTIQALHHTANTGVSGGKFEI-DKAYFADNGLYGKVANLAKVKDMQPKNAITQNLDLKLGIGAALGLAAGAAVLALC-LFPPVGLALATTA....LGIAGVTALAAVVTFLTILLLTAGVGVIQNIRHDKQIQASADKGLEMAES------TLANAHSSNNDRLHQLLGVDH---VGSDAHPDNEHRKIVSKDQTEHGVSLGYSDGDEDQAHKGISLS................................................................
Q5ZSD5_LEGPH/79-910                 ....................DNLVAAAKSLIDKDKKGEKDLRKNAIDEMAKTFKKSISETIPSDKAKADLFSSKKSSANKDFLEQLAKVEGSLQQFTQAVAKASGHKLKALDKEGHNIRSHNRDTLIHRFKAPNSKEGEEQFIMYIPCGRYTKRQQRLMGKDESEVNRDHDTTSHKRSDLVLGNSSMARMIAGTRHSDGTVTIHHDSFSGPGARMPYSDFKGADDYKKLAIKAVTLINQEEVIQTLAQRQIDRMTNEDLWNKIPEEYRPDELPPDAEKARAQLIKLYVEHNP---LSVTECYTQVVTAGQRVAAENQKEQFEYVRQMMDAFDGSKAKITIQTGSNTEVETAVGYQARMSSWGVNWFRQVGALNPLSDNSVTKNQNARFVNQMTDDVIRNLDKVAQNLGDYDKAGALHTLLKGPDVSDLNQQITEKENA-LKEVKGAYREALFSYFEEYQKGEGKWDQAKLDQLKNQVDGYEKSIKKQESAIYELHNQIDALRKAYYTEHKGQINKALQELKEQISPVIQNKETDPETKSRLQHFYNSCAYLTQAQELYYENTWHHGKNNFKLQTLMASLSCELDYANTKGCKSNNDRGQRLAQKIVGNALWTAMSEDGLYTGEFLDHRRTHGKEVSNVEQLDRELTTIQALHHTANTGVSGGKFEIQDKANFADNGLFGKVANFAKIKEMGPENAFTKNMGTKIKAGLGLGLLAAGGFVALTLLFPPAGLAVAALG....IGVAAGAAIVAGVTFAATYLFGTAIDAINNKIEEGKIKSIVREGMKAASENSPQHKTEQKDHLTVNAKLHQQLGVTRESVLERQSTPKQEFEK--PKDMTSK-VDLTAAMEDDNRSESTPTPV................................................................
#=GC seq_cons                       ....................DNLsAAAKuLIDKDp.t-K-LRKpAIDphAcsFKKoIp-sIsscKApusLFpSKKposNKDFL-pLspspt.LppaTQAluKhoGHKLKtLDctGHplRSpNRsTLIHRFpAPNuKEGEEQFIMYIPCGRYTKRQQpLMGKsES..NRDHDTTSHpRusLVLGNSSMARMlAGTRHuDGTVTIhHDSFoGPGARMPYSDFKuADsYKKLAIKAVTLINQEElIQTLAQRQIDRMoN--LhpKIP.EahPscLP.DtccARtpLIcLYlt.sP...LSVTECYTQVVTAGQ+VAAENQ+EQFpYVRphMDAFDGoKsKlTIQTGpsoEsEstVsYQARMuSWGVNWFR..GthNPLuDNSlTppQNARFlNQMTcDVlcNLcpVttpLtDaD+hsALapLLpsscsp-.pptIsphENu.Lh.l+uhYRcALFpYFpEYpKGEtpWspscLDpLKsQV-hYEtpIKhQEptIYclHppIDshRKu.ah-p+spI.+sLt-LKpQIpPslpscETsPEhKu+LQHFYNoCAYLTpAQELYYcsTWa+sKNNFpLQsLMASLupELDYANTKGCKSNNDRGQRLAQKIVGNALWTtMS-sGLYTtpFLD++RTHtcEVSslEtLDRcLTTIQALHHTANTGVSGGKFEI.DKA.FADNGLaGKVANhAKlK-MtPcNAhTpNhshKltlGLGLGLlAuuGhVALClLFPPAGLAlAALG....LGVAGuTAllAVVTFlATlLhGAulssIpNhhc-tpIpu.sccGhchApp......T.tpsH.osNs+LHQ.LGVs+...ltppupPcpEacK..sKD.Tp+.VsLshu.tD-spucps.o.s................................................................
//