#=GF ID   Sigma_1_2
#=GF AC   PF03084.18
#=GF DE   Reoviral Sigma1/Sigma2 family
#=GF AU   Mifsud W;0000-0002-9805-6461
#=GF SE   Pfam-B_1759 (release 6.4)
#=GF GA   25.00 25.00;
#=GF TC   44.20 43.90;
#=GF NC   20.40 18.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11239401
#=GF RT   Junction adhesion molecule is a receptor for reovirus. 
#=GF RA   Barton ES, Forrest JC, Connolly JL, Chappell JD, Liu Y, Schnell
#=GF RA   FJ, Nusrat A, Parkos CA, Dermody TS; 
#=GF RL   Cell 2001;104:441-451.
#=GF RN   [2]
#=GF RM   11438552
#=GF RT   Hsp90 phosphorylation is linked to its chaperoning function:
#=GF RT   Assembly of the reovirus cell attachment protein. 
#=GF RA   Zhao YG, Gilmore R, Leone G, Coffey MC, Weber B, Lee PW; 
#=GF RL   J Biol Chem 2001;0:0-0.
#=GF RN   [3]
#=GF RM   9311901
#=GF RT   Localization of a C-terminal region of lambda2 protein in
#=GF RT   reovirus cores. 
#=GF RA   Luongo CL, Dryden KA, Farsetta DL, Margraf RL, Severson TF,
#=GF RA   Olson NH, Fields BN, Baker TS, Nibert ML; 
#=GF RL   J Virol 1997;71:8035-8040.
#=GF RN   [4]
#=GF RM   11287552
#=GF RT   Reovirus binding to cell surface sialic acid potentiates
#=GF RT   virus-induced apoptosis. 
#=GF RA   Connolly JL, Barton ES, Dermody TS; 
#=GF RL   J Virol 2001;75:4029-4039.
#=GF RN   [5]
#=GF RM   9971813
#=GF RT   The reovirus mutant tsA279 L2 gene is associated with generation
#=GF RT   of a spikeless core particle: implications for capsid assembly. 
#=GF RA   Hazelton PR, Coombs KM; 
#=GF RL   J Virol 1999;73:2298-2308.
#=GF DR   INTERPRO; IPR004317;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Reoviruses are double-stranded RNA viruses. They lack a membrane
#=GF CC   envelope and their capsid is organised in two concentric
#=GF CC   icosahedral layers: an inner core and an outer capsid layer. The
#=GF CC   sigma1 protein is found in the outer capsid, and the sigma2
#=GF CC   protein is found in the core. There are four other kinds of
#=GF CC   protein (besides sigma2) in the core, termed lambda 1-3, mu2.
#=GF CC   Interactions between sigma2 and lambda 1 and lambda 3 are
#=GF CC   thought to initiate core formation, followed by mu2 and lambda2
#=GF CC   [5]. Sigma1 is a trimeric protein, and is positioned at the 12
#=GF CC   vertices of the icosahedral outer capsid layer. Its N-terminal
#=GF CC   fibrous tail, arranged as a triple coiled coil, anchors it in
#=GF CC   the virion, and a C-terminal globular head interacts with the
#=GF CC   cellular receptor [2].  These two parts form by separate
#=GF CC   trimerisation events. The N-terminal fibrous tail forms on the
#=GF CC   polysome, without the involvement of ATP or chaperones. The
#=GF CC   post- translational assembly of the C-terminal globular head
#=GF CC   involves the chaperone activity of Hsp90, which is associated
#=GF CC   with  phosphorylation of Hsp90 during the process [2]. Sigma1
#=GF CC   protein acts as a cell attachment protein, and determines viral
#=GF CC   virulence, pathways of spread, and tropism. Junctional adhesion
#=GF CC   molecule has been identified as a receptor for sigma1 [1]. In
#=GF CC   type 3  reoviruses, a small region, predicted to form a beta
#=GF CC   sheet, in the N-terminal tail was found to bind target cell
#=GF CC   surface sialic acid (i.e. sialic acid acts as a co-receptor) and
#=GF CC   promote apoptosis [4]. The sigma1 protein also binds to the
#=GF CC   lambda2 core protein [3].
#=GF SQ   21
#=GS A0A1B2FIA7_9REOV/44-412  AC A0A1B2FIA7.1
#=GS VP6_AQRVC/1-407          AC Q8JU54.1
#=GS A0A0S2EGR5_9VIRU/44-383  AC A0A0S2EGR5.1
#=GS VP6_AQRVG/2-409          AC B2BNE7.1
#=GS W0FYR4_9VIRU/1-414       AC W0FYR4.1
#=GS Q9DGX2_9VIRU/1-414       AC Q9DGX2.1
#=GS A0A3G1DHL4_9VIRU/1-415   AC A0A3G1DHL4.1
#=GS E7DDL0_9VIRU/1-413       AC E7DDL0.1
#=GS A0A193BJ77_9VIRU/1-412   AC A0A193BJ77.1
#=GS A0A0A1EFP2_9VIRU/1-415   AC A0A0A1EFP2.1
#=GS A0A0A1CHH8_9VIRU/1-415   AC A0A0A1CHH8.1
#=GS O72462_9VIRU/2-403       AC O72462.1
#=GS E0ZPU4_9REOV/1-405       AC E0ZPU4.3
#=GS F1ARM8_9VIRU/1-418       AC F1ARM8.1
#=GS A0A1S6PCW7_9VIRU/1-416   AC A0A1S6PCW7.1
#=GS SIGM2_REOVJ/1-418        AC P32922.1
#=GS SIGM2_REOVD/1-418        AC P03525.2
#=GS A0A0B4ULK4_9REOV/1-413   AC A0A0B4ULK4.1
#=GS D6MM26_9VIRU/1-412       AC D6MM26.1
#=GS W8P904_9VIRU/1-415       AC W8P904.1
#=GS SIGM2_REOVL/1-418        AC P11314.2
A0A1B2FIA7_9REOV/44-412             .....iptlsttiagdigmpvpy-------------------------------------------------.-.--.----------------TNVYQTGMLRSALLQTPLI----ARGRWADRSYQGVMFTTSAMVNVRL....NPPRN-P...P....QAVVPQ..SNYI-YDLDTVPLWAANTSKRNYVYTDLCLTTLEQMDTDGfaiPLLFNELDNDV---DSLLGLTSRVGQNWTSIVCSMYDSYGNMPIQINDP---IHSLARSLMILYLGSAVGYFNSQVTWNGFYFrQVG.KNTTWFHDVDPVL-TRGDSALQNRVNGP-NQ..I.NRW..IVYRDPLWQMSRSTIAAMILGAMITNV-EVPADTLVNTHVQGGVDV.PGWCTPGG---RPA--DFVTTYGIRFV---CI.DILRQIGYYTAAEAQDAT---DKAeR.SME..RD--.RAFMIQIRDADDANFAAGN---FVRRVKPWAN-------------------gamdtrvqdcra................................................................................
VP6_AQRVC/1-407                     .......................MAQRQFFGLTYNFYG-QPAPLFDLNDLQELAGCYAR----PWT-SRFSH.L.AI.STGSLPVWSARYPSVASRNIIVNTLLGAHLN-PFAGGQVTSHQ-------GITWRDPVLSSL--....APVPAIQ...P....PPVWAV..AENVPLDSNNYPTYVLNLSSMWPINQDVHIMTMWALSDQG...PIYHLEVPVDPMPAATTAALMAYIGVPIAHLAQTAYRFAGQLPQSPDST---MVSTIRWLSAIWFGSLTGRLNRSRTCNGFYF.EFA.KPALNPDQAVLKW------NDGARAAPPAAA..Q.SSY..MRCISPHWQHQIVEVAGALMSQSVTAVTGLPALIDEATLPAWSQGV.ANLTGNGQGVVPCLDYNPVPMAAARHL-----.-QWRQDGLITAAQEAQLN------.-.---..-NDY.TAYALTIERHLTAMLVANPIAAGRMPIQPFNAADFGQ--AGQTAAAVA---la..........................................................................................
A0A0S2EGR5_9VIRU/44-383             .........yptlstsyqgdtdl-------------------------------------------------.-.--.------------PTPFTVMYQTAMVRSALFQVPLFGGLWNARSYRDLVFTSQAMLNVKTNTSVT....CPPPVIP...R....PAY---..---V-YNVMNNQRFAQSATARNKVYVDFSITTLFQMDING...FALPLLFNPDDNGIDVTLALTSLVGQSWSTIVGARYESAGNAAMDIDNP---IHRTNRALMLLYLGSACGYFNPTMTWNGFYF.RQAgKPG--SWGADLDPILV--RGDSALINRATFV..RlNRW..VVFKDFLWQMSRGTLHALVLGGMICAVEQ-P-LRGLSVISVLANTVcAPWTG---------------------------.------------------------.-.---..----.---------------------------------------------------vngragdevttiglkyvaienlirsgsytvaegvvadaqiaawgvrntdhmdrvraaddan...............................
VP6_AQRVG/2-409                     .........alrrflrtspitst---------------AQPAPLYDNQDIQDIVGAYAR----PWQ-SRFGD.I.TI.TTTSAPVWSGRYPSVAARNIIVNTILGAHLN-AFSGGVIAQYR-------GLTWRDNIMSSL--....APPSQNP...P....PPAWVP..AENVQLDSDNYPQYALNLSKMWSVNLDVHIMTMWALSDYG...PLYEISVPTAPMPAMTTAALMAYIGCSITQLAMTAYQYAGQLPQTAAAT---MTTTLRWLAAIWFGSLCGVVHRNHTVNGFYF.DFG.KPGFNPDHAVLKW------NDGNRAAPPAAA..R.FRV..YRVRSPHWQQMTSEVAGAILAQSVTAVAGLTAMFNNRGLPVWAQNI.PHFTGAAAGTRVSRTYNPVTMAAARHQ-----.-NWQAAGLITAVKQAELD------.-.---..-QQY.TDYAQAIEVHLTAQLAANPVANGRMPIQPFLPADFAA--AGGTNQVVA---dar.........................................................................................
W0FYR4_9VIRU/1-414                  .maravydflstpfgnrglatnr---------------------------TQLSSLLS-SSNSPWQ--RFLSaL.TP.LTAPGIVSTPEAPYPGSSLYQESMLHSATIP----GILGNRDAWRNFNVFGFSWTDEGLSGLVA....AQDPPPA...P....PYQPAS..GQW--SDLLQYPRWANRQRELQSKYPILLRSTLLSAMRAG...PVLYVETWPNMISGRLADWFMSQYGNNFVDMCARLTQSCMNMPVEPDGNYD---QQMRALISLWLLSYIGVVNQSNTINGFYF.ASK.TRG----QAMDNWTLFYATNTN-RVQI-TQR..H.FAY..VCARSPDWNVDKSWISAANLTAIVMACRQPPAF-ANQGVINQAQNR.PGFSMNGG--TPVHELNLLTTAQACI------.QQWVVAGLISAAKGQSMTQEANDF.S.NLI..----.QADLGRIKAQDDALYNQQP--GYARRIKPFANGDWTPGMTAQALALL----atf.........................................................................................
Q9DGX2_9VIRU/1-414                  .maraiydffstpfgnrglatnr---------------------------TQLSSLLS-SSNSPWQ--RFLS.S.MTpLTAPGIVSTPEAPYPGSLMYQESMLHSATVP----GVLGSRDAWRTFNVFGLSWTDEGLSGLVA....AQDPPPA...A....PYQPAS..AQWS--DLLNYPRWANRRRELQSKYPLLLRSTLLSAMRAG...PVLYVETWPNMISGRLADWFMSQYGNNFVDMCARLTQSCSNMPVEPDGNYD---QQMRDLISLWLLSYIGVVNQTNTISGFYF.SSK.TRG----QALDSWTLFYTTNTN-RVQI-TQR..H.FAY..VCARSPDWNVDKSWIAAANLTAIVMACRQPP-VFANQGVINQAQNR.PGFSMNGG--TPVHELNLLTTAQ------ECI.RQWVMAGLVSAAKGQALTQEANDF.S.N--..--LI.QADLGQIKAQDDALYNQQP--GYARRIKPFVNGDWTPGMTAQALAVLA---tf..........................................................................................
A0A3G1DHL4_9VIRU/1-415              .......................MARAIFPFFTTQWGD-PRVPLSE----KS-LGKLLTSSNALWQSSNFIN.Y.-L.PTLQSRIKTQEWPFPGSVWYQMSLTYTGFITTALA----ARESWRDHFFLNTVWDGPDLRQLVV....RPPDPTY...V....EVVPNP..GQ-W-LDLLDYMRWSNRRHELMAIYPQIYRLSLLNMSIYG...PVFFIETDPLITAGQVSVWLTSMIGHDFRDIAFRLIQSVGNLPITRDTSYDD---NIKALIAIFMMSYIGVVHQNRTMHGFYF.QTK.QRG----TGLEAW--TLQFNHVGQRVTPTIR..H.AGY..FGVRSPDWHACAELLFVTALSSIRQAVRQTP-VIANSSVIPAARDY.PGVTAPVG---ENIGYFTLDVAATRCL-----.DRWYNDDLISREERGVMI--CDKD.H.YFNhvHDEI.EGVF----REDNALMQIDPT--HSRRLKPYAQQDWNIGA---SNVVIA---qlstfi......................................................................................
E7DDL0_9VIRU/1-413                  .......................MERSTYNICTPGFFG-ANVPPFKTIDIQRST----TGGNTLWN-ARGHD.A.FR.TYPKVVSHEKDFPLIYTEQFTFNLLIGAFLQQPLL--QNSI----DRQWRGMIWTSDRLSSLRI....APPNSR-...-....VADLPR..AYRT-LDLANYPLWGTAPAALQTLWMDSCLMTLESLSARG...PFLYLRHPQARPDGNVLRALQQHISKPMEAIVSEAYQSIAVGPLTLQDGYYRALSVI---TLIYLASLTGRLGPDRTYYGFYV.QFP.KKRKFEDLGYFAY------NADGRNVAVLQS..I.NAY..IYCASPDWQYSCALYYLHVLSALSLSWTDPVGMIDGFSCVNQFTDV.PGWFATNR------------------------.------------------------.-.---..----.---------------------------------------------------alhthsfnwfnlledaidtlvarrywtnavgqairqewtaardrwrvimdatrdeddlvvfrtpddcrrrlkpygdnnwtraydtadvvrvl
A0A193BJ77_9VIRU/1-412              .......................MARRTFVGFTPSFYG-QPGPLFTNDDYLDLAGTTVR----PWQ-NRITN.I.AI.NSGGYPVWGGKYPTVASRQLILNALLGAHVA-PYAAGAVNQFN-------GVAWRDALLSSFVN....VPPAIA-...PappdPPIWVP..ADNVRLDSNVYPTYGLKFDAMWPQNQDLHMMTMWSLTDRG...PIAMLTFPRQNIPAMVSTAMKSLVGASVTQIAIRAYRYSGQLPQEGTSI---QALVYQWLACILFGSLTGRLHRGRTCEGFFF.AYS.KPAANQDDMILRW------SDGPRALKPVND..V.TVY..VAAGSPHWQQSMLHISFAMLAQSTSCLRPLVTLIRDRNLPARSRNI.AGLTGGAGGLRDVERYNVPDLAIQCH------.AAWLADGIIDAAAQVTYDA--ATN.-.---..----.AQFA-TFMAHINAMEIANPLANGRIVVQPFANGDDV---------------aafetaqvvaga................................................................................
A0A0A1EFP2_9VIRU/1-415              .......................MARAVFDFFTTLFGN-RGLPTDQ----RQLTSLLTS-SNSPWQ-KQYSP.L.AL.SLTSSTISTSQQPFPGSAWYQESMLFSALLP-PVL---VNQDAWRDANYKRFCWTDAALSGLVA....APDPPRA...P....PYVPVS..G-AW-FDLTQYPRWANRRRELETKYPLLLRITLLNMMQNG...PLVYVETWPNMLSGALVNFAMSCYGKDFREIAMVLAQSCSNMPFAPESSYDQQ---MRMMVSLWILSYIGVVHQNATIAGFFF.STK.TRG-VRDEA---WTLF--YNTNGQRLNITQR..H.FGY..FCARSADWNADSSWLAASQLSALIMSCRQFP-LLANQGVVNQAQNR.PGYSSPNG--------VPVRELQLLACTTECI.RSHVQAGLIDQAKGQTLTQNATDV.N.QVL..QREI.DD----IKAADDALYNQNP--EYARRLKPFQARSWTVGQSMQSLAALAA--fa..........................................................................................
A0A0A1CHH8_9VIRU/1-415              .......................MARAVFDFFTTLFGN-RGLPTDQ----RQLTSLLTS-SNSPWQ-KQYSP.L.AL.SLTSSTISTPQQPFPGSAWYQESMLFSALLP-PVL---ANQDAWRDANYKRFCWTDAALSGLVA....APDPPRA...P....PYVPVS..G-AW-FDLTQYPRWANRRRELETKYPLLLRITLLNMMQNG...PLVYVETWPNMLSGALVNFAMSCYGKDFREIAMVLAQSCSNMPFAPESSYDRQMRMM---VSLWILSYVGVVHQNATIAGFFF.STK.NRG-VRDEA---WTLF--YNTNGQRLNITQR..H.FGY..FCARSADWNADSSWLAASQLSALIMSCRQFP-LLANQGVVNQAQNR.PGYSSPNG--V------PVRELQLLACATECI.RSHVQAGLIDQAKGQTLTQNATDV.N.QVL..QREI.DD----IKAADDALYNQNP--EYARRLKPFQARSWTVGQSMQSLAALTA--fa..........................................................................................
O72462_9VIRU/2-403                  arahypyvtglwsepvipfqksq------------------------------INHLLRSSNSVWQDATLSK.T.-W.PVIRSRVYTREIPCAGSVLYQRNLLYSSFVPILL----IDKDAWKEYQFQDTTWTGPEGKNLVR...rTPYQEM-...-....VEYDPQ..PARY-YDVHEYRTWQRQLLLLQRIYPQLMVSNMLNLSQFG...PITYLDTDARMLEPLVLNILTTWIGKSFEEIAIKLLQTINNHALVADSNNDLALRLI--NTIFWL-SSAGILNQNRTIRGFFF.LTK.RRGVSEESFILNY-----NHHGERVNL-EGY..K.YGF..FAIRSPDWNRYLSYSLSAGLSAMVLSN-RSPKLLSNNDVNDSYTSL.PHLTGPLG--------DRVYYISSSVLADEYI.DTQYIIGQISGKERDQMI----LN.K.DVE..YDRS.RAYLTAVLDEDDELQIARR-------IKPFNEVDWL---------------pgesrigi....................................................................................
E0ZPU4_9REOV/1-405                  .......................MARVVYVFYGSQWFTLQN-PAFNVDDVSVIST----SGAGIWG--KLAE.VnAI.DGVRQTTGNDRSPLFISRLLKLGQLATVWLPSLSR---ALQFR--FEQYHGAILRSPAIDALVL....VPRARV-...P....PAVV-P..AEAGLYDLMNFPRFTELPGQMWEMVLDSCGITMDAMAVQS...MPLYIGFENQAPVADLMSQMPTFVGRSITSIAAILYSQSRNSSGVPDPL---IGRTARLLSTITLLSFTGHMHNDATYYGFYV.SRP.RETKSVEGAILMY------QQGANIIPLTNAnpN.GAYtaVGIGDPLWQISPDLYAMFLLNIVYAANCVTP-VLDTTHLAP----M.RTWAVAGGMNMYRLNWRD---ALRRKI-----.RVDRQRGIITQPEENDCL---QAV.D.DYA..RDC-.AALLDDVLARQTAFNRANP-GGETMRVKPFAQADYR---------------npfe........................................................................................
F1ARM8_9VIRU/1-418                  .......................MARAAFLFKTVGFGGLQNVPIND-----ELSSHLLRAGNSPWQLTQFLD.W.-I.SLGRGLATSALVPTAGSRYYQMSCLLSGTLQIPFR----PNHRWGDIRFLRLVWSAPTLDGLVV....APPQVLA...Q....PALQAQ..ADRV-YDCDDYPFLARDPRFKHRVYQQLSAVTLLNLTGFG...PISYVRVDEDMWSGDVNQLLMNYFGHTFAEIAYTLCQASANRPWEYDGTYARMTQIV--LSLFWL-SYVGVIHQQNTYRTFYF.QCN.RRG----DAAEVWILSCSLNHSAQIRP--GN..R.SLF..VMPTSPDWNMDVNLILSSTLTGCLCSGSQLP-LIDNNSVPAVSRNI.HGWTGRAG--------NQLHGFQVRRMVTEFC.DRLRRDGVMTQAQQNQVEALADQT.Q.QFK..RDKL.ETWA----REDDQYNQAHP-NSTMFRTKPFTNAQWGRGNTGATSAAIAALI............................................................................................
A0A1S6PCW7_9VIRU/1-416              .......................MAQRAFAGVTPSFYN-QPNPLYDDDDFANLGGTAVR----PWQ-NRIAH.L.SI.NTGGYPVWSGQYPTVACRNLIINAMLGAHLN-AFSTGVITTYR-------NVTWRDRLLSSLSLppipRPPPAPQ...P....PPAWVP..AESVPLSSANYQMYALNFDRMWPLNLDIHVMSLMSLTDRG...PVILLERPATHIPTMVLTAMLSYVGTSVVHIALQAYIYAGQLPQPGNSI---QAMAFQWLACILFGSLTGRLHRSRSCEGFYF.GFS.KATDNQDDITLRW------NDGVRTALPANR..I.TRY..VACGSPHWQQSMLHTCFALLAQASSSLRPLPALIDSANLALHAAAV.PGLTGIGPAARALDRYNYTQLNVAMHA-----.-EWAASGIVTAAQQAVYDA-----.-.---..--AT.NAQAAGFMAHLTAMELAHPLNRGRIVVQPFAAGDVNA--AFETANVVAA--anam........................................................................................
SIGM2_REOVJ/1-418                   .......................MARAAFLFKTVGFGGLQNVPIND-----ELASHLLRAGNSPWQLTQFLD.W.-I.SLGRGLATSALVPTAGSRYYQMSCLLSGTLQIPFR----PNHRWGDVRFLRLVWSAPTLDGLVI....APPPILA...Q....PAIQAQ..ADRA-YDCDDYPFLARDPRFKHRVYQQLSAITLLNLTGFG...PISYVRVDEDMWSGDVSQLLMNYFGHTFAEIAYTLCQASANRPWEHDGTYARMTQIV--LSLFWL-SYVGVIHQHNTYRTFYF.QCN.RRG----DAAEVWILSCSLTHSAQIRA--GN..R.SLF..VMPTSPDWNMDVNLILSSTLTGCLCSGSQLP-LIDNNSVPNVSRNI.HGWTGRGG--------NQLHGFQVRRMITEYC.DRLRRDGVMTPAQQMQIEALGDQT.Q.QFK..RDKL.EAWA----LEDDQYNRAHP-NSTMFRTKPFTNAQWGRGNTAATSAAIAALI............................................................................................
SIGM2_REOVD/1-418                   .......................MARAAFLFKTVGFGGLQNVPIND-----ELSSHLLRAGNSPWQLTQFLD.W.-I.SLGRGLATSALVPTAGSRYYQMSCLLSGTLQIPFR----PNHRWGDIRFLRLVWSAPTLDGLVV....APPQVLA...Q....PALQAQ..ADRV-YDCDDYPFLARDPRFKHRVYQQLSAVTLLNLTGFG...PISYVRVDEDMWSGDVNQLLMNYFGHTFAEIAYTLCQASANRPWEYDGTYARMTQIV--LSLFWL-SYVGVIHQQNTYRTFYF.QCN.RRG----DAAEVWILSCSLNHSAQIRP--GN..R.SLF..VMPTSPDWNMDVNLILSSTLTGCLCSGSQLP-LIDNNSVPAVSRNI.HGWTGRAG--------NQLHGFQVRRMVTEFC.DRLRRDGVMTQAQQNQVEALADQT.Q.QFK..RDKL.ETWA----REDDQYNQAHP-NSTMFRTKPFTNAQWGRGNTGATSAAIAALI............................................................................................
A0A0B4ULK4_9REOV/1-413              .......................MARRTFIGFTPSFYG-QPGPLFTNDDYLDLAGTTVR----PWQ-NRITN.L.AI.NSGGYPVWGGKYPTVASRQLILNALLGAHVA-PYSAGAINQFN-------GVAWRDALLSSFTT....IPPAIAPappD....PPIWVP..AGDVRIDSNQYPTYGLKFDAMWPQNQDLHMMTMWSLTDRG...PISLLTFPRQNIPAMVATAMRSLVGASVVQIAIRAYRYSGQLPQEGTSI---QAQVHQWLACILFGSLTGRLHRGRTCEGFFF.AYA.KPAANQDDMILRW------NDGTRAAKPVND..V.TVY..VAAGSPHWQQSMLHVSFAMLSQSTSCLRALPTRIRNNNLPQRAHNI.AGLTGGGGGLRDVERYN-VPDLAVRCH-----.AAWLADGIIDVATQAAYDAA--TN.A.---..----.-QFA-TFMAHITAMEAANPIANGRIVVQPFANGD-----------------dvaafetvqviaaar.............................................................................
D6MM26_9VIRU/1-412                  .......................MARVDFYFLTTSWND-AYFPLNE-KQINELLSSS----CSVWQNQNFLS.Y.-V.NSRTNNYMSNNFPCVGAFWYQRSCMLSGFLLIATD-GP---IAWRNESFRRMSWIDGCFEQVAV....TGD--TT...Q....DVV--P..RSNVWLNMFDARCWVNRAFVLRRIYPQMLRLTLLNASLFG...PMFFIDVVPLMFDDPTQMWLTSLIGHDFKDISYRLIQSTYNLPFELDGLHDR---CIRALTLLFILSYTGVVHQNRTLLGYYF.QSK.TRGLSTDAWTLRY-----NTTGQRVRPLAPN..Q.Q-Y..YGIRSPSWNYSNDLCYLCALSSIVLSCRIAP-LIRNDSVIPPARDQ.HGFSSPRG--LPVFYFSLTVAANACLL-----.-NWRDGQLITDGEYREMN------.Q.QMT..LEQLrQRHALEVILAHDDDSMAGP--DGCRRIKPFTARDWTPGQSGAAIAAL----rglv........................................................................................
W8P904_9VIRU/1-415                  ..................marvv-----YPYFTTPWND-RTVPLTQ----KQLYN-LLTSSNALWQMQNLTS.F.-I.PSVQTQVSTPLLPVPGSAWYQVSLIYSAFINIAVG----PPNNWRDHYFRDTVWTGPDLESVVQ....KPN----...A....PAYVEQnpQPAVFLDMLRSMTWANQRFPMYRIYAQTYRLSLLNASLHG...PIFWVETGPNFISATDATWLSSMIGRDMREISFRLVQSTVNMPFAADDHYDTSLRAL--IAVFIL-SYLGVINQNSTLRGYYF.ATK.ERG----TGLETWTLEENL-HGARVNILA-A..H.RGY..FGVKSPDWNVDPAILALAALSSIRQSIRAVA-PIRNATVIQQAQNR.PGFTERNG--VPVLYFTLLTA-------SEFClNQWLLANLISPLQRQEMQ---RKT.QaYFQ..AQEM.RVDA--ILAEDDDRMRANP-ALG-RRIKPYPPVDWLPGNSRAALNALAAY-v...........................................................................................
SIGM2_REOVL/1-418                   .......................MARAAFLFKTVGFGGLQNVPIND-----ELSSHLLRAGNSPWQLTQFLD.W.-I.SLGRGLATSALVPTAGSRYYQMSCLLSGTLQIPFR----PNHRWGDIRFLRLVWSAPTLDGLVV....APPQVLA...Q....PALQAQ..ADRV-YDCDDYPFLARDPRFKHRVYQQLSAVTLLNLTGFG...PISYVRVDEDMWSGDVNQLLMNYFGHTFAEIAYTLCQASANRPWEHDGTYARMTQII--LSLFWL-SYVGVIHQQNTYRTFYF.QCN.RRG----DAAEVWILSCSLNHSAQIRP--GN..R.SLF..VMPTSPDWNMDVNLILSSTLTGCLCSGSQLP-LIDNNSVPAVSRNI.HGWTGRAG--------NQLHGFQVRRMVTEFC.DRLRRDGVMTQAQQNQIEALADQT.Q.QFK..RDKL.EAWA----REDDQYNQANP-NSTMFRTKPFTNAQWGRGNTGATSAAIAALI............................................................................................
#=GC seq_cons                       .......................MAph.a.hhTs.ahs.pshPh.p.....pLsuhhhp.usuPWQ.pphhs.h..l.shsps.shosphPssuSphYQhuhLhSAhLs.sht....spppWtshpahshsWssssLsuLVh....sPssshs...s....Psl.s...upts.hDhssYPpaApphpthpplY.plphhTLhshottG...PlhalcsssshhsuslsshLhohlGpsascIAhpLhQusuNhPhphDus....hphhp.LshlalhShsGllHpspThpGFYF.pss.++G....suh.tW......Ncusphts.sss..+.stY..lsspSPcWphshshltuuhLouhlpuspphP.llsNsslss.upsl.sGaTusuG........s.lphhthpth......pphhtsGllotApptphp...tps.p..h....pph.pshh..h.tccssh.tApP..tthhRlKPFssssas...shts.ssl.....s..........................................................................................
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