#=GF ID Sir1
#=GF AC PF11603.12
#=GF DE Sir1, ORC-binding domain
#=GF AU Pollington J;0000-0002-8158-8998
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE pdb_1z1a
#=GF GA 24.00 24.00;
#=GF TC 27.80 24.80;
#=GF NC 23.80 21.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 15932939
#=GF RT Structural basis of the Sir1-origin recognition complex
#=GF RT interaction in transcriptional silencing.
#=GF RA Hou Z, Bernstein DA, Fox CA, Keck JL;
#=GF RL Proc Natl Acad Sci U S A. 2005;102:8489-8494.
#=GF RN [2]
#=GF RM 9837911
#=GF RT Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y'
#=GF RT element, is induced in survivors defective for telomerase.
#=GF RA Yamada M, Hayatsu N, Matsuura A, Ishikawa F;
#=GF RL J Biol Chem. 1998;273:33360-33366.
#=GF DR INTERPRO; IPR021646;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This entry represents the ORC-binding domain of Sir1. Sir1
#=GF CC interacts with the BAH domain of the Orc1 subunit of the origin
#=GF CC recognition complex (ORC) resulting in the establishment of
#=GF CC silent chromatin at HMR and HML in S.cerevisiae [1]. The amino
#=GF CC acids from the ORC interaction region of Sir1 are presented on a
#=GF CC conserved, convex surface that forms a complementary interface
#=GF CC with the Orc1 BAH domain, critical for transcriptional silencing
#=GF CC [1]. Proteins containing this domain also include Y' element
#=GF CC ATP-dependent helicase protein 1, which catalyses DNA unwinding
#=GF CC and is involved in telomerase-independent telomere maintenance
#=GF CC [2].
#=GF SQ 89
#=GS YB111_YEAST/1-89 AC Q3E7Y5.1
#=GS G0V9E1_NAUCC/9-126 AC G0V9E1.1
#=GS G0VG78_NAUCC/432-547 AC G0VG78.1
#=GS A0A1S7HDJ6_9SACH/3-89 AC A0A1S7HDJ6.1
#=GS YRF18_YEAST/2-89 AC P0CX22.1
#=GS YP202_YEAST/35-153 AC Q08993.1
#=GS YMN3_YEAST/2-89 AC Q03099.1
#=GS G0VIJ5_NAUCC/46-171 AC G0VIJ5.1
#=GS G0VDM8_NAUCC/3-128 AC G0VDM8.1
#=GS G0W7A8_NAUDC/5-125 AC G0W7A8.1
#=GS A0A1S7HDI1_9SACH/3-89 AC A0A1S7HDI1.1
#=GS YL066_YEAST/2-89 AC Q99208.2
#=GS G0VL22_NAUCC/458-572 AC G0VL22.1
#=GS G0V535_NAUCC/46-171 AC G0V535.1
#=GS G0WHB8_NAUDC/435-550 AC G0WHB8.1
#=GS A7TSQ3_VANPO/13-137 AC A7TSQ3.1
#=GS J7S9Y8_KAZNA/1-89 AC J7S9Y8.1
#=GS G0VG78_NAUCC/153-269 AC G0VG78.1
#=GS G0WAQ6_NAUDC/1-112 AC G0WAQ6.1
#=GS A0A1S7HS48_9SACH/3-89 AC A0A1S7HS48.1
#=GS YJW5_YEAST/2-89 AC P40889.2
#=GS G0WHD9_NAUDC/10-137 AC G0WHD9.1
#=GS A0A1S7HI15_9SACH/14-132 AC A0A1S7HI15.1
#=GS J7RQM5_KAZNA/3-120 AC J7RQM5.1
#=GS J7R2S7_KAZNA/69-186 AC J7R2S7.1
#=GS G0W962_NAUDC/3-128 AC G0W962.1
#=GS YFG4_YEAST/1-89 AC P43540.1
#=GS A0A1S7HY70_9SACH/3-89 AC A0A1S7HY70.1
#=GS SIR1_YEAST/465-585 AC P21691.2
#=GS G0WAK9_NAUDC/3-126 AC G0WAK9.1
#=GS A7TTH5_VANPO/29-149 AC A7TTH5.1
#=GS A0A1G4MCC7_LACFM/21-141 AC A0A1G4MCC7.1
#=GS H2B1W9_KAZAF/6-126 AC H2B1W9.1
#=GS J7S9Y6_KAZNA/61-178 AC J7S9Y6.1
#=GS A0A875RXN8_EENNA/5-120 AC A0A875RXN8.1
#=GS H2AYL2_KAZAF/4-124 AC H2AYL2.1
#=GS YHE9_YEAST/1-89 AC P38722.1
#=GS G0VAX2_NAUCC/9-127 AC G0VAX2.1
#=GS A0A7H9HQ16_9SACH/293-407 AC A0A7H9HQ16.1
#=GS A0A1S7HKD6_9SACH/3-89 AC A0A1S7HKD6.1
#=GS G0VF17_NAUCC/47-172 AC G0VF17.1
#=GS J7S5G0_KAZNA/4-121 AC J7S5G0.1
#=GS G0VBZ4_NAUCC/81-206 AC G0VBZ4.1
#=GS G0WAK9_NAUDC/436-553 AC G0WAK9.1
#=GS YL067_YEAST/2-89 AC Q07888.2
#=GS A0A1S7HAQ1_9SACH/283-401 AC A0A1S7HAQ1.1
#=GS A0A1G4M8S9_LACFM/3-123 AC A0A1G4M8S9.1
#=GS J7RUF2_KAZNA/25-137 AC J7RUF2.1
#=GS A0A1S7HNJ2_9SACH/283-401 AC A0A1S7HNJ2.1
#=GS G0V602_NAUCC/176-286 AC G0V602.1
#=GS G0VL22_NAUCC/3-122 AC G0VL22.1
#=GS YEI5_YEAST/1-89 AC P39972.1
#=GS YRF17_YEAST/35-153 AC P0CX15.1
#=GS C5DLF8_LACTC/3-119 AC C5DLF8.1
#=GS C5DFV4_LACTC/3-123 AC C5DFV4.1
#=GS A0A7H9HKN9_9SACH/293-407 AC A0A7H9HKN9.1
#=GS YIR7_YEAST/2-89 AC P40434.1
#=GS G0W7A9_NAUDC/5-125 AC G0W7A9.1
#=GS A0A7H9HPZ6_9SACH/8-128 AC A0A7H9HPZ6.1
#=GS G8ZUI4_TORDC/11-128 AC G8ZUI4.1
#=GS G0V602_NAUCC/1350-1472 AC G0V602.1
#=GS G0VIY8_NAUCC/593-713 AC G0VIY8.1
#=GS C5DDD6_LACTC/3-123 AC C5DDD6.1
#=GS G0WHE0_NAUDC/3-128 AC G0WHE0.1
#=GS A0A1S7HS27_9SACH/3-89 AC A0A1S7HS27.1
#=GS A0A4C2EAQ0_9SACH/283-397 AC A0A4C2EAQ0.1
#=GS SIR1_YEAST/3-125 AC P21691.2
#=GS YRF13_YEAST/35-153 AC P0CX14.1
#=GS A0A7H9HWF0_9SACH/3-124 AC A0A7H9HWF0.1
#=GS YE19_YEAST/1-89 AC P40104.1
#=GS YL462_YEAST/1-89 AC O13556.1
#=GS A0A1S7H7T7_9SACH/2-89 AC A0A1S7H7T7.1
#=GS G0WHB8_NAUDC/3-120 AC G0WHB8.1
#=GS A0A7H9B0U5_ZYGMR/5-126 AC A0A7H9B0U5.1
#=GS A7TTF0_VANPO/47-171 AC A7TTF0.1
#=GS G0WEH4_NAUDC/296-413 AC G0WEH4.1
#=GS G0VET8_NAUCC/79-204 AC G0VET8.1
#=GS G0V9E1_NAUCC/298-414 AC G0V9E1.1
#=GS J5RW32_SACK1/2-89 AC J5RW32.1
#=GS YRF15_YEAST/2-89 AC P0CX21.1
#=GS G0VG78_NAUCC/3-123 AC G0VG78.1
#=GS G0WAQ5_NAUDC/3-128 AC G0WAQ5.1
#=GS YRF16_YEAST/35-153 AC P53819.1
#=GS A0A7H9HNL1_9SACH/3-124 AC A0A7H9HNL1.1
#=GS J7RNF0_KAZNA/56-173 AC J7RNF0.1
#=GS C5DDD3_LACTC/3-123 AC C5DDD3.1
#=GS G0W5M5_NAUDC/1-58 AC G0W5M5.1
#=GS YRF11_YEAST/2-89 AC P0CX20.1
#=GS A7TSQ1_VANPO/16-149 AC A7TSQ1.1
YB111_YEAST/1-89 ...................mkvsdrr---------.------------.....--------------.----KFEK.--..-ANFDEFESAlnnKNDLVHCPSITLFESIPTEVRSFYED.EkSGL.IKVVKFR.......TGAMDRKRSFEKIVVSVMVGKNVQKFL-t....................
G0V9E1_NAUCC/9-126 ........................ip--SGQFTVI.DGFLISLDNRTA.....NDISSESAKELLTPgSWYILKNS.YN..PISLTVLQLM..sSNYMFTNHPLLLFVLRPTVYVRFVRK.N.NKY.HCVKT--.......NKAHGTHKAFALDCE-------------rtdepktkfiv..........
G0VG78_NAUCC/432-547 ..........................KPSKRYIIV.DRFIVDLTERRI.....INPNGEEISDILTR.WELSVLAK.RD..IFDWDVFLF-...DQSLVPVFSSMLFNLVQCQDILLTRD.E.KMR.VHIQP--.......-DFETGQNFDKRRCIILDLKEHGLRYLY.....................
A0A1S7HDJ6_9SACH/3-89 .................vsdkrefek---------.------------.....--------------.--------.--..-ANFEEFELAlnnKNDLVDCHSITLFESIRTEVRSFYED.EkSGL.IKVVKFR.......TSAMDRKRSFEKIVIAVMVKKNVQKFL-t....................
YRF18_YEAST/2-89 ...................kvsdrrk---------.------------.....--------------.--------.FE..KANFDEFESAlnnKNDLVHCPSITLFESIPTEVRSFYED.EkSGL.IKVVKFR.......TGAMDRKRSFEKIVISVMVGKNVQKFL-t....................
YP202_YEAST/35-153 ........................gq----SFVYI.DGFLVKKHNNQH.....TIVNFETYKNKMKV.SDRRKFEK.AN..FDEFESALNN...KNDLVHCPSITLFESIPTEVRSFYED.EkSGL.IKVVKFR.......TGAMDRKRSFEKIVISVMVGKNVQKFL-t....................
YMN3_YEAST/2-89 ...................kvsdrrk---------.------------.....--------------.--------.FE..KANFDEFESAlnnKNDLVHCPSITLFESIPTEVRSFYED.EkSGL.IKVVKFR.......TGAMDRKRSFEKIVVSVMVGKNVQKFL-t....................
G0VIJ5_NAUCC/46-171 ..........................YISDNVSVV.DGFVVLTIEKEGasvrkVVKKFHPKSKLFLL.EERTKLAN.YA..LVDLDEYHTAf.pGSDLVPVPSSQLFSVCTTSKRLFYTT.P.DGF.RIVNS-K.......TPDRHRRCSQEYTVIPVVYKDKPTKYLY.....................
G0VDM8_NAUCC/3-128 ..........................YISDNVSVV.DGFVVLTIEKEGasvrkVVKKFHPKSKLFLL.EERTKLAN.YA..LVDLDEYHTAf.pGSDLVPVPSSQLFSVCTTSKRLFYTT.P.DGF.RIVNS-K.......TPDRHRRCSQEYTVIPVVYKDKPTKYLY.....................
G0W7A8_NAUDC/5-125 .........................e-IDKNHWVI.DNFLVEENDGVK.....RIRHFTGTNKTMPQ.YTIDKLKL.MN..TINLKELKDAy.pYTSLIPCQSKLLFAHVQTFTYEFYRK.G.EGF.HKVNA-R.......TAKIFRNISSPFTVIPLILKGCPVKYLY.....................
A0A1S7HDI1_9SACH/3-89 .................vsdkrefek---------.------------.....--------------.--------.--..-ANFEEFELAlnnKNDLVDCHSITLFESIRTEVRSFYED.EkSGL.IKVVKFR.......TSAMDRKRSFEKIVIAVMVKKNVQKFL-t....................
YL066_YEAST/2-89 ...................kvsdrrk---------.------------.....--------------.--------.FE..KANFDEFESAlnnKNDLVHCPSITLFESIPTEVRSFYED.EkSGL.IKVVKFR.......TGAMDRKRSFEKIVVSVMVGKNVQKFL-t....................
G0VL22_NAUCC/458-572 .........................f-LSPRFLII.DNFLIDLAENKL.....VNPMDSKIRELLTE.NEREDIET.FK..FFDWNNFEQ-...SNEPMGVYSKGLFQTLDSSKTQFTLD.T.IGC.THH----.......IGTAYDGVVVTRHCMKLDIPNIGVRFLY.....................
G0V535_NAUCC/46-171 ..........................YISDNVSVV.DGFVVLTIEKEGasvrkVVKKFHPKSKLFLL.EERTKLAN.YA..LVDLDEYHTAf.pGSDLVPVPSSQLFSVCTTSKRLFYTT.P.DGF.RIVNS-K.......TPDRHRRCSQEYTVIPVVYKDKPTKYLY.....................
G0WHB8_NAUDC/435-550 ..........................YITLRFLLInDKFIIDLAENKL.....INPKSKTFLESIPE.YVADALGQ.FD..FFDWSIFNF-...SNEPFPIYCSELFEELHMEEREFILD.D.RGV.LHVN---.......-NSGYSGMIVKVPCAAIELKDKSVIYIY.....................
A7TSQ3_VANPO/13-137 ..........................TISERYTVI.DGFLIYTEKNNGnv.trKIVDVNFRKGFLRD.DERIELKK.FD..LINIDELRERn.kHSEMIPCNSTELFNYCDTITRRYYWE.Y.-GN.LILFTDR.......SKKEKEKDAERFTVIPLRKYNKATKYLY.....................
J7S9Y8_KAZNA/1-89 ........................mg---------.------------.....----------YLRK.AELEILLA.IK..TVDLDELFDIh.aSSDLIPCSSKHLFETVTTESFPVRSD.A.EGM.HIA----.......VTPADKEHATSMDLICYRPLRRKYKYLY.....................
G0VG78_NAUCC/153-269 ........................ad---ENVIEI.DGFLLELESRQL.....WSLHSSRIRSFLSL.TEWAKLKKvCN..ATSLEKLKAV...SSNYIFTKSQGLFHLLDNHVYVNFKK.V.NNF.FTCQ---.......NCRKEEATHIGYYVT-------------fhqsngptskyiv........
G0WAQ6_NAUDC/1-112 .........................m-------VT.GRFLVDIIEKKI.....INPNEQHYLRNLTD.EEKEYIEE.CD..LLDWNILKL-...TKHPYAVDSPQLFDVLNANNEDFYED.K.NGD.LWIVPP-.......TEYKGELTPRKYRSIPLHFKSFGWRHIY.....................
A0A1S7HS48_9SACH/3-89 .................vsdkrefek---------.------------.....--------------.--------.--..-ANFEEFELAlnnKNDLVDCHSITLFESIRTEVRSFYED.EkSGL.IKVVKFR.......TSAMDRKRSFEKIVIAVMVKKNVQKFL-t....................
YJW5_YEAST/2-89 ...................kvsdrrk---------.------------.....--------------.--------.FE..KANFDEFESAlnnKNDLVHCPSITLFESIPTEVRSFYED.EkSGL.IKVVKFR.......TGAMDRKRSFEKVVISVMVGKNVKKFL-t....................
G0WHD9_NAUDC/10-137 .........................n-VSDRISIV.DGFFVMVETSENnvtkkVIKNYETSTWKLTN.KEITMVSN.YKdrLFDITSYHTEy.pNSELIPHNSHLLFENCTTIEKKFYPT.N.EGF.KSVNS-R.......TSKKDISESQTYSVIPIRLKGLPNKYLY.....................
A0A1S7HI15_9SACH/14-132 ........................gt----SFVYI.DGFLVRKHNNQH.....TIVNFETYKNKMKV.SDKREFEK.AN..FEEFELALNN...KNDLVDCHSITLFESIRTEVRSFYED.EkSGL.IKVVKFR.......TSAMDRKRSFEKIVIAVMVKKNVQKFL-t....................
J7RQM5_KAZNA/3-120 .........................d-VSDRYIVS.NVYLIFINKDGS....kVLRSGLPKDRYMRK.EEADVLKK.LK..IIDLDDLYTKy.sSSDLMSCSSTKLFQYMECEKIRVIKT.E.SGY.QI-----.......DRGQEKAQAMEMAVIRYRTMHKKVKYLF.....................
J7R2S7_KAZNA/69-186 .........................e-VSDRYTVI.EGYLVFINKNGT....kAVRSYIPQSNTINK.REGEVLEK.LN..IIDMNELYNRy.sYSDLIPCSSSKLFDYMGTETVSVIET.E.SGF.QI-----.......ASGRQKSEARPMQVIRYRPLHKKIKCLY.....................
G0W962_NAUDC/3-128 ..........................TISENVVLI.EGFIVLKSKDKQgvetkIIRNLTKTSKFFST.WERELLSI.QS..LVDIDEYQTTh.sKCDLIPMPCKELFDYCTTVEKNCYVS.E.DGY.QIVNA-R.......TPKRFHQLAQKYLVIPLYCKHKRTKYFY.....................
YFG4_YEAST/1-89 ...................mkvsdrr---------.------------.....--------------.----KFEK.--..-ANFDEFESAlnnKNDLVHCPSITLFESIPTEVRSFYED.EkSGL.IKVVKFR.......TGAMNRKRSFEKIVISVMVGKNVQKFL-t....................
A0A1S7HY70_9SACH/3-89 .................vsdkrefek---------.------------.....--------------.--------.--..-ANFEEFELAlnnKNDLVDCHSITLFESIRTEVRSFYED.EkSGL.IKVVKFR.......TSAMDRKRSFEKIVIAVMVKKNVQKFL-t....................
SIR1_YEAST/465-585 ..........................YVSPRFLVA.DGFLIDLAEEKP.....INPKDPRLLTLLKD.HQRAMIDQ.MN..LVKWNDFKK-...YQDPIPLKAKTLFKFCKQIKKKFLRG.A.DFK.LHTLPTEa.....nLKYEPERMTVLCSCVPILLDDQTVQYLY.....................
G0WAK9_NAUDC/3-126 .........................m-LNTRYTFI.NGWIVDLENGKI.....INPDLKTYK-----.PLKKLLGD.LQ..YWNWDEYFKQs.dHCQLYCDDSSVLFGLIEMEDYNFLRM.K.DHT.ITREKESiwnrnrnRNRNRIVDIIEVQAHKISISNHKVVYLH.....................
A7TTH5_VANPO/29-149 .............yeegnsgyfylns---------.------------.....TIVSYKDHLKFLTE.KQQTEFNG.KN..FLDSEKLFQEy.pNQTFIPWSCEKLFKNLFGNTNTIFMG.G.PQN.LKYDYSLpsgyepiSSEDNANQLSKYSIIPIQYNNEPNKYLY.....................
A0A1G4MCC7_LACFM/21-141 ..........................KISERFTVV.DGFVVKKEKDGS....rKVVNVTRGLARPTK.EERAKISV.HR..LQDLSFFLAQ...SDELLPCSSRMLFETADTVRKLFYRS.P.NGY.KAVVKRR.......TKSPDIKKAREFEVIPINYPHKKFRFLY.....................
H2B1W9_KAZAF/6-126 ..........................YITNNIAII.DGWIVDTSKN--.....FVLTMYNCKQQLDS.YVFTKLNQ.HV..LQNYKSLANP...KNQIFAVESEMLFQHAKLEAHRFYKL.R.DHS.VTLRKSRr....aeRTKKIVEQTIDVKCHRLALGRRNYIYL-a....................
J7S9Y6_KAZNA/61-178 ..........................KISDRCLVI.DGYIVLINANGT....kTLRIKTSSVLFLRK.SKQKAICQ.LK..TVNDEALYNLh.tSSRFIPCTSSKLFKFMETESVYVMET.A.HGL.QL-----.......ATREQKPMARKLDVIRFRPQLQMFKYLY.....................
A0A875RXN8_EENNA/5-120 .........................e-VNSKLSII.DGFLYDKELKQV.....IDPESKRSLDDLGFrSLFQKYSN.KV..LCIHDAFDN-...LDEVYIVSCSSLFKEISNKVVRFVYS.I.NTF.EHMST--.......DRKPLTKNSEEVPLIPVYDG--------grvfyi...............
H2AYL2_KAZAF/4-124 .........................i-ISERYCVI.EGWIVDQVDR--.....IIVPKSKIVKNLVP.KKLELLNR.QF..LIDFKNVDLS...QSVIYEYTSQELHDLIDKEFYEFSEL.L.DGR.IINKDGRi....yqRSKTKIKRTFTKRCHRVSIHGRQYVYL-l....................
YHE9_YEAST/1-89 ...................mkvsdrr---------.------------.....--------------.----KFEK.--..-ANFDEFESAlnnKNDLVHCPSITLFESIPTEVRSFYED.EkSGL.IKVVKFR.......TGAMDRKRSFEKIVVSVMVGKNVQKFL-t....................
G0VAX2_NAUCC/9-127 ........................ip--SGQFTVI.DGFLISLDNRTA.....NDISSESAKELLTPgSWYILKNS.YN..PISLTVLQLM..sSNYMFTNHPLLLFVLRPTVYVRFVRK.N.NKY.HCVKT--.......NKAHGTHKAFALDCE-------------rtdepktkfivf.........
A0A7H9HQ16_9SACH/293-407 ..........................KISDRFVIV.DRLLIDLESRMV.....INPEGTNFLKTATV.EEKERLAK.HR..LMSWAALES-...AKEPIIIRTQPLVDVIDHTLQEF---.R.AGA.KNPSK-K.......ISSARLPNTVTQRQIMLHFENLGTKC--vi...................
A0A1S7HKD6_9SACH/3-89 .................vsdkrefek---------.------------.....--------------.--------.--..-ANFEEFELAlnnKNDLVDCHSITLFESIRTEVRSFYED.EkSGL.IKVVKFR.......TSAMDRKRSFEKIVIAVMVKKNVQKFL-t....................
G0VF17_NAUCC/47-172 ..........................YISDNVSVV.DGFVVLTIEKEGasvrkVVKKFHPKSKLFLL.EERTKLAN.YA..LVDLDEYHTAf.pGSDLVPVPSSQLFSVCTTSKRLFYTT.P.DGF.RIVNS-K.......TPDRHRRCSQEYTVIPVVYKDKPTKYLY.....................
J7S5G0_KAZNA/4-121 ..........................QITDDIVVI.DRWIVSIPDRKV.....--VSSFAAKRQLSQ.ANYRKLVA.IE..PVDLTRFT--...-TTFHTVDSPELFQHIDLHPHEFAVL.P.NGD.AVPRSSVa....yrRADKSKCNLFTRMSHRVSTGGRRVVYLV.....................
G0VBZ4_NAUCC/81-206 ..........................YISDNVSVV.DGFVVLTIEKEGasvrkVVKKFHPKSKLFLL.EERTKLAN.YA..LVDLDEYHTAf.pGSDLVPVPSSQLFSVCTTSKRLFYTT.P.DGF.RIVNS-K.......TPDRHRRCSQEYTVIPVVYKDKPTKYLY.....................
G0WAK9_NAUDC/436-553 .........................i-PSKRYIIV.DRFLIDIVGKRV.....VDPMDHELLKEMTY.REREITFG.KG..LYDWNLLLF-...NEDPIPTFSTILFNLVEYSSSQILWD.R.YGD.IHLQPT-.......MINANGSNVQIRRTVAIDLKENGIRYIY.....................
YL067_YEAST/2-89 ...................kvsdrrk---------.------------.....--------------.--------.FE..KANFDEFESAlnnKNDLVHCPSITLFESIPTEVRSFYED.EkSGL.IKVVKFR.......TGAMDRKRSFEKIVVSVMVGKNVQKFL-t....................
A0A1S7HAQ1_9SACH/283-401 .........................d-ISSRYVVI.ENFVVDLESKSL.....VDPQNEEWLANLSA.LEKEQLES.TN..PLDWNVLKL-...CKEAYPVYNRKLFDLAESTEKNLFRD.S.SGG.VHILEPE.......GKSADVWAQFTCRCIIVNFQDFGPRVLY.....................
A0A1G4M8S9_LACFM/3-123 .........................v-VSDRYTAI.GGFLIKTTKDGS....kRIVNPNPNTLKLRK.SEAQRILE.LK..LRDLSMYERW...KEDLIFLDCPLLFEAVTNQKKYFYHT.I.NGM.RAVKAHM.......TCRADMKRAIAYRVLPIVLPNRSRKYLY.....................
J7RUF2_KAZNA/25-137 ..llgdrwlrcldqrqrhqdsayqnv---------.------------.....-------QRVFLRK.SEQKAICQ.LK..TVNDEALYNLh.tSSRFIPCTSSKLFEFMETNSVYVMET.A.HGL.QL-----.......ATREQKPMARKLDVIRFRPQLQMFKYLY.....................
A0A1S7HNJ2_9SACH/283-401 ..........................KISDRYVVI.EDFVVDLESKSL.....MDPQNGEWLANLSP.LEKEQLKS.AN..PLDWNVLKL-...YKEAYPVYNRKLFDLAESTEKNLFRD.S.SGG.VHVLEPE.......GEGANVCSQFTCRCINVNFQDFGPRVLY.....................
G0V602_NAUCC/176-286 ..........................TISDRITWV.DGFVVFTKEDGR....kIIDGYPEYTS----.DELAKLAS.YE..VIDITSFFLDy.pDEILIEINSSSLFHYATTIQKTF---.-.-EP.SVIN---.......YKRSCGPNHSTFTVIPLKDLASNDKFLY.....................
G0VL22_NAUCC/3-122 .........................s-LNDQYSII.DGWLVDFINKCV.....VDPLHQSIKSSFRD.GNYNELLK.HK..FVHFRDLEDA...KTILIGIDSKQLFEHVQQRMYIFVKT.V.DGE.LKLKNSV.......IANQSIVNEFTKKCHKITLENGKEVYLF.....................
YEI5_YEAST/1-89 ...................mkvsdrr---------.------------.....--------------.----KFEK.--..-ANFDEFESAlnnKNDLVHCPSITLFESIPTEVRSFYED.EkSGL.IKVVKFR.......TGAMDRKRSFEKVVISVMVGKNVKKFL-t....................
YRF17_YEAST/35-153 ........................gq----SFVYI.DGFLVKKHNNQH.....TIVNFETYKNKMKV.SDRRKFEK.AN..FDEFESALNN...KNDLVHCPSITLFESIPTEVRSFYED.EkSGL.IKVVKFR.......TGAMDRKRSFEKIVVSVMVGKNVQKFL-t....................
C5DLF8_LACTC/3-119 .........................l-ISSRYSVV.DGFLIASQQNGT....kVIIDHETCCLSLNK.AEKDLISA.KK..LRDLSRYRKS...KSKLVACESQLLFEIVTAAPQVFIQN.S.NYT.REA----.......NKGNNIKYTQSLLVIPAFFFSDVKKYFF.....................
C5DFV4_LACTC/3-123 ..........................KISDRFAAI.HGFLIKTNRDGT....kRITCPNISSLKPTK.KEVQRILE.LK..LQNLAVYLGM...KEDLIYVDCPLLFETVTSEQRYFYST.E.DGM.KAVRSGR.......TNSANTRRSIEYRVLPITLPNKTRKYLC.....................
A0A7H9HKN9_9SACH/293-407 ..........................KISDRFVIV.DRLLIDLESRMV.....INPEGANFLKTATV.EEKERLAK.HR..LMSWAALES-...AKEPIIIRTQPLVDVIDHTLQEF---.R.AGA.KNPSK-K.......ISSARLPNTVTQRQIMLHFENLGTKC--vi...................
YIR7_YEAST/2-89 ...................kvsdrrk---------.------------.....--------------.--------.FE..KANFDEFESAlnnKNDLVHCPSITLFESIPTEVRSFYED.EkSGL.IKVVKFR.......TGAMDRKRSFEKVVISVMVGKNVKKFL-t....................
G0W7A9_NAUDC/5-125 .........................r-IDENHWVI.DHFLVQERNGVK.....YIKHFTNSDRYLDQ.YRRHKVNL.MN..TINLKKLSSEy.pNTSIIPCQSKLIFDHVQTFTYEFYRK.G.EGL.FKVNA-R.......TPRRFRDISSPFTVIPFFPKAGPAKYLY.....................
A0A7H9HPZ6_9SACH/8-128 ........................qi----RFIAV.GGFLLQAVKSDQr...yKIVNFKYALRTMNE.AEKKRLQN.EE..LFDIDEYLSY...ENDLLDTSSKMLFEYIAPEQKDFYVDsE.TGA.IKVVTGR.......TASAVKKSSATELVITITYPTNKKKYL-r....................
G8ZUI4_TORDC/11-128 .......................kgq-----LTVI.DGFVVKLTTQKN....dERNGSETQDPDTTQ.KIRALQSA.FQ..CESLRRLQHV...SSNFVVTNNSMLFEVVTEKEYIMFVN.S.KGR.FYCRKIH.......HSKATH----------------------vaiairmtrkrgqrtskyvvy
G0V602_NAUCC/1350-1472 ..........................MISDRFFVV.NGFIVDTSCRVTg..kdIIRPKDFVLERCSE.FEKALLNK.QY..LFDVDSFQFE..dTADIFPIDAPALFFQCTTSVERFIYT.E.CGF.LHWNPHG.......KYKPKRGELETHRVIPVSLGD-ITKY--vr...................
G0VIY8_NAUCC/593-713 .........................f-VSQRWSVI.DGYLLEKVAGKC.....FIRDYGNIAHRLRT.YEKMKLSN.YK..LLSLSSIRLQy.pNTDLVPCSSKELFAQSHLEVKKFVRT.D.EGF.KLLSK-S.......VRRKARRDAIEFTVIPIRYRSGPEKYFY.....................
C5DDD6_LACTC/3-123 ..........................KISDRFAAI.HGFLIKTDRDGT....kRITCPNISSLKPTK.KEVQRILE.LK..LQNLAVYLGM...KEDLIYVDCPLLFETVTSEQRYFYST.E.DGM.KAVRSGR.......TNSANTRRSIEYRVLPITLPNKTRKYLC.....................
G0WHE0_NAUDC/3-128 ..........................TISETVAVI.DGYVILTSKDEHgvetkTIKQLTEKTRYFSF.VERTKQSN.QK..LVDLDEFQTAy.sNSSLIPVASQELFEYCTTYEREFYTT.D.DGF.AIINA-R.......TSKKYRQRGQSFTVIPVHFKKKATKYLY.....................
A0A1S7HS27_9SACH/3-89 .................vsdkrefek---------.------------.....--------------.--------.--..-ANFEEFELAlnnKNDLVDCHSITLFESIRTEVRSFYED.EkSGL.IKVVKFR.......TSAMDRKRSFEKIVIAVMVKKNVQKFL-t....................
A0A4C2EAQ0_9SACH/283-397 ..........................KINDNYGIV.DKFVIDLPAKCI.....--VDPETIN--LSL.KERVFLQE.QN..TIDWSAFKL-...LRGPIPIHNTVLFDHVNWELRRFSKD.H.QGH.ISILEDI.......NENFADSNSIACRCIAVNLKEFGIMYLY.....................
SIR1_YEAST/3-125 ..........................QINSRLAVI.DGWLVDTVKRKP.....INFRSPEVRLLLPNdDDYKKLSQ.QN..LVDWTRLKKD..sNSVLVGVKSMELFKHIKLVLREFFLL.E.DGR.IILKRIR......sKLRYKVVKKLTCKCCRLYLPKWGTVYIH.....................
YRF13_YEAST/35-153 ........................gq----SFVYI.DGFLVKKHNNQH.....TIVNFETYKNKMKV.SDRRKFEK.AN..FDEFESALNN...KNDLVHCPSITLFESIPTEVRSFYED.EkSGL.IKVVKFR.......TGAMDRKRSFEKIVVSVMVGKNVQKFL-t....................
A0A7H9HWF0_9SACH/3-124 ........................qq---TRYINV.DGYLLQAVDGETs...yKIVSFKNARSRMSM.KEREQFEK.DE..LVDIDGYLSQ...ESDLFDCTSKRLFEMIPTQQRLFWEQ.L.EPRaTKVVTTR.......TPAECKRSSTNEDVIQITYKANRKKFL-r....................
YE19_YEAST/1-89 ...................mkvsdrr---------.------------.....--------------.----KFEK.--..-ANFDEFESAlnnKNDLVHCPSITLFESIPTEVRSFYED.EkSGL.IKVVKFR.......TGAMDRKRSFEKIVISVMVGKNVQKFL-t....................
YL462_YEAST/1-89 ...................mkvsdrr---------.------------.....--------------.----KFEK.--..-ANFDEFESAlnnKNDLVHCPSITLFESIPTEVRSFYED.EkSGL.IKVVKFR.......TGAMDRKRSFEKVVISVMVGKNVKKFL-t....................
A0A1S7H7T7_9SACH/2-89 ................kvsdkrefek---------.------------.....--------------.--------.--..-ANFEEFELAlnnKNDLVDCHSITLFESIRTEVRSFYED.EkSGL.IKVVKFR.......TSAMDRKRSFEKIVIAVMVKKNVQKFL-t....................
G0WHB8_NAUDC/3-120 ..........................KLNSRYVAI.DGWLVDIDQKR-.....-IINPEDIADDLPN.EDYFKLSQ.LH..LKNWEEVSDE...PQLFISTKSQLLVEKIRWRLQDFVEL.L.DGR.IVPKSTQ.......IPTTEVLDEFSRKCHKLTLSNKISKYLF.....................
A0A7H9B0U5_ZYGMR/5-126 .........................e-VSDKYVVV.NGWLVDRKEKKV.....-VNPSWRSRRKLSK.QRQNVILD.QD..LSAWDRYLTS...ESVILPVADPELFSFIQVRPYDFAEL.R.DGK.TVAQSKEl....yrRNPGSVRRSFTLQCHRVNIRARKHKYI-r....................
A7TTF0_VANPO/47-171 ..........................TISERYTII.DRFLIHTEKKNGnv.irKIVDANFRKGFIRD.DERTEIEK.YD..LINLDELRETn.kHSEMIPCYSTELFDYCDTITRRYYWD.N.RNL.VLFTD-R.......SKKEKERETKTYTVIPLRKRHSVIKYLY.....................
G0WEH4_NAUDC/296-413 ..........................KISDSLMVT.GGFLVDIIEKKI.....INPNEQDYLRNLTD.EEKEYIEE.CD..LVDWNILKL-...TKHPYAVDSPQLFDTLNANNEDFYED.K.NGD.LWIVPP-.......TEYKGALTPRKYRSIPLHFKSFGWRHIY.....................
G0VET8_NAUCC/79-204 ..........................YISDNVSVV.DGFVVLTIEKEGasvrkVVKKFHPKSKLFLL.EERTKLAN.YA..LVDLDEYHTAf.pGSDLVPVPSSQLFSVCTTSKRLFYTT.P.DGF.RIVNS-K.......TPDRHRRCSQEYTVIPVVYKDKPTKYLY.....................
G0V9E1_NAUCC/298-414 .........................a-ISERYTVV.DKYVVDTQERKL.....--IDPEVLRRSGTD.EEKDQLSN.YT..LLDWNVLKL-...SKYPYGSDAEELFDILNAPSEDFYED.I.KGN.ISTNREM.......LDQKGKIKTVPHRSVSIYFEEFGWKHIY.....................
J5RW32_SACK1/2-89 ....................kisdkr---------.------------.....--------------.-------K.FE..KVNFEEFESAlnnKNDLVHCHSITLFESIRTEVRSFYED.E.KSSlIKVVKYR.......TDAMDRKRSFEKIVIAVMVKKNVQKFL-t....................
YRF15_YEAST/2-89 ...................kvsdrrk---------.------------.....--------------.--------.FE..KANFDEFESAlnnKNDLVHCPSITLFESIPTEVRSFYED.EkSGL.IKVVKFR.......TGAMDRKRSFEKIVISVMVGKNVQKFL-t....................
G0VG78_NAUCC/3-123 ..........................KFNDRYAII.NGWIVDLVDSKI.....IN-PYSRSDRFTIGaSLMKEIWK.WH..PRNLNDYYNP...NCFLYCEDSEELLKYLPTKQYSFHKL.K.SGS.ILPNTMH......rQSPRNVVEVLSYPCYQLSFGKNRTIFIH.....................
G0WAQ5_NAUDC/3-128 ..........................TISENVVLI.KGFIVLKSKDKQgvetkIIRNLTKTSKFFST.WERELLSI.QS..LVDIDEYQTTh.sKCDLIPMPCKELFDYCTTVEKNCYVS.E.DGY.QIVNA-R.......TPKRFQQLAQKYVVIPLYCKHKRTKYFY.....................
YRF16_YEAST/35-153 ........................gq----SFVYI.DGFLVKKHNNQH.....TIVNFETYKNKMKV.SDRRKFEK.AN..FDEFESALNN...KNDLVHCPSITLFESIPTEVRSFYED.EkSGL.IKVVKFR.......TGAMDRKRSFEKIVVSVMVGKNVQKFL-t....................
A0A7H9HNL1_9SACH/3-124 ........................qq---TRYINV.DGYLLQAVDGETs...yKIVSFKNARCKMSM.KEREQFEK.DE..LVDIDGYLSQ...ESDLFDCTSKRLFEMIPTQQRLFWEQ.L.EPRaTKVVTTR.......TPAECKRSSTTEDVIQITYKANRKKFL-r....................
J7RNF0_KAZNA/56-173 ..........................KISDRCFVI.DGYIVFINANGT....kTLRIKMFSVSFLHK.FEQEALCQ.LE..TVNIEALYNLh.tCSRFIPCTSSKLFEFMETNSVYVMET.A.HGL.QL-----.......ATREQKPMARKLDVIRFRPQLQMFKYLY.....................
C5DDD3_LACTC/3-123 ..........................KISDRFAAI.DGFLVKKDKSGL....rRIVNTISTTFKPNK.QEARCIEK.LQ..LRNLALYFDC...KDDLLPHDCPLLFKTVSSKRKLFYHT.E.DGI.KVVKSGK.......TSSRDMRRAIEHAVIEIPLSGSQKKYLV.....................
G0W5M5_NAUDC/1-58 .........................m---------.------------.....--------------.--------.--..----------...-------PCKELFDYCTTVEKNCYVS.E.DGH.QIVNA-R.......TPKRFHQLAQKYLVIPLYCKHKRTKYFY.....................
YRF11_YEAST/2-89 ...................kvsdrrk---------.------------.....--------------.--------.FE..KANFDEFESAlnnKNDLVHCPSITLFESIPTEVRSFYED.EkSGL.IKVVKFR.......TGAMDRKRSFEKIVISVMVGKNVQKFL-t....................
A7TSQ1_VANPO/16-149 sysisdglfirenyegypcdliylnf---------.------------.....TIVSYKGHLQFLTE.EEQINFSG.KN..FLDSEKLFQQy.pNQTFIPWSCEELFEGIFNGTHVVCMG.G.PQE.LKYDYSLlsgyrpiSSEDNAYQFSKYSVIPIQYNNEPHKYLY.....................
#=GC seq_cons ..............................ph.hl.stall.h.ppt......h..t.t.....h....phthhtp.hp..hhsh-phpst...ps-LlsssS.pLF-hlsTph+pFacs.p.sGh.hplsp.+.......osstsccpuhchhVIslhhtcpspKaL......................
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