#=GF ID SopE_GEF
#=GF AC PF07487.17
#=GF DE SopE GEF domain
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF SE Pfam-B_18665 (release 7.8)
#=GF GA 25.00 25.00;
#=GF TC 25.70 26.00;
#=GF NC 24.60 24.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 12093730
#=GF RT Structural basis for the reversible activation of a Rho protein
#=GF RT by the bacterial toxin SopE.
#=GF RA Buchwald G, Friebel A, Galan JE, Hardt WD, Wittinghofer A,
#=GF RA Scheffzek K;
#=GF RL EMBO J 2002;21:3286-3295.
#=GF DR INTERPRO; IPR016019;
#=GF DR SCOP; 1gzs; fa;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This family represents the C-terminal guanine nucleotide
#=GF CC exchange factor (GEF) domain of SopE. Salmonella typhimurium
#=GF CC employs a type III secretion system to inject bacterial toxins
#=GF CC into the host cell cytosol. These toxins transiently activate
#=GF CC Rho family GTP-binding protein-dependent signaling cascades to
#=GF CC induce cytoskeletal rearrangements. SopE, can activate Cdc42, an
#=GF CC essential component of the host cellular signaling cascade, in a
#=GF CC Dbl-like fashion despite its lack of sequence similarity to
#=GF CC Dbl-like proteins, the Rho-specific eukaryotic guanine
#=GF CC nucleotide exchange factors [1].
#=GF SQ 17
#=GS A0A509D3H2_9ENTR/11-80 AC A0A509D3H2.1
#=GS A0A8J7H008_9ENTR/124-185 AC A0A8J7H008.1
#=GS A9MNG9_SALAR/103-238 AC A9MNG9.1
#=GS A0A0N1J5N7_9PSED/89-226 AC A0A0N1J5N7.1
#=GS Q7P1B7_CHRVO/107-240 AC Q7P1B7.1
#=GS A0A4Z0PIE8_SALET/103-225 AC A0A4Z0PIE8.1
#=GS A0A2G3K6S2_9BURK/148-294 AC A0A2G3K6S2.1
#=GS A0A2X4T8T3_SALER/103-238 AC A0A2X4T8T3.1
#=GS A0A8J7GUR8_9ENTR/399-505 AC A0A8J7GUR8.1
#=GS A0A656YHN9_SALNE/27-162 AC A0A656YHN9.1
#=GS C4K8Y0_HAMD5/331-475 AC C4K8Y0.1
#=GS A0A8J7KR15_9ENTR/166-215 AC A0A8J7KR15.1
#=GS A0A447M3A7_SALBN/3-80 AC A0A447M3A7.1
#=GS SOPE2_SALTY/103-238 AC Q7CQD4.3
#=GS BOPE_BURPS/107-243 AC Q63K41.1
#=GS A0A839VX08_9BURK/49-183 AC A0A839VX08.1
#=GS A0A4R1NMY8_9GAMM/123-262 AC A0A4R1NMY8.1
A0A509D3H2_9ENTR/11-80 ..............ktri----....RSQTREAILSAVYSKNKDQCCKLL.....I....SK....G.INIAP.FLKEIGEAAQNAGLPGAT..K..ND....VFTPSGA..GANPL--------..------------------....----------------------------------------..........
A0A8J7H008_9ENTR/124-185 .............dkrgf----....-EQLVEATMASAYSEASDAMTAYC.....Q....RI....G.QPVPKgYVHEIGMASMENGLKCAD..K..H-....-------..-------------..------------------....----------------------------------------agkn......
A9MNG9_SALAR/103-238 ..................DPDY....ARQTCEAMLSSVYSNNKDQCCKLL.....V....SK....G.ISITP.FLKEIGEAAQNAGLPGEI..K..NG....IFTPGGA..GTNPFVVPLIASA..SVEYPHMFINYSQQVSFK....AYAEKIIMKEVTPLFNEGTMPTPQQFQLTVENIANKYLQN..........
A0A0N1J5N7_9PSED/89-226 ..dpknreelvagcftli----....----------------HDNCEK-L.....V....DKqkmpS.DQALS.FKQQLGRLAWKVGLPGEA.nK..QG....VFVPRGAgsGANPLLNPLKDLI..LREHAHIFKHPVLREKIF....AMAEKKIIAFVSDHMNPEESKRLDCFQHERALLEKQWRN-d.........
Q7P1B7_CHRVO/107-240 ..................DPVY....RRQALESTYATIYSEAKQAFYR--.....A....NG....G.KMPEG.YLRELGEAARAAGLPGEN..K..HG....VFIPSGD..GASPFVNYLLIPV..QKEFGHRLRNESQQRLFR....DFARQLSMELVAPHAAERGWEPPAAFAARLEAVGRPWLAQ..........
A0A4Z0PIE8_SALET/103-225 ..................DPAY....ARQTCEAILAAVYSNNKDQCCKLL.....I....SK....G.ISITP.FLKEIGEAAQNAGLPGEM..K..NG....VFTPGGA..GANPFVVPLIAAA..SIKYPHMFINHNQQVSFK....AHAEKIVMKEVTPLFNKGTMPTPQQFQ-------------..........
A0A2G3K6S2_9BURK/148-294 .............nenii----....-KQYYNAIYASIYSDVKDRIGKSY.....V...gTG....M.KTPNK.AWEEIGLVAKEIGLDGGEetKieNNvetiIFTPKAA..GANPLITQILTPVsmDKRYGPHMTRPEQQREYR....EYAKNLAIEQIRSFALQDGWPDPSEFEARLTEIEKKWQ--fn........
A0A2X4T8T3_SALER/103-238 ..................DPDY....ARQTCEAMLSSVYSNNKDQCCKLL.....V....SK....G.ISITP.FLKEIGEAAQNAGLPGEI..K..NG....IFTPGGA..GTNPFVVPLIASA..SVEYPHMFINYSQQVSFK....AYAEKIIMKEVTPLFNEGTMPTPQQFQLTVENIANKYLQN..........
A0A8J7GUR8_9ENTR/399-505 vlsaaaqiayhkglcdgi----....------------------------.....-....--....-.--RNS.YLHTIGSAAQDAGLSGNTphR..DK....AFTPTGA..GANPYIRPTLDAV..TQHYPDALMNPEIKDQLS....KHAHHQLMAEIDTLSK------------------------hlkpklesl.
A0A656YHN9_SALNE/27-162 ..................DPAY....ASQTREAILSAVYSKNKDQCCNLL.....I....SK....G.INIAP.FLQEIGEAAENAGLPGTT..K..ND....VFTPSGA..GANPFITPLISSA..NSKYPRMFINQHQQASFK....IYAEKIIMTEVAPLFNECAMPTPQQFQLILENIANKYIQ-y.........
C4K8Y0_HAMD5/331-475 ..................EAKYnqttRNQLIDAGLASVYAQKIDDFKKKY.....G....ES....S.ETGQK.FLFEIGKVCKENGVKCTQ.nK..NG....TWVVNGA..GAHPVIYPISQNI..FTKFKMHLKLSNNKTKMYdksiSYITNKVYKKTDELCKQENRITTSDLRSLLDDVEKKVLD-g.........
A0A8J7KR15_9ENTR/166-215 ..................DTHY....DSQAIDSALCAIYSNHKDTFLKRL.....E....HS....A.KPVQNkLL----------------..-..--....-------..-------------..------------------....----------------------------------------stlpadtqqs
A0A447M3A7_SALBN/3-80 ...............clp----....------------------------.....-....--....-.-----.------------------..-..--....---PGGA..GANPFITPLVSSA..SIKYPYTFINHNQQTSFK....AYAEKLIMEEVTPLFKEQNLPTPQQFHLTLENIASKYIQN..........
SOPE2_SALTY/103-238 ..................DPAY....ARQTCEAILSAVYSNNKDQCCKLL.....I....SK....G.VSITP.FLKEIGEAAQNAGLPGEI..K..NG....VFTPGGA..GANPFVVPLIASA..SIKYPHMFINHNQQVSFK....AYAEKIVMKEVTPLFNKGTMPTPQQFQLTIENIANKYLQN..........
BOPE_BURPS/107-243 ..................DAEF....GRQVYEATLCAIFSEAKDRFCMDP.....A....TR....A.GNVRPaFIEALGDAARATGLPGAD..K..QG....VFTPSGA..GTNPLYTEIRLRA..DTLMGAELAARPEYRELQ....PYARQQAIDLVANALPAERSNTLVEFRQTVQTLEATYRR-a.........
A0A839VX08_9BURK/49-183 .............dkeat----....-VQMVDSLFCSVYFSRKNEFDHLN.....T....EL....GyKTPSD.YLRDIGQAAKEMGVLCGE..K..DD....YLVPNGA..GADIFTNIFISEI..LKTMPGQNGQPCDPTKYQ....RIAKNIAFNVVADLTGERTR--VEAFSNKLAVLANKY---apg.......
A0A4R1NMY8_9GAMM/123-262 ..................DEKY....KEQVIDAIFSAMYRDVKTSFKIHYfhnkpGvlgeNE....S.SLPRE.YLKTMGQAAYDWGVACYE..K..EG....IYFPKGE..GANPLLNAVLSIL..QKNNPIATR---DQKNIE....RINRE-INVMVDAYCTAHGLKSPVAFESALIDINKNW---ql........
#=GC seq_cons ..........................tpQhh-AhhuulYSpsKDphp+hh.....h....sp....u.hshps.aLc-IGpAAppsGLsGtt..K..ps....lFsPsGA..GANPhls.lls.h..phcashhhhp.ppphphp....taAcphhhp.Vsshhtttsh.ssttFp.hlt.ltppa.............
//
