#=GF ID Spidroin_N
#=GF AC PF16763.9
#=GF DE Major ampullate spidroin 1, spider silk protein 1, N-term
#=GF PI Spidrion_N;
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE pdb_3lr8
#=GF GA 27.00 27.00;
#=GF TC 27.90 27.30;
#=GF NC 26.90 24.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF WK Spidroin
#=GF RN [1]
#=GF RM 20463740
#=GF RT Self-assembly of spider silk proteins is controlled by a
#=GF RT pH-sensitive relay.
#=GF RA Askarieh G, Hedhammar M, Nordling K, Saenz A, Casals C, Rising
#=GF RA A, Johansson J, Knight SD;
#=GF RL Nature. 2010;465:236-238.
#=GF DR INTERPRO; IPR031913;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Spidroin is produced by a number of arachnids. Spidrions are
#=GF CC made up of repetitive segments flanked by conserved
#=GF CC non-repetitive domains, and this domain is the conserved
#=GF CC non-repetitive region. Aggregation to form the rigid silk occurs
#=GF CC due to association at the repetitive regions, and the N-terminal
#=GF CC domain is necessary to prevent premature aggregation during
#=GF CC storage before extrusion. This N_terminal region inhibits
#=GF CC precocious aggregation and then accelerates and directs
#=GF CC self-assembly as the pH is lowered along the extrusion duct [1].
#=GF SQ 48
#=GS A0A087UQ25_STEMI/26-141 AC A0A087UQ25.1
#=GS A0A087TBZ4_STEMI/27-147 AC A0A087TBZ4.1
#=GS A0A4Y2MH26_ARAVE/29-151 AC A0A4Y2MH26.1
#=GS A0A4Y2H2M6_ARAVE/42-166 AC A0A4Y2H2M6.1
#=GS A0A4Y2BXZ1_ARAVE/38-160 AC A0A4Y2BXZ1.1
#=GS A0A4Y2DF07_ARAVE/28-151 AC A0A4Y2DF07.1
#=GS A0A087U971_STEMI/30-155 AC A0A087U971.1
#=GS A0A4Y2JZE6_ARAVE/30-154 AC A0A4Y2JZE6.1
#=GS A0A4Y2MS00_ARAVE/28-151 AC A0A4Y2MS00.1
#=GS A0A4Y2VNC2_ARAVE/29-153 AC A0A4Y2VNC2.1
#=GS A0A4Y2M3Y8_ARAVE/1-78 AC A0A4Y2M3Y8.1
#=GS A0A4Y2KDY5_ARAVE/29-153 AC A0A4Y2KDY5.1
#=GS A0A4Y2P658_ARAVE/26-147 AC A0A4Y2P658.1
#=GS A0A4Y2DG99_ARAVE/33-155 AC A0A4Y2DG99.1
#=GS A0A4Y2EIK3_ARAVE/29-153 AC A0A4Y2EIK3.1
#=GS A0A4Y2JAB1_ARAVE/32-156 AC A0A4Y2JAB1.1
#=GS A0A4Y2UEJ0_ARAVE/5-94 AC A0A4Y2UEJ0.1
#=GS A0A4Y2A7M9_ARAVE/33-158 AC A0A4Y2A7M9.1
#=GS A0A087T9K9_STEMI/28-152 AC A0A087T9K9.1
#=GS A0A4Y2JAB1_ARAVE/291-415 AC A0A4Y2JAB1.1
#=GS A0A087UC47_STEMI/28-152 AC A0A087UC47.1
#=GS A0A087T2Y4_STEMI/1-96 AC A0A087T2Y4.1
#=GS A0A4Y2MPA4_ARAVE/28-151 AC A0A4Y2MPA4.1
#=GS A0A4Y2MZ64_ARAVE/28-151 AC A0A4Y2MZ64.1
#=GS A0A4Y2PU13_ARAVE/34-159 AC A0A4Y2PU13.1
#=GS A0A087SXX8_STEMI/28-152 AC A0A087SXX8.1
#=GS A0A4Y2KG20_ARAVE/28-152 AC A0A4Y2KG20.1
#=GS A0A087UCS9_STEMI/29-146 AC A0A087UCS9.1
#=GS A0A4Y2R483_ARAVE/32-158 AC A0A4Y2R483.1
#=GS A0A087URD1_STEMI/45-171 AC A0A087URD1.1
#=GS A0A4Y2H963_ARAVE/30-152 AC A0A4Y2H963.1
#=GS A0A4Y2RUY4_ARAVE/28-151 AC A0A4Y2RUY4.1
#=GS A0A4Y2VIT6_ARAVE/28-152 AC A0A4Y2VIT6.1
#=GS A0A4Y2MMJ3_ARAVE/28-151 AC A0A4Y2MMJ3.1
#=GS A0A4Y2GZW4_ARAVE/17-56 AC A0A4Y2GZW4.1
#=GS A0A087TBY8_STEMI/28-152 AC A0A087TBY8.1
#=GS A0A087U004_STEMI/31-158 AC A0A087U004.1
#=GS A0A4Y2CXY4_ARAVE/38-154 AC A0A4Y2CXY4.1
#=GS A0A4Y2VKG9_ARAVE/28-152 AC A0A4Y2VKG9.1
#=GS A0A087T9L3_STEMI/28-152 AC A0A087T9L3.1
#=GS A0A4Y2GM25_ARAVE/27-151 AC A0A4Y2GM25.1
#=GS A0A4Y2HWF9_ARAVE/47-171 AC A0A4Y2HWF9.1
#=GS A0A4Y2JSI9_ARAVE/52-175 AC A0A4Y2JSI9.1
#=GS A0A087UPM4_STEMI/28-152 AC A0A087UPM4.1
#=GS A0A4Y2K2Y0_ARAVE/26-147 AC A0A4Y2K2Y0.1
#=GS A0A4Y2J9R3_ARAVE/33-156 AC A0A4Y2J9R3.1
#=GS A0A4Y2K281_ARAVE/26-147 AC A0A4Y2K281.1
#=GS A0A4Y2GLI0_ARAVE/58-182 AC A0A4Y2GLI0.1
A0A087UQ25_STEMI/26-141 ..vd--SSPDTALRFAQCMIQRITQSPFFTEEDTENLIVVTDVMAAAMHDRA----I---PPKIV..MDAFATSMSGIVIG.D.NAFR...NLQRKAEY-SSDLEQCSIAVTGFIDTPFINEALRLVSVLERA---ks........
A0A087TBZ4_STEMI/27-147 ...m-WCDKDIREKFTDCWHNKIVENPTFTNMSISGLDDIKSRLITIPEPIQ--ERLDEVINKAL..EDEITRLLHSVAKS.S.--VQ...SMQEVIEAMMNDIRNCYVEVTGNTQVYLIYSIRDLIDLIMNK---hqp.......
A0A4Y2MH26_ARAVE/29-151 ....PWKDMKSMETFMDIATEKLSSSGRFNDDDVDAVREVGDTLKQSAENMWKKGKMSPKQLGMM..NMAFTAVLADMVYS.D.--GS...NLEEKKNAVDNALSAALVASIGKIDPIFMNEINTLMSTFGQSN--ql........
A0A4Y2H2M6_ARAVE/42-166 ....PWDSPNMAESFMNNFMSGIANSGAFSGDQMGDMQDIAGTMQDSVNKMASTGRSSKSKLQAM..NMAFASSMAEIAAA.E.AGGS...SMAAKTSAITNALRGAFLQTTGVSNEQFINEIATLINLISQSNVN..........
A0A4Y2BXZ1_ARAVE/38-160 .pll---DEDTGENFANVFAQSLENCGAFSHEESQEYREIIQVLTRAFGSFPDLQKAPPGVLKAT..AAGFASAVAERTAS.D.IEQG...ELFAKTRCVIQALREAFIVTTGVTNPYFISEVERLIEVF------yitr......
A0A4Y2DF07_ARAVE/28-151 ...i-LSNPNTAMTFARTFVSNIAGCGEFGSQGTEDFDDIMQSLIQA-QRMGKGRHDTNAKAKAM..QMALASSIAELIVE.E.SGGV...NMQQKTNAAINALRNALRSTSGQVDEGFVSEIVELVNLFSQEQF-n.........
A0A087U971_STEMI/30-155 ....PFANHDTATAFVHSFVRYVSSSEAFGNQGNEDFEEILETLLTAMQQSTYNKKESSARIKTM..TMAFASSIAELIVV.E.DSQE..dELDIKTKIITDALEYAFSEVMGNVDIHFIEEIKILVKIFAEEQ--vq........
A0A4Y2JZE6_ARAVE/30-154 ....PWSSNEKADFFIRSFNEVISRSSAFTSQQIDDMTSIGDTLITSIDNMAKSGKSSTKKLQAL..NMAFASSMAEIAVA.E.QGGQ...NIDVKTNAIIDALNEAFIRTSGRVNNEFISEIRQLILMFSQVSMN..........
A0A4Y2MS00_ARAVE/28-151 ....PFSDPNTAMTFARAFVNNIAGCGEFGSQGTEDFEDIIQSLIQA-QNIGKGRYDSKARAKTM..QIALASSIAELIVE.E.SEGV...NVQQKTNAAINALRNALSSTTGRVDVGFVNEILELVNLFSEEQF-n.........
A0A4Y2VNC2_ARAVE/29-153 ....PWDSPNMAESFMNNFMSGIASSGAFSGDQMGDMQDIAGTMQDSVNKMASTGRSSKSKLQAM..NMAFASSMAEIAAA.E.AGGS...SMAAKTSAITNALRGAFLQTTGVSNEQFINEIATLINLISQSNVN..........
A0A4Y2M3Y8_ARAVE/1-78 ..mn-------------------------------------------------KRHDSNAKAKAM..QMAFASSIAELVIA.E.SEGS...NIQRRTGSVSNCMRNALQSTTGGVSEEFVREIEDLINLFSQESF-n.........
A0A4Y2KDY5_ARAVE/29-153 ....PWENTALAEAFINSFLESIGRTGAFSASQQDDMSTIGDTLKTAMEKMAQSRKSSKSKLQAL..NMAFASSMAEIAVA.E.QGGL...SIQAKTEAIASALSSAFLQTTGVINYQFVSEIKSLIYMIAQATTN..........
A0A4Y2P658_ARAVE/26-147 ....IWTDQAAAMTMTNNFVACASQSGMLSADQMDDMAMMADTINMQATRMG--PNAPLHKLKAL..NSAMAASIAEVAAS.S.PPE-...SYSAVLNTIGGCLRDSMMQATGAVDEIFTTEVMKMVTLFAMDNAN..........
A0A4Y2DG99_ARAVE/33-155 .efn-----ETEKKFAKVFIKNVMNSEEFGKKGNMDFVEVTETLLKAISLLQQTKYADSSEKEAL..MYAFASAIAELIVD.Q.CDES..vGIAQKTNIVTSALQNAYLKTSGYPNDELIKEVRILVMIF------ltidn.....
A0A4Y2EIK3_ARAVE/29-153 ....PWESPQLAQSFINSFLRAISRSGAFSYSQLDDMSTIGETLTIAMDKFTGSNKNIKSKLQAL..DMAFASSMAEIAVA.E.QGGL...SISEKTNAIENALNAAFLETTGVIFTQFVSEIKSLIFLIAQASTN..........
A0A4Y2JAB1_ARAVE/32-156 ...p-FGFNETEKKFADSFVDNVINSGSFSKIGEDDIEEITNILLKAVQLLKKSQDADANQKKTL..MVAFASSMAELILD.RcDTNL...GIEKKTEIIVNALKQAYLQTTGKPNNPLLKEVRFLVALFL-----tlek......
A0A4Y2UEJ0_ARAVE/5-94 vyek--------------------------------------HLPAAMEKFNNSNTTSKTKFQAL..NMVFASAVAEITAA.E.DAV-...NKELKPNAIQNALYSAFLETIGIINTQFASDIKNLIYTLAHTTSN..........
A0A4Y2A7M9_ARAVE/33-158 ....PFANYDTAEAFTRSFVHHVIQSNIFGNQTVQDIEGIVDTLVMAMKESIQGQTESRAKIKAM..TMAFASSIAELIVS.E.NSGE..tDIQKKTHLIVKSLEDAFKETTGEVNRGFIQQVKILVELFSLES--ge........
A0A087T9K9_STEMI/28-152 ....VWGNPSTAEGLLQAFTQQLQASGAFSYDQMDDISSISDTIMDAIERSARSNRSSKSKLQAL..NMAFASSVAEIAAA.G.EGGQ...PLSFKTGAIIDALASAFIQTTGMVDQVFLNEMNELITMFTQASAN..........
A0A4Y2JAB1_ARAVE/291-415 ...p-FGFNETEKKFADSFVDNVINSGSFSKIGEDDIEEITNILLKAVQLLKKSQDADANQKKTL..MVAFASSMAELILD.RcDTNL...GIEKKTEIIVNALKQAYLQTTGKPNNPLLKEVRFLVALFL-----tlek......
A0A087UC47_STEMI/28-152 ....IWGNPSKAESFLQGFTRALQYSGVFTYEQMDDISSISDTIMGAIGRSARSNRNSRSKLQAL..NTAFASSVAEIAAS.T.EGGQ...PISVKTGAIINALESAFLETTGSVDQAFLNEISQLIKMFTEE---vkr.......
A0A087T2Y4_STEMI/1-96 ....-----------------------------MDDISSISDTIMDAIERSSRSNKNSKSKLQAL..NMAFASSVAEIAAS.G.EGGQ...PLSVKTGAIIDALASAFLQTTGAVDQVFLNEMNELISMFTQASAN..........
A0A4Y2MPA4_ARAVE/28-151 ....PFSDPNTAMTFARAFVNNIAGCGEFGSQGTEDFEDIIQSLIQA-QNIGKGRYDSKARAKTM..QIALASSIAELIVE.E.SEGV...NVQQKTNAAINALRNALSSTTGRVDVGFVNEILELVNLFSEEQF-n.........
A0A4Y2MZ64_ARAVE/28-151 ....PFSNPNTAMTFARAFVNNIAGCGEFGSQGTEDFEDIIQSLIQA-QNIGKGRYDSSARAKTM..QIALASSIAELIVE.E.SEGV...NVQQKTNAAINALRNALSSTTGRVDVGFVNEILELVNLFSEEQF-n.........
A0A4Y2PU13_ARAVE/34-159 ....PWADPVKAKAFMDCLIKKIEQSDVIPQQEKQDMESLVQSLMSALAGNT-KGNNSKATLQAM..NMAFASALAELVVA.E.GADDp.nGIEVKTNALINILQQCFKKTMHKVDKKFIYEIKDLIQMFVKEAA-e.........
A0A087SXX8_STEMI/28-152 ....IWGNPRMAEGLLQAFTQHLQGSGAFSYDQMDDISSISDTIMDAIERSARSNKSSKSKLQAL..NMAFASSVAEIAAS.G.EGGQ...PLSIKTGAIIDALASAFLQTTGTVDQVFLNEMNELISMFTQASIN..........
A0A4Y2KG20_ARAVE/28-152 ....PWDSPNMAEAFMNNFMSGIANSGAFSGDQMGDMQDIAGTMQDSVNKMASTGRSSKSKLQAM..NMAFASSMAEIAAA.E.AGGS...SMAAKTSAITNALRGAFLQTTGVSNEQFINEIATLINLISQSNVN..........
A0A087UCS9_STEMI/29-146 ....IFREEELLRYFLETVTDYLENYGVIQKDQERDILESYNGIIASLQKNQ-KGNK-------I..KHAVASKIAEIIVE.S.VEQN..tDVTYNLEGALQATAAAFQDIIGIVDENFIETVRDMVAVMIN----tdle......
A0A4Y2R483_ARAVE/32-158 ....PWANPAKASSLMNCLLTKIASSNVLPQQEKEDLESIMDTLMSAIKGASAKGKSSGAQLQAI..NMAVASSLAEIVVA.E.DVGNq.aSMAVKTQALSGALEQCFQAVMGRVDRKFINEINDLISMFARQAA-t.........
A0A087URD1_STEMI/45-171 ....PWTNPIKANAFMKCLIQKIAQSPVFPQQEKEDMESIVETMMSAITSMSNSRSTSSATLQAM..NMAFASSMAELVIA.E.DADNq.eGIAVKTDALSKALKQCFIATIGSVNKQFIAEIKDLIVMFAKEAS-e.........
A0A4Y2H963_ARAVE/30-152 ....VFSSSTLASSFLQCLTSGIGSSPAFPSQEQEDLDAIAQVILSAVSSNT--GATSSARAQAL..STALASSLTDLLIS.E.SAEG...NYDNQLSTLTSILSNCFVTTTGSDSPAFVSRIKSLISVLSQNNN-a.........
A0A4Y2RUY4_ARAVE/28-151 ...i-LSNPNTAATFARSFVSNIAGCGEFGSQGTEDFDDIMQSLIQA-QRMGKGRHDTNAKAKAM..QMALASSIAELIVE.E.SGGV...NMQQKTNAAINALRNALRSTSGQVDESFVNEIVELVNLFSQDQF-n.........
A0A4Y2VIT6_ARAVE/28-152 ....PWDSPNMAEAFMNNFMSGIASSGAFSGDQMGDMQDIAGTMQDSVNKMASTGRSSKSKLQAM..NMAFASSMAEIAAA.E.AGGS...SMAAKTSAITNALRGAFLQTTGVSNEQFINEIATLINLISQSNVN..........
A0A4Y2MMJ3_ARAVE/28-151 ....PFSDPNTAMTFARAFVNNIAGCGEFGSQGTEDFEDIIQSLIQA-QNIGKGRYDSKARAKTM..QIALASSIAELIVE.E.SEGV...NVQQKTNAAINALRNALSSTTGRVDVGFVNEILELVNLFSEEQF-n.........
A0A4Y2GZW4_ARAVE/17-56 ....PWDSPNMAEAFMNNFMSGIASSGTFSGDQMGDMQDIA------------------------..--------------.-.----...---------------------------------------------gsg.......
A0A087TBY8_STEMI/28-152 ....IWSDPVIAENFLGSFTESLLNSGIFSSAQLGDISSISQTILDAFGKSGFSNNISKSKVQAL..NMAFASSVAEIIVS.E.DSMV...PLSVAISTMMGALRNSMLKTTGGVDEFFLKEINHLINMIAADR--ln........
A0A087U004_STEMI/31-158 ..is--SRPNSAQTFATSFVNYIVASGVFPEQEEEDMKEFIETLSMAVTSLTNNKWASRAKIEAL..SMAFASAMAELIVI.E.DDDGenvSTDVKVKVISDGLGQAFKETTGSVNEGFIEEIQELLGMFAHA---vvs.......
A0A4Y2CXY4_ARAVE/38-154 .llq------IADEFLYCFMDQS--SKKFPPTGQTYTDAVSGV----IRSFAHQNNDSLSKTQAIvfQTNLATSIADNVDA.E.SQQN...DHPQIFPMVLQLISDCFTEITGYQPSKLIRSITSFLALLLE----dtd.......
A0A4Y2VKG9_ARAVE/28-152 ....PWDSPNMAEAFMNNFMSGIASSGAFSGDQMGDMQDIAGTMQDSVNKMASTGRSSKSKLQAM..NMAFASSMAEIAAA.E.AGGS...SMAAKTSAITNALRGAFLQTTGVSNEQFINEIATLINLISQSNVN..........
A0A087T9L3_STEMI/28-152 ....VWGNPATAEGLLQAFTQQLQASGAFSYDQMDDISSISDTIMDAIERSARSNKSSKSKLQAL..NMAFASSVAEIAAS.G.QGGQ...PLSVKTGAIIDALASAFLQTTGAVDQVFLNEMNELITMFTQASAN..........
A0A4Y2GM25_ARAVE/27-151 ....PWQNARMAENFMSSFSTALGQSQAFSSDQMDDIMSICDSIQSGVDRMDRSGKTSANKLQAM..NMAFASAVAEIAIA.E.GGGQ...SAQVKTNAVADALASAFLQTTGVVNTQFVNEIRTLISMFAQANA-v.........
A0A4Y2HWF9_ARAVE/47-171 lgfn-----ELGDQFAKTFVQNVVNNPKFGKGADTDFTEVTFALSDAMNLLRQAHHAPPEQKRTI..MIAFSATIAELIVI.E.CRDS..lTIFEKVHIVTDALKTAYRQTTGRTNRPLINEVTFLVIIFLDE---tsq.......
A0A4Y2JSI9_ARAVE/52-175 ....IWCNKKTENDFLDCVSKKITRNRELNIP-PDVVEAMVTSLKAA-SSVI--NTSDNIKSEIM..KGAFAGEVLGMVVSiQ.SPGR...NTNSVVASVMGSIEECYIAVTGQSGTKFSSSINRAVT--------nmmlgedsds
A0A087UPM4_STEMI/28-152 ....IWGNPAIAESLLQSFTQSIARSGAFTYDQMDDISSISDTIMDAMDRMARSKKSSKSKLQAL..NMAFASSVAEIAVS.S.DGGQ...PLGVKTNAIMDALADAFMQTTGTIDQVFLREMGELITMFAQASIN..........
A0A4Y2K2Y0_ARAVE/26-147 ....IWSNPGAAMAMTNNLVQCAGRSGALTADQMDDMGMMADSVNTQMQKMG--PNPPKHRLRAM..NTAMAAAAAEVVAS.S.PPQ-...SYNAVLNTIGGCLRDSMMQATGSVDNVFISEVTQMINMFAADNAN..........
A0A4Y2J9R3_ARAVE/33-156 .efn-----ETEKKFAKVFIKNVMKSKEFGTKGNMDFMEVTETLLKAISLLQQTKYSDSWETEAL..MYAFASAIAELIVD.Q.CDER..vGIVEKTNIVTNALQKAYLKTSGHTNDELIKEVRILVMIFL-----sidnm.....
A0A4Y2K281_ARAVE/26-147 ....IWSNPGAAMAMTNNLVQCAGRSGALTADQMDDMGMMADSVNSQMQKMG--PNPPKHRLRAM..NTAMAAAAAEVVAS.S.PPQ-...SYNAVLNTIGGCLRDSMMQATGSVDNVFISEVTQMINMFAADNAN..........
A0A4Y2GLI0_ARAVE/58-182 ....PWQNARMAESFMNSFSSDLGQSGAFSSDQMDDIMSICDSIQSGIARMDRSGKISANKLQAM..NMAFASAVAEIAMA.E.GGGQ...SAQVKTNAVADSLASAFLQTTGVVNTQFINEIRTLISMFAQAN--dv........
#=GC seq_cons .....asssshApsFhpsFspslspSGsFutpph-DhpsIspolhsAhpphspsppsSpu+hpAh..shAFASSlAElssu.-.sssp...shptKTsulhsALpsAahpTTGtlsptFlsEIppLlshFuptp............
//
