#=GF ID   Staphopain_pro
#=GF AC   PF14731.10
#=GF DE   Staphopain proregion
#=GF AU   Eberhardt R;0000-0001-6152-1369
#=GF SE   CATH:1x9y_A_0
#=GF GA   27.00 27.00;
#=GF TC   28.50 28.50;
#=GF NC   26.10 26.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0320
#=GF RN   [1]
#=GF RM   15518582
#=GF RT   Prostaphopain B structure: a comparison of proregion-mediated
#=GF RT   and staphostatin-mediated protease inhibition.
#=GF RA   Filipek R, Szczepanowski R, Sabat A, Potempa J, Bochtler M;
#=GF RL   Biochemistry. 2004;43:14306-14315.
#=GF DR   INTERPRO; IPR028076;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is the proregion of the cysteine protease
#=GF CC   staphopain. Like many papain type peptidases, staphopain is
#=GF CC   synthesised as an inactive precursor and cleavage of the
#=GF CC   proregion is required for activation. This proregion has a
#=GF CC   half-barrel or barrel-sandwich hybrid fold. The proregion blocks
#=GF CC   the active site cleft of the mature enzyme on one side of the
#=GF CC   nucleophilic cysteine [1]
#=GF SQ   7
#=GS A0A1E5GT34_9ENTE/17-128  AC A0A1E5GT34.1
#=GS SSPB_STAA8/41-210        AC Q2FZL3.1
#=GS W1W5U6_9STAP/42-210      AC W1W5U6.1
#=GS SSPP_STAA8/37-203        AC Q2G2R8.1
#=GS A0A143PC52_9STAP/46-216  AC A0A143PC52.1
#=GS R6EHT1_9FIRM/35-137      AC R6EHT1.1
#=GS ECPA_STAEQ/42-210        AC Q5HKF6.1
A0A1E5GT34_9ENTE/17-128             ..daas----LYVKSTDVPNETTVLATQNWQDYLNKMMLADN...G.RSTDYYLGQPFTIS---YPE.STTYNYPIIAKENkQIAYLLQIDSSDSK-.---------------------------..---------------------------------------------------------npdsfilskalakkleelslmipfdgnqai
SSPB_STAA8/41-210                   ......KQLEINVKSDKVPQKVKDLAQQQFAGYAKALDKQSN...A.KTGKYELGEAFKIYKFNGEE.DNSYYYPVI-KDG.KIVYTLTLSPKNKDDlNKSKEDMNYSVKISNFIAKDLDQIKDKnsNITVLTDEKGFY-FEEDGKVRLVKATPLPGNVKEKESAKTVSAKLKQELKNTVTPTK..............................
W1W5U6_9STAP/42-210                 ......KTTKVTVSNKDVPDAVRKLAEEQYLSRVALLDKASN...H.KATSYTLGEPFKIYKFNKES.DGNYYYPVLNKKG.DVVYVVTISPNPSNS.KASKQQNNYSINVSPFLSKILNQYKNQ..KITILTNTKGYFALTEDGKVTLVLKTPRNNEKTYENATESTKSKDLNDFKQTATVTK..............................
SSPP_STAA8/37-203                   ......KHVQVNVEDKSVPTDVRNLAQKDYLSYVTSLDKIYN...K.EKASYTLGEPFKIYKFNKKS.DGNYYFPVLNTEG.NIDYIVTISPKIT--.KYSSSSSKYTINVSPFLSKVLNQYKDQ..QITILTNSKGYYVVTQNHKAKLVLKTPRLEDKKLKKTESIPTGNNVTQLKQKASVTM..............................
A0A143PC52_9STAP/46-216             ....as--LKVKVSNTEVPANAEQQAESQFSSYAQALSQIDK...SgTNGEYKLGKPFKIYKFNGQE.DGNYYFPVL-QGE.HIKYVLTVTPKNENDvNADKNSANYSVRISKFIADSLNQYRQAntPITIFTNKDGYF-AEHNHKIEMIKQTKLADDKTAPSTPAAPKMQ-------------mnktvdasqpisq.................
R6EHT1_9FIRM/35-137                 tqtfei--------STQVPPEAKEFANEHYLDVIEVYATYSDvtfE.KDEKYELGEPFVIYSPAEENqEELYYFPIFCNR-.KV--ILNIS------.---------------------------..---------------------------------------------------------vintskgwtlsaskelvdelnqlgy.....
ECPA_STAEQ/42-210                   ......KTTKVTVSNKDVPDAVRKLAEEQYLSRVALLDKASN...H.KATSYTLGEPFKIYKFNKES.DGNYYYPVLNKKG.DVVYVVTISPNPSNS.KASKQQNNYSINVSPFLSKILNQYKNQ..KITILTNTKGYFALTEDGKVTLVLKTPRNNEKTYENATESTKPKDLNDFKQTASVTK..............................
#=GC seq_cons                       ........hplpVpspcVPsps+pLApppahuhlphLsphsN...p.+sspYpLGEPFKIYKFNtcp.DssYYaPVlspcs.clsYllTISPpspp..phsppp.pYolplS.Fluc.LsQh+pt...ITlhTspcGaa.hppstKhphlhtT.h.tphp..ps.t.sp.p...........................................
//