#=GF ID T4SS_CagC
#=GF AC PF16943.9
#=GF DE Cag pathogenicity island, type IV secretory system
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE HMMER:O25278-TCDB
#=GF GA 27.90 27.90;
#=GF TC 31.30 52.10;
#=GF NC 24.10 23.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Family
#=GF CL CL0690
#=GF RN [1]
#=GF RM 15019987
#=GF RT Comparative analysis of the complete cag pathogenicity island
#=GF RT sequence in four Helicobacter pylori isolates.
#=GF RA Blomstergren A, Lundin A, Nilsson C, Engstrand L, Lundeberg J;
#=GF RL Gene. 2004;328:85-93.
#=GF RN [2]
#=GF RM 17942650
#=GF RT Microevolution of Helicobacter pylori type IV secretion systems
#=GF RT in an ulcer disease patient over a ten-year period.
#=GF RA Alvi A, Devi SM, Ahmed I, Hussain MA, Rizwan M, Lamouliatte H,
#=GF RA Megraud F, Ahmed N;
#=GF RL J Clin Microbiol. 2007;45:4039-4043.
#=GF DR INTERPRO; IPR031607;
#=GF DR TC; 3.A.7;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC T4SS_CagC is a family of putative pathogenicity island, type IV,
#=GF CC conjugal DNA-protein transfer, secretory system proteins from
#=GF CC Gram-negative bacteria.
#=GF SQ 37
#=GS G9WII9_9LACO/2-111 AC G9WII9.1
#=GS A0A075LPX3_9BACI/2-108 AC A0A075LPX3.1
#=GS A0A150LGG2_9BACI/6-117 AC A0A150LGG2.1
#=GS A0A660E7C9_9LACO/2-111 AC A0A660E7C9.1
#=GS G8PF94_PEDCP/2-112 AC G8PF94.1
#=GS G9WHR5_9LACO/2-111 AC G9WHR5.1
#=GS E6LIQ6_ENTI1/4-110 AC E6LIQ6.1
#=GS A0A0D6A5F7_9LACO/2-111 AC A0A0D6A5F7.1
#=GS A0A081BJK8_9LACO/2-111 AC A0A081BJK8.1
#=GS A0A433RNP6_9BACL/2-112 AC A0A433RNP6.1
#=GS A0A1I6U3D2_9BACI/6-112 AC A0A1I6U3D2.1
#=GS K0D9D5_LEUCJ/2-114 AC K0D9D5.1
#=GS A0A7X2D2R1_9LACT/4-114 AC A0A7X2D2R1.1
#=GS A0A0R2L3B6_9LACO/2-111 AC A0A0R2L3B6.1
#=GS A0A3G9M6J4_RHOOP/1-47 AC A0A3G9M6J4.1
#=GS A0A1Z5IEJ4_9LACO/2-111 AC A0A1Z5IEJ4.1
#=GS A0A0R1SL85_9LACO/2-111 AC A0A0R1SL85.1
#=GS A0A2C1K463_9BACI/8-116 AC A0A2C1K463.1
#=GS U5SGF7_9LACT/3-111 AC U5SGF7.1
#=GS A0A429ZSC7_9ENTE/3-110 AC A0A429ZSC7.1
#=GS W6N409_CLOTY/2-112 AC W6N409.1
#=GS A0A377JX76_9ENTE/5-110 AC A0A377JX76.1
#=GS A0A0A0M544_9LACO/2-111 AC A0A0A0M544.1
#=GS A0A0A5FZF9_9BACI/8-115 AC A0A0A5FZF9.1
#=GS A0A0R1VNY9_9LACO/1-90 AC A0A0R1VNY9.1
#=GS A0A0K0G9C6_9FIRM/1-90 AC A0A0K0G9C6.1
#=GS O25278_HELPY/6-107 AC O25278.1
#=GS A0A4R2AZ18_9BACI/3-108 AC A0A4R2AZ18.1
#=GS A0A4Y9H5Y3_9BACL/1-86 AC A0A4Y9H5Y3.1
#=GS A0A660E0M8_9LACO/2-114 AC A0A660E0M8.1
#=GS U6FKK9_LACHE/2-111 AC U6FKK9.1
#=GS G9ZNJ2_9LACO/2-111 AC G9ZNJ2.1
#=GS A0A6G7WKK5_9LACT/1-107 AC A0A6G7WKK5.1
#=GS A0A0R2BA24_SECCO/1-90 AC A0A0R2BA24.1
#=GS U5SCY9_9LACT/4-111 AC U5SCY9.1
#=GS Q6LWE2_LACPL/2-111 AC Q6LWE2.1
#=GS A0A1I3DA45_9LACT/2-109 AC A0A1I3DA45.1
G9WII9_9LACO/2-111 ...................ilnk------VKVLATTGATAIYLG.LMN..AQVVLAADG.GEVKSKLTSAGKTIQGILTGLVVLVGICVALFIIIKRMPD----ADDPREKSEVYHAVGRVAGLVALAAAIIWLLPWVYSL-----ft
A0A075LPX3_9BACI/2-108 ....................pyl----------KTAGVLAFTAG.LFLivPDISFAESD.SSITKRINTGVKSIQTVLTGIVVVVGIVAALKIIIKHLPG----IDDPHVKNEMWKSLGGVLLAVGAAAAVIWLLPWIYGL-----fk
A0A150LGG2_9BACI/6-117 kfnnvywksfaliafacflyfva---------------------.---..PHMGLAAETtASVQTKIKKGTTGFQTVLTGIAVAVGIVASLKIVIKHLPG----IDDPHTKNEMWKSIGNVILAVAAAAALIWIVPWVYAL-----fk
A0A660E7C9_9LACO/2-111 ...................kfnk------MKALTVSSATAIYLG.LMN..TQVVLAADG.GEVKSKLTSAGKTIQGILTGLVVLVGICVALFIIIKRMPD----ADDPREKSEVYHAVGRVAGLVALAAAIIWLLPWVYSL-----ft
G8PF94_PEDCP/2-112 ..................skyrk------MKALATTGATAIYLG.LMN..AQVVLAAGG.GEVKSKLTQAGKTIQGILTGLVVLVGICVALFIIIKRMPD----ADDPREKSEVYHAVGRVAGLVALAAAIIWILPWVYSL-----ft
G9WHR5_9LACO/2-111 ....................kfs-----KIKALATTGATAIYLG.LMN..AQVVLAADG.GEVKSKLTSAGKTIQGILTGLVVLVGICVALFIIIKRMPD----ADDPREKSEVYHAVGRVAGLVALAAAIIWLLPWVYSL-----ft
E6LIQ6_ENTI1/4-110 ..............wiadskckl------ESAVVALGMLVMTNP.VV-..-AATDP---.---AAKLVEAANTIKGVLTALIVVVGGIACAKIVIKYLPS----IDDPQEKNIMYKSLGTALLVTALGGALVWLVPWAYGL-----la
A0A0D6A5F7_9LACO/2-111 .....................kf----SKVKALATTGATAIYLG.LMN..AQVVFAADG.GEVKSKLTSAGKTIQGILTGLVVLVGICVALFIIIKRMPD----ADDPREKSEVYHAVGRVAGLVALAAAIIWILPWVYSL-----ft
A0A081BJK8_9LACO/2-111 .....................kf----SKVKALATTGATAIYLG.LMN..AQVVLAADG.GEVKSKLTSAGKTIQGILTGLVVLVGICVALFIIIKRMPD----ADDPREKSEVYHAVGRVAGLVALAAAIIWLLPWVYSL-----ft
A0A433RNP6_9BACL/2-112 ............tnntkatslvm-----------GTALAIVVCY.FIT..PEIVFASAG.-QVQAKLTNAANVVKGILTALVVLVGICAALFIIIKRMPS----ADDPHEKNEVFKSVGRVCALVALAAAIIWLLPWLYSL-----ft
A0A1I6U3D2_9BACI/6-112 .........lkktskiilaigfl------------------YFI.LL-..PEVSFAAST.SQVKTKLNSGFTAIQGVLTGVVVVIGVIAAIKIFLKYMPS----LDDPHSKNEMWKSIGGVGVAVGGAAAAVWLVPWIFSL-----fq
K0D9D5_LEUCJ/2-114 ..........kilnkskitsila------------SVSTAGYLM.LTN..AQIVLAADG.GEVQSKITNAANTIKGILTGIVVLVGVCVALFIIIKRLPD----ADDPREKSEVYKAVGRVAGLVALAAAIVWILPWVYSL-----ft
A0A7X2D2R1_9LACT/4-114 ...............lgkgkvak---------LATSTLTAGYLM.VMT..AQTAFAADG.TAIQGKLTTAANTIKGILTGIVVLVGVCVALFIIIKRLPD----ADDPREKSEVFKSVGRVAGLVALAAAIVWLLPWVYSL-----lt
A0A0R2L3B6_9LACO/2-111 ....................kfs-----KVKTLATTGATAIYLG.LMN..AQVVLAADG.GEVKSKLTSAGKTIQGILTGLVVLVGICVALFIIIKRMPD----ADDPREKSEVYHAVGRVAGLVALAAAIIWLLPWVYSL-----ft
A0A3G9M6J4_RHOOP/1-47 .......................---------------------.---..---------.----------------------------------VKGIADIWKISDDIKRGQATVFAYAQPIAMLAVAGGIIYL-----STKFGFN..
A0A1Z5IEJ4_9LACO/2-111 ...................kfnr------MKALTVSSATAIYLG.LMN..AQVVFAADG.GEVKSKLTSAGKTIQGILTGLVVLVGICVALFIIIKRMPD----ADDPREKSEVYHAVGRVAGLVALAAAIIWLLPWVYSL-----ft
A0A0R1SL85_9LACO/2-111 .....................kf----SKVKALATTGATTIYLG.LMN..AQVAFAADG.GEVKSKLTQAGKTIQGILTGLVVLVGICVALFIIIKRMPD----ADDPREKSEVYHAVGRVAGLVALAAAIIWLLPWVYSL-----ft
A0A2C1K463_9BACI/8-116 .........dngffkfvgvlafa-----------------ILMF.FVA..PEIGLAAST.GTVQTKIKSGVTAFQTVLTGIVVVVGIAASLKIIVKHLPS----IDDPHVKNEMWKSIGGVLAAIGAAAALIWLLPWVYSL-----fk
U5SGF7_9LACT/3-111 ..............kkrkskvvs--------AIMATGLTVMSHP.---..-AIVYGASA.GQVEAKLQNAGDIVQGILTGLVVLVGTVVGLFIIIKRMPA----ADNPHEKNEVYQAVGRVAGLVALAAAIIWLLPWVYSL-----fv
A0A429ZSC7_9ENTE/3-110 ..............kfikdtkfk------------LGSAVVALGtLFI..TDLVFAATD.--PQAKLVQAGNTIKGVLTALIVVVGGIACAKIVIKYLPS----IDDPQEKNTMYKALGTALLVTALGGALVWLVPWAYGL-----la
W6N409_CLOTY/2-112 ..................kiknk-----ITKCLVSAYTAILVLD.ST-..GIVSAASDA.GEVQSKLNQGLTTIKVVITSIIAIVGVIAAAKIVISKLPS----LDDPNMKNEMWRGVGMVGAAVAAGGALTWLIPWIYAL-----fq
A0A377JX76_9ENTE/5-110 .............ikntkfkles--------AVIALGTLFITDP.VF-..----AATDP.---QAKLVQAGNTIKGVLTALIVVVGGIACAKIVIKYLPS----IDDPQEKNTMYKALGTALLVTALGGALVWLVPWAYGL-----la
A0A0A0M544_9LACO/2-111 ...................klnk------VKALAISGATASYLA.LMN..AQVAFAADG.GEVKSKLTSAGKTIQGILTGLVVLVGICVALFIIIKRMPD----ADDPREKSEVYHAVGRVAGLVALAAAIIWVLPWVYSL-----ft
A0A0A5FZF9_9BACI/8-115 ...........gfpfkvvllmsf----------------AALLL.LIT..PDFALAAST.SQVQSKLNQGAKAIQLVLTSLVVVMGIIAAIKIVVKHLPS----IDDAHVKNEMWKGIGQVFAGVIAGAALVWIIPWAYSL-----fv
A0A0R1VNY9_9LACO/1-90 .......................---------------------.-MA..ATPVLAASG.SEVQGKISKALQTIQGILTGIVVLAGVCVALWIIIKRMPD----ADDPREKSEVYHAVGRVAGLVALSAAVIWLLPWFYSL-----fs
A0A0K0G9C6_9FIRM/1-90 .............mnflnffils---------------------.---..-----AA--.-NVQGKINSALLTVQGVLTGIVVTVGVCVALFNVVTKLPN----LSDPHEKNQFWKTQGYILAGVAFGAAVIWLIPWAYGL-----ft
O25278_HELPY/6-107 .......................RITDSYKKVVVTLGLVVTTNP.LM-..-AVTSPAEG.-------VTETKTLVIQIISVLAIVGGCA---LGVKGIADIWKISDDIKRGQATVFAYAQPIAMLAVAGGIIYL-----STKFGFN..
A0A4R2AZ18_9BACI/3-108 ..............spklkqilf------------LAVILLYAT.FV-..PDQVLAATG.--VEAKVKEGLKQIQAFLTGIVVIVGICVGVWIVIKKLPG----VDDPHTKNDMFRGVGMTLAGVGLAAALVWLVPWVYEL-----fa
A0A4Y9H5Y3_9BACL/1-86 ......................v---------------------.---..---AFGADA.GQVEERVTNAGNIIKGIISGLIVLAGVCVGSWIVIKRMKD----ADNAREKSEIYSGIGRIAGLVALGAALPWLLPWVFSL-----fq
A0A660E0M8_9LACO/2-114 ..........kilnkskitsila------------SVSTAGYLM.LTN..AQIVLAADG.SEVQSKITNAANTIKGILTGIVVLVGVCVALFIIIKRLPD----ADDPREKSEVYKAVGRVAGLVALAAAIVWILPWVYSL-----ft
U6FKK9_LACHE/2-111 .....................kf----SKVKALATTGATAIYLG.LMN..AQVVLAAGG.GEVKSKLTSAGKTIQGILTGLVVLVGICVALFIIIKRMPD----ADDPREKSEVYHAVGRVAGLVALAAAIIWLLPWVYSL-----ft
G9ZNJ2_9LACO/2-111 .....................kf----SKVKALATTGATAIYLG.LMN..AQVVFAADG.GEVKSKLTSAGKTIQGILTGLVVLVGICVALFIIIKRMPD----ADDPREKSEVYHAVGRVAGLVALAAAIIWLLPWVYSL-----ft
A0A6G7WKK5_9LACT/1-107 ..............mkknrktli-------------GTSLVGFF.MM-..NPVLASANA.AQVEAKLQSAGNIVQSLLTGLVVLVGVCVALFIIIKRLPQ----ADNPHEKNEVYQAIGRVAGLVALAAAIVWLLPWVYGL-----fv
A0A0R2BA24_SECCO/1-90 .......................---------------------.-MN..AQVVLAADG.GEVKSKLTSAGKTIQGILTGLVVLVGICVALFIIIKRMPD----ADDPREKSEVYHAVGRVAGLVALAAAIIWLLPWVYSL-----ft
U5SCY9_9LACT/4-111 ................krkskii-------SAIVATGLTVMSHP.AI-..---VYGASA.GQVEAKLQNAGDIVQGILTGLVVLVGTVVGLFIIIKRMPA----ADNPHEKNEVYQAVGRVAGLVALAAAIIWLLPWVYSL-----fv
Q6LWE2_LACPL/2-111 .....................kf----SKVKALATTGATAIYLG.LMN..TQVVLAADG.GEVQSKLTSAGKTIQGILTGLVVLVGICVALFIIIKRMPD----ADDPREKSEVYHAVGRVAGLVALAAAVIWLLPWVYSL-----ft
A0A1I3DA45_9LACT/2-109 ...............klknkliq----------FTVGVSALTA-.LTY..PTV-AYASA.TEVQSRLTEAGNTIQQLLTGLIVIVGICVALWIIIKRMPS----ADDPQEKSEVYKAVGRVLGLVAIGAAIVWVVPWVYSL-----fq
#=GC seq_cons ....................hhh.............uhsshhhh.lh...splshAAsu.upVpuKLssAupTIQGlLTGLVVLVGlCVALaIIIKRhPs....ADDP+EKsEVY+AVGRVuGLVALAAAIIWLLPWVYSL.....Fs
//
