#=GF ID TBPIP
#=GF AC PF07106.17
#=GF DE TBPIP/Hop2 winged helix domain
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE Pfam-B_14830 (release 10.0)
#=GF GA 22.80 22.80;
#=GF TC 22.80 23.00;
#=GF NC 22.70 22.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF CL CL0123
#=GF RN [1]
#=GF RM 10806355
#=GF RT Molecular cloning and characterization of a human homologue of
#=GF RT TBPIP, a BRCA1 locus-related gene.
#=GF RA Ijichi H, Tanaka T, Nakamura T, Yagi H, Hakuba A, Sato M;
#=GF RL Gene 2000;248:99-107.
#=GF RN [2]
#=GF RM 9708739
#=GF RT The meiosis-specific Hop2 protein of S. cerevisiae ensures
#=GF RT synapsis between homologous chromosomes.
#=GF RA Leu JY, Chua PR, Roeder GS;
#=GF RL Cell. 1998;94:375-386.
#=GF RN [3]
#=GF RM 11447128
#=GF RT A novel meiosis-specific protein of fission yeast, Meu13p,
#=GF RT promotes homologous pairing independently of homologous
#=GF RT recombination.
#=GF RA Nabeshima K, Kakihara Y, Hiraoka Y, Nojima H;
#=GF RL EMBO J. 2001;20:3871-3881.
#=GF RN [4]
#=GF RM 15192114
#=GF RT Positive role of the mammalian TBPIP/HOP2 protein in
#=GF RT DMC1-mediated homologous pairing.
#=GF RA Enomoto R, Kinebuchi T, Sato M, Yagi H, Shibata T, Kurumizaka H,
#=GF RA Yokoyama S;
#=GF RL J Biol Chem. 2004;279:35263-35272.
#=GF RN [5]
#=GF RM 9345291
#=GF RT Molecular cloning and characterization of a novel TBP-1
#=GF RT interacting protein (TBPIP):enhancement of TBP-1 action on Tat
#=GF RT by TBPIP.
#=GF RA Tanaka T, Nakamura T, Takagi H, Sato M;
#=GF RL Biochem Biophys Res Commun. 1997;239:176-181.
#=GF DR INTERPRO; IPR010776;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This family consists of several eukaryotic TBP-1 interacting
#=GF CC protein (TBPIP) sequences. TBP-1 has been demonstrated to
#=GF CC interact with the human immunodeficiency virus type 1 (HIV-1)
#=GF CC viral protein Tat, then modulate the essential replication
#=GF CC process of HIV. In addition, TBP-1 has been shown to be a
#=GF CC component of the 26S proteasome, a basic multiprotein complex
#=GF CC that degrades ubiquitinated proteins in an ATP-dependent
#=GF CC fashion. Human TBPIP interacts with human TBP-1 then modulates
#=GF CC the inhibitory action of human TBP-1 on HIV-Tat-mediated
#=GF CC transactivation [1]. TBPIP was found to be an activator that
#=GF CC specifically stimulates the homologous pairing catalyzed by
#=GF CC DMC1. Family members also include yeast homologous-pairing
#=GF CC protein 2 (Hop2) and its homologues from animals and plants.
#=GF CC They are required for proper homologous pairing and efficient
#=GF CC cross-over and intragenic recombination during meiosis [2, 3, 4,
#=GF CC 5].
#=GF SQ 1560
#=GS A0A0D3C9E7_BRAOL/49-111 AC A0A0D3C9E7.1
#=GS A0A6P6EN20_OCTDE/10-73 AC A0A6P6EN20.1
#=GS A0A4W6CQT0_LATCA/6-69 AC A0A4W6CQT0.1
#=GS A0A2I0JVZ0_PUNGR/1-55 AC A0A2I0JVZ0.1
#=GS A0A482WE69_LAOST/1-62 AC A0A482WE69.1
#=GS A0A4Y7JEF2_PAPSO/7-69 AC A0A4Y7JEF2.1
#=GS A0A1B8ECZ4_9PEZI/21-81 AC A0A1B8ECZ4.1
#=GS A0A7J7ER78_DICBM/17-79 AC A0A7J7ER78.1
#=GS E4XW38_OIKDI/1-53 AC E4XW38.1
#=GS A0A422NZE2_9TRYP/14-74 AC A0A422NZE2.1
#=GS G8Y6M7_PICSO/16-77 AC G8Y6M7.1
#=GS A8BZF2_GIAIC/7-69 AC A8BZF2.1
#=GS A0A2R6XGX7_MARPO/7-69 AC A0A2R6XGX7.1
#=GS A0A8C4N218_EPTBU/8-71 AC A0A8C4N218.1
#=GS V8NU44_OPHHA/13-76 AC V8NU44.1
#=GS A0A7J8VYD0_9ROSI/1-51 AC A0A7J8VYD0.1
#=GS A0A811MS84_9POAL/202-264 AC A0A811MS84.1
#=GS A0A484KQ21_9ASTE/7-69 AC A0A484KQ21.1
#=GS A0A4T0M6P8_9BASI/298-343 AC A0A4T0M6P8.1
#=GS S9VC97_9TRYP/17-78 AC S9VC97.1
#=GS A0A2P6R1T2_ROSCH/7-69 AC A0A2P6R1T2.1
#=GS S7WC51_SPRLO/66-126 AC S7WC51.1
#=GS A0A7F5RN36_AGRPL/2-62 AC A0A7F5RN36.1
#=GS A0A7I4CR99_PHYPA/1-43 AC A0A7I4CR99.1
#=GS A0A409XX42_9AGAR/1-50 AC A0A409XX42.1
#=GS A0A0R0J2A3_SOYBN/1-55 AC A0A0R0J2A3.1
#=GS Q6IQF3_DANRE/7-70 AC Q6IQF3.1
#=GS A0A813EGQ0_POLGL/219-280 AC A0A813EGQ0.1
#=GS A0A5C3QRK0_9AGAR/14-75 AC A0A5C3QRK0.1
#=GS A0A6I9M5A1_PERMB/11-74 AC A0A6I9M5A1.1
#=GS A0A5N7A1B2_9EURO/17-78 AC A0A5N7A1B2.1
#=GS A0A6I9YWB8_9SAUR/13-76 AC A0A6I9YWB8.1
#=GS A0A8H6C4Z6_CANAX/13-75 AC A0A8H6C4Z6.1
#=GS I1KWU1_SOYBN/7-69 AC I1KWU1.1
#=GS A0A8J1LSH4_XENLA/8-48 AC A0A8J1LSH4.1
#=GS A0A5N5H8M7_9ROSA/7-69 AC A0A5N5H8M7.1
#=GS A0A286UUT2_9AGAM/19-80 AC A0A286UUT2.1
#=GS A0A8C4Y0J8_9SAUR/13-76 AC A0A8C4Y0J8.1
#=GS A0A7J6S0T6_PEROL/39-84 AC A0A7J6S0T6.1
#=GS A4I343_LEIIN/16-77 AC A4I343.1
#=GS A0A673XD89_SALTR/8-70 AC A0A673XD89.1
#=GS A0A4W5RXJ1_9TELE/8-70 AC A0A4W5RXJ1.1
#=GS D7T969_VITVI/7-69 AC D7T969.1
#=GS G8ZWT5_TORDC/16-77 AC G8ZWT5.1
#=GS A0A1E1KQB4_9HELO/110-154 AC A0A1E1KQB4.1
#=GS A0A6A6Y6Q3_9PEZI/15-76 AC A0A6A6Y6Q3.1
#=GS A0A8C9YTW1_SANLU/6-69 AC A0A8C9YTW1.1
#=GS A0A1J7HIR5_LUPAN/40-87 AC A0A1J7HIR5.1
#=GS A0A196S5Z0_BLAHN/87-148 AC A0A196S5Z0.1
#=GS Q23VW9_TETTS/140-203 AC Q23VW9.3
#=GS A0A559M831_9HELO/106-158 AC A0A559M831.1
#=GS A0A1Y1XIV4_9FUNG/15-76 AC A0A1Y1XIV4.1
#=GS A0A267FQR8_9PLAT/7-68 AC A0A267FQR8.1
#=GS A0A6J2Y2C2_SITOR/2-58 AC A0A6J2Y2C2.1
#=GS A0A7N8YH85_9TELE/6-69 AC A0A7N8YH85.1
#=GS A0A2V1CRR1_9HELO/110-162 AC A0A2V1CRR1.1
#=GS K0KH65_WICCF/22-83 AC K0KH65.1
#=GS A0A4E0RLN9_9HYME/2-63 AC A0A4E0RLN9.1
#=GS W4H9V3_APHAT/116-177 AC W4H9V3.1
#=GS A0A2S6C4Q3_9PEZI/16-73 AC A0A2S6C4Q3.1
#=GS A0A1V9ZG93_9STRA/104-165 AC A0A1V9ZG93.1
#=GS A0A2A9NWK0_9AGAR/1-50 AC A0A2A9NWK0.1
#=GS A0A6J3E630_AYTFU/12-75 AC A0A6J3E630.1
#=GS A0A8W8MDY8_CRAGI/8-69 AC A0A8W8MDY8.1
#=GS A0A0M3JWN8_ANISI/1-36 AC A0A0M3JWN8.1
#=GS A0A8C3V1Q9_CATUS/11-64 AC A0A8C3V1Q9.1
#=GS A0A0D9ZCB3_9ORYZ/856-908 AC A0A0D9ZCB3.1
#=GS A0A8B9PGJ9_APTOW/59-122 AC A0A8B9PGJ9.1
#=GS A0A7J7LWZ4_9MAGN/7-69 AC A0A7J7LWZ4.1
#=GS K1XD62_MARBU/130-163 AC K1XD62.1
#=GS A0A5N5SKK5_9CRUS/6-67 AC A0A5N5SKK5.1
#=GS A0A0F9YRT8_9MICR/192-253 AC A0A0F9YRT8.1
#=GS A0A2N5W0R6_9BASI/18-78 AC A0A2N5W0R6.1
#=GS A0A6P8Z938_THRPL/3-63 AC A0A6P8Z938.1
#=GS A0A7H9HRC2_9SACH/16-77 AC A0A7H9HRC2.1
#=GS A0A8K0C9T5_9COLE/2-63 AC A0A8K0C9T5.1
#=GS A0A485MM52_LYNPA/11-74 AC A0A485MM52.1
#=GS A0A3P9D712_9CICH/6-69 AC A0A3P9D712.1
#=GS A0A6J1BJC3_9ROSI/7-69 AC A0A6J1BJC3.1
#=GS A0A1X2IT77_9FUNG/12-72 AC A0A1X2IT77.1
#=GS A0A8C4N9M3_EPTBU/8-71 AC A0A8C4N9M3.1
#=GS M4DTI2_BRARP/7-69 AC M4DTI2.1
#=GS A0A8B7UN28_CASCN/11-74 AC A0A8B7UN28.1
#=GS A0A6J1QA27_9HYME/2-62 AC A0A6J1QA27.1
#=GS M7YX62_TRIUA/7-69 AC M7YX62.1
#=GS R7VAA4_CAPTE/28-89 AC R7VAA4.1
#=GS A0A8M1GP39_URSMA/11-74 AC A0A8M1GP39.1
#=GS G8B9B9_CANPC/12-73 AC G8B9B9.1
#=GS E9FTT0_DAPPU/8-70 AC E9FTT0.1
#=GS A0A8J2SE12_9STRA/54-116 AC A0A8J2SE12.1
#=GS A0A671S486_9TELE/8-70 AC A0A671S486.1
#=GS A0A8C3R5Q0_9PASS/12-75 AC A0A8C3R5Q0.1
#=GS A0A0C3HEY5_9PEZI/55-107 AC A0A0C3HEY5.1
#=GS A0A2I2GFU4_9EURO/18-78 AC A0A2I2GFU4.1
#=GS A0A668SZF3_OREAU/6-69 AC A0A668SZF3.1
#=GS H2QD27_PANTR/11-74 AC H2QD27.1
#=GS A0A150VIN3_9PEZI/18-79 AC A0A150VIN3.1
#=GS A0A218ZCD8_9HELO/102-154 AC A0A218ZCD8.1
#=GS A0A0C3AUN0_9AGAM/17-78 AC A0A0C3AUN0.1
#=GS A0A5A8CNI8_CAFRO/141-202 AC A0A5A8CNI8.1
#=GS A0A452QT24_URSAM/11-74 AC A0A452QT24.1
#=GS V4AS65_LOTGI/8-68 AC V4AS65.1
#=GS A0A8V5GXY3_MELUD/13-76 AC A0A8V5GXY3.1
#=GS A0A8I3NBI2_CANLF/11-74 AC A0A8I3NBI2.1
#=GS A0A3Q7RKM3_VULVU/11-74 AC A0A3Q7RKM3.1
#=GS A0A8B9PL13_APTOW/59-122 AC A0A8B9PL13.1
#=GS U9SVB4_RHIID/14-75 AC U9SVB4.1
#=GS A0A4Z2BYD3_9TELE/6-69 AC A0A4Z2BYD3.1
#=GS A0A6J1HZ82_CUCMA/7-69 AC A0A6J1HZ82.1
#=GS A0A094HKH5_9PEZI/20-80 AC A0A094HKH5.1
#=GS A0A1U8LZ61_GOSHI/7-69 AC A0A1U8LZ61.1
#=GS A0A663DQJ2_AQUCH/14-77 AC A0A663DQJ2.1
#=GS A0A3B5Q9J9_XIPMA/6-69 AC A0A3B5Q9J9.1
#=GS A0A178ABV3_9PLEO/15-76 AC A0A178ABV3.1
#=GS A0A8C8R5D8_9SAUR/13-76 AC A0A8C8R5D8.1
#=GS A0A6P3RFH6_PTEVA/11-74 AC A0A6P3RFH6.1
#=GS A0A8R1XYX0_ONCVO/16-77 AC A0A8R1XYX0.1
#=GS A0A1S2Z3P5_CICAR/7-69 AC A0A1S2Z3P5.1
#=GS A0A232F0T2_9HYME/20-81 AC A0A232F0T2.1
#=GS A0A3N4MNW2_9PEZI/37-98 AC A0A3N4MNW2.1
#=GS K7EK12_HUMAN/11-74 AC K7EK12.1
#=GS A0A0R3TQY0_RODNA/1-53 AC A0A0R3TQY0.1
#=GS A0A1V6QQS9_9EURO/15-50 AC A0A1V6QQS9.1
#=GS A0A0K9Q345_ZOSMR/7-69 AC A0A0K9Q345.1
#=GS A0A4Z1SWB1_GIAMU/6-68 AC A0A4Z1SWB1.1
#=GS B5FZP3_TAEGU/12-75 AC B5FZP3.1
#=GS A0A669D3M7_ORENI/6-69 AC A0A669D3M7.1
#=GS I1GP62_BRADI/7-69 AC I1GP62.1
#=GS A0A7J5YCA6_DISMA/1-55 AC A0A7J5YCA6.1
#=GS W2TYK6_NECAM/1-53 AC W2TYK6.1
#=GS A0A0E9NFE4_SAICN/1-39 AC A0A0E9NFE4.1
#=GS A0A8C7XAC4_9TELE/7-70 AC A0A8C7XAC4.1
#=GS A0A8C0KMR5_CANLU/11-74 AC A0A8C0KMR5.1
#=GS A0A550CWS9_9AGAR/19-80 AC A0A550CWS9.1
#=GS A0A2H3D8Q7_ARMGA/15-76 AC A0A2H3D8Q7.1
#=GS A0A8H3IW81_9LECA/45-90 AC A0A8H3IW81.1
#=GS G1PV64_MYOLU/11-74 AC G1PV64.1
#=GS A0A0V0QCH6_PSEPJ/321-382 AC A0A0V0QCH6.1
#=GS A0A061EIG9_THECC/7-69 AC A0A061EIG9.1
#=GS A0A672SHU0_SINGR/8-70 AC A0A672SHU0.1
#=GS A0A2K6V3F7_SAIBB/11-74 AC A0A2K6V3F7.1
#=GS A0A5N5MHD1_PANHP/7-70 AC A0A5N5MHD1.1
#=GS A0A8B7TFT2_HIPAR/11-74 AC A0A8B7TFT2.1
#=GS A0A6P5E1L9_BOSIN/11-74 AC A0A6P5E1L9.1
#=GS A0A8H8JIQ3_9AGAM/20-81 AC A0A8H8JIQ3.1
#=GS A0A2K5DJX2_AOTNA/11-74 AC A0A2K5DJX2.1
#=GS A0A811XRB6_NYCPR/11-74 AC A0A811XRB6.1
#=GS A0A1R3KI87_9ROSI/7-69 AC A0A1R3KI87.1
#=GS A0A024VPI5_PLAFA/350-411 AC A0A024VPI5.1
#=GS A0A2T7P8P2_POMCA/125-186 AC A0A2T7P8P2.1
#=GS A0A0L0SQC1_ALLM3/16-76 AC A0A0L0SQC1.1
#=GS A0A8H8QYP9_9HELO/109-161 AC A0A8H8QYP9.1
#=GS A0A8H5MCC0_9AGAR/22-71 AC A0A8H5MCC0.1
#=GS A0A094A3M7_9PEZI/20-80 AC A0A094A3M7.1
#=GS A0A7K3NKU7_9DELT/4-60 AC A0A7K3NKU7.1
#=GS A0A1U7RN04_ALLSI/1-34 AC A0A1U7RN04.1
#=GS A0A812GX60_9DINO/522-583 AC A0A812GX60.1
#=GS A0A8C3HV99_CHRPI/11-74 AC A0A8C3HV99.1
#=GS A0A2J6RVU8_9HELO/98-152 AC A0A2J6RVU8.1
#=GS A0A1L9PHJ6_ASPVE/14-65 AC A0A1L9PHJ6.1
#=GS A0A804P8P6_MAIZE/7-54 AC A0A804P8P6.1
#=GS T1KZW4_TETUR/1-61 AC T1KZW4.2
#=GS M3WFI4_FELCA/11-74 AC M3WFI4.1
#=GS Q4D830_TRYCC/14-75 AC Q4D830.1
#=GS A0A8J7P4C5_ATRSP/15-78 AC A0A8J7P4C5.1
#=GS H2LHY5_ORYLA/6-69 AC H2LHY5.2
#=GS A0A4W3HTQ5_CALMI/58-121 AC A0A4W3HTQ5.1
#=GS A0A8C6TL26_9GOBI/7-70 AC A0A8C6TL26.1
#=GS A0A667HNY0_LYNCA/11-74 AC A0A667HNY0.1
#=GS A0A1L9S871_9EURO/17-78 AC A0A1L9S871.1
#=GS A0A016VZ93_9BILA/138-199 AC A0A016VZ93.1
#=GS F4X7T1_ACREC/2-62 AC F4X7T1.1
#=GS D2UYQ1_NAEGR/5-66 AC D2UYQ1.1
#=GS A0A364N6B0_9PLEO/776-829 AC A0A364N6B0.1
#=GS M3YFL9_MUSPF/11-74 AC M3YFL9.1
#=GS A0A5C7HJ14_9ROSI/7-69 AC A0A5C7HJ14.1
#=GS A0A6J3QPP1_TURTR/11-74 AC A0A6J3QPP1.1
#=GS A0A4V5PA20_MONMO/1-62 AC A0A4V5PA20.1
#=GS A0A6J3B352_VICPA/11-74 AC A0A6J3B352.1
#=GS A0A0C2H799_9BILA/30-91 AC A0A0C2H799.1
#=GS A0A2K5S137_CEBIM/11-74 AC A0A2K5S137.1
#=GS A0A4V3XFK7_9AGAM/16-77 AC A0A4V3XFK7.1
#=GS B2W8E9_PYRTR/15-71 AC B2W8E9.1
#=GS A0A482VKH0_9CUCU/1-59 AC A0A482VKH0.1
#=GS A0A672R670_SINGR/1-24 AC A0A672R670.1
#=GS A7RI40_NEMVE/8-69 AC A7RI40.1
#=GS A0A0C3MKW8_9AGAM/16-94 AC A0A0C3MKW8.1
#=GS A0A453H6T9_AEGTS/4-67 AC A0A453H6T9.1
#=GS A0A0E0GSL9_ORYNI/954-1009 AC A0A0E0GSL9.1
#=GS A0A8B9URW3_9AVES/12-75 AC A0A8B9URW3.1
#=GS V2YPR3_MONRO/17-78 AC V2YPR3.1
#=GS A0A094DBB0_9PEZI/20-80 AC A0A094DBB0.1
#=GS A0A8H3EKG2_9LECA/66-111 AC A0A8H3EKG2.1
#=GS A0A6J1HXK8_CUCMA/20-74 AC A0A6J1HXK8.1
#=GS A0A2U1N0F7_ARTAN/7-69 AC A0A2U1N0F7.1
#=GS A0A813HL94_POLGL/221-282 AC A0A813HL94.1
#=GS A0A433Q0P6_9FUNG/68-114 AC A0A433Q0P6.1
#=GS A0A834J576_VESGE/2-62 AC A0A834J576.1
#=GS A0A6G1DC34_9ORYZ/7-69 AC A0A6G1DC34.1
#=GS A0A0D9ZCB1_9ORYZ/904-959 AC A0A0D9ZCB1.1
#=GS A0A226NV78_COLVI/2-65 AC A0A226NV78.1
#=GS A0A5N3WZR5_MUNRE/11-74 AC A0A5N3WZR5.1
#=GS A0A803WGJ5_FICAL/12-75 AC A0A803WGJ5.1
#=GS A0A066WNI5_TILAU/4-65 AC A0A066WNI5.1
#=GS A0A7J7U8G6_PIPKU/11-74 AC A0A7J7U8G6.1
#=GS A0A0R0LVI8_9MICR/189-250 AC A0A0R0LVI8.1
#=GS A0A5N4D5E8_CAMDR/11-74 AC A0A5N4D5E8.1
#=GS F7BQN1_HORSE/11-74 AC F7BQN1.1
#=GS D8SYW3_SELML/9-71 AC D8SYW3.1
#=GS A8J273_CHLRE/5-66 AC A8J273.1
#=GS A0BQ77_PARTE/74-133 AC A0BQ77.1
#=GS A0A6P9BPY9_PANGU/13-76 AC A0A6P9BPY9.1
#=GS A0A0E0GSM0_ORYNI/962-1017 AC A0A0E0GSM0.1
#=GS A0A4U0WQ67_9PEZI/21-77 AC A0A4U0WQ67.1
#=GS A0A154P2T7_DUFNO/1-53 AC A0A154P2T7.1
#=GS A0A834ST47_9FABA/7-69 AC A0A834ST47.1
#=GS A0A7N2KQF4_QUELO/7-69 AC A0A7N2KQF4.1
#=GS A0A6P4B1B3_ZIZJJ/29-82 AC A0A6P4B1B3.1
#=GS A0A5E8BFY1_9ASCO/1-53 AC A0A5E8BFY1.1
#=GS A0A409Y5Z1_9AGAR/21-78 AC A0A409Y5Z1.1
#=GS A0A7J0DXC8_9ERIC/7-69 AC A0A7J0DXC8.1
#=GS A0A6P6EN27_OCTDE/10-73 AC A0A6P6EN27.1
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