#=GF ID   TFIIB_C_1
#=GF AC   PF18542.5
#=GF DE   Transcription factor IIB C-terminal module 1
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF05297
#=GF GA   25.00 25.00;
#=GF TC   47.50 46.10;
#=GF NC   24.90 22.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0065
#=GF RN   [1]
#=GF RM   19666603
#=GF RT   Structure of the C-terminal domain of transcription factor IIB
#=GF RT   from Trypanosoma brucei.
#=GF RA   Ibrahim BS, Kanneganti N, Rieckhof GE, Das A, Laurents DV,
#=GF RA   Palenchar JB, Bellofatto V, Wah DA;
#=GF RL   Proc Natl Acad Sci U S A. 2009;106:13242-13247.
#=GF DR   INTERPRO; IPR041189;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   In the pathogenic trypanosome, Trypanosoma brucei, transcription
#=GF CC   factor IIB (tTFIIB) is essential for spliced leader (SL) RNA
#=GF CC   gene transcription and cell viability, but has a highly
#=GF CC   divergent primary sequence in comparison to TFIIB in other
#=GF CC   eukaryotes. Structure analysis of the C-terminal region of
#=GF CC   trypanosome TFIIB, reveals 2, closely packed helical modules
#=GF CC   followed by a C-terminal extension of 32 aa. The
#=GF CC   trypanosome-specific region comprises the second helical module
#=GF CC   and the C-terminal extension.  Both helical modules contain the
#=GF CC   canonical 5-helix cyclin fold characteristic of TFIIB proteins
#=GF CC   [1]. This domain is mostly found in Trypanosomatidae.
#=GF SQ   16
#=GS A0A0M9FSL0_LEPPY/119-217  AC A0A0M9FSL0.1
#=GS V5BK49_TRYCR/97-194       AC V5BK49.1
#=GS A0A3R7MLE9_TRYRA/97-194   AC A0A3R7MLE9.1
#=GS S9TY01_9TRYP/116-213      AC S9TY01.1
#=GS A0A1X0NU06_9TRYP/101-198  AC A0A1X0NU06.1
#=GS A0A422Q5Z9_9TRYP/97-194   AC A0A422Q5Z9.1
#=GS A0A061IZG4_TRYRA/97-194   AC A0A061IZG4.1
#=GS A4H880_LEIBR/125-223      AC A4H880.1
#=GS Q4D2Z7_TRYCC/97-194       AC Q4D2Z7.1
#=GS Q4CVR3_TRYCC/97-194       AC Q4CVR3.1
#=GS Q38EY4_TRYB2/96-193       AC Q38EY4.1
#=GS A0A0S4JKE3_BODSA/85-183   AC A0A0S4JKE3.1
#=GS Q4QF67_LEIMA/125-223      AC Q4QF67.1
#=GS K2MTG0_TRYCR/97-194       AC K2MTG0.1
#=GS A0A7G2CUK4_9TRYP/106-205  AC A0A7G2CUK4.1
#=GS A4HWK6_LEIIN/125-223      AC A4HWK6.1
A0A0M9FSL0_LEPPY/119-217             .....LHPRQSRALEALFRLSRRHDEDILLDAMALAKRFVGHRRERSVRVEHQTEVAAACLMLAAERHGQPIPLGEVRVLDPSLK..DVESRRREVIEETNLRDE-v.
V5BK49_TRYCR/97-194                  .....LHPAMLNCIRGLQKKSAL-PEQVIGRAVELARRFVGGRRARGQRIEKQQDVAAACFMIAAEQMSHPVPLAELRHLDAALG..DVEYRRAEIVKETQMEEEE..
A0A3R7MLE9_TRYRA/97-194              .....LHPAMLNCIRSLQKKSAV-PEQVIARAVNIAKRFVAGRRARGQRVEKQQEVAAACFMIAAEQMSHPVPMLELRHLDPAIG..NVEYRRAEIVKETRMEEEE..
S9TY01_9TRYP/116-213                 .....LHPKMRDIMDVLCESIKS-GDVVRYKAYELARHFVGQRRERGHRVDQLEETAAACFQLAAEMHRRPVPLAELRQMAPSLK..DVESRRKEVVREVGLGE--vd
A0A1X0NU06_9TRYP/101-198             .....LHPAMLNCIRGLQKKSAV-QEQVIGRAVDLAKHVVGGRRARGQRVERQNDIAAACFMIAAEQLNHPVPLAELRCLDASLG..DVEFRRAEIVRELHMEEEE..
A0A422Q5Z9_9TRYP/97-194              .....LHPAMLNCIRSLQKKSGV-PEQAIGRAVNIARRFVGGRRARGQRVGKQQDVAAACFMIAAEQLSHPVPMLELRQLDPAIG..NVEYPRAEIVKETHMEDEE..
A0A061IZG4_TRYRA/97-194              .....LHPAMLNCIRSLQKKSAV-PEQVIARAVNIAKRFVGGRRARGQRVEKQQEVAAACFMIAAEQMSHPVPLLELRHLDPAIG..NVEYRRAEIVKETRMEDEE..
A4H880_LEIBR/125-223                 .....LHPRMSAQLEVFFRLSRRYDEAILRDAIALAKHFVGFRRERGVRVEHQTEVAAASLMLASERLGQPIPLSEMRVLDGTLK..DIESRRLEIIDATNLREEM..
Q4D2Z7_TRYCC/97-194                  .....LHPAMLNCIRGLQKKSAL-PEQVIGRAVELARRFVGGRRARGQRIEKQQDVAAACFMIAAEQMNHPVPLAELRHLDAALG..DVEYRRAEIVKETHMEEEE..
Q4CVR3_TRYCC/97-194                  .....LHPAMINCIRGLQKKSAL-PEQVIGRAVELARRFVGGRRARGQRIEKQQDVAAACFMIAAEQMSHPVPLAELRHLDAALG..DVEYRRAEIVKETHMEEEE..
Q38EY4_TRYB2/96-193                  .....LHPTMLNCMRGLHKKAVL-PEPVLDRGIELARAFVGGRRARGQRVERQPDVAAACLMIAAEEAQQPLPLAEVRCLDSSLG..DVELRRADIVRELHLEDSE..
A0A0S4JKE3_BODSA/85-183              lssqa-----VTYLRRLQEKSKT-SDAVLNDAIELCRVVSVKKRELNERIEKPFAVAAACFLFASQRQHVPISHHELLCIDRSLNplDIKLKLGEMLRSLNLS---pt
Q4QF67_LEIMA/125-223                 .....LHPRMSAQLEVFFRLSRRHDEAILRDAIALAKHFVGFRRERGMRVEHQTEVAAASVMLAAEHLGQPIPLSEMRVLDGTLK..DVESRRQEILDATNLGEEM..
K2MTG0_TRYCR/97-194                  .....LHPAMLNCIRGLQKKSAL-PEQVIGRAVELAKRFVGGRRARGQRIERQLDVAAACFMIAAEQMNHPVPLAELRHLDASLG..DVGYRRAEIVKETHMEGE-e.
A0A7G2CUK4_9TRYP/106-205             lhgqe---RVRQRLETLCDLIRR-GDPVKEEALEILSVFVGRRKERNEKLDKMNESIAACVMLAAARCRTPLPLPELRTLDPSLG..DVDLRRKDVVREVQLAEEE..
A4HWK6_LEIIN/125-223                 .....LHPRMSAQLEVFFRLSRRHDEAILRDAIALAKHFVGFRRERGMRVEHQTEVAAASVMLAAERLGQPIPLSEMRVLDGTLK..DVESRRQEILDATNLGEEM..
#=GC seq_cons                        .....LHPtMlsslRuLp+KSth.sEtVls+AlpLA++FVGtRRtRGpRVE+Qp-VAAACFMlAAEphspPlPLuELRpLDsoLG..DVEhRRuEIV+ETphcEE...
//