#=GF ID   TP0453
#=GF AC   PF20740.1
#=GF DE   Outer membrane-associated lipoprotein TP0453
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF SE   ECOD:881.3.1
#=GF GA   27.00 27.00;
#=GF TC   29.90 29.50;
#=GF NC   26.60 24.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF RC   Paper describing PDB structure 3k8g
#=GF RN   [1]
#=GF RM   21965687
#=GF RT   The transition from closed to open conformation of Treponema
#=GF RT   pallidum outer membrane-associated lipoprotein TP0453 involves
#=GF RT   membrane sensing and integration  by two amphipathic helices.
#=GF RA   Luthra A, Zhu G, Desrosiers DC, Eggers CH, Mulay V, Anand A,
#=GF RA   McArthur FA, Romano FB, Caimano MJ, Heuck AP, Malkowski MG,
#=GF RA   Radolf JD;
#=GF RL   J Biol Chem. 2011;286:41656-41668.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found in TP0453, a lipoprotein associated with
#=GF CC   the inner leaflet of the outer membrane of Treponema pallidum.
#=GF CC   This protein consists of an alpha/beta/alpha-fold and includes
#=GF CC   five stably folded amphipathic helices and may function as a
#=GF CC   carrier of lipids, glycolipids, and/or derivatives during the
#=GF CC   biogenesis of the outer membrane [1]. 
#=GF SQ   18
#=GS A0A1T4M7R7_TREPO/29-293  AC A0A1T4M7R7.1
#=GS A0A7W8G8E3_9SPIR/29-285  AC A0A7W8G8E3.1
#=GS I0X628_9SPIR/39-300      AC I0X628.1
#=GS TP453_TREPA/31-274       AC O67998.1
#=GS U1F7Q3_TRESO/26-282      AC U1F7Q3.1
#=GS E7NPR9_TREPH/28-275      AC E7NPR9.1
#=GS A0A7T3RBP8_9SPIR/27-293  AC A0A7T3RBP8.1
#=GS A0A1H9IZJ1_9SPIR/19-279  AC A0A1H9IZJ1.1
#=GS A0A840SF50_9SPIR/30-297  AC A0A840SF50.1
#=GS F4LP88_TREBD/37-280      AC F4LP88.1
#=GS A0A0A0WXI9_9SPIR/31-275  AC A0A0A0WXI9.1
#=GS S5ZZ34_9SPIR/29-275      AC S5ZZ34.1
#=GS H7EP70_9SPIR/34-273      AC H7EP70.1
#=GS S3L238_TREMA/34-301      AC S3L238.1
#=GS A0A1T4KFD8_9SPIR/35-293  AC A0A1T4KFD8.1
#=GS F2NXH1_TRES6/27-285      AC F2NXH1.1
#=GS A0A841RC14_9SPIO/29-270  AC A0A841RC14.1
#=GS Q73JB3_TREDE/34-278      AC Q73JB3.1
A0A1T4M7R7_TREPO/29-293             .....av--RVDPLLLLDNESSFYLRIPS.SADEKLISR...VVQGavkGISESDARLISSRIDVVYAGLN.KK.....RTKTDYQIAAFCDFPKAAVSKAFSRKNGWtkdslllND...GDgN..PV.........E...YG...IYS..DGRILASFPEQMTACVGRNv...pSM----VETYHNAYYNlsPSASV............LDEN..IYSWLFFD..SEN.PDGKIKYYASKP.QSFLTMLT..GA.VLNFN..LVYVR...GSIESDPK....RDDQF..VMDFE..FEFRDKKFVPAARGSLA.VAF...G...LTDSDvyleTPT.HLVVSNIKISKEQLY..........................
A0A7W8G8E3_9SPIR/29-285             .....la--PVDPFELLDGDAALYLSLPV.QAHQDFVLS...AIQKv.aGANEADAQKIAERLNTAYIALG.IN.....GN---LQLSCSGKIPQNFVGMALNEKKGW.......KP...GV.I..AQ.........Q...TV...YTH.qESLYQLCLPSSSNAFLS--.....-NNIEPMVLRFNKIAY..SDQSIse........klLSES..MNEGLYRL..LHDnNTSDIVMYSPLP.QAFMKSML..GSaGINLP..IESFF...AVLSQYRG....VKEQF..NVKLI..INMSDPRTVKATSALLK.TAL...FgvpAKISQ...tGQK.QITITDLPVSKARL-l.........................
I0X628_9SPIR/39-300                 ......e-NPVNALDLLDDDSAFYIAIPN.DVDPELVVR...FLQNnikNLSEKEAKLVSGRVNKVYCGLN.HK.....KNKTQIQISAQADFGNALASKLLTQANGWqs...siVT...TQ.V..NK.........S...YD...LYE..QNSVEVCFPSKEIALVGRD.....------IPVMLSQFDY..IRSIDlele....epshLLNDvvYNYLQ---..EAE.EAHEIRFYAGRP.QSFLTILT..GA.QLDLK..LDHVC...GSFVCDEK....YPTQY..ILNLD..FKFKDAKFLKSGRALLT.LAF...G...LSNSNcqmiGDD.ELIISDIQIAKKQLY..........................
TP453_TREPA/31-274                  .......KASVDPLGVVGSGADVYLYFPV.AGNENLISR...IIEN...HESKADIKKIVDRTTAVYGAFF.AR.....SK--EFRLFGSGSYPYAFTNLIFSRSDGW.......AS...TK.T..EH.........G...IT...YYE..SEHTDVSIPAPHFSCVIFG.....SSKRERMSKMLSRLVN..PDRPQ............LPPR..FEK--ECT..SEG.TSQTVALYIKNG.GHFITKLL..NFpQLNLP..LGAME...LYLTARR-....--NEY..LYTLS..LQLGNAKINFPIQFLIS.RVL...N...AHIHV....EGD.RLIIEDGTISAERLA..........................
U1F7Q3_TRESO/26-282                 ......g-AEVNPIDLLSGDASFYMRIPK.KTDGELVER...ILRAsaqHISESDAKLISGRIDTIYAAIS.RT.....KTSFSVEAAVSGNIPRRTAQALLLKSAQWk.....tET...HI.P..ER.........S...IRpyfYYA..SNGVSLAFPSPSIVCAA--.....----NDVRPMLSAFDA.hAYGGS............ISHN..VSDAVYDW..LDV.SGSEIRFYAPNP.LSFLTILT..GT.NLNLQ..LNYVK...GAMISDSA....HEDQY..LMSIE..FDFNNKNIVRAGEAMLA.LAF...G...LTNAQttrnSPT.NITVSGIRINKRQLY..........................
E7NPR9_TREPH/28-275                 .......KGTFNPLGLIGPDADMYMYIPV.APNKALLYE...ILEG...NNNAKDIKKVLNRTKAVYAGFF.IE.....SN--EFRICSSGGYPFSLTNMLFPKSKGW.......KP...GK.T..AK.........G...IR...YYQ..SGYMDISIPSGNTACVVLG.....STARQDMNDFLAKLDN..PQPVS............LSSR..FEALMNAS..DAA.PKKNIGVFITNS.QYFLAKVT..GIaNLDLP..LGAIE...MHVIKKEK....-TNDY..TYSLS..VEADNNRAAFAVRFLLA.KVL...N...GKIGG....TGN.SITVEDGTIPSEKLA..........................
A0A7T3RBP8_9SPIR/27-293             ......e-EQVNVLALLEQDSSIYVRIPV.SSHVDLTSA...VLSSafdGVSKKDARSFAQRVSELYAGIG.TV.....EDRSRIQVASSASIPQVAVGTVFSKKHGWsk..rtyN-...AK.T..TDave...kngS...FT...VYDpsAGELSVSFPSPS---VFVS.....-AAK--VEPLLNRYAE.ySDYAD............LSAT..SYSSWVSQ..Q--.-SSDILFYITRP.GQYLRNLI..GQ.SVSIG..TDAIYg.sLSYIPSKK....NPDSYsgLYSMMfrIHLLDKRAAAAFRSVLS.LSFgmmG...AKITQ....TDDfTIEISDVEITQKQI-e.........................
A0A1H9IZJ1_9SPIR/19-279             ......g-RPVDALELIDDQSAFYIAVPK.EADNILIER...IITGfykDATESDAKMIADHVNKIYCGLN.RS.....KHETEVQASVEGSIPSSFIPKVLNAKKGWi.....vND...FT.P..AE.........S...LN...KYKvyTGPVEMTFPSPKIACIGRG.....------LEGMLTKYDR.lAALPAdd.......tteLYSD..LDEELTSY..LKG.AENEIRFFANKP.QSFLTILT..GA.--QLD..LKLID...VKGNFTTDp..kHPNQY..FLDLD..FRFKNGTFLKAGRTLLI.LAF...G...LTNSQeeiiGDS.ELIINDIRIDKQQLY..........................
A0A840SF50_9SPIR/30-297             ......e-GSVSPLALLDDQSSIYINIPV.QKHQKLFAD...ILCSqveGLAEKDAMSLASRTGHLYAGLG.TV.....KDRSRLEAAATVDIPKVGINSVFKKKNGWysa.eyvSA...AK.P..ENgvsaagvpsK...YT...VYS..RNDNPLKISFPVKQILCVS.....----KNVEVMLDKYSS..QA--A............LA--..-DNDMNAY..LTQ.DSDDILFYVTRP.GQYLRNMI..GV.TVQGAdrVWGTL...AYVPDEKKp.knDTGKY..SMSFY..MHLQDKKTMKAFQGLLA.LSF...A...MSDGSveqiDEL.TIKVSGVEVSR----kqin......................
F4LP88_TREBD/37-280                 .....ag--RLQPFSLMPENTVLYVQFPA.VPNEGAVRA...FTDAlapQLAPADIRKVLKRVDTVYAGFD.AS.....GN---LSSAVTGSFPSFALGAVFSKKNGW.......RK...IP.A..AS.........GggaGA...YYA..RPDIPLQFAFPSSSLAFIA.....----ADVSAMFAGGTE..PDIGAa.........iaIDGR..AEAVSSSYgfTHA.AADDIRFYIKDP.IFVMRRLRqsGF.VFDFP..LAAVS...GTLSFAGLdpetGSPAY..ALTAL..IELSDSRALRPALAMLG.IA-...-...-----....---.---------------vriggknfd.................
A0A0A0WXI9_9SPIR/31-275             ......e-YDIRAFGAVGSDADVYIVAPV.IGNEPLLKA...LFTA...FVPERTALQYLNRTSVLYIGAD.YG.....AP-PSVTVVSSGSYPVSLGDLLFSKKDGWe.....kRR...SA.A..LN.........N...RT...YYS..SAVADIVVQE-KIAFMCLG.....GNQR-NSAAFLQRIAE..PQPPI............FPPR..FQALSEAG..RVG.---EIGLYARSG.GSVVSALL..GLeDIELP..IRSIE...LYLKRDIN....--SMY..RCSAV..FEAIDARAALVVRLLLS.HGL...N...GAFSV....QDS.SIFVENADITETELI..........................
S5ZZ34_9SPIR/29-275                 ......k-GIEEPFGIIGDDADIYVYMPV.EKNRKIVEQ...VLPA...-ATGQSMKQALSRTTAIYSGIT.IS.....AAGVEVRVCARGKYPYGMTDSFFKKKDGW.......NP...KK.T..KE.........G...YK...YYE..SPYLDVSIPSPLIACMGLG.....PQNRKDMQELLSRMKK..PVDPE............FPEK..FNFLINSN..L--.--QDIGIFVKNP.DLFLSGIL..GV.SLGLP..LGKIE...MYLKKASDg..mQQNEY..RYDLY..IESGTPQTTKVAKMILQ.RAL...K...AEVKV....EEN.MLIVEGGNISEEKIT..........................
H7EP70_9SPIR/34-273                 ...padv----AARDLLVPDAEIYFSVPV.EPNKSFLMKassLALS...GTKPGDVRKMLERIDAVYISCSgID.....GASPTIGAVASGSFPATLAGFFLKEGNGW......rRR...EV.G..AH.........K...CY...DHM..DTGYGLSFASSSLACLASD.....GD---ALSAELSRFDS..ALSGS............LLEH..VDF---AE..SD-.--GAISFFIPDG.GWFMETFL..SNgF--IK..IGGVE...SVAGFLSQv..eGAEAF..DVSLS..LKVPDERMRRAVSGMMRiFGL...R...AEVLG....E--.---------------disvsgvrl.................
S3L238_TREMA/34-301                 .......NKQIDLFTLFDDGADVYLHIPVnEANKSFVRN...LVNSwtdDVNESDLNNMLNRTEEIAAAFF.IEwganlKSTVKFQLASRGKYPSLLINAGLTKKNGWt.....dVS...EK.A..AD.........M...IL...NRK..RHSNNIELASPDNNHIFISnkdvlSMQKKYFLSLISPVSV..LDWPS............LPGE..NTALPVRT..LMD.DAELVSVYMPTA.GSLLPKMV..GS.----P..IELGI...KYAAGTLKs..yKEDHA..IVTLK..LQMSDERSLKIAEKLFR.FAV...L...GTNIIvkqdRGT.VLILDNFVVWPAALT..........................
A0A1T4KFD8_9SPIR/35-293             .....le--QVEPLKLIDGGSPVIVYIPV.SASKTFVEY...AMTDf.fDFSQKNVQSIVSRMENIALALD.SD.....EK---IQIAVEGSFPKAGIKMAFSEKKGW.......NTqiiKG.T..SF.........P...FA...VYS..SAAVPFKVAFPDSKTFVAS.....----ENVSKMLARYER..EQNIFefgengknsqdsLSDE..IYDFLTDN..N--.-ASQIRFYSQNP.GNLFGKIV..GK.TINLG..LKSLS...GSLEASKA....-DEKF..ALVLN..LELSNPAIAKAAVKMLK.VAL...F...-----....---.---------------pipakivqkgasqiqlsdislsynql
F2NXH1_TRES6/27-285                 .....vq--NVDPLSLLEENSSIYMSVPA.SKNQELVSK...ILCSkisGLAEKDARAIAARTEILYAGLG.TV.....DDRSRLQIVSETSIPRIVVQSSLSKKNGW......eKS...FV.SyyEK.........V...FE...KFT..HASDGFQASFPSSNLVCAS.....----QNVDLLLKKFAE..NNPA-............PETA..WKNWIAQD..L--.SQGEILFYITKP.GQYLRSLI..GQ.SINVG..TDAIFgslCYFPDKKDs.akYSGKY..ELSFS..IHLLDKRSVVALRSLLG.LSF...AmtgGAVEQ...tDDF.TLRISGIEISENKI-e.........................
A0A841RC14_9SPIO/29-270             kritwlp-----------ADSKVFLNVNI.DGNRELFNR...TITK..mGIDNKDLQSIIDRSHTVCLGLE.NPl...dLADPGIHMISEGEYNSGMMKLGLRVSKDW.......AQ...TD.R..ES.........G...TI...TNA..EAGIQIV---PEKGKILFS.....-EG--KIDEILTNRVD..PVPVY............LPRD..VRDHFIE-..---.--SDIILYYPQPsRDVLTALS.pNLaDLEVD..LFYIS...MNKVEPVAe..gEEPEY..EIMGL..VRMKDITKTRPFSTALK.WVI...L...GVVVS....---.---------------senpdtkqflktikidtq........
Q73JB3_TREDE/34-278                 ......p-GVVRPFGMIGDDADMYIYMPI.EKNKKIAEP...ILTS...-VGGESMKQALSRTTAVYSGVF.VK.....DRLTEIRICSTGKYPYGMTDSIFKKKNGW.......EP...KK.T..KE.........K...YK...YYK..SSYVDISIPSPQIACLVMG.....PDNRQNMEVFLGKLSK..PEEAM............FSER..FGTLVNSG..S--.--QDIGIFVTNG.DFFLGQII..GV.QLGLP..VGVIE...MYLKKNPE....VENEY..LYDLS..IETKNVMTASLLKLFFK.KQL...K...ADVRL....EEN.KLIIENRSVTESRII..........................
#=GC seq_cons                       ......t..pVsPhsLlss-uslYltlPl.psscpLlpp...llsu...slscpDs+plhsRssslYuGls.ts.....pstsplplsupGsaPpshssthhs+KsGW.......ps...tp.s..tc.........s...hp...hYp..ssshslshsuPphuplshu.........tslpshLs+hsp..ss.st............Lspc..hpshh.st.......ts-IthYhspP.tpaLspll..Gh.slsls..lsslp...hhhtpspp.....pspY..hhslp..lchpDt+ts+uscslLp.huh...t...upstt....pts.plhlpshplspppl...........................
//