#=GF ID TTC3_DZIP3_dom
#=GF AC PF19179.4
#=GF DE E3 ubiquitin-protein ligase TTC3/DZIP3 domain
#=GF PI DUF5861;
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Moenttinen H;0000-0003-2461-0690
#=GF SE Manual
#=GF GA 26.90 26.90;
#=GF TC 27.00 27.10;
#=GF NC 25.50 26.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 20059950
#=GF RT The E3 ligase TTC3 facilitates ubiquitination and degradation of
#=GF RT phosphorylated Akt.
#=GF RA Suizu F, Hiramuki Y, Okumura F, Matsuda M, Okumura AJ, Hirata N,
#=GF RA Narita M, Kohno T, Yokota J, Bohgaki M, Obuse C, Hatakeyama S,
#=GF RA Obata T, Noguchi M;
#=GF RL Dev Cell. 2009;17:800-810.
#=GF RN [2]
#=GF RM 12538761
#=GF RT hRUL138, a novel human RNA-binding RING-H2 ubiquitin-protein
#=GF RT ligase.
#=GF RA Kreft SG, Nassal M;
#=GF RL J Cell Sci. 2003;116:605-616.
#=GF DR INTERPRO; IPR043866;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain is found in E3 ubiquitin-protein ligases TTC3 and
#=GF CC DZIP3 and its function is unknown. TTC3 mediates ubiquitination
#=GF CC and degradation of phosphorylated Akt, apparently its preferable
#=GF CC target [1]. DZIP3 is also able to bind RNA through a Lys-rich
#=GF CC region which enhances is ubiquitination activity. It is
#=GF CC suggested that RNA-binding proteins or ribonucleoprotein
#=GF CC particles might be physiological targets for this enzyme, which
#=GF CC could be important during viral infections, especially for those
#=GF CC replicating through RNA intermediates [2]. This domain is also
#=GF CC found in uncharacterised proteins found in viruses.
#=GF SQ 888
#=GS A0A6J3RAU1_TURTR/311-426 AC A0A6J3RAU1.1
#=GS A0A2U4ABX2_TURTR/223-336 AC A0A2U4ABX2.1
#=GS A0A8C5P3T2_JACJA/225-337 AC A0A8C5P3T2.1
#=GS A0A6P5KZU4_PHACI/600-715 AC A0A6P5KZU4.1
#=GS A0A452QIX9_URSAM/597-712 AC A0A452QIX9.1
#=GS A0A8N5EYB4_GEOFO/633-748 AC A0A8N5EYB4.1
#=GS A0A8Q3WLL9_HUMAN/312-427 AC A0A8Q3WLL9.1
#=GS A0A2Y9KKC6_ENHLU/621-736 AC A0A2Y9KKC6.1
#=GS C9J9M8_HUMAN/223-336 AC C9J9M8.1
#=GS A0A6L2Q7W4_COPFO/381-511 AC A0A6L2Q7W4.1
#=GS A0A8C9BCA7_PHOSS/621-736 AC A0A8C9BCA7.1
#=GS A0A8C4VQV3_9SAUR/588-703 AC A0A8C4VQV3.1
#=GS A0A6P3QIX4_PTEVA/665-780 AC A0A6P3QIX4.1
#=GS D3Z485_MOUSE/221-336 AC D3Z485.1
#=GS A0A1S3G6X3_DIPOR/224-337 AC A0A1S3G6X3.1
#=GS A0A8C8ZCR9_PROSS/617-732 AC A0A8C8ZCR9.1
#=GS H0WL24_OTOGA/223-336 AC H0WL24.1
#=GS A0A6P5D2I5_BOSIN/223-336 AC A0A6P5D2I5.1
#=GS A0A3Q7P010_CALUR/621-736 AC A0A3Q7P010.1
#=GS A0A6P6H2G7_PUMCO/621-736 AC A0A6P6H2G7.1
#=GS A0A7J7ZVE2_MYOMY/171-285 AC A0A7J7ZVE2.1
#=GS A0A218UT02_9PASE/206-321 AC A0A218UT02.1
#=GS A0A8C8R812_9SAUR/574-689 AC A0A8C8R812.1
#=GS A0A6J1XXX9_ACIJB/621-736 AC A0A6J1XXX9.1
#=GS A0A8C6GPT9_MUSSI/225-337 AC A0A8C6GPT9.1
#=GS A0A1S2ZNS6_ERIEU/222-335 AC A0A1S2ZNS6.1
#=GS A0A8C6RY54_NANGA/225-338 AC A0A8C6RY54.1
#=GS A0A093HDP3_STRCA/540-655 AC A0A093HDP3.1
#=GS A0A8D2CMW2_SCIVU/224-336 AC A0A8D2CMW2.1
#=GS M3YF32_MUSPF/224-337 AC M3YF32.1
#=GS A0A7K9X0C1_9GRUI/546-661 AC A0A7K9X0C1.1
#=GS A0A3Q7RE94_VULVU/221-336 AC A0A3Q7RE94.1
#=GS A0A384DDI4_URSMA/223-336 AC A0A384DDI4.1
#=GS A0A093HXX1_GAVST/532-647 AC A0A093HXX1.1
#=GS A0A8C6GTL2_MUSSI/641-756 AC A0A8C6GTL2.1
#=GS A0A6J2WUS6_CHACN/585-700 AC A0A6J2WUS6.1
#=GS A0A6J3HRU2_SAPAP/640-755 AC A0A6J3HRU2.1
#=GS A0A6J3A429_VICPA/226-339 AC A0A6J3A429.1
#=GS A0A5F5XKN4_FELCA/224-337 AC A0A5F5XKN4.1
#=GS A0A3M0K4Y5_HIRRU/555-644 AC A0A3M0K4Y5.1
#=GS F6U2A3_MONDO/207-320 AC F6U2A3.2
#=GS H7C3Z1_HUMAN/20-74 AC H7C3Z1.1
#=GS A0A7K9UYA7_ANSSE/546-661 AC A0A7K9UYA7.1
#=GS A0A6J3RBJ1_TURTR/621-736 AC A0A6J3RBJ1.1
#=GS A0A7J8A2Y3_MYOMY/940-1055 AC A0A7J8A2Y3.1
#=GS A0A5E4B6K1_MARMO/312-427 AC A0A5E4B6K1.1
#=GS A0A452CI85_BALAS/221-336 AC A0A452CI85.1
#=GS A0A663EC69_AQUCH/589-704 AC A0A663EC69.1
#=GS A0A2K5M2B0_CERAT/458-512 AC A0A2K5M2B0.1
#=GS A0A6G1AWV7_CROCR/629-744 AC A0A6G1AWV7.1
#=GS A0A8C3L1I0_CHRPC/602-717 AC A0A8C3L1I0.1
#=GS A0A8C3WA32_9CETA/621-736 AC A0A8C3WA32.1
#=GS A0A2R9A1G2_PANPA/223-336 AC A0A2R9A1G2.1
#=GS A0A151ME93_ALLMI/518-633 AC A0A151ME93.1
#=GS A0A455BIA1_PHYMC/221-336 AC A0A455BIA1.1
#=GS A0A2I2UA76_FELCA/185-298 AC A0A2I2UA76.2
#=GS A0A8C4XXR1_9SAUR/588-703 AC A0A8C4XXR1.1
#=GS A0A455BI13_PHYMC/620-735 AC A0A455BI13.1
#=GS A0A2R9A1H0_PANPA/223-336 AC A0A2R9A1H0.1
#=GS A0A8U0V8R9_MUSPF/224-337 AC A0A8U0V8R9.1
#=GS G3QVQ1_GORGO/223-336 AC G3QVQ1.2
#=GS A0A8C5LB82_JACJA/221-333 AC A0A8C5LB82.1
#=GS A0A6J1XXY4_ACIJB/457-572 AC A0A6J1XXY4.1
#=GS A0A1S3RLD5_SALSA/614-729 AC A0A1S3RLD5.1
#=GS A0A7M7SVC2_STRPU/807-919 AC A0A7M7SVC2.1
#=GS A0A673Z1Y0_SALTR/475-593 AC A0A673Z1Y0.1
#=GS A0A8C6GVQ9_MUSSI/267-382 AC A0A8C6GVQ9.1
#=GS A0A6J3RB21_TURTR/621-736 AC A0A6J3RB21.1
#=GS A0A6J1XY29_ACIJB/311-426 AC A0A6J1XY29.1
#=GS A0A8M3BCR2_DANRE/591-705 AC A0A8M3BCR2.1
#=GS A0A3Q2VY74_HAPBU/573-688 AC A0A3Q2VY74.1
#=GS A0A7J8A5D0_PIPKU/223-337 AC A0A7J8A5D0.1
#=GS A0A7J8HQ04_ROUAE/3-110 AC A0A7J8HQ04.1
#=GS A0A2K5JNA7_COLAP/622-737 AC A0A2K5JNA7.1
#=GS A0A6P3QF79_PTEVA/659-774 AC A0A6P3QF79.1
#=GS A0A2I3RYZ1_PANTR/594-709 AC A0A2I3RYZ1.1
#=GS A0A6P6CQG2_PTEVA/659-774 AC A0A6P6CQG2.1
#=GS E9PCE7_HUMAN/604-719 AC E9PCE7.1
#=GS A0A8C6GPI1_MUSSI/225-337 AC A0A8C6GPI1.1
#=GS A0A2B4S6E2_STYPI/676-787 AC A0A2B4S6E2.1
#=GS A0A0Q3URR5_AMAAE/432-519 AC A0A0Q3URR5.1
#=GS A0A3B3HPV8_ORYLA/546-661 AC A0A3B3HPV8.1
#=GS A0A2K5YS50_MANLE/223-336 AC A0A2K5YS50.1
#=GS A0A6J2AYG0_ACIJB/224-337 AC A0A6J2AYG0.1
#=GS A0A7J8A2P7_MYOMY/220-335 AC A0A7J8A2P7.1
#=GS A0A3Q0HBL3_ALLSI/593-672 AC A0A3Q0HBL3.1
#=GS A0A3Q4BID7_MOLML/375-490 AC A0A3Q4BID7.1
#=GS A0A6P7JKD1_9TELE/573-688 AC A0A6P7JKD1.1
#=GS A0A3Q1JPQ5_ANATE/577-692 AC A0A3Q1JPQ5.2
#=GS A0A6I9KHA7_CHRAS/223-336 AC A0A6I9KHA7.1
#=GS A0A7K8PBR4_COCCO/555-670 AC A0A7K8PBR4.1
#=GS A0A672HKB7_SALFA/320-435 AC A0A672HKB7.1
#=GS A0A7M5V1T6_9CNID/584-689 AC A0A7M5V1T6.1
#=GS A0A8B8XA93_BALMU/223-336 AC A0A8B8XA93.1
#=GS A0A452GA52_CAPHI/238-351 AC A0A452GA52.1
#=GS A0A8C8XNS0_PANLE/224-337 AC A0A8C8XNS0.1
#=GS A0A7K9YST6_9GALL/565-680 AC A0A7K9YST6.1
#=GS A0A485MNU4_LYNPA/170-283 AC A0A485MNU4.1
#=GS A0A2K5PV96_CEBIM/224-337 AC A0A2K5PV96.1
#=GS A0A6J1SBI9_FRAOC/480-603 AC A0A6J1SBI9.1
#=GS H7BZ57_HUMAN/622-737 AC H7BZ57.2
#=GS A0A452IDD6_9SAUR/570-685 AC A0A452IDD6.1
#=GS A0A8C6E0L2_MOSMO/744-859 AC A0A8C6E0L2.1
#=GS A0A7K4KTF0_9AVES/544-659 AC A0A7K4KTF0.1
#=GS A0A8B6GFN5_MYTGA/615-730 AC A0A8B6GFN5.1
#=GS A0A7J7J7Q1_BUGNE/731-840 AC A0A7J7J7Q1.1
#=GS A0A287CSW4_ICTTR/225-337 AC A0A287CSW4.1
#=GS A0A5F4W5M5_CALJA/624-739 AC A0A5F4W5M5.2
#=GS A0A8C2T5K7_COTJA/590-705 AC A0A8C2T5K7.1
#=GS A0A5F5Y772_FELCA/185-298 AC A0A5F5Y772.1
#=GS A0A2J7QJ52_9NEOP/383-510 AC A0A2J7QJ52.1
#=GS A0A8I3Q015_CANLF/491-606 AC A0A8I3Q015.1
#=GS A0A493T9I7_ANAPP/212-327 AC A0A493T9I7.1
#=GS A0A455BI23_PHYMC/311-426 AC A0A455BI23.1
#=GS A0A2Y9SJI4_PHYMC/223-336 AC A0A2Y9SJI4.1
#=GS A0A8C8EJN2_ONCTS/598-713 AC A0A8C8EJN2.1
#=GS A0A6P8R337_GEOSA/601-716 AC A0A6P8R337.1
#=GS A0A2K6E8S9_MACNE/223-336 AC A0A2K6E8S9.1
#=GS A0A8M1F7X4_URSMA/596-711 AC A0A8M1F7X4.1
#=GS A0A3Q7RUS7_VULVU/224-337 AC A0A3Q7RUS7.1
#=GS F6V479_MACMU/622-737 AC F6V479.3
#=GS F6WIK4_ORNAN/261-375 AC F6WIK4.3
#=GS A0A3Q7PHZ5_CALUR/223-336 AC A0A3Q7PHZ5.1
#=GS A0A665XBK5_ECHNA/405-520 AC A0A665XBK5.1
#=GS A0A8C9UEG5_SERCA/296-411 AC A0A8C9UEG5.1
#=GS A0A6P6C635_PTEVA/1-90 AC A0A6P6C635.1
#=GS A0A2K6QP96_RHIRO/208-321 AC A0A2K6QP96.1
#=GS A0A8B8CY81_CRAVI/719-833 AC A0A8B8CY81.1
#=GS A0A8B9WNL8_BOSMU/223-336 AC A0A8B9WNL8.1
#=GS A0A7M7GDZ6_NASVI/151-278 AC A0A7M7GDZ6.1
#=GS A0A091MQI3_9PASS/1-32 AC A0A091MQI3.1
#=GS A0A455BI90_PHYMC/602-717 AC A0A455BI90.1
#=GS A0A3Q0H6Z8_ALLSI/598-713 AC A0A3Q0H6Z8.1
#=GS A0A6P5D127_BOSIN/223-336 AC A0A6P5D127.1
#=GS A0A2K5K155_COLAP/223-336 AC A0A2K5K155.1
#=GS A0A6P3H489_BISBI/223-336 AC A0A6P3H489.1
#=GS A0A2I2YK06_GORGO/223-336 AC A0A2I2YK06.1
#=GS A0A7N9ANH6_9TELE/559-674 AC A0A7N9ANH6.1
#=GS A0A7J7ZVT8_MYOMY/223-337 AC A0A7J7ZVT8.1
#=GS W5MC87_LEPOC/568-683 AC W5MC87.1
#=GS A0A3Q7RCM2_VULVU/621-736 AC A0A3Q7RCM2.1
#=GS A0A6J0XS37_ODOVR/223-336 AC A0A6J0XS37.1
#=GS A0A8C8YSE1_PROSS/223-336 AC A0A8C8YSE1.1
#=GS A0A6P6H1H2_PUMCO/643-758 AC A0A6P6H1H2.1
#=GS A0A3N0XGM1_ANAGA/552-666 AC A0A3N0XGM1.1
#=GS A0A7J8HZK6_MOLMO/223-336 AC A0A7J8HZK6.1
#=GS A0A669QY82_PHACC/581-696 AC A0A669QY82.1
#=GS G5APD4_HETGA/223-336 AC G5APD4.1
#=GS A0A8C5B2U2_GADMO/632-663 AC A0A8C5B2U2.1
#=GS A0A7J8ACV1_PIPKU/690-805 AC A0A7J8ACV1.1
#=GS A0A2Y9LGN9_DELLE/221-336 AC A0A2Y9LGN9.1
#=GS A0A087V5N0_BALRE/1-107 AC A0A087V5N0.1
#=GS A0A7L0BYK9_9AVES/540-655 AC A0A7L0BYK9.1
#=GS D3YZ03_MOUSE/312-427 AC D3YZ03.2
#=GS A0A7J8A3D5_MYOMY/490-605 AC A0A7J8A3D5.1
#=GS A0A7J8A451_MYOMY/136-251 AC A0A7J8A451.1
#=GS A0A5N5SNP8_9CRUS/182-271 AC A0A5N5SNP8.1
#=GS A0A8B9M421_9AVES/589-704 AC A0A8B9M421.1
#=GS A0A6J1XXV9_ACIJB/603-718 AC A0A6J1XXV9.1
#=GS A0A212CIV3_CEREH/311-405 AC A0A212CIV3.1
#=GS A0A6J0XS35_ODOVR/223-336 AC A0A6J0XS35.1
#=GS A0A8C9HYD8_9PRIM/223-336 AC A0A8C9HYD8.1
#=GS A0A5F9CAR5_RABIT/223-337 AC A0A5F9CAR5.1
#=GS A0A091SBT9_9GRUI/536-651 AC A0A091SBT9.1
#=GS A0A6P5L7C4_PHACI/599-714 AC A0A6P5L7C4.1
#=GS A0A5F9DK03_RABIT/223-337 AC A0A5F9DK03.1
#=GS A0A2Y9K176_ENHLU/224-337 AC A0A2Y9K176.1
#=GS A0A8B7VE72_CASCN/623-738 AC A0A8B7VE72.1
#=GS A0A7N4NTC9_SARHA/599-714 AC A0A7N4NTC9.1
#=GS A0A0R4J1T2_MOUSE/221-336 AC A0A0R4J1T2.1
#=GS A0A5N4EM98_CAMDR/519-634 AC A0A5N4EM98.1
#=GS A0A484GW99_SOUCH/621-736 AC A0A484GW99.1
#=GS A0A8C4M0W0_EQUAS/172-285 AC A0A8C4M0W0.1
#=GS A0A6J2AZ54_ACIJB/224-337 AC A0A6J2AZ54.1
#=GS A0A2K6RBK9_RHIRO/622-737 AC A0A2K6RBK9.1
#=GS A0A7J8I3A4_MOLMO/620-735 AC A0A7J8I3A4.1
#=GS A0A091PNV0_HALAL/167-282 AC A0A091PNV0.1
#=GS A0A3S0ZN07_ELYCH/458-568 AC A0A3S0ZN07.1
#=GS A0A7F8RLR0_LEPWE/549-658 AC A0A7F8RLR0.1
#=GS A0A8B7D7E6_HYDVU/394-508 AC A0A8B7D7E6.1
#=GS A0A1V4J292_PATFA/713-828 AC A0A1V4J292.1
#=GS A0A8I5NHI5_PAPAN/312-427 AC A0A8I5NHI5.1
#=GS D6RDD2_MOUSE/604-719 AC D6RDD2.1
#=GS F1P0T0_CHICK/602-717 AC F1P0T0.2
#=GS A0A812BK95_SEPPH/687-807 AC A0A812BK95.1
#=GS A0A384A918_BALAS/621-736 AC A0A384A918.1
#=GS A0A8C4LVB4_EQUAS/207-320 AC A0A8C4LVB4.1
#=GS A0A485NUM2_LYNPA/311-426 AC A0A485NUM2.1
#=GS A0A485MKL5_LYNPA/224-337 AC A0A485MKL5.1
#=GS A0A8J5R1U6_9HYME/145-275 AC A0A8J5R1U6.1
#=GS A0A7J8ADC4_PIPKU/572-687 AC A0A7J8ADC4.1
#=GS A0A8W8KL84_CRAGI/705-819 AC A0A8W8KL84.1
#=GS A0A3Q1M3P6_BOVIN/619-734 AC A0A3Q1M3P6.1
#=GS A0A6J3HT25_SAPAP/389-504 AC A0A6J3HT25.1
#=GS G1SJ16_RABIT/223-337 AC G1SJ16.2
#=GS A0A8C9UU98_SPEDA/221-336 AC A0A8C9UU98.1
#=GS A0A4W3GSS1_CALMI/20-135 AC A0A4W3GSS1.1
#=GS M7BHZ3_CHEMY/540-632 AC M7BHZ3.1
#=GS A0A6P5D217_BOSIN/223-336 AC A0A6P5D217.1
#=GS A0A226NMR0_CALSU/189-221 AC A0A226NMR0.1
#=GS A0A669R5I5_PHACC/608-723 AC A0A669R5I5.1
#=GS A0A8M1F465_URSMA/375-490 AC A0A8M1F465.1
#=GS A0A452CKI8_BALAS/223-336 AC A0A452CKI8.1
#=GS A0A2K5WTA2_MACFA/223-336 AC A0A2K5WTA2.2
#=GS A0A8C4S4P5_ERPCA/217-332 AC A0A8C4S4P5.1
#=GS A0A8C9I180_9PRIM/209-322 AC A0A8C9I180.1
#=GS A0A455BKP3_PHYMC/621-736 AC A0A455BKP3.1
#=GS G3HXM1_CRIGR/136-251 AC G3HXM1.1
#=GS A0A6P5L3Z2_PHACI/600-715 AC A0A6P5L3Z2.1
#=GS A0A3Q7QN13_CALUR/222-335 AC A0A3Q7QN13.1
#=GS A0A835TUK7_9PASS/401-432 AC A0A835TUK7.1
#=GS A0A485MMV0_LYNPA/224-337 AC A0A485MMV0.1
#=GS A0A3P9BSW2_9CICH/479-594 AC A0A3P9BSW2.1
#=GS A0A091S8L2_NESNO/539-654 AC A0A091S8L2.1
#=GS A0A3Q0H724_ALLSI/590-705 AC A0A3Q0H724.1
#=GS A0A3Q0H729_ALLSI/297-412 AC A0A3Q0H729.1
#=GS A0A6J0XSU9_ODOVR/184-297 AC A0A6J0XSU9.1
#=GS A0A7M7ND06_STRPU/655-767 AC A0A7M7ND06.1
#=GS A0A7J8I3N4_MOLMO/220-335 AC A0A7J8I3N4.1
#=GS A0A6P9DPP7_PANGU/601-715 AC A0A6P9DPP7.1
#=GS A0A226PIL4_COLVI/440-555 AC A0A226PIL4.1
#=GS A0A6J2AYF4_ACIJB/224-337 AC A0A6J2AYF4.1
#=GS A0A452IDR2_9SAUR/588-703 AC A0A452IDR2.1
#=GS A0A1U8BWJ0_MESAU/660-775 AC A0A1U8BWJ0.2
#=GS G3STQ6_LOXAF/627-742 AC G3STQ6.1
#=GS A0A2I0U1M5_LIMLA/335-383 AC A0A2I0U1M5.1
#=GS A0A8B8XBP1_BALMU/603-718 AC A0A8B8XBP1.1
#=GS A0A455BKP9_PHYMC/602-717 AC A0A455BKP9.1
#=GS A0A7M7M1V9_NASVI/151-278 AC A0A7M7M1V9.1
#=GS A0A1S3RLD9_SALSA/600-715 AC A0A1S3RLD9.1
#=GS A0A8C3K4D2_9CHAR/384-499 AC A0A8C3K4D2.1
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A0A3Q7QN13_CALUR/222-335 .......................................ededl-----P..TTFK..DLLNDFIKTT.ENN..IMKQ....TICSYL..DC..ER...S.....C...............E......A.........DIL.....K-NTNY.KGFFQLMCS....KS...CCVYFHKICWKKFKN...L...K...YP....G......E....ND.QTFSG.KKCLKEGC......T......G...D......MVRMLQCDVPGIV---ki..................................
A0A835TUK7_9PASS/401-432 ............................................------..----..----------.---..----....------..--..--...-.....-...............-......-.........---.....------.---------....--...---------------...-...-...--....-......-....--.KDFLK.EMCFTPDC......K......G...L......ISKIVIFSSSGLVKCE....................................
A0A485MMV0_LYNPA/224-337 .......................................ededl-----P..TTFK..DLLNDFIKTT.ESN..IMKQ....TICSYL..DC..ER...S.....C...............E......A.........DIL.....K-NTNY.KGFFQLMCS....KS...CCVYFHKICWKKFKN...L...K...YP....G......E....ND.QSFSG.RKCLKEGC......T......G...D......MVRMLQCDVPGIV---ki..................................
A0A3P9BSW2_9CICH/479-594 ............................................VKETQP..DCFK..EILEDAIELC.KFP..PLPD....AICRLD..KC..LC...P.....V...............K......A.........EIY.....FTDPDF.KGFIRICCC....ED...CTVEYHVTCWKTLKA...S...A...FS....E......K....SE.KDLLQ.EACLTPDC......I......G...Q......ICSITIFCPTGVVKCK....................................
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A0A6J2AYF4_ACIJB/224-337 .......................................ededl-----P..TTFK..DLLNDFIKTT.ESN..IMKQ....TICSYL..DC..ER...S.....C...............E......A.........DIL.....K-NTNY.KGFFQLMCS....KS...CCVYFHKICWKKFKN...L...K...YP....G......E....ND.QSFSG.RKCLKEGC......T......G...D......MVRMLQCDVPGIV---ki..................................
A0A452IDR2_9SAUR/588-703 ............................................IEETRT..EKLQ..LMLENFIVEC.KFP..PEPD....AVCSYQ..QC..HG...H.....S...............K......I.........QIY.....FTDPDF.KGFIQITCC....QQ...CKVEFHISCWKKMKT...T...I...YS....D......K....ND.KDFLQ.ESCFTPDC......K......G...L......ISKIVIFSSSGLVKCE....................................
A0A1U8BWJ0_MESAU/660-775 ............................................IEESKP..EKIK..TMLEKFVEEC.KFP..PVPD....AVCCYP..KC..RG...Y.....S...............K......I.........QIY.....LTDPDF.KGFIRISCC....QY...CKVEFHMNCWKKLKT...T...T...FN....D......K....ID.KDFLQ.GICLTPDC......E......G...I......ISKIIIFSSGGQVKCE....................................
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A0A8B8XBP1_BALMU/603-718 ............................................IEETQP..GKIK..MLLEKFIEEC.RFP..PVPD....AICCYQ..KC..RG...Y.....S...............K......I.........QIY.....ITDPDF.KGFIRISCC....QY...CKIEFHMNCWKKLKT...T...T...FN....D......K....ID.KDFLQ.GICLTPDC......E......G...I......ISKIIIFSSGGQVKCE....................................
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A0A7M7M1V9_NASVI/151-278 ................................eqnpkgkmwsiv------..----..------EKEC.AIY..HKPD....AICASK..EC..NQ...I.....T...............KpyvspnK.........NIY.....VKDPAF.NGMVIVHCN....NKergCILKFHPSCWKVIKD...E...Tn.lVQ....K......V....LD.KDMLG.VQCFTPNC......My....eN...N......ICRISLIE--------vlgpngevkaq.........................
A0A1S3RLD9_SALSA/600-715 ............................................VEETKL..DYFK..ELLEESIEIC.KFP..PKPD....AICRHQ..NC..LV...H.....S...............K......M.........EIY.....FTDPDF.KGFIRVVCC....QG...CKVEYHISCWKKLKA...T...A...FS....D......K....NE.KDFLQ.EICFTPEC......R......G...R......ICHIKIYGSTGLVKCE....................................
A0A8C3K4D2_9CHAR/384-499 ............................................IEETRT..ENLK..LILKNCIEEC.KFP..PEPD....AICRYQ..QC..HG...H.....S...............K......I.........QIF.....FTDPDF.KGFIRITCC....QQ...CRVEFHISCWKKLKT...T...N...FN....D......K....ND.KDFLQ.ELCFTPDC......K......G...F......ISKIVIFNSSGLVKCE....................................
A0A8C7KJJ7_ONCKI/598-713 ............................................VEESKL..DYFK..ELLEESIEMC.KFP..PKPD....AICRHQ..NC..HG...H.....S...............K......I.........EIY.....FTDPDF.KGFIRMVCC....QS...CKVEYHINCWKKLKA...T...A...FS....D......K....NE.KDFLQ.GMCFTPDC......G......G...R......ICHIKIYGSTGLVKCE....................................
A0A7N9C7S0_MACFA/223-336 .......................................ededl-----P..TTFK..DHLNNFIKTT.ESN..IMKQ....TICSYL..DC..ER...S.....C...............E......A.........DIL.....K-NTSY.KGFFQLMCG....KS...CCVYFHKICWKKFKN...L...K...YP....G......E....ND.QSFSG.KKCLKEGC......T......G...D......MVRMLQCDVPGIV---ki..................................
K7FZ63_PELSI/599-714 ............................................IEETRT..EKLQ..LMLENFIGEC.KFP..PEPD....AVCSYQ..QF..HG...H.....S...............K......I.........QIY.....FTDPDF.KGFIRITCS....EQ...CKVEFHISCWKKLKT...T...V...YS....D......K....ND.KDLLQ.ASCFTPDC......R......G...L......ISKIIIFSSSGIIKC-m...................................
A0A7J6CQ12_9TELE/598-712 ............................................VEETQP..DCLK..EHLENFIEMC.KFP..PKPD....AVCRYQ..HC..LS...H.....-...............T......V.........EIY.....FSDPDF.KGFIQLTCC....QS...CRVEFHMSCWKKLKT...L...S...FS....D......K....ND.KDFLK.DSCFTPDC......G......G...Q......VCDIVIYGSTGLIKCE....................................
A0A6P6C5M3_PTEVA/223-336 .......................................edkdl-----P..TTFK..GLLNNFIKTT.ENN..IMKQ....TICSYL..DC..ER...S.....C...............E......A.........DIL.....K-NTNY.KGFFQLMCS....KS...CCVYFHKICWKKFKN...L...K...YP....G......E....ND.QSFSG.KKCLKEGC......T......G...D......MVRMLQCDVPGIV---ki..................................
A0A6P6EH88_OCTDE/622-737 ............................................IEESQP..NRIK..MILEKFVEEC.KFP..PVPD....AICSYQ..KC..LG...L.....S...............K......I.........QIY.....VTDPDF.KGFIRISCC....QY...CKIEFHINCWKKLKA...T...T...FN....D......K....ID.KDFLQ.GVCLTPDC......E......G...I......ISKIIIFSRGGRVKCE....................................
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A0A2K5PVA7_CEBIM/224-337 .......................................ededl-----P..TTFK..DLLNNFIKTT.ESN..IMKQ....TICSYL..DC..ER...S.....C...............E......A.........DIV.....K-NTSY.KGFFQLMCS....KN...CCVYFHKICWKRFKN...L...K...YP....G......E....ND.QSFIA.KKCLKEGC......T......G...D......MARMLQCDVPGI----vki.................................
A0A6P9DPF8_PANGU/617-731 ............................................IKETRS..ETLQ..VILEDCITEC.KFP..PKPD....AVCRYQ..QC..QA...H.....-...............K......V.........KIY.....FNDPDF.KGFIRIACC....KQ...CIVEFHLSCWKKVKA...T...R...YC....D......K....ND.KDILQ.EMCFTPDC......S......G...L......ISKITVFSSSGIVKCE....................................
A0A8C0K485_CANLU/173-286 .......................................ededl-----P..TTFK..DLLNDFIKTT.ESN..IMKQ....TICSYL..DC..ER...S.....C...............E......A.........DIL.....K-NTNY.KGFFQLMCS....KS...CCVYFHKICWKKFKN...L...K...YP....G......E....ND.QTFSG.KKCLKEGC......T......G...D......MVRMLQCDVPGIV---ki..................................
A0A2I0MSJ9_COLLI/590-705 ............................................IEETRT..EKLQ..LTLRNCIEEC.KFP..PEPD....AVCRYQ..QC..HG...H.....S...............K......I.........QIY.....FTDPDF.KGFIRITCC....QQ...CRVEFHISCWKKLKT...T...N...YS....D......K....ND.KDFLQ.ELCFTPDC......T......G...L......ISKIVIFSSSGLVKCE....................................
A0A8I6ABF8_RAT/605-720 ............................................IEESKP..EKVK..VMLEKFVEEC.KFP..PVPD....AVCCYQ..KC..RG...F.....S...............K......I.........QIY.....LTDPDF.KGFIRISCC....QY...CKVEFHMNCWKKLKT...T...T...FN....D......K....ID.KDFLQ.GICLTPDC......E......G...I......ISKIIIFSSGGQVKCE....................................
A0A2U3VBJ2_ODORO/223-336 .......................................ededl-----P..TTFK..DLLNDFIKTT.ENN..IMKQ....TICSYL..DC..ER...S.....C...............E......A.........DIL.....K-NTNY.KGFFQLMCS....KS...CCVYFHKICWKKFKN...L...K...YP....G......E....ND.QTFSG.KKCLKEGC......T......G...D......MVRMLQCDVPGIV---ki..................................
A0A8U0SCH9_MUSPF/621-736 ............................................IEETQP..GKIK..MLLEKFIEEC.RFP..PVPD....AICCYQ..KC..RG...Y.....S...............K......I.........QIY.....ITDPDF.KGFIRISCC....QY...CKIEFHMNCWKKLKT...T...T...FN....D......K....ID.KDFLQ.GICLTPDC......E......G...I......ISKIIIFSSGGQVKCE....................................
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A0A834FQS2_ORYME/564-679 ............................................VRETEP..EQFK..EILESAIDLC.KFP..PAPD....AVCRLD..KC..LF...P.....L...............K......A.........EIY.....FTDPDF.KGFIRLCCC....QK...CSVEYHITCWKSVKT...S...V...FS....E......K....NE.KDILH.DACLTPDC......V......G...Q......ICCIKIFGPTGLVKCK....................................
A0A7J7ZU38_MYOMY/178-292 .......................................ededl-----P..TTFK..DLLNNFIKTT.ESN..IMKQ....TICSYL..DC..EG...S.....C...............E......A.........DIL.....R-NTNY.KGFFQLMCS....KS...CCVYFHKICWKKFKN...L...K...YP....G......E....ND.QSFSG.KKCLKEGC......T......G...D......MVRMLQCDEPGIVK--il..................................
A0A667HV46_LYNCA/223-336 .......................................ededl-----P..TTFK..DLLNDFIKTT.ESN..IMKQ....TICSYL..DC..ER...S.....C...............E......A.........DIL.....K-NTNY.KGFFQLMCS....KS...CCVYFHKICWKKFKN...L...K...YP....G......E....ND.QSFSG.RKCLKEGC......T......G...D......MVRMLQCDVPGIV---ki..................................
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A0A6P6C5J1_PTEVA/223-336 .......................................edkdl-----P..TTFK..GLLNNFIKTT.ENN..IMKQ....TICSYL..DC..ER...S.....C...............E......A.........DIL.....K-NTNY.KGFFQLMCS....KS...CCVYFHKICWKKFKN...L...K...YP....G......E....ND.QSFSG.KKCLKEGC......T......G...D......MVRMLQCDVPGIV---ki..................................
A0A4W2F459_BOBOX/223-336 .......................................ededl-----P..TTFK..DLLNNFIKTT.EGN..IMKQ....TICSYL..DC..ER...S.....C...............E......A.........DVL.....-KNTNY.KGFFQLMCS....KS...CCVYFHKICWKKFKN...L...K...YP....G......E....ND.QSFSG.KKCLKEGC......T......G...D......MVRMLQCEVPG-----ivki................................
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A0A091DKJ1_FUKDA/223-336 .......................................ededl-----P..TNFK..DLLNSFIKTT.ENN..IMKQ....TICSYL..DC..ER...S.....C...............E......A.........DIL.....K-NTNY.KGFFQLMCS....KN...CCIYFHKICWKKFKN...L...K...YP....G......E....ND.QSFSG.KTCLKEGC......T......G...D......MVRM------------lqgdvpgtvki.........................
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A0A8C0CA03_BALMU/223-336 .......................................ededl-----P..TTFK..DLLNNFIKTT.EGN..IMKQ....TICSYL..DC..ER...S.....C...............E......A.........DIL.....K-NTNY.KGFFQLMCS....KS...CCVYFHKICWKKFKN...L...K...YP....G......E....ND.QSFSG.KKCLKEGC......T......G...D......MVRMLQCEVPG-----ivki................................
A0A2R9CEM5_PANPA/606-721 ............................................IEESQP..EKIK..MLLEKFVEEC.KFP..PVPD....AICCYQ..KC..CG...Y.....S...............K......M.........QIY.....ITDPDF.KGFIRISCC....QY...CKIEFHMNCWKKLKT...T...T...FN....D......K....ID.KDFLQ.GICLTPDC......Q......G...V......ISKIIIFSSGGQVKCE....................................
A0A6P5C2I3_BOSIN/311-426 ............................................IEETQP..GKIK..MLLEKFVEEC.RFP..PVPD....ATCCYQ..KC..HG...Y.....S...............K......I.........QIY.....ITDPDF.KGFIRISCC....QY...CKIEFHMNCWKKLKT...T...T...FN....D......K....ID.KDFLQ.GICLTPDC......E......G...I......ISKIIIFSSGGQVKCE....................................
A0A7M7M844_VARDE/458-569 .........................................hpv----NQ..EAFE..KACSSLLAQL.ENS..PQAD....HVCCNR..NT..CA...-.....-...............K......P.........EIF.....ERSLDF.SGFVRVFCQ....EG...CVLVLHPRCWKAMVG...N...-...LA....G......R....RT.KHGTG.AQCCTPDC......Q......G...R......INLLIMFNSRMEIT--ke..................................
A0A834MMV7_VESVU/139-268 ............................................INETTK..EGLL..ISLMDLQEKA.SSW..HCPN....AKCFLE..YC..QN...NiphcsP...............C......K.........DIF.....FSDPAF.SGLVVITCS....NAsnpCKLNFHPVCWKFQKS...Kl.cI...VN....K......L....SD.KDMIG.RSCFTSNCgt..edR......S...V......ITKIEILNDDAKV---vsv.................................
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A0A8J6B514_ELECQ/1-43 ............................................------..----..----------.---..----....------..--..--...-.....-...............-......-.........---.....------.---------....--...------------MKA...T...L...YC....D......K....ND.KDFLK.YTCLTPDC......R......G...V......ISHIVIFDSMAQVKCE....................................
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A0A4W5PBH0_9TELE/352-467 ............................................VEETKL..DYFK..ELLEESIERC.KFP..PKPD....AICQHQ..NC..HG...H.....S...............K......M.........EIY.....FTDPDF.KGFIRVVCC....QN...CKVEYHISCWKKLKA...T...A...FS....D......K....NE.KDFLQ.EICFTPEC......G......G...R......ICHIKIYDSTGLVKCE....................................
A0A4W3HDJ5_CALMI/731-847 ............................................IEETKD..GVLK..ELLDSLLKEC.WFH..PRPD....AVCHYE..LC..HM...H....nI...............K......C.........NIY.....RSDPDF.KGFVRVHCS....QN...CRIEYHIYCWKRCKI...K...A...FQ....D......K....IE.KEILG.FNCHTPDC......V......G...C......IWKVDIFQDSRH----kiie................................
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A0A455BNK4_PHYMC/223-336 .......................................ededl-----P..TTFK..DLLNNFIKTT.EGN..IMKQ....TVCSYL..DC..ER...S.....C...............E......A.........DIL.....K-NTNY.KGFFQLMCS....KS...CCVYFHKICWKKFKN...L...K...YP....G......E....ND.QSFSG.KKCLKEGC......T......G...D......MVRMLQCEVPG-----ivki................................
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A0A8P0TLW7_CANLF/133-246 .......................................ededl-----P..TTFK..DLLNDFIKTT.ESN..IMKQ....TICSYL..DC..ER...S.....C...............E......A.........DIL.....K-NTNY.KGFFQLMCS....KS...CCVYFHKICWKKFKN...L...K...YP....G......E....ND.QTFSG.KKCLKEGC......T......G...D......MVRMLQCDVPGIV---ki..................................
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A0A2K5CZ42_AOTNA/312-427 ............................................IEESQP..EKIK..MLLEKFVEEC.KFP..PVPD....AICCYQ..KC..RG...Y.....S...............K......I.........QIY.....ITDPDF.KGFIRISCC....QY...CKIEFHINCWKKLKT...T...T...FN....D......K....ID.KDFLQ.GICLTPDC......E......G...I......ISKIIIFSSGGQVKCE....................................
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A0A485MKL4_LYNPA/224-337 .......................................ededl-----P..TTFK..DLLNDFIKTT.ESN..IMKQ....TICSYL..DC..ER...S.....C...............E......A.........DIL.....K-NTNY.KGFFQLMCS....KS...CCVYFHKICWKKFKN...L...K...YP....G......E....ND.QSFSG.RKCLKEGC......T......G...D......MVRMLQCDVPGIV---ki..................................
A0A2J7QJ41_9NEOP/316-443 ............................................ISETTR..NGLE..DGLKGLLKMC.RVY..HEPD....AICKYN..QC..HK...I.....S...............Shi.ipsE.........HIF.....YSDPDF.SGFVTVICQ....EK...CRIEYHLGCWKDYKE...A...I...MSteigK......L....SD.KDFIG.RSCPTTDC......V......T...Q......ANECSVITKIEIV---gddatv..............................
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A0A1S3G241_DIPOR/621-736 ............................................IEESHP..EKIK..MLLEKFVEEC.RFP..PVPD....AVCCYQ..KC..HG...Y.....S...............K......I.........QIY.....ITDPDF.KGFIRISCC....QY...CKIEFHMNCWKKLKT...T...T...FN....D......K....ID.KDFLQ.GICLTPDC......E......G...T......ISKIIIFSSGGQVKCE....................................
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A0A8C2YRA0_CHILA/223-336 .......................................ededl-----P..TAFK..DLLNNFIKTT.ESN..IMKQ....TICSYL..DC..ER...S.....C...............E......A.........DIL.....K-NTNY.KGFFQLMCS....KS...CCVYFHKMCWKKFKN...L...K...YP....G......E....ND.QSFSG.KKCLKEGC......T......G...D......MVRMLQCDVPGIV---ki..................................
A0A6D2XDK7_PONAB/622-737 ............................................IEESQP..QKIK..MLLEKFVEEC.KFP..PVPD....AICCYQ..KC..HG...Y.....S...............K......I.........QIY.....ITDPDF.KGFIRISCC....QY...CKIEFHMNCWKKLKT...T...T...FN....D......K....ID.KDFLQ.GICLTPDC......E......G...V......ISKIIIFSSGGEVKCE....................................
A0A4X2L2A9_VOMUR/207-319 ........................................kded----LP..ETFQ..DLLDDYIKKY.ENL..IEKG....TICSSR..DC..ER...S.....C...............E......T.........DIL.....K-KSKY.KGFVHLICS....EN...CSIYFHKICWEKFKN...I...K...HS....G......K....SD.ESFSE.KTCLKKGC......I......G...N......IVKMQ-----------kcegpgvfn...........................
A0A8I3PSR1_CANLF/224-337 .......................................ededl-----P..TTFK..DLLNDFIKTT.ESN..IMKQ....TICSYL..DC..ER...S.....C...............E......A.........DIL.....K-NTNY.KGFFQLMCS....KS...CCVYFHKICWKKFKN...L...K...YP....G......E....ND.QTFSG.KKCLKEGC......T......G...D......MVRMLQCDVPGIV---ki..................................
A0A1S3WT38_ERIEU/634-749 ............................................IEETHP..GKIK..MLLGKFIEEC.KFP..PVPD....ATCCYQ..KC..RG...Y.....S...............K......V.........QIY.....VSDPDF.KGFIRISCC....QY...CKIEFHMNCWKKLKT...T...T...FN....D......K....ID.KDFLQ.GICLTPDC......E......G...I......ISKIIIFSSGGQVKCE....................................
#=GC seq_cons ............................................lpEopP..pphK...lLcpFIcpC.+hP..PhPD....AICsYp..cC..cs.........s...............+......h.........pIa.....hoDPDF.KGFlplhCs....pp...Cpl-FHhsCWKKlKs...t...p...as....c......+....sD.KDFLp.thCLTPDC......p......G..........Is+IllasssG.VKp.....................................
//
