#=GF ID TTc_toxin_rep
#=GF AC PF18807.5
#=GF DE Tripartite Tc toxins repeat
#=GF AU Paladin L;0000-0003-0011-9397
#=GF AU Piovesan D;0000-0001-8210-2390
#=GF SE RepeatsDB
#=GF GA 29.00 25.00;
#=GF TC 29.30 28.80;
#=GF NC 28.70 23.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 24572368
#=GF RT Mechanism of Tc toxin action revealed in molecular detail.
#=GF RA Meusch D, Gatsogiannis C, Efremov RG, Lang AE, Hofnagel O,
#=GF RA Vetter IR, Aktories K, Raunser S;
#=GF RL Nature. 2014;508:61-65.
#=GF DR INTERPRO; IPR041508;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Tripartite Tc toxin complexes of bacterial pathogens perforate
#=GF CC the host membrane and translocate toxic enzymes into the host
#=GF CC cell. These structures undergo a transition between a prepore to
#=GF CC a pore state [1] and they are mainly constituted by closed
#=GF CC beta-layer repeats. This Pfam entry includes a single repeat
#=GF CC unit.
#=GF SQ 57
#=GS Q7MZV7_PHOLL/425-469 AC Q7MZV7.1
#=GS A0A2X4TMW6_SALER/422-466 AC A0A2X4TMW6.1
#=GS A0A3N1I575_9ENTR/413-457 AC A0A3N1I575.1
#=GS A0A0L0M000_9BURK/375-419 AC A0A0L0M000.1
#=GS T0QMZ1_PHOTE/396-439 AC T0QMZ1.1
#=GS E5AU94_MYCRK/1847-1891 AC E5AU94.1
#=GS T0PBV8_PHOTE/412-456 AC T0PBV8.1
#=GS C0ATU3_9GAMM/72-116 AC C0ATU3.1
#=GS D3VGF9_XENNA/433-482 AC D3VGF9.1
#=GS Q7MZU2_PHOLL/419-463 AC Q7MZU2.1
#=GS Q7N7Z1_PHOLL/412-456 AC Q7N7Z1.1
#=GS T0NYT3_PHOTE/425-468 AC T0NYT3.1
#=GS W1IQG7_9GAMM/426-470 AC W1IQG7.1
#=GS A0A2Z6EYD0_9BURK/428-472 AC A0A2Z6EYD0.1
#=GS Q0WAX8_YERPE/479-523 AC Q0WAX8.1
#=GS T0P160_PHOTE/425-469 AC T0P160.1
#=GS C0AQZ0_9GAMM/135-179 AC C0AQZ0.1
#=GS A0A2A2HMI0_9GAMM/48-92 AC A0A2A2HMI0.1
#=GS A0A509CWT2_9ENTR/62-103 AC A0A509CWT2.1
#=GS T0NXK1_PHOTE/420-464 AC T0NXK1.1
#=GS L1M7U2_9PSED/425-469 AC L1M7U2.1
#=GS A0A4P7KQ39_9GAMM/432-468 AC A0A4P7KQ39.1
#=GS A0A2D0KBY3_9GAMM/434-478 AC A0A2D0KBY3.1
#=GS A0A2Z6EY43_9BURK/426-470 AC A0A2Z6EY43.1
#=GS A0A103EJW6_9BURK/239-287 AC A0A103EJW6.1
#=GS D3V0Q1_XENBS/423-467 AC D3V0Q1.1
#=GS A0A2S0PAL3_9NEIS/425-470 AC A0A2S0PAL3.1
#=GS A0A7K4EAZ5_9PSED/427-471 AC A0A7K4EAZ5.1
#=GS Q7N7Y4_PHOLL/424-468 AC Q7N7Y4.1
#=GS D3V3H9_XENBS/414-458 AC D3V3H9.1
#=GS T0QFH4_PHOTE/416-460 AC T0QFH4.1
#=GS A0A2Z6EY71_9BURK/428-472 AC A0A2Z6EY71.1
#=GS Q7N7X5_PHOLL/420-464 AC Q7N7X5.1
#=GS M1SJJ1_MORMO/70-114 AC M1SJJ1.1
#=GS W1J412_9GAMM/431-475 AC W1J412.1
#=GS A0A2V2YWD9_9BACL/1659-1699 AC A0A2V2YWD9.1
#=GS A0A380SCC3_YERPE/429-473 AC A0A380SCC3.1
#=GS A0A509CYK4_9ENTR/432-476 AC A0A509CYK4.1
#=GS A0A4Q1BA74_9GAMM/234-257 AC A0A4Q1BA74.1
#=GS Q7N7Y7_PHOLL/417-461 AC Q7N7Y7.1
#=GS A9MLT1_SALAR/422-466 AC A9MLT1.1
#=GS A0A014NAG0_9GAMM/431-475 AC A0A014NAG0.1
#=GS W1J3J6_9GAMM/422-466 AC W1J3J6.1
#=GS M1SR07_MORMO/421-465 AC M1SR07.1
#=GS A0A089YU68_9PSED/417-461 AC A0A089YU68.1
#=GS D3VFD3_XENNA/420-464 AC D3VFD3.1
#=GS W1J1L4_9GAMM/432-476 AC W1J1L4.1
#=GS A0A3N1J6A9_9ENTR/414-458 AC A0A3N1J6A9.1
#=GS A0A2S0P8T4_9NEIS/420-464 AC A0A2S0P8T4.1
#=GS A0A089Q1C3_9ENTR/428-472 AC A0A089Q1C3.1
#=GS A0A2U8I357_9GAMM/416-460 AC A0A2U8I357.1
#=GS D3VHI0_XENNA/422-466 AC D3VHI0.1
#=GS A0A089YQU6_9PSED/422-466 AC A0A089YQU6.1
#=GS A0A3B0J4V9_9GAMM/172-216 AC A0A3B0J4V9.1
#=GS Q7MZ20_PHOLL/416-460 AC Q7MZ20.1
#=GS Q0WEK9_YERPE/432-476 AC Q0WEK9.1
#=GS Q0WAX9_YERPE/411-455 AC Q0WAX9.1
Q7MZV7_PHOLL/425-469 ........QNSYTTEMTVSSRSNRTVLSTLTT.....DPTQVDG..LFDAGGHQKTLIPG....
A0A2X4TMW6_SALER/422-466 ........GNCHTTYITVSDSSNRAVLRSLAA.....TPAEVEM..HFGPSGEQLQLQPG....
A0A3N1I575_9ENTR/413-457 ........GNNYTADITVSNRSNRAVLSTLTK.....NPAEVDV..LFTAGGQQKQLSPG....
A0A0L0M000_9BURK/375-419 ........NNRYTTDITVSDRSNRGVLSTLTE.....NRSAVDG..LFTASGQQKQLQPG....
T0QMZ1_PHOTE/396-439 ......sp---WTRGMVVSTTSNRAILKTVPP.....LASSPDM..GFTPGGRQRTLVDG....
E5AU94_MYCRK/1847-1891 ......aq--HYTLRMVVAAGSNRAVPEAWDA.....APEQVDR..YFDANGNLTQLQPG....
T0PBV8_PHOTE/412-456 ........QNNYTTDITISNRSNRGVLSTLTT.....DPSKVDA..LFDAGGHQTSLLPG....
C0ATU3_9GAMM/72-116 ........QQSFTQDITVSNKTNRALLKSQCS.....DPKNVDS..YFDESGNLTQLLNG....
D3VGF9_XENNA/433-482 ........GNNWTTDIAISTTANRGVSTALFTditpqNPEQVDT..LFDRAGNQLQLQPG....
Q7MZU2_PHOLL/419-463 ........QNNYTTDITVSNRSNRAVLSTLTT.....DPTKVDA..LFQAGGHQETLLPG....
Q7N7Z1_PHOLL/412-456 ........QNNYTTAITISNRSNRGVLSTLTT.....DPNQVDT..LFDAGGHQTSLLPG....
T0NYT3_PHOTE/425-468 ........QNNHTRGITVSNRSNRAVLSMLTD.....KPEEVDS..WFDAGGHQKTLH--r...
W1IQG7_9GAMM/426-470 .......r-NNHATSLTVSSRNNRAVLSAFTT.....DPEQVDT..WFDAGGHQTSLLPG....
A0A2Z6EYD0_9BURK/428-472 ........NNNYTTDITVSNRSNRAVLSQPGL.....MPDGVDA..LFDAGGHQKSLLPG....
Q0WAX8_YERPE/479-523 .......a-SQYSTHITVSDSSNHGIQQQEGI.....TARDIRS..QFDAAGNQQQLQPG....
T0P160_PHOTE/425-469 ........QNNYTTDMTVSSRSNRAVLSTLTT.....DPTQVDA..LFDSGGHQKTLMPG....
C0AQZ0_9GAMM/135-179 ......rq--SFTQDITVSNKTNRALLKSQCS.....DPKNVDS..YFDEGGNLTQLLNG....
A0A2A2HMI0_9GAMM/48-92 ........NNNYTVNITVSDRTNRAVLSSLTE.....DPTMVDR..LFTSGGQQQQLLSG....
A0A509CWT2_9ENTR/62-103 trqispsa-----------TASNRAVLRSLAA.....TPAEVEM..HFGREGKQLQLQPG....
T0NXK1_PHOTE/420-464 ........QGSYTTQITVSNRSNRAVWSTLTD.....NPMLVDD..LFDAGGHQNTLVQG....
L1M7U2_9PSED/425-469 .......a-SSHSVEITVSERSNRALLASLAG.....NPQEVEA..LFSAAGAQRCLQPG....
A0A4P7KQ39_9GAMM/432-468 ........NNNYTINITISDRSNRGVLSTLTE.....DPTEVDA..LFTAA---------v...
A0A2D0KBY3_9GAMM/434-478 ........NNCYTTNFTVSNRSNRSVLNTLTK.....EISEVDA..LFDGSGHQKQMQPG....
A0A2Z6EY43_9BURK/426-470 ........GNNYTTEITVSDRSNRAVLSQPGL.....TPGEVDV..LFDAGGHQKSLQPG....
A0A103EJW6_9BURK/239-287 ......av--NYTQEIVVSDRSNHALQQNATGt...lTPAGVDDgsWFDASGNQRMLLP-d...
D3V0Q1_XENBS/423-467 .......d-NSYTTKMTVSDRSNRAVLSTLTE.....NPAEVDA..LFTTGGQQNQLLPG....
A0A2S0PAL3_9NEIS/425-470 ......av--SFTQDFVVSARSNRSVLQTATG....iDPGAVDA..LFDAQGNPATLSTG....
A0A7K4EAZ5_9PSED/427-471 ........GNNYTLEHTLSERSCRGVPNALAS.....DPAQVEA..LFTPGGQQRLLQPG....
Q7N7Y4_PHOLL/424-468 ........QNNYTTNITVSHQSNRAVLSTLTE.....DPTQVDA..LFDAGGHQNTLIAG....
D3V3H9_XENBS/414-458 ........NNNYTLNITVSNRNNHAVSQDLAE.....KPEQVDA..QFDAGGHQMNLIPG....
T0QFH4_PHOTE/416-460 ........QNDYTTNITVSNRSNHAVLNLLTT.....DPTQVDT..LFDAGGHQKKLLPG....
A0A2Z6EY71_9BURK/428-472 ........NNNYTTDITVSDRSNRAVLSQPGL.....TPGGVDA..LFDAGGNQKSLLPG....
Q7N7X5_PHOLL/420-464 ........QNNYTTDITVSNRSNHAVLNSLTT.....DPTQVDT..LFDAGGHQKKLLPG....
M1SJJ1_MORMO/70-114 ........GNNHTTDITVSQRSNRAVLKTLAD.....TPEKAEA..LFTPGGQQTQLQPG....
W1J412_9GAMM/431-475 ........GNSYTTQITVSDRSNRAVLNLLAE.....DTTKVDA..LFDAGGHQSQLLPG....
A0A2V2YWD9_9BACL/1659-1699 ......tr----TLSLTVSSCSNRAVPSSQTM.....DAAQVDA..LFDASGCL------kqde
A0A380SCC3_YERPE/429-473 ........GSGHTTDITVSDRSNQGVLSTLTT.....NPAEVDA..LFTAGGQQKQLQPG....
A0A509CYK4_9ENTR/432-476 ........GNNYTTDITVSDRSNRGVLSTLTE.....NPSGVDA..LFTAGGQQKQLQPG....
A0A4Q1BA74_9GAMM/234-257 ........NNNYIVNITVSDRTNRAVLSNLS-.....-------..--------------s...
Q7N7Y7_PHOLL/417-461 ........QNNYTTNITVSNYSNRAVLSTLTE.....DPTQVDA..LFDSGGHQTNLLSG....
A9MLT1_SALAR/422-466 ........GNCHTTYITVSDSSNRAVLRSLAA.....TPAEVEM..HFGPSGEQLQLQPG....
A0A014NAG0_9GAMM/431-475 ........GNNYTTKITVSDRSNRAVLSSLVA.....RAEEVDA..LFTNRGCQTELVSG....
W1J3J6_9GAMM/422-466 ........GNNYTTNMTVSDYSNRAVLEALAE.....DPAKVDM..LFTPGGHQTRLVPG....
M1SR07_MORMO/421-465 ........NNNYTTDITVSQRSNRAVLKTLAD.....TPEKAEA..LFTPGGQQTQLQPG....
A0A089YU68_9PSED/417-461 ........GAGFITELTTSTRSNRTLPSSLCD.....DPSQIDD..HFDAAGQQRALDHS....
D3VFD3_XENNA/420-464 ........QNNHTINITVSNRTNRGVLSSLTD.....DPNKVDA..LFNAGGQQINLLPG....
W1J1L4_9GAMM/432-476 ........GNNYTTTVTVSNRSNRAVLSTLTE.....NPADVDM..LFNANGSQRQLQPG....
A0A3N1J6A9_9ENTR/414-458 ........GSGYTTDITVSDRSNKAVLSTLTT.....KPAEVDA..LFTAGGQQKQLLQG....
A0A2S0P8T4_9NEIS/420-464 .......a-SAYTLAMIVAQTSNRAVRQTGDL.....TPADIDG..LFDACGNLLQLQPG....
A0A089Q1C3_9ENTR/428-472 ........NNRYTTDITISDRSNRGVLSTLAK.....SPSDVDG..LFTPGGQQKQLQPG....
A0A2U8I357_9GAMM/416-460 .......a-NRYTTHINVSQQSNHALFQDGDE....rQSHQIES..LFDAAGNQQQLQ--y...
D3VHI0_XENNA/422-466 ........GNNYTTNMTVSDHSNRAVLEELAQ.....DPTQVDM..LFTPGGHQTRLVPG....
A0A089YQU6_9PSED/422-466 ........GNDFTLDMTVARTSNRAVISDMCA.....DPEQVDD..CFLAAGQQKRLPEG....
A0A3B0J4V9_9GAMM/172-216 ........NNSYTTNITVSNRSNRAVLSNLTT.....DPLQVDE..LIDAGGHQSELQP-a...
Q7MZ20_PHOLL/416-460 ........NNNYTTNITISNRNNRGVLSTLTN.....DPNLVDT..FFDAGGHQTSLFSG....
Q0WEK9_YERPE/432-476 ........NNSYTTKITVSDRSNRGVLSTLTE.....NAADVDA..LFTAGGQQTKLQPG....
Q0WAX9_YERPE/411-455 .......a-SQYSTHITVSDSSNHGIQQQDGI.....IARDIRS..QFDAAGNQQQLQPG....
#=GC seq_cons ........tNsYTTsITVSsRSNRAVLsoLsp.....sPspVDs..LFsAGGpQppL.PG....
//
