#=GF ID   TcpA
#=GF AC   PF05946.16
#=GF DE   Toxin-coregulated pilus subunit TcpA
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_3639 (release 9.0)
#=GF GA   25.00 25.00;
#=GF TC   25.90 29.00;
#=GF NC   22.60 21.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0327
#=GF RN   [1]
#=GF RM   12540588
#=GF RT   Pathogenic potential of environmental Vibrio cholerae strains
#=GF RT   carrying genetic variants of the toxin-coregulated pilus
#=GF RT   pathogenicity island. 
#=GF RA   Faruque SM, Kamruzzaman M, Meraj IM, Chowdhury N, Nair GB, Sack
#=GF RA   RB, Colwell RR, Sack DA; 
#=GF RL   Infect Immun 2003;71:1020-1025.
#=GF DR   INTERPRO; IPR010271;
#=GF DR   SCOP; 1oqv; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of toxin-coregulated pilus subunit (TcpA)
#=GF CC   proteins from Vibrio cholerae and related sequences. The major
#=GF CC   virulence factors of toxigenic Vibrio cholerae are cholera toxin
#=GF CC   (CT), which is encoded by a lysogenic bacteriophage (CTXPhi),
#=GF CC   and toxin-coregulated pilus (TCP), an essential colonisation
#=GF CC   factor which is also the receptor for CTXPhi. The genes for the
#=GF CC   biosynthesis of TCP are part of a larger genetic element known
#=GF CC   as the TCP pathogenicity island [1].
#=GF SQ   13
#=GS F9RBA0_VIBSN/92-217       AC F9RBA0.1
#=GS A0A085GMR1_9GAMM/107-221  AC A0A085GMR1.1
#=GS TCPA_VIBCH/97-222         AC Q60153.1
#=GS Q5DZ51_ALIF1/81-206       AC Q5DZ51.1
#=GS A0A0L0AX53_9ENTR/109-233  AC A0A0L0AX53.1
#=GS A0A090UYB8_PSEVU/105-231  AC A0A090UYB8.1
#=GS A0A447M9I7_SALBN/116-243  AC A0A447M9I7.1
#=GS A0A1Y0DCH2_VIBCL/97-222   AC A0A1Y0DCH2.1
#=GS D2TPA8_CITRI/112-229      AC D2TPA8.1
#=GS A0A859PS25_9ENTR/108-221  AC A0A859PS25.1
#=GS E3G6F3_ENTLS/112-232      AC E3G6F3.1
#=GS L0LY75_ENTBF/111-232      AC L0LY75.1
#=GS A0A370QRK9_9GAMM/110-234  AC A0A370QRK9.1
F9RBA0_VIBSN/92-217                  .ALISMGKISTSDIVNPFTGA..Q..LEV....YTT..AD.....NK..A..AN..RGFAIKAGNLSQNQCRAIVSSSNELFAFIQ.VEPVGGTLA...TDM-.---YVDPKA.NEP...TG.VIKSTK..GGV.NQFDISNLDQL.TALCGGDAGATTYYDLFVG.....................
A0A085GMR1_9GAMM/107-221             s-LVQLGKLSESEAKNGISGDyfH..MGG....VRI.tTG.....PT..A..GL..KGFYLTINGLDQAQCRNIITQIGNQWDYVG.V----VAAA...AGVD.AVAPSSLDA.TLV...SG.VLRSLH..AS-.-----------.-------------------gnvtitpaatlgvctnt....
TCPA_VIBCH/97-222                    .GLVSLGKVSADEAKNPFTGT..A..MGI....FSF..PR.....NS..A..AN..KAFAITVGGLTQAQCKTLVTSVGDMFPFIN.VKEGAFAAV...ADLG.DFETSVADA.ATG...AG.VIKSIA..PGS.ANLNLTNITHV.EKLC----TGTAPFTVAFG.....................
Q5DZ51_ALIF1/81-206                  .ALVSMGRVTESDLINPFTGA..P..MLI....FTA..KD.....NK..A..AN..RGFAIKVSDLSKDQCTSLISNSADLFSFIE.VQNRGTAMA...ADF-.---YVDPDA.TKS...VG.VIKSTK..GGA.KTLDLTNLDHI.SALCGGPGAGDSYFDVFVG.....................
A0A0L0AX53_9ENTR/109-233             t-LVKLGKISPDESFNGVSND..AfqMGN....AKI..DT.....SS..S..QN..KAFVLAVNGLETEECRNLISLMGNQWDYVE.ALKADAGAG...KDIT.SLDGRDLSV.AKS...GA.VLKSLT..SGEiKAADIT----A.SGICDGAG-----------aingvif..............
A0A090UYB8_PSEVU/105-231             t-LNKLGKVSPSESFNGISGD..A..FQI....GQAlvDS.....ES..T..VH..KGFVLLVSGLDQQTCRNLLSQMGNQWDYVG.IISA-PAGE...DEST.VLNATELDA.DKK...AGtVLKSLS..-VA.E--DITSTDIVdEATCN--------------igganngivfg..........
A0A447M9I7_SALBN/116-243             r-LVQLGKISVDEARNGISND..Y..LNI....GGA..IT.....STgaT..TD..KGFVIEINGLDQSQCRSVISQVGNNWDYVAtVTAPAGSYTvngSNF-.DMTTAAVAApTSA...QA.VLRSLDttTGS.QTI--------.-------------------taamtaavcsddssngv....
A0A1Y0DCH2_VIBCL/97-222              .GLVSLGKVSADEAKNPFTGT..A..MGI....FSF..PR.....NS..A..AN..KAFAITVGGLTQAQCKTLVTSVGDMFPFIN.VKEGAFAAV...ADLG.DFETSVADA.ATG...AG.VIKSIA..PGS.ANLNLTNITHV.EKLC----TGTAPFTVAFG.....................
D2TPA8_CITRI/112-229                 t-LVRLGKISADEAFNGFSND..A..FQI....ANA..QT.....DS..SssQK..KGFVVMVNGLASEECRNLISQMGNQWDYVE.AVNTNAAAG...SEP-.TITGKDFSV.GKS...GA.ILKTLT..S--.-----------.-------------------geiapadivadgvcdgqgs..
A0A859PS25_9ENTR/108-221             t-LVQLGQVSATEIKNGMSGD..Y..FMMqgvkLTA..DA.....ED..G..ST..KGFVLALNGLDAGSCRSILTQVGNTWDFVQ.VATAAAGAD...PTLPtSLDGDVAIT.ATGggpTG.VMKSLA..A--.-----------.-------------------aggvtisp.............
E3G6F3_ENTLS/112-232                 q-LTQLGKITPDEVRNNISGD..F..IGI....GGA..ITvagatGP..N..AL..KGFAMELNGLSQEQCRSILGQVGNNWEYVA.VGTSGSGNY...S-LT.AGGVDMTAA.SDG...TA.ILRSL-..---.-----------.-------------------gadgqeslnsakllatctatv
L0LY75_ENTBF/111-232                 t-LVRMGKIAADEAFNGFSND..A..FQI....DQA..KT.....DS..T..SNqyKGFVVLVNGLAADECRNLISQMGNQWDYVE.ALNTGATAG...KQI-.TLTGRSLDV.AAS...GA.ILKTLV..SGD.V----------.-------------------apdqivatgvcdgsgsvngv.
A0A370QRK9_9GAMM/110-234             t-LVKMGKISADEAFNGFSSD..AfqMGP....ART..SG.....NS..T..VN..KGFVLVVNGLDTETCRNLVSQMGPQWDYVA.TTTAAAGAD...ANID.DMDLTGAVN.-IT...NG.LLKTLD..--A.DSLNPTNIVN-.NGVCNQSGST---------naaifg...............
#=GC seq_cons                        p.LVpLGKlSsDEuhNGhSGD..s..htI....sss..ss.....so..u..us..KGFsltVNGLspspCRsLlSQhGNpWDYVp.VtssuuuAs...usls.shssssssA.spu...sG.VLKSLs..sus.t..............................s.sh.................
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