#=GF ID   TcpS
#=GF AC   PF17456.6
#=GF DE   Toxin-coregulated pilus protein S
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   PRODOM:PD091271
#=GF GA   28.00 28.00;
#=GF TC   28.10 226.40;
#=GF NC   27.80 23.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   27668288
#=GF RT   Single Nucleotide Polymorphisms in Regulator-Encoding Genes Have
#=GF RT   an Additive Effect on Virulence Gene Expression in a Vibrio
#=GF RT   cholerae Clinical Isolate.
#=GF RA   Carignan BM, Brumfield KD, Son MS;
#=GF RL   mSphere. 2016; [Epub ahead of print]
#=GF DR   INTERPRO; IPR020213;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The toxin-coregulated pilus (TCP) and cholera toxin (CT) are two
#=GF CC   main virulence factors produced by V. cholerae, which allows the
#=GF CC   bacterium to colonize and establish an infection in a host and
#=GF CC   to cause the physical symptoms of the disease, respectively.
#=GF CC   Increased expression of the TCP, a type IV pilus expressed by
#=GF CC   the tcp operon (tcpABQCRDSTEF) located on the Vibrio
#=GF CC   pathogenicity island (VPI), has been associated with enhanced
#=GF CC   attachment and is essential for colonization of the intestinal
#=GF CC   epithelium [1]. This domain of unknown function is found in TcpS
#=GF CC   proteins in Vibrionaceae such as Vibrio choleae.
#=GF SQ   4
#=GS Q5DZ57_ALIF1/1-149  AC Q5DZ57.1
#=GS TCPS_VIBCH/1-151    AC P29484.2
#=GS F9RBA6_VIBSN/1-152  AC F9RBA6.1
#=GS Q7BGC3_VIBCL/1-151  AC Q7BGC3.1
Q5DZ57_ALIF1/1-149             MKYILIF-CASF.LSMN-NVFADELSVFENNYKNINSLKNKLEQLELKKKIQEVEIKILQNESILNPKVINT-PQIDKPKAVVKV..KFMDESDVFDPKL.VKLLYLVGNNEEKTAVLSYKNKTQNVKDGGYYYGWRLKINNRNVVISKGSNAVAL
TCPS_VIBCH/1-151               MNIKLSFISIAF.LSLSFNVAANEFEKSQEHYKSVTDLKNKIEILELEKKITELSGEIRNAR---MPKIDKSAPVLS-PQPVVKSseELQKSIEHIEEELkVELAYLVNNGQQKKYTFNLNGKLITLVNGDFVNGWKFIEDQNKIQFSKGNKVIDV
F9RBA6_VIBSN/1-152             MIMKNKFICVSFmLAFSTVSLAQDVKFYENNISSIESLKMKLEQLELKKKILDVEIEIKEGSDKLQPTVSKAISTSSESKAVVRL..ELLKE-ESFDPKL.VRLMYLVGSGDHVAAILAYKDKTENVMNGRSYKGWRLNIKDRKASLVKGPEVIEL
Q7BGC3_VIBCL/1-151             MNIKLSFISIAF.LSLSFNVAANEFEKSQEHYKSVTDLKNKIEILELEKKITELSGEIRNAR---MPKIDKSAPVLS-PQPVVKSseELQKSIEHIEEELkVELAYLVNNGQQKKYTFNLNGKLITLVNGDFVNGWKFIEDQNKIQFSKGNKVIDV
#=GC seq_cons                  MphKLpFIsluF.LShShNVhAsEhch.pppYKSlssLKNKlE.LELcKKIpElphEI+puc....PKlsKohPslS.PpsVVKs..EL.Kp.Eph-.cL.VcLhYLVsNGppKphshshpsKh.slhNGcahpGW+hh.cppKlphSKGscVI-l
//