#=GF ID TelK_muzzle
#=GF AC PF20849.1
#=GF DE Protelomerase, muzzle domain
#=GF AU Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE ECOD:3587.1.1
#=GF GA 27.00 27.00;
#=GF TC 27.00 39.90;
#=GF NC 26.90 26.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF RC Paper describing PDB structure 2v6e
#=GF RN [1]
#=GF RM 17889664
#=GF RT An interlocked dimer of the protelomerase TelK distorts DNA
#=GF RT structure for the formation of hairpin telomeres.
#=GF RA Aihara H, Huang WM, Ellenberger T;
#=GF RL Mol Cell. 2007;27:901-913.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain is found in Protelomerase from Klebsiella phage
#=GF CC phiKO2 (TelK) and similar proteins from tailed bacteriophages
#=GF CC and bacterial prophages mainly from Gammaproteobacteria. TelK is
#=GF CC a hairpin telomere resolvase with DNA cleavage-rejoining
#=GF CC activity that resolves the catenated circular dimer produced
#=GF CC from the bidirectional replication of a chromosome. The core of
#=GF CC the TelK monomer consists of an N-terminal domain and a
#=GF CC catalytic domain connected by a long alpha- helical linker.
#=GF CC However, there are two extensions of the protein: a C-terminal
#=GF CC DNA binding domain named the stirrup (Pfam:PF20818) and an
#=GF CC N-terminal domain. The latter has an insertion termed the muzzle
#=GF CC (this entry), which folds into two long alpha-helices. This
#=GF CC protruding element is packed against the DNA-binding catalytic
#=GF CC and N-terminal domains of the opposite subunit in each dimer
#=GF CC [1].
#=GF SQ 11
#=GS A0A7L5GJP0_9CAUD/103-223 AC A0A7L5GJP0.1
#=GS A0A2Z2EKN0_9CAUD/81-198 AC A0A2Z2EKN0.1
#=GS A0A2I6TCJ0_9CAUD/12-90 AC A0A2I6TCJ0.1
#=GS A0A1X0WAW6_9GAMM/81-198 AC A0A1X0WAW6.1
#=GS W1HXV1_KLEPN/81-154 AC W1HXV1.1
#=GS Q37967_BPN15/81-198 AC Q37967.1
#=GS A0A484G9V0_9GAMM/73-172 AC A0A484G9V0.1
#=GS Q7Y3Y3_9CAUD/91-205 AC Q7Y3Y3.1
#=GS A0A1G8HZV4_9VIBR/99-219 AC A0A1G8HZV4.1
#=GS Q6UAV6_9CAUD/81-198 AC Q6UAV6.1
#=GS A0A2I6TCW8_9CAUD/81-198 AC A0A2I6TCW8.1
A0A7L5GJP0_9CAUD/103-223 .MHHSFDKSISSLRNNFPHCSYLVDEIDGYPLQETRERWSKLREKITHVVRVEKQLRKLSPDISNYATVVNKMARDFPAWSHEIEslkTL...KKEDRADAIERLQTIFDETREFYPALDKLKI-d.....
A0A2Z2EKN0_9CAUD/81-198 .LHHNFERNVIKLSEKYPLYNEELSSWLSMPAASIRQNMSALQAKLKEIMPLAEDLSNIKIGAKNSDAKLAKLANKYPEWQFAIS...DL...NSDDWKGKRDYLYKLFQQGSSLLEDLNNLKVN......
A0A2I6TCJ0_9CAUD/12-90 .LHHSFEKNIHRLSEKYPLYNEELLSWLSLPAADIRQRMSALQAKLKLILPLSEDLSNIRIGDNKSHNKLLKLS-----------...--...--------------------------------iniksg
A0A1X0WAW6_9GAMM/81-198 .LHHHFEANIHRLAAKYPLYANELNEWLTLPAADIRRRYSDLLEHLKSILSLAEDLTGIKPAVKANAGKLARIAKKYPSWEFAVL...EL...ADEDGKAALAHLHKLFQQGRLLLEDISKLRIN......
W1HXV1_KLEPN/81-154 .LHHNFEKNVIKLSEKYPLYNEELSSWLSMPAASIRQNMSALQAKLKEIMPLAEDLSNIKIGAKNSDAKLAK-------------...--...--------------------------------tcq...
Q37967_BPN15/81-198 .LHHSFDKNINKLSEKYPLYSEELSSWLSMPTANIRQHMSSLQSKLKEIMPLAEELSNVRIGSKGSDAKIARLIKKYPDWSFALS...DL...NSDDWKERRDYLYKLFQQGSALLEELHQLKVN......
A0A484G9V0_9GAMM/73-172 .LHHLFFKKINKLTINYPTYKPLFESWHNKKASTIRIELLSLKVKLKSCILLLEKY------NPSSTNDL--LKKAYPEWEKSIH...DK...TIEE----EAK------IARLLLNDLNKLKVN......
Q7Y3Y3_9CAUD/91-205 .LHHSFPQSIATISNKYPAFSEIIKDLDNRPAHEVRIKLKELITHLESGVNLLEKIGSLGKIKPSTAKKIVSLKKMYPSWANDLD...TL...ISTE---DATELQQKLEQGTDLLNALHSLKVN......
A0A1G8HZV4_9VIBR/99-219 k-HHSFDETIERLRNKYPLCAYMLHGWDELSLEETRKSWKTLTDKLKLVTALEKNLKGLTPETPRYASVVNERIKTLPEWSSELE...ALktiKPAERAEKIAHLHDVINQVPDFYSQLSSLKI-d.....
Q6UAV6_9CAUD/81-198 .LHHNFEKNVIKLSEKYPLYSEELSSWLSMPAASIRQHMSRLQAKLKEIMPLAEDLSNIKIGTKNSEAKINKLANKYPEWQFAIS...DL...NSEDWKDKRDYLYKLFQQGSSLLEDLNNLKVN......
A0A2I6TCW8_9CAUD/81-198 .LHHSFEKNIHRLSEKYPLYNEELLSWLSLPAADIRQRMSALQAKLKLILPLSEDLSNIRIGDNKSHNKLLKLSNKYKEWQFAIS...DL...TSDNWKDKRDYLYKLLQQGSALLEELNQLKVN......
#=GC seq_cons .LHHsF-KNIp+LSpKYPLYsEELpSWLohPAAsIRp+hSsLpsKLKpIhsLuE-Losl+huspsSssKls+LtppYPpWphslp...sL...ps--httthshL.plhpQuptLLppLspLKlN......
//
