#=GF ID TetR_C_15
#=GF AC PF17918.5
#=GF DE Tetracyclin repressor-like, C-terminal domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF03130
#=GF GA 26.80 26.80;
#=GF TC 26.80 26.80;
#=GF NC 26.70 26.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF CL CL0174
#=GF RN [1]
#=GF RM 15944459
#=GF RT The TetR family of transcriptional repressors.
#=GF RA Ramos JL, Martinez-Bueno M, Molina-Henares AJ, Teran W, Watanabe
#=GF RA K, Zhang X, Gallegos MT, Brennan R, Tobes R;
#=GF RL Microbiol Mol Biol Rev. 2005;69:326-356.
#=GF RN [2]
#=GF RM 27091999
#=GF RT Structures of the nucleoid occlusion protein SlmA bound to DNA
#=GF RT and the C-terminal domain of the cytoskeletal protein FtsZ.
#=GF RA Schumacher MA, Zeng W;
#=GF RL Proc Natl Acad Sci U S A. 2016;113:4988-4993.
#=GF RN [3]
#=GF RM 7707374
#=GF RT The complex formed between Tet repressor and tetracycline-Mg2+
#=GF RT reveals mechanism of antibiotic resistance.
#=GF RA Kisker C, Hinrichs W, Tovar K, Hillen W, Saenger W;
#=GF RL J Mol Biol. 1995;247:260-280.
#=GF DR INTERPRO; IPR041669;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC TetR family regulators are involved in the transcriptional
#=GF CC control of multidrug efflux pumps, pathways for the biosynthesis
#=GF CC of antibiotics, response to osmotic stress and toxic chemicals,
#=GF CC control of catabolic pathways, differentiation processes, and
#=GF CC pathogenicity [1]. The TetR proteins identified in overm ultiple
#=GF CC genera of bacteria and archaea share a common helix-turn-helix
#=GF CC (HTH) structure in their DNA-binding domain. However, TetR
#=GF CC proteins can work in different ways: they can bind a target
#=GF CC operator directly to exert their effect (e.g. TetR binds Tet(A)
#=GF CC gene to repress it in the absence of tetracycline), or they can
#=GF CC be involved in complex regulatory cascades in which the TetR
#=GF CC protein can either be modulated by another regulator or TetR can
#=GF CC trigger the cellular response. This entry represents the
#=GF CC C-terminal domain found in a number of different TetR
#=GF CC transcription regulator proteins including SlmA proteins found
#=GF CC in E. coli. Unlike other TetR proteins, SlmA functions not as a
#=GF CC transcription regulator but rather as an NO (nucleoid occlusion)
#=GF CC factor [2]. TetR regulates the expression of the
#=GF CC membrane-associated tetracycline resistance protein, TetA, which
#=GF CC exports the tetracycline antibiotic out of the cell before it
#=GF CC can attach to the ribosomes and inhibit protein synthesis [3].
#=GF CC TetR blocks transcription from the genes encoding both TetA and
#=GF CC TetR in the absence of antibiotic. The C-terminal domain is
#=GF CC multi-helical and is interlocked in the homodimer with the
#=GF CC helix-turn-helix (HTH) DNA-binding domain [3].
#=GF SQ 1357
#=GS A0A100VXZ9_9MYCO/79-186 AC A0A100VXZ9.1
#=GS A0A014NXF4_9BURK/62-171 AC A0A014NXF4.1
#=GS X6L2D9_9RHOB/96-204 AC X6L2D9.1
#=GS K9U816_CHRTP/105-212 AC K9U816.1
#=GS A0A1S1R6I8_9ACTN/99-205 AC A0A1S1R6I8.1
#=GS A0A1P8XV57_9ACTN/99-206 AC A0A1P8XV57.1
#=GS A0A345P9P5_9GAMM/94-206 AC A0A345P9P5.1
#=GS A0A8J6PYS9_9HYPH/96-204 AC A0A8J6PYS9.1
#=GS A0A1W2DIP9_9DELT/94-202 AC A0A1W2DIP9.1
#=GS A0A1I2EN43_9ACTN/94-202 AC A0A1I2EN43.1
#=GS A0A1Y5T275_9RHOB/92-195 AC A0A1Y5T275.1
#=GS A0A7W6DXC9_9RHOB/96-204 AC A0A7W6DXC9.1
#=GS A0A239CRG5_9BACT/101-204 AC A0A239CRG5.1
#=GS A0A1Q2CF80_9ACTN/94-194 AC A0A1Q2CF80.1
#=GS A0A7V7PLV7_9HYPH/95-201 AC A0A7V7PLV7.1
#=GS A0A6G9YF76_9NOCA/91-194 AC A0A6G9YF76.1
#=GS A0A2M9ARJ3_9ACTN/106-212 AC A0A2M9ARJ3.1
#=GS D3FBD4_CONWI/87-183 AC D3FBD4.1
#=GS A0A7W9BVI5_9SPHN/75-183 AC A0A7W9BVI5.1
#=GS F0RMD3_DEIPM/100-202 AC F0RMD3.1
#=GS A0A4S8NNM2_9ACTN/90-199 AC A0A4S8NNM2.1
#=GS A0A5M8SE34_9BACT/95-201 AC A0A5M8SE34.1
#=GS A0A1V0B7Q8_9PSED/90-201 AC A0A1V0B7Q8.1
#=GS A0A6B2DNH4_9PSEU/95-202 AC A0A6B2DNH4.1
#=GS B9JP64_AGRRK/84-192 AC B9JP64.1
#=GS F8B3T7_9ACTN/92-197 AC F8B3T7.1
#=GS A0A1P8KB13_9BURK/94-202 AC A0A1P8KB13.1
#=GS A0A7W8EMG0_9ACTN/89-194 AC A0A7W8EMG0.1
#=GS A0A399EVB2_9DEIN/95-202 AC A0A399EVB2.1
#=GS A0A438AK28_9RHOB/96-204 AC A0A438AK28.1
#=GS A0A1V4CBW8_9BURK/67-169 AC A0A1V4CBW8.1
#=GS A0A1Q9UXA6_9PSEU/90-185 AC A0A1Q9UXA6.1
#=GS A0A0F6W1X0_9DELT/98-208 AC A0A0F6W1X0.1
#=GS A0A0J8Y681_9ENTR/97-203 AC A0A0J8Y681.1
#=GS A0A5R9M193_9ACTN/119-226 AC A0A5R9M193.1
#=GS E2SFY7_9ACTN/95-201 AC E2SFY7.1
#=GS A0A318KD31_9NOCA/92-199 AC A0A318KD31.1
#=GS G7CDB6_MYCT3/68-170 AC G7CDB6.1
#=GS A0A853B972_9PSEU/109-212 AC A0A853B972.1
#=GS E6VXJ5_PSEA9/94-201 AC E6VXJ5.1
#=GS A0A344L9N1_9PSEU/74-181 AC A0A344L9N1.1
#=GS A0A0N9HUI8_9PSEU/77-184 AC A0A0N9HUI8.1
#=GS S9P1T1_9DELT/94-203 AC S9P1T1.1
#=GS A0A7U3UPN3_9ACTN/106-205 AC A0A7U3UPN3.1
#=GS A0A2U1VSU2_9PROT/89-197 AC A0A2U1VSU2.1
#=GS A0A1R1MGH9_9GAMM/110-216 AC A0A1R1MGH9.1
#=GS A0A2P2GRC7_9ACTN/122-230 AC A0A2P2GRC7.1
#=GS A0A3P0X4G4_9BACT/96-199 AC A0A3P0X4G4.1
#=GS A0A0Q8VGX2_9ACTN/90-197 AC A0A0Q8VGX2.1
#=GS A0A1E8Q3J4_9MYCO/84-187 AC A0A1E8Q3J4.1
#=GS A0A162JX45_9ACTN/96-202 AC A0A162JX45.1
#=GS Q5YVI5_NOCFA/74-176 AC Q5YVI5.1
#=GS A0A327W3N2_9ACTN/74-183 AC A0A327W3N2.1
#=GS A0A178WP22_9PSEU/94-203 AC A0A178WP22.1
#=GS A0A4R6SDZ9_LABRH/68-175 AC A0A4R6SDZ9.1
#=GS A0A8E6B9P0_9BACT/85-189 AC A0A8E6B9P0.1
#=GS A0A430KN29_9GAMM/76-183 AC A0A430KN29.1
#=GS A0A1D9H6T9_9BURK/101-208 AC A0A1D9H6T9.1
#=GS A0A178X5J2_9PSEU/1-91 AC A0A178X5J2.1
#=GS A0A1I4VLJ6_9PSEU/81-186 AC A0A1I4VLJ6.1
#=GS A4JA45_BURVG/108-217 AC A4JA45.1
#=GS A0A1V9KIQ4_9ACTN/98-205 AC A0A1V9KIQ4.1
#=GS A0A850JUH4_9ACTN/94-202 AC A0A850JUH4.1
#=GS A0A0D7EXL9_RHOPL/96-204 AC A0A0D7EXL9.1
#=GS A0A4Q2J3X9_9BURK/91-198 AC A0A4Q2J3X9.1
#=GS A0A4Y8UKP2_9GAMM/94-201 AC A0A4Y8UKP2.1
#=GS A0A1X7DXD8_TRICW/101-205 AC A0A1X7DXD8.1
#=GS A0A1H1IPZ6_9HYPH/96-202 AC A0A1H1IPZ6.1
#=GS A0A2T1C7E6_9CYAN/97-205 AC A0A2T1C7E6.1
#=GS A0A8J7BN94_9CYAN/97-205 AC A0A8J7BN94.1
#=GS A0A0Q8PVQ9_9ACTN/76-183 AC A0A0Q8PVQ9.1
#=GS S2YI05_9ACTN/95-203 AC S2YI05.1
#=GS A0A1I1BDV8_9PSEU/91-198 AC A0A1I1BDV8.1
#=GS A0A7Y6UHW5_9DELT/95-201 AC A0A7Y6UHW5.1
#=GS A0A0G3AJX8_9ACTN/95-200 AC A0A0G3AJX8.1
#=GS A0A1C4M8H3_9ACTN/94-202 AC A0A1C4M8H3.1
#=GS A0A3A4AZR3_9ACTN/75-182 AC A0A3A4AZR3.1
#=GS S3N2K9_9GAMM/92-199 AC S3N2K9.1
#=GS A0A0M2WIR6_9BURK/93-196 AC A0A0M2WIR6.1
#=GS A0A4R3VBM6_PELSC/97-204 AC A0A4R3VBM6.1
#=GS A0A494X8B7_9BURK/92-201 AC A0A494X8B7.1
#=GS A0A1H0S0P2_9BRAD/94-206 AC A0A1H0S0P2.1
#=GS A0A0D8ZQN2_9CYAN/94-199 AC A0A0D8ZQN2.1
#=GS A0A4R2QIS4_9PSEU/72-172 AC A0A4R2QIS4.1
#=GS A0A0K1K650_9BURK/105-213 AC A0A0K1K650.1
#=GS A0A8J7DNM2_9CYAN/97-205 AC A0A8J7DNM2.1
#=GS A0A437M6N5_9SPHN/96-204 AC A0A437M6N5.1
#=GS A0A0L0K4T0_9ACTN/91-198 AC A0A0L0K4T0.1
#=GS A0A4V3YUZ5_9ACTN/114-225 AC A0A4V3YUZ5.1
#=GS A0A657B1E7_9GAMM/73-141 AC A0A657B1E7.1
#=GS A0A1G8K376_9ACTN/92-204 AC A0A1G8K376.1
#=GS A0A2T6APW4_9RHOB/96-204 AC A0A2T6APW4.1
#=GS A0A1M7RJT7_9ACTN/93-196 AC A0A1M7RJT7.1
#=GS A0A2G4F4N3_9CYAN/97-205 AC A0A2G4F4N3.1
#=GS A0A2J6MKA3_9BURK/68-166 AC A0A2J6MKA3.1
#=GS A0A059FEI0_9PROT/94-200 AC A0A059FEI0.1
#=GS J3HI42_9BURK/96-199 AC J3HI42.1
#=GS A0A1H0GFL8_9FIRM/95-204 AC A0A1H0GFL8.1
#=GS A0A4Q9HSA1_STRKA/95-203 AC A0A4Q9HSA1.1
#=GS A0A117QMW6_9ACTN/95-200 AC A0A117QMW6.1
#=GS H0E879_9ACTN/70-169 AC H0E879.1
#=GS A0A1Z2LEE1_9ACTN/101-207 AC A0A1Z2LEE1.1
#=GS A0A1T4T5T5_9HYPH/96-204 AC A0A1T4T5T5.1
#=GS A0A4R6FX75_9SPHN/70-174 AC A0A4R6FX75.1
#=GS A0A1T4T4A2_9ACTN/92-199 AC A0A1T4T4A2.1
#=GS A0A1P8XSH3_9ACTN/118-227 AC A0A1P8XSH3.1
#=GS A0A2N7QVS0_9GAMM/94-199 AC A0A2N7QVS0.1
#=GS W9B2Q3_MYCCO/94-202 AC W9B2Q3.1
#=GS A0A7K0DNH6_9NOCA/74-186 AC A0A7K0DNH6.1
#=GS A0A370HVF6_9HYPH/98-200 AC A0A370HVF6.1
#=GS A0A5C9A5M1_9GAMM/96-207 AC A0A5C9A5M1.1
#=GS A0A132BQV1_9RHOB/96-203 AC A0A132BQV1.1
#=GS A0A2V4N6D6_9ACTN/126-233 AC A0A2V4N6D6.1
#=GS Q63PJ2_BURPS/126-234 AC Q63PJ2.1
#=GS A0A1S2QP36_9ACTN/94-202 AC A0A1S2QP36.1
#=GS A0A1H6BD85_9ACTN/97-196 AC A0A1H6BD85.1
#=GS A0A841HWP7_9GAMM/111-219 AC A0A841HWP7.1
#=GS A0A100W730_9MYCO/77-180 AC A0A100W730.1
#=GS A0A376AJ97_9HYPH/49-157 AC A0A376AJ97.1
#=GS A0A0M2WMA8_9BURK/100-211 AC A0A0M2WMA8.1
#=GS A0A1H8JR20_9PROT/94-205 AC A0A1H8JR20.1
#=GS A0A378TM12_9MYCO/91-199 AC A0A378TM12.1
#=GS A0A0L6CMJ9_9MICO/87-191 AC A0A0L6CMJ9.1
#=GS A1T3P3_MYCVP/94-203 AC A1T3P3.1
#=GS A0A4Q0T6D6_9BACT/96-204 AC A0A4Q0T6D6.1
#=GS A0A7W3M0T9_ACTNM/91-192 AC A0A7W3M0T9.1
#=GS A0A1C3MZB5_9ACTN/102-210 AC A0A1C3MZB5.1
#=GS A0A2N7VU11_9BURK/106-210 AC A0A2N7VU11.1
#=GS A0A7W7WYJ9_9PSEU/120-227 AC A0A7W7WYJ9.1
#=GS A0A839LK44_9BURK/93-203 AC A0A839LK44.1
#=GS A0A840EWP1_9ACTN/92-197 AC A0A840EWP1.1
#=GS A0A8J8HF25_9ACTN/87-193 AC A0A8J8HF25.1
#=GS A0A2N8KJU4_9BURK/5-74 AC A0A2N8KJU4.1
#=GS A0A2T0PX95_9ACTN/91-199 AC A0A2T0PX95.1
#=GS A0A0N9HZS4_9PSEU/89-188 AC A0A0N9HZS4.1
#=GS A0A0Q7ZM61_9ACTN/74-183 AC A0A0Q7ZM61.1
#=GS A0A5B0GIY3_9BURK/103-207 AC A0A5B0GIY3.1
#=GS H3SAJ9_9BACL/96-203 AC H3SAJ9.1
#=GS A0A5C8JZD5_9ACTN/93-200 AC A0A5C8JZD5.1
#=GS A0A7K2FED9_9ACTN/92-200 AC A0A7K2FED9.1
#=GS A0A1G7E2T1_9RHOB/94-197 AC A0A1G7E2T1.1
#=GS R4LMA9_9ACTN/94-202 AC R4LMA9.1
#=GS A0A0Q8IBH8_9HYPH/96-204 AC A0A0Q8IBH8.1
#=GS A0A3N6DAJ1_9ACTN/93-204 AC A0A3N6DAJ1.1
#=GS A0A0B0HWM0_9BACL/99-206 AC A0A0B0HWM0.1
#=GS A0A0B4XA64_9HYPH/97-204 AC A0A0B4XA64.1
#=GS A0A6N8HY61_9FIRM/88-196 AC A0A6N8HY61.1
#=GS A0A4R3YL32_9GAMM/95-198 AC A0A4R3YL32.1
#=GS A0A850EQF9_9BACL/97-204 AC A0A850EQF9.1
#=GS U5QNB3_9CYAN/98-205 AC U5QNB3.1
#=GS A0A0Q8UNT3_9ACTN/76-183 AC A0A0Q8UNT3.1
#=GS A0A3Q9IDP4_9BACL/125-231 AC A0A3Q9IDP4.1
#=GS A0A7Y6I4L6_9ACTN/74-181 AC A0A7Y6I4L6.1
#=GS A0A0N7Z4S3_9CYAN/94-203 AC A0A0N7Z4S3.1
#=GS A0A7K2KS05_9ACTN/91-199 AC A0A7K2KS05.1
#=GS A0A1H8IGX0_9ACTN/91-199 AC A0A1H8IGX0.1
#=GS C6W9A3_ACTMD/87-194 AC C6W9A3.1
#=GS K9UFW2_CHAP6/92-201 AC K9UFW2.1
#=GS A0A5S9R746_MYCVN/74-176 AC A0A5S9R746.1
#=GS A0A5B7R5E2_9ACTN/132-236 AC A0A5B7R5E2.1
#=GS A0A7W7ZG48_9BACT/89-196 AC A0A7W7ZG48.1
#=GS B2HPW6_MYCMM/97-198 AC B2HPW6.1
#=GS A0A3M0IAR5_9ACTN/98-205 AC A0A3M0IAR5.1
#=GS A0A5D0QQN7_9ACTN/99-203 AC A0A5D0QQN7.1
#=GS A0A1I5G7Y1_PSUAM/75-180 AC A0A1I5G7Y1.1
#=GS A0A844MF92_9CYAN/94-203 AC A0A844MF92.1
#=GS A0A8J8CNF0_9CYAN/96-203 AC A0A8J8CNF0.1
#=GS A0A2S5TFG5_9GAMM/101-210 AC A0A2S5TFG5.1
#=GS U9VJ77_9CYAN/101-210 AC U9VJ77.1
#=GS B1FSZ5_PARG4/95-199 AC B1FSZ5.1
#=GS A0A1Z4R624_9CYAN/96-203 AC A0A1Z4R624.1
#=GS A0A540WCF3_9ACTN/103-210 AC A0A540WCF3.1
#=GS K9RNF4_9CYAN/94-201 AC K9RNF4.1
#=GS A0A0V7ZMU5_9CYAN/87-194 AC A0A0V7ZMU5.1
#=GS A0A1D9H7K6_9BURK/110-221 AC A0A1D9H7K6.1
#=GS A0A840NAR2_9PSEU/95-203 AC A0A840NAR2.1
#=GS A0A5P0YWA8_9ACTN/74-181 AC A0A5P0YWA8.1
#=GS A0A5K7ZA86_9DELT/93-200 AC A0A5K7ZA86.1
#=GS A0A7I7Y2J0_9MYCO/84-188 AC A0A7I7Y2J0.1
#=GS A0A840RK22_9NEIS/96-204 AC A0A840RK22.1
#=GS A0A1T5I6F6_9MICO/98-205 AC A0A1T5I6F6.1
#=GS A0A4T0UW08_9ACTN/90-196 AC A0A4T0UW08.1
#=GS A0A7W8E2T8_9BACT/96-204 AC A0A7W8E2T8.1
#=GS A0A370H1M3_9NOCA/75-177 AC A0A370H1M3.1
#=GS A0A7W8MSK3_9BACT/94-199 AC A0A7W8MSK3.1
#=GS A0A4Z0LXB6_9GAMM/107-207 AC A0A4Z0LXB6.1
#=GS A0A6A7MDS1_9PROT/94-205 AC A0A6A7MDS1.1
#=GS A0A1M5KYE4_STRHI/74-181 AC A0A1M5KYE4.1
#=GS A0A255ZJ13_9BURK/98-202 AC A0A255ZJ13.1
#=GS D7B2L3_NOCDD/74-176 AC D7B2L3.1
#=GS A0A4V3FTP7_9PSEU/77-183 AC A0A4V3FTP7.1
#=GS A0A7W7QXW2_KITKI/97-204 AC A0A7W7QXW2.1
#=GS A0A1G6PIU2_9BURK/87-193 AC A0A1G6PIU2.1
#=GS C1ABP0_GEMAT/99-204 AC C1ABP0.1
#=GS A0A8X8KMB5_9RHOB/93-200 AC A0A8X8KMB5.1
#=GS A0A0D8ZMA5_9CYAN/94-201 AC A0A0D8ZMA5.1
#=GS A0A8A8D266_9BURK/108-217 AC A0A8A8D266.1
#=GS A0A5N0UWX9_9PSEU/93-201 AC A0A5N0UWX9.1
#=GS A0A0T1W5S9_9MYCO/84-202 AC A0A0T1W5S9.1
#=GS A0A7W8JNW6_9GAMM/97-204 AC A0A7W8JNW6.1
#=GS A0A6N4V7P5_9MYCO/72-174 AC A0A6N4V7P5.1
#=GS A0A844MI08_9CYAN/97-205 AC A0A844MI08.1
#=GS A0A1X1SXR5_9MYCO/86-187 AC A0A1X1SXR5.1
#=GS A0A3N1DC37_9ACTN/101-210 AC A0A3N1DC37.1
#=GS A0A1W6MWJ9_9HYPH/96-203 AC A0A1W6MWJ9.1
#=GS A0A3D8JTR4_9BURK/94-206 AC A0A3D8JTR4.1
#=GS A0A1Q4RIC8_9CYAN/87-194 AC A0A1Q4RIC8.1
#=GS A0A239DLY4_9BACT/96-204 AC A0A239DLY4.1
#=GS A0A2L0W984_9HYPH/84-192 AC A0A2L0W984.1
#=GS A0A4P8IPT4_9BURK/97-199 AC A0A4P8IPT4.1
#=GS A0A2V3U742_9HYPH/95-203 AC A0A2V3U742.1
#=GS A0A3G9J4M6_9ACTN/74-179 AC A0A3G9J4M6.1
#=GS A0A318LR29_9PSEU/80-188 AC A0A318LR29.1
#=GS A0A7Y6UJK0_9DELT/94-203 AC A0A7Y6UJK0.1
#=GS K0EV10_NOCBR/74-182 AC K0EV10.1
#=GS A0A844M4P7_9CYAN/68-178 AC A0A844M4P7.1
#=GS J2WC83_9BURK/94-197 AC J2WC83.1
#=GS A0A1J0VP83_9NOCA/86-193 AC A0A1J0VP83.1
#=GS A0A2Z3IJQ1_9HYPH/100-202 AC A0A2Z3IJQ1.1
#=GS A6GGL0_9DELT/98-204 AC A6GGL0.1
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A0A1I6AED7_9PSEU/93-201 ...............................................pvev----WLPALTEAVVGLH..VE.N.....PR.LHQV......L....F...........E.......E........A.....P.........R.......P.........P.........E.........L.....lA.......R.........F..........R...........Q.......V.......E......Q......E..........A...V..A...A.V....A...A..........L......L.....R..T.............D..........T....G....L........H....V.....-......T....R..P........D.....Q..A..A..R..F....VVATI.ESLTHR......FMG...HNP........qLATNDLVDQIVSMILKYL.........................
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