#=GF ID TetR_C_30
#=GF AC PF17939.5
#=GF DE Tetracyclin repressor-like, C-terminal domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF03841
#=GF GA 26.30 26.30;
#=GF TC 26.30 26.30;
#=GF NC 26.20 26.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0174
#=GF RN [1]
#=GF RM 15944459
#=GF RT The TetR family of transcriptional repressors.
#=GF RA Ramos JL, Martinez-Bueno M, Molina-Henares AJ, Teran W, Watanabe
#=GF RA K, Zhang X, Gallegos MT, Brennan R, Tobes R;
#=GF RL Microbiol Mol Biol Rev. 2005;69:326-356.
#=GF RN [2]
#=GF RM 7707374
#=GF RT The complex formed between Tet repressor and tetracycline-Mg2+
#=GF RT reveals mechanism of antibiotic resistance.
#=GF RA Kisker C, Hinrichs W, Tovar K, Hillen W, Saenger W;
#=GF RL J Mol Biol. 1995;247:260-280.
#=GF RN [3]
#=GF RM 18524913
#=GF RT The Pseudomonas aeruginosa PsrA responds to long-chain fatty
#=GF RT acid signals to regulate the fadBA5 beta-oxidation operon.
#=GF RA Kang Y, Nguyen DT, Son MS, Hoang TT;
#=GF RL Microbiology. 2008;154:1584-1598.
#=GF RN [4]
#=GF RM 11914368
#=GF RT TetR family member psrA directly binds the Pseudomonas rpoS and
#=GF RT psrA promoters.
#=GF RA Kojic M, Aguilar C, Venturi V;
#=GF RL J Bacteriol. 2002;184:2324-2330.
#=GF DR INTERPRO; IPR041586;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC TetR family regulators are involved in the transcriptional
#=GF CC control of multidrug efflux pumps, pathways for the biosynthesis
#=GF CC of antibiotics, response to osmotic stress and toxic chemicals,
#=GF CC control of catabolic pathways, differentiation processes, and
#=GF CC pathogenicity [1]. The TetR proteins identified in overm ultiple
#=GF CC genera of bacteria and archaea share a common helix-turn-helix
#=GF CC (HTH) structure in their DNA-binding domain. However, TetR
#=GF CC proteins can work in different ways: they can bind a target
#=GF CC operator directly to exert their effect (e.g. TetR binds Tet(A)
#=GF CC gene to repress it in the absence of tetracycline), or they can
#=GF CC be involved in complex regulatory cascades in which the TetR
#=GF CC protein can either be modulated by another regulator or TetR can
#=GF CC trigger the cellular response [1]. TetR regulates the expression
#=GF CC of the membrane-associated tetracycline resistance protein,
#=GF CC TetA, which exports the tetracycline antibiotic out of the cell
#=GF CC before it can attach to the ribosomes and inhibit protein
#=GF CC synthesis [2]. TetR blocks transcription from the genes encoding
#=GF CC both TetA and TetR in the absence of antibiotic. The C-terminal
#=GF CC domain is multi-helical and is interlocked in the homodimer with
#=GF CC the helix-turn-helix (HTH) DNA-binding domain [2]. This entry
#=GF CC represents the C-terminal domain present in the Pseudomonas
#=GF CC aeruginosa PsrA which regulates the fadBA5 beta-oxidation
#=GF CC operon. Functional analysis of PsrA indicated its importance in
#=GF CC regulating b-oxidative enzymes [3]. It has also been suggested
#=GF CC that PsrA, a member of the TetR family of repressors, could
#=GF CC affect global gene expression including activation of rpoS [4].
#=GF SQ 1888
#=GS A0A1S1Q9B2_9ACTN/87-198 AC A0A1S1Q9B2.1
#=GS K2PM59_9HYPH/104-217 AC K2PM59.1
#=GS B1G711_PARG4/97-212 AC B1G711.1
#=GS A0A0D1NRD9_BRAEL/99-213 AC A0A0D1NRD9.1
#=GS A0A0Q4Y6Y4_9BURK/117-227 AC A0A0Q4Y6Y4.1
#=GS A0A6C0TYN4_9PSED/91-206 AC A0A6C0TYN4.1
#=GS A0A4R5QL27_9PROT/108-220 AC A0A4R5QL27.1
#=GS A0A127EQU7_9HYPH/101-218 AC A0A127EQU7.1
#=GS A0A7W9LE30_9ACTN/95-207 AC A0A7W9LE30.1
#=GS A0A1M7EW79_9GAMM/91-205 AC A0A1M7EW79.1
#=GS A0A5D3WJJ3_9DELT/93-206 AC A0A5D3WJJ3.1
#=GS A0A095VSP7_9GAMM/93-206 AC A0A095VSP7.1
#=GS A0A101JDC9_9ACTN/95-207 AC A0A101JDC9.1
#=GS A0A397PMN4_9SPHN/105-218 AC A0A397PMN4.1
#=GS S6GJJ2_9GAMM/91-206 AC S6GJJ2.1
#=GS A0A370GWX8_9NOCA/89-201 AC A0A370GWX8.1
#=GS A0A1H0F8F0_9GAMM/91-205 AC A0A1H0F8F0.1
#=GS B9JQ99_AGRRK/110-222 AC B9JQ99.1
#=GS A0A3E0G532_9PSEU/96-202 AC A0A3E0G532.1
#=GS A0A0B8PMH9_9VIBR/89-204 AC A0A0B8PMH9.1
#=GS A0A5B8SRN0_9GAMM/91-205 AC A0A5B8SRN0.1
#=GS A0A512E147_9PROT/91-204 AC A0A512E147.1
#=GS A0A1E7ZDY1_9ALTE/89-203 AC A0A1E7ZDY1.1
#=GS A0A4Q1KEK5_9SPHN/93-209 AC A0A4Q1KEK5.1
#=GS A0A7H9BHR3_9NEIS/92-207 AC A0A7H9BHR3.1
#=GS A0A2U2CB06_9RHOB/100-217 AC A0A2U2CB06.1
#=GS A0A7K0DZL8_9NOCA/107-217 AC A0A7K0DZL8.1
#=GS A0A8E0KKF6_9CAUL/127-239 AC A0A8E0KKF6.1
#=GS A0A7S7NKX1_9BACT/105-217 AC A0A7S7NKX1.1
#=GS A0A328AJG1_9CAUL/103-216 AC A0A328AJG1.1
#=GS A0A838L615_9SPHN/84-197 AC A0A838L615.1
#=GS A6GLE6_9BURK/98-214 AC A6GLE6.1
#=GS H2FWH0_OCESG/88-203 AC H2FWH0.1
#=GS A0A2S0MS39_9RHOB/100-215 AC A0A2S0MS39.1
#=GS Q8CJK3_STRCO/98-210 AC Q8CJK3.1
#=GS A0A844GG10_9NEIS/91-206 AC A0A844GG10.1
#=GS A0A2D2AZE6_9CAUL/113-225 AC A0A2D2AZE6.1
#=GS A0A1X0Y065_9DELT/116-229 AC A0A1X0Y065.1
#=GS F4QJT7_9CAUL/84-196 AC F4QJT7.1
#=GS A0A371Q922_STRIH/95-206 AC A0A371Q922.1
#=GS A0A4U6BZK7_9HYPH/89-203 AC A0A4U6BZK7.1
#=GS A0A0R0D7D0_9GAMM/91-203 AC A0A0R0D7D0.1
#=GS A0A5S4GBH6_9ACTN/92-203 AC A0A5S4GBH6.1
#=GS A0A1Y0KU75_9PSED/90-205 AC A0A1Y0KU75.1
#=GS A0A1Y6KSW8_9GAMM/90-204 AC A0A1Y6KSW8.1
#=GS A0A0Q8Q927_9SPHN/93-209 AC A0A0Q8Q927.1
#=GS A0A366CYR6_9NOCA/97-206 AC A0A366CYR6.1
#=GS T0GV73_9SPHN/102-214 AC T0GV73.1
#=GS A0A556AIM1_9BURK/112-220 AC A0A556AIM1.1
#=GS A0A2K2FSU1_9SPHN/113-226 AC A0A2K2FSU1.1
#=GS A0A316F0R3_9BURK/113-224 AC A0A316F0R3.1
#=GS A0A1C3EM64_9GAMM/92-204 AC A0A1C3EM64.1
#=GS A0A074KGX3_9RHOB/73-181 AC A0A074KGX3.1
#=GS A0A1Y5TN51_9RHOB/98-205 AC A0A1Y5TN51.1
#=GS A0A2V1GT64_9GAMM/101-216 AC A0A2V1GT64.1
#=GS A0A2A4FPH8_9SPHN/99-212 AC A0A2A4FPH8.1
#=GS A0A6L7EYZ8_9ACTN/96-209 AC A0A6L7EYZ8.1
#=GS A0A1V4A203_9ACTN/89-201 AC A0A1V4A203.1
#=GS A3VAN3_9RHOB/97-209 AC A3VAN3.1
#=GS A0A1H7V258_9BURK/119-233 AC A0A1H7V258.1
#=GS A0A1G6S7K1_9BURK/96-211 AC A0A1G6S7K1.1
#=GS A0A1X0DV21_MYCHE/97-211 AC A0A1X0DV21.1
#=GS A0A0D0H9E0_9MICO/89-199 AC A0A0D0H9E0.1
#=GS A0A1P8FED8_9PROT/105-220 AC A0A1P8FED8.1
#=GS A0A3F2U441_9HYPH/123-237 AC A0A3F2U441.1
#=GS W9V2K5_9GAMM/90-205 AC W9V2K5.1
#=GS A0A366HS63_9BACT/107-224 AC A0A366HS63.1
#=GS A0A2U1CA82_9BURK/105-215 AC A0A2U1CA82.1
#=GS A0A7I7XKP5_9MYCO/100-212 AC A0A7I7XKP5.1
#=GS A0A1K2HAH7_9BURK/97-212 AC A0A1K2HAH7.1
#=GS A0A0B4XAS1_9HYPH/69-183 AC A0A0B4XAS1.1
#=GS A0A1B1ZHQ7_9PSEU/99-210 AC A0A1B1ZHQ7.1
#=GS A0A1N7RP92_9BURK/97-212 AC A0A1N7RP92.1
#=GS T0GSE3_9SPHN/91-203 AC T0GSE3.1
#=GS A0A1S2T052_9GAMM/106-221 AC A0A1S2T052.1
#=GS A0A0Q8QZJ7_9SPHN/98-209 AC A0A0Q8QZJ7.1
#=GS A0A1V3PXY7_9GAMM/94-205 AC A0A1V3PXY7.1
#=GS A0A0R0CP19_9GAMM/91-203 AC A0A0R0CP19.1
#=GS A0A0S2DI92_LYSEN/96-208 AC A0A0S2DI92.1
#=GS A0A0R0ADM7_9GAMM/91-203 AC A0A0R0ADM7.1
#=GS A0A0H3C524_CAUVN/108-221 AC A0A0H3C524.1
#=GS A0A2T0XF62_9BURK/115-228 AC A0A2T0XF62.1
#=GS A0A0Q5ZFB0_9BURK/107-219 AC A0A0Q5ZFB0.1
#=GS A0A1M6I218_9RHOB/89-199 AC A0A1M6I218.1
#=GS N6XC11_9RHOO/99-212 AC N6XC11.1
#=GS A0A4Q5S5I0_9SPHN/84-197 AC A0A4Q5S5I0.1
#=GS A0A840RJC3_9NEIS/78-187 AC A0A840RJC3.1
#=GS A0A1S8FH08_9BURK/85-199 AC A0A1S8FH08.1
#=GS A0A556ACH6_9BURK/100-214 AC A0A556ACH6.1
#=GS A0A1H4QJA7_9HYPH/118-230 AC A0A1H4QJA7.1
#=GS A0A4R3M1W1_9HYPH/100-210 AC A0A4R3M1W1.1
#=GS A0A089WXN6_9PSED/90-205 AC A0A089WXN6.1
#=GS F8JK67_STREN/21-70 AC F8JK67.1
#=GS A0A556AEA5_9BURK/121-233 AC A0A556AEA5.1
#=GS A0A3P1SVR8_9GAMM/91-206 AC A0A3P1SVR8.1
#=GS A0A4R5TSR6_9GAMM/92-204 AC A0A4R5TSR6.1
#=GS A0A263DRF5_9PSEU/94-199 AC A0A263DRF5.1
#=GS F3NDJ9_9ACTN/97-203 AC F3NDJ9.1
#=GS A0A8J2UVY7_9PROT/123-235 AC A0A8J2UVY7.1
#=GS A0A2U3C852_9ACTN/94-202 AC A0A2U3C852.1
#=GS A0A7Y9IY63_9BURK/117-230 AC A0A7Y9IY63.1
#=GS A0A3N2R352_9GAMM/92-206 AC A0A3N2R352.1
#=GS B4RFK5_PHEZH/116-229 AC B4RFK5.1
#=GS W9B001_MYCCO/106-217 AC W9B001.1
#=GS A0A4Q5P6D2_9BRAD/90-203 AC A0A4Q5P6D2.1
#=GS A0A1W6Z4M0_9BORD/130-242 AC A0A1W6Z4M0.1
#=GS A0A1G6YM29_9PROT/109-223 AC A0A1G6YM29.1
#=GS A0A840WG64_9RHOB/92-203 AC A0A840WG64.1
#=GS J2Q369_9SPHN/101-215 AC J2Q369.1
#=GS A0A1M6T774_9RHOB/101-212 AC A0A1M6T774.1
#=GS A0A1B9YL85_9BRAD/90-203 AC A0A1B9YL85.1
#=GS A0A3B7A4N8_9RHOO/94-212 AC A0A3B7A4N8.1
#=GS A0A0M0HTH3_VIBNE/89-204 AC A0A0M0HTH3.1
#=GS A0A1H7P5W3_STRJI/96-202 AC A0A1H7P5W3.1
#=GS A0A1I6H594_9GAMM/91-206 AC A0A1I6H594.1
#=GS A0A1Q4HL20_9MYCO/109-220 AC A0A1Q4HL20.1
#=GS A0A346BJJ8_9BURK/97-212 AC A0A346BJJ8.1
#=GS A4JE06_BURVG/112-227 AC A4JE06.1
#=GS A0A5D0RPT9_9RHOB/126-239 AC A0A5D0RPT9.1
#=GS A0A0Q9EU35_9GAMM/91-203 AC A0A0Q9EU35.1
#=GS Q1N545_9GAMM/90-206 AC Q1N545.1
#=GS A0A4Q3S873_9CAUL/108-221 AC A0A4Q3S873.1
#=GS A0A073IZF7_9RHOB/106-217 AC A0A073IZF7.1
#=GS A0A7W6FQL3_9SPHN/107-222 AC A0A7W6FQL3.1
#=GS A0A231H6B4_9NOCA/91-202 AC A0A231H6B4.1
#=GS A0A1N7N945_9GAMM/91-206 AC A0A1N7N945.1
#=GS A0A1X7GCU5_9SPHN/125-238 AC A0A1X7GCU5.1
#=GS A0A1U9NQJ2_9BACT/123-236 AC A0A1U9NQJ2.1
#=GS A0A4R6V333_9ACTN/91-202 AC A0A4R6V333.1
#=GS A0A844W8K7_9RHOB/91-203 AC A0A844W8K7.1
#=GS I4N5G0_9PSED/90-205 AC I4N5G0.1
#=GS A0A1I4UYE9_9BURK/105-218 AC A0A1I4UYE9.1
#=GS A0A1I5IM47_9BURK/115-225 AC A0A1I5IM47.1
#=GS A0A6G4TY50_9ACTN/94-206 AC A0A6G4TY50.1
#=GS A0A845UYX0_9GAMM/89-192 AC A0A845UYX0.1
#=GS A0A1I4QU75_9RHOB/104-213 AC A0A1I4QU75.1
#=GS A0A4U6CEV7_9HYPH/110-222 AC A0A4U6CEV7.1
#=GS A0A161Z2Q0_9NOCA/101-211 AC A0A161Z2Q0.1
#=GS A0A345ZIZ5_9GAMM/91-203 AC A0A345ZIZ5.1
#=GS A0A839ISU8_9GAMM/91-206 AC A0A839ISU8.1
#=GS A0A399RJX2_9PROT/95-208 AC A0A399RJX2.1
#=GS A0A0N9XME1_MYCFO/97-208 AC A0A0N9XME1.1
#=GS A0A2S7UX64_9GAMM/90-205 AC A0A2S7UX64.1
#=GS A0A0Q7UCJ1_9CAUL/107-219 AC A0A0Q7UCJ1.1
#=GS A0A366FT78_9HYPH/94-206 AC A0A366FT78.1
#=GS F9R801_VIBSN/89-204 AC F9R801.1
#=GS W8WZY4_CASDE/94-210 AC W8WZY4.1
#=GS A0A2P8NC52_9HYPH/93-207 AC A0A2P8NC52.1
#=GS A0A7W9UG83_9NOCA/89-203 AC A0A7W9UG83.1
#=GS A0A3N6GQP3_9ACTN/97-209 AC A0A3N6GQP3.1
#=GS A0A0Q7SUF4_9CAUL/102-215 AC A0A0Q7SUF4.1
#=GS A0A1T4JR62_9HYPH/85-198 AC A0A1T4JR62.1
#=GS A0A2A2I766_9GAMM/91-206 AC A0A2A2I766.1
#=GS T0B349_9RHOO/91-205 AC T0B349.1
#=GS A0A1G9DFQ5_9ACTN/95-206 AC A0A1G9DFQ5.1
#=GS A0A4P6UCS8_9NOCA/100-213 AC A0A4P6UCS8.1
#=GS A0A059FU58_9PROT/104-216 AC A0A059FU58.1
#=GS A0A099KYG8_9GAMM/86-201 AC A0A099KYG8.1
#=GS A0A2G4JTV9_9CAUL/108-221 AC A0A2G4JTV9.1
#=GS A0A844TMJ6_9BORD/104-198 AC A0A844TMJ6.1
#=GS A0A0M4QEN7_9PSEU/96-207 AC A0A0M4QEN7.1
#=GS A0A328ADS7_9CAUL/121-234 AC A0A328ADS7.1
#=GS A0A2T7USD6_9RHOB/104-212 AC A0A2T7USD6.1
#=GS I1DV32_9GAMM/115-230 AC I1DV32.1
#=GS A0A1B1M1U5_STRLN/97-209 AC A0A1B1M1U5.1
#=GS A0A839DYI5_9PSEU/94-205 AC A0A839DYI5.1
#=GS A0A0F7KL77_9SPHN/86-195 AC A0A0F7KL77.1
#=GS A0A7W7VZ93_KITKI/76-182 AC A0A7W7VZ93.1
#=GS A0A1G7F7A0_9BURK/104-218 AC A0A1G7F7A0.1
#=GS A0A1H2PTQ0_9BURK/117-229 AC A0A1H2PTQ0.1
#=GS A0A1Y5TRX3_9PROT/92-205 AC A0A1Y5TRX3.1
#=GS A0A5Q0H5K1_SACSY/95-206 AC A0A5Q0H5K1.1
#=GS C1D803_LARHH/107-223 AC C1D803.1
#=GS V2JLK9_9BURK/120-226 AC V2JLK9.1
#=GS A0A514C5W1_9CAUL/102-215 AC A0A514C5W1.1
#=GS A0A858RNW0_9BACT/97-211 AC A0A858RNW0.1
#=GS A0A101U7K6_9ACTN/95-207 AC A0A101U7K6.1
#=GS A0A1W2EXX4_KIBAR/90-201 AC A0A1W2EXX4.1
#=GS A0A6P1IPZ5_9BURK/108-218 AC A0A6P1IPZ5.1
#=GS A0A370I5N1_9NOCA/85-194 AC A0A370I5N1.1
#=GS A0A1M6HGB6_9BACT/89-201 AC A0A1M6HGB6.1
#=GS S2KR70_HALAF/91-205 AC S2KR70.1
#=GS A0A127F7H8_STEDE/99-210 AC A0A127F7H8.1
#=GS A0A4R5HGN0_9ALTE/88-203 AC A0A4R5HGN0.1
#=GS Q8P985_XANCP/91-203 AC Q8P985.1
#=GS A0A1I3CGN9_9ACTN/93-207 AC A0A1I3CGN9.1
#=GS A0A812ZIC3_9DINO/98-211 AC A0A812ZIC3.1
#=GS A0A7R7HF52_9HYPH/83-195 AC A0A7R7HF52.1
#=GS A0A1B2ABR0_9SPHN/136-250 AC A0A1B2ABR0.1
#=GS A0A2X0IMM0_9ACTN/76-182 AC A0A2X0IMM0.1
#=GS A0A7X0MW21_9GAMM/97-211 AC A0A7X0MW21.1
#=GS A0A124GV68_9ACTN/95-207 AC A0A124GV68.1
#=GS A8I8F9_AZOC5/121-238 AC A8I8F9.1
#=GS A0A0A0F3B5_9GAMM/90-202 AC A0A0A0F3B5.1
#=GS D0I6P6_GRIHO/89-204 AC D0I6P6.1
#=GS A0A3A6UL07_9GAMM/87-202 AC A0A3A6UL07.1
#=GS A0A4R3UT26_9BURK/94-211 AC A0A4R3UT26.1
#=GS A0A4R6RE42_9BURK/97-212 AC A0A4R6RE42.1
#=GS A0A2Z3I136_9GAMM/105-222 AC A0A2Z3I136.1
#=GS A0A1H7R0X4_9SPHN/104-217 AC A0A1H7R0X4.1
#=GS A0A239HCR6_9PROT/117-228 AC A0A239HCR6.1
#=GS A0A2N3Y1Z7_SACSN/97-209 AC A0A2N3Y1Z7.1
#=GS A0A0F0GHA8_LENAE/98-209 AC A0A0F0GHA8.1
#=GS A0A0B8P1W3_9VIBR/89-204 AC A0A0B8P1W3.1
#=GS A0A846XQK6_9NOCA/96-205 AC A0A846XQK6.1
#=GS A0A1Q2M4B4_9GAMM/89-204 AC A0A1Q2M4B4.1
#=GS A0A2N5X3V4_9GAMM/94-207 AC A0A2N5X3V4.1
#=GS A0A4Q9GXG6_9BURK/115-231 AC A0A4Q9GXG6.1
#=GS A0A6B3LA82_9BACT/80-193 AC A0A6B3LA82.1
#=GS A0A1B9YYK4_9BRAD/102-216 AC A0A1B9YYK4.1
#=GS A0A1B3WA46_9GAMM/90-202 AC A0A1B3WA46.1
#=GS A0A2T6L422_9MICO/100-215 AC A0A2T6L422.1
#=GS A0A285V2J9_9HYPH/104-217 AC A0A285V2J9.1
#=GS A7MYE0_VIBC1/89-204 AC A7MYE0.1
#=GS A0A845AJM6_9SPHN/84-197 AC A0A845AJM6.1
#=GS W7Q4F1_9GAMM/91-205 AC W7Q4F1.1
#=GS A0A840NDR8_9PSEU/95-207 AC A0A840NDR8.1
#=GS A0A091B2Y9_9GAMM/90-202 AC A0A091B2Y9.1
#=GS A0A1N7FK14_9ACTN/118-227 AC A0A1N7FK14.1
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A0A2N5Y5B8_9GAMM/94-207 ............................EAFLRP.L.EL....A....Q.ET....G..DPGW..QH..Y..LAL..I..A.Y..I..NN..S.P..-.YW.G..P.R.M.M..S..K..L...F...D...Q..L..V..E...EFIAALR.K.A..L....PG..ALEED......LYWC.Y.HNLSGALT..LT....L...A......Q....T....G....R...ID...K.......L......S....G....G....K....C.....R.....S....A...D...F....E.A.....A..YDHMIPFVAAG....................................
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A0A0B5DIU6_9ACTN/89-202 ............................DAFVGP.L.FD....K....M.PA....G..DESG..AR..T..SRL..I..V.T..I..LS..D.P..A.EE.A..R.S.W.T..G..P..D...E...D...T..V..R..E...RYLAAFA.R.A..L....PG..LAPEE......LLFR.M.RGIFAVTA..VD...rV...E......V....Y....N....R...PS...P.......A......C....R....P....T....A.....T.....-....-...E...G....E.E.....A..RRWAITFLTAA....................................
A0A5K8A448_9DELT/99-212 ............................RAFVEP.S.FS....L....T.RG....-..GDGG..QR..F..LLI..I..G.R..V..MA..E.S..D.ES.I..R.N.I.F..I..R..S...F...K...P..S..F..M...LFFSLMR.K.S..L....PG..LPKNE......LFWR.L.HFVASALG..HA....M...R......V....H....G....A...AM...P.......S......S....E....L....F....P.....P.....K....S...D...V....D.T.....V..VRILMAFLTAG....................................
A0A2V3U3V9_9HYPH/90-202 ...........................a-ALVGP.S.IR....W....S.LD....P..QSSY..RV..L..RHM..T..T.I..A..QA..S.H..H.PE.I..F.R.P.M..V..E..D...V...E...H..H..-..R...MFIPHFR.A.V..A....PG..LSEVD......IGFR.I.SCVLGVRS..QI....I...R......N....R....H....R...TE...M.......L......T....G....H....A....I.....D.....L....G...N...A....D.I.....V..LEQVVAA----tap.................................
A0A840CKB7_9RHOB/141-256 .........................alvRAFLEP.S.AK....Y....R.KT....-..-KQG..RA..F..LRL..H..A.R..L..HM..E.P..E.AL.S..F.Q.L.R..R..E..A...Y...N...E..S..T..K...AYAEAFH.R.V..L....PH..LPIAS......VYHK.L.SLMIGAYL..YA....F...S......D....T....N....R...LD...E.......L......I....D....M....E....K.....K.....A....T...V...Q....A.D.....L..FEDIVRFAVAG....................................
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A0A0D2JQJ4_9DELT/99-212 ............................EAFIEP.V.FE....K....S.RS....-..LPDR..NR..F..MAL..E..G.R..A..MW..E.A..N.AK.I..R.N.I.F..T..G..L...F...V...Q..S..F..T...IFYNTMS.L.A..L....PE..MPKED......LLWR.L.HYGVGALS..HC....M...R......M....C....-....S...IR..lS.......A......Q....G....S....P....T.....Y.....K....A...E...I....T.Q.....V..VDSLVDFIATG....................................
A0A4S2HA12_9PROT/105-218 ............................RAFLDT.D.LD....L....Y.IE....G..GDGW..RN..Y..GAL..S..A.Q..I..AN..T.P..-.QW.G..A.E.M.M..D..Q..H...F...D...P..V..V..L...RLIEILG.K.A..L....PD..ASKED......IFWG.Y.HFVSGALM..VT....L...A......R....T....G....R...ID...K.......L......S....G....G....L....C.....K.....S....D...D...Y....A.A.....V..KARMARFMAGG....................................
A0A5D8ZB96_9GAMM/91-203 ...........................a-AFVEP.A.LA....M....A.QD....-..RHGG..AS..F..MRV..I..A.R..A..YA..E.K..N.DA.L..R.K.F.L..S..D..H...Y...G...H..V..L..R...DFAKAIS.A.V..V....PE..LSKEE......LYWR.L.DFLAGSLT..YA....M...S......D....F....G....L...IK...R.......P......S....G....T....S....D.....A.....-....A...H...R....A.R.....A..ARELIRFAAAG....................................
A0A553GZC6_9PSED/90-205 ...........................e-ILVEQ.A.LA....V....K.PR....S..GNDL..SI..F..MRL..L..G.L..A..FS..Q.S..Q.GH.L..R.K.Y.L..E..E..V...Y...G...K..V..F..R...RYMLLVH.E.A..A....PR..LPPLE......LFWR.V.HFMLGAAA..FS....M...S......G....I....K....A...LR..aM.......A......E....T....D....F....G.....V.....N....T...S...I....E.Q.....V..MRMMVPFLAAG....................................
A0A316F636_9BURK/96-211 ...........................g-ALFVP.A.LQ....M....A.RE....P..DIGG..PS..F..LRL..L..G.R..V..YS..D.T..S.PF.I..Q.S.Y.L..V..G..H...Y...A...P..V..F..G...RFFEAFA.R.A..L....PD..VPRQE......LGWR.L.HFALKALA..GV....L...A......G....D....E....L...GN..lM.......P......T....F....T....Q....G.....Q.....Q....M...S...D....A.H.....V..LAQLTSMVVA-a...................................
A0A518BHW7_9BACT/122-233 ............................RALVEP.A.AA....L....R.AT....-..-PAG..RS..F..ACL..I..G.R..S..LS..A.D..G.PH.W..K.T.I.-..E..R..E...F...E...G..V..K..A...EFMPVFV.R.L..C....PE..LSTAD......LVWR.L.HFGLASLC..MV....L...S......D....T....D....R...LR...L.......A......T....G....G....L....C.....D.....P....D...D...V....G.T.....V..VEQIVSFTAAG....................................
A0A845FXB9_9GAMM/107-220 ............................EAFLRP.L.EV....A....Q.ES....D..DEGW..RN..Y..CAL..L..A.Y..V..NN..-.S..A.VW.G..P.V.L.M..S..K..H...Y...N...D..L..V..D...VFIDALR.Q.A..L....PK..ADDAD......LYWC.Y.HYMSGAMS..LT....F...A......N....T....G....R...ID...K.......M......S....G....G....L....C.....R.....S....D...D...F....Q.A.....A..YDRMIPFIAAG....................................
W9TSF9_9PSED/90-205 ...........................e-ILVEQ.A.LA....V....K.PR....S..GDDL..SI..F..MRL..L..G.L..S..FS..Q.S..Q.GH.L..R.R.Y.L..E..D..M...Y...G...K..V..F..R...RYMLKVH.E.A..A....PA..IPPLE......LFWR.V.HFMLGAAA..FS....M...S......G....I....K....A...LR..aI.......A......E....N....D....F....G.....V.....K....T...S...I....E.Q.....V..MRMMVPFLAAG....................................
A0A1D8T542_9NOCA/91-204 ...........................t-AFVRP.D.LE....V....L.AE....L..RAKN..PR..I..ARF..I..G.R..A..YT..Q.P..S.EA.V..S.G.F.M..H..A..Q...F...A...P..V..A..E...RLVPLLQ.Q.A..L....PT..VPAAE......LRIR.L.GFVVSIIT..GL....F...A......T....A....T....S...PS...D.......G......H....H....-....P....M.....E.....S....P...D...I....D.I.....Q..LARLIAFLE--pg..................................
A0A317ZG93_9BACT/98-212 ............................EALFRP.L.FE....H....A.TT....E..KGND..HT..F..MQM..V..G.R..A..LT..E.P..A.DF.M..R.N.M.H..R..E..F...F...A...E..L..S..R...RFLTELK.R.S..C....PE..LSEQA......LQLR.F.YLSVSTML..GT....I...I......E....Q....V....R...LE...S.......I......S....G....G....K....L.....S.....G....K...D...L....D.K.....I..CDELTAFVVAG....................................
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A0A1V1VXZ1_9ACTN/90-203 ............................EAIVRP.S.VE....L....A.ET....-..GPSG..RR..Y..LVI..V..G.Q..L..VD..E.F..D.RV.S..P.Q.V.E..E..A..L...E...R...T..G..G..Y...AVYALLA.E.R..L....AA..YDEAL......RNER.L.ALVTGFIL..RS....V...A......D....R....A....R...AT..eR.......T......T....P....G....R....P.....Q.....-....L...T...T....E.R.....F..VANLVSMATG-m...................................
A0A1I2RWR6_9GAMM/91-206 ...........................e-MVMRA.L.LH....V....R.QN....N..SHAL..PM..F..MRL..L..D.L..A..YM..K.N..Q.KE.L..R.D.Y.I..L..L..E...H...Y...T..K..L..E...VFLAQLR.I.D..A....SP..MEDDE......FFWR.L.HFLLGSMV..FT....L...S......N....V....H....T...LM..eI.......E......K....K....E....F....D.....K.....E....D...E...I....E.K.....I..LHRMVPVISAG....................................
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A0A2U1CSW5_9BURK/91-204 ............................DALFRP.T.VS....F....G.HE....-..QPGG..NL..F..SRV..L..V.S..T..NN..A.D..D.QA.S..R.D.L.I..S..S..F...Y...D...P..T..A..K...RFISAIQ.R.V..V....PS..LKEEE......AVWG.Y.MFAIGVGM..TM....M...A......T....T....G....R...AG...R.......L......S....G....G....Q....C.....D.....D....S...D...V....E.A.....M..MARIVPFICAG....................................
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A0A2M9DZL0_9GAMM/90-201 ............................RAFIIP.A.LG....V....S.TE....-..-RGG..VA..F..IRV..I..A.R..A..YA..E.K..N.DS.L..R.T.F.L..S..A..R...Y...G...H..V..L..R...EFAKALA.P.C..L....PG..ISKEQ......LYWR.L.DFVIGALT..YA....M...S......D....F....G....V...IK...R.......P......S....G....I....S....E.....A.....-....A...H...R....E.R.....A..TQELIAFAVAG....................................
A0A2W2DXU2_9ACTN/98-209 ...........................t-CLVRP.I.TA....H....L.AT....-..LDHP..TW..F..ARF..A..A.Q..V..MT..-.-..D.PV.L..R.P.I.I..M..E..Ea.lT...S...P..T..L..Q...RIIDGLN.R.C..L....PH..LPAEV......RAER.D.DMARQLLV..HM....C...A......E....R....E....R...AL...A.......E......G....G....P....T....F.....R.....-....S...S...W....H.D.....A..GTGLIDAIT--g...................................
A0A841J230_9SPHN/93-209 ...........................t-AIVLP.M.MK....L....A.LK....G..EPGW..RN..Y..ISL..F..C.R..L..MY..V.T..T.ED.H..N.K.I.I..P..Q..L...L...D...P..I..G..I...ELLGWLK.A.A..C....PP..STHTN......LAYA.Y.QFMIGCML..DS....Vv.eA......K....N....D....R...LN...R.......I......S....A....G....A....A.....S.....A....A...N...F....L.A.....V..SERLLPFVIAG....................................
A0A4R5EXK0_9RHOB/161-269 ...........................c-CFLEP.Y.VR....M....A.RE....G..GPQW..LA..Y..ARL..V..A.H..V..SA..-.-..D.PR.W..R.G.L.A..A..E..W...F...D...P..T..M..G...RFIDEIA.A.L..H....PG..VPRRA......VATG.F.VYSVAAML..AH....V...T......S....G....W....R...IA...A.......L......A....G....E....Q....E.....A.....-....-...-...-....T.A.....V..AEDLVTFCAAG....................................
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A0A1X2C7F7_9MYCO/104-215 ...........................a-CLVRP.L.TE....H....L.EE....-..LGNP..TW..Y..ARF..A..A.Q..A..MT..D.P..A.YY.N..I.I.V.K..G..A..L...S...S...P..S..L..V...QVVEGIN.R.C..L....PD..LPPEV......HFER.N.IMARNLLM..HT....C...A......D....R....E....R...AL...-.......A......S....G....A....S....P.....A.....H....R...S...W....R.A.....A..ASGLIDAVVG-....................................
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//
