#=GF ID   TgMIC1
#=GF AC   PF11476.12
#=GF DE   Toxoplasma gondii micronemal protein 1 TgMIC1
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF SE   pdb_2bvb
#=GF GA   25.00 25.00;
#=GF TC   27.90 36.40;
#=GF NC   21.60 20.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0004
#=GF RN   [1]
#=GF RM   16166092
#=GF RT   A novel galectin-like domain from Toxoplasma gondii micronemal
#=GF RT   protein 1 assists the folding, assembly, and transport of a cell
#=GF RT   adhesion complex. 
#=GF RA   Saouros S, Edwards-Jones B, Reiss M, Sawmynaden K, Cota E,
#=GF RA   Simpson P, Dowse TJ, Jakle U, Ramboarina S, Shivarattan T,
#=GF RA   Matthews S, Soldati-Favre D; 
#=GF RL   J Biol Chem. 2005;280:38583-38591.
#=GF DR   INTERPRO; IPR024691;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   TgMIC1 is released as part of a complex by Toxoplasma gondii
#=GF CC   prior to invasion. The complex which consists of
#=GF CC   TgMIC4-MIC1-MIC6 participates in host cell attachment and
#=GF CC   penetration and is critical in invasion. This is the C terminal
#=GF CC   domain of TgMIC1 which has a Galectin-like fold which interacts
#=GF CC   with and stabilises TgMIC6 providing a mechanism for an exit
#=GF CC   from the early secretory compartments and trafficking of the
#=GF CC   complex to micronemes [1].
#=GF SQ   4
#=GS A0A2A9M1X6_9APIC/573-706  AC A0A2A9M1X6.1
#=GS B6KL08_TOXGV/320-456      AC B6KL08.1
#=GS F0VCC5_NEOCL/323-458      AC F0VCC5.1
#=GS A0A2C6KIJ9_9APIC/414-548  AC A0A2C6KIJ9.1
A0A2A9M1X6_9APIC/573-706             ..........qtva-----DDKADMQLKQGEQLVLGVESPALNVTIGSCDQFTVNISESVLSIAGGSQSEAITYPLEGAIGRAIFTVGLGNAGR.IGVTLKYGIDTGYTRSLGYVLENSVCGSSADVSFHDIGSGATLVRLPVGENRVA---a..........
B6KL08_TOXGV/320-456                 ..............KTEIHGDSTKATLEEGQQLTLTFISTKLDVAVGSCHSLVANFLDGFLKFQTGSNSAFDVVEVEEPAGPAVLTIGLGHKGR.LAVVLDYTRLNAALGSAAYVVEDSGCSSSEEVSFQGVGSGATLVVTTLGESPTAVSA...........
F0VCC5_NEOCL/323-458                 ...........eir---VIGDSLQAMLHAGQQLMVTYSSPQLHVSVGSCHKLTVNFSDYYLSFDTTSKSGSDEVELDDAAGSGELTIGLGSSGR.VTVVFQYATNGGGNRYVAYTVGDSGCKTIEAVLLHGLNPGAKLVRNTIGDN------spges......
A0A2C6KIJ9_9APIC/414-548             gslhsepvtaylrf-------------TSGEEVTVEFDSDRVSGEIGNCHSFEVNTHDQLLRYHSDTGEEVSEVNLEDATGHVKLTV--RHTGSyIMVGLQYSVQNGS-RSLFYVAPDSRCNQAEELVFRDLAVGASLTR------------saatrrsssit
#=GC seq_cons                        ............hh.....sDphph.LcpGpQLslsapSspLsVslGSCHphsVNhpDthLpaposSpStsspVpLE-AsGpuhLTlGLGpsGR.lsVsLpYuhpsGu.RSluYVltDSsCsouE-VsF+slusGAoLVR.slG-s......u..........
//