#=GF ID   Tipalpha
#=GF AC   PF16753.9
#=GF DE   TNF-alpha-Inducing protein of Helicobacter
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   pdb_3gio
#=GF GA   26.60 26.60;
#=GF TC   34.20 33.90;
#=GF NC   25.10 24.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0319
#=GF RN   [1]
#=GF RM   22593569
#=GF RT   Structural and mechanistic studies of pesticin, a bacterial
#=GF RT   homolog of phage lysozymes.
#=GF RA   Patzer SI, Albrecht R, Braun V, Zeth K;
#=GF RL   J Biol Chem. 2012;287:23381-23396.
#=GF RN   [2]
#=GF RM   19596016
#=GF RT   Crystal structure of the TNF-alpha-Inducing protein (Tipalpha)
#=GF RT   from Helicobacter  pylori: Insights into Its DNA-binding
#=GF RT   activity.
#=GF RA   Jang JY, Yoon HJ, Yoon JY, Kim HS, Lee SJ, Kim KH, Kim do J,
#=GF RA   Jang S, Han BG, Lee BI, Suh SW;
#=GF RL   J Mol Biol. 2009;392:191-197.
#=GF DR   INTERPRO; IPR031923;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Tipalpha is secreted from H. pylori as dimers and enters the
#=GF CC   gastric cells. It binds to DNA via the positively charged
#=GF CC   surface-patch formed between the two monomers of the crystal
#=GF CC   structure by the loop between helices alpha1 and alpha2. Each
#=GF CC   monomer consists of a helical domain and a mixed domain [1].
#=GF SQ   7
#=GS A0A1B1U4F4_9HELI/27-160  AC A0A1B1U4F4.1
#=GS A0A268U059_9HELI/31-174  AC A0A268U059.1
#=GS F8KQ06_HELBC/29-178      AC F8KQ06.1
#=GS H5VDX4_HELBI/29-178      AC H5VDX4.1
#=GS A0A268TD80_9HELI/30-174  AC A0A268TD80.1
#=GS E7G593_9HELI/32-181      AC E7G593.1
#=GS O25318_HELPY/32-181      AC O25318.1
A0A1B1U4F4_9HELI/27-160             .............qktg-----LKGAPSWVIEGG-VGLYSGIGDAPIIDG-NVNFARTEATAAARAEVSKQIGVKVTSYLNKQTDRKNK.TLNEQVAGKIGENAQKYLTNTQPAGFWINDSGTRVYVLVKLADKEVEAIKKNLMD------------------------nqidpkelea
A0A268U059_9HELI/31-174             vsknapswvyqtpagla-----------------------AVDSAPI--GNNFSAAMDIATIKARNQIAQTIAQKIETKTKTLRNQDGLgNTDEQTVTAMRTTVAANLGGAKRTNFYVDKDTNTVWVLVEVQKLDTALLNKNLQQAKLVDANAAKAVSEAVDEII----dgkt......
F8KQ06_HELBC/29-178                 .................EKRVFLQNMPRWMIEDQSMYINRGIDSSHVIDG-QVARSEGIARERARFRVAIHIANKIKEFYKQSQNAHQK.PYDDAIFTQITQAIAASLDQEIQLGEYINPNNQEVFMLVRVDGYQPARLERLLFNIKALDVATVRLILAKVQAIFKAAL..........
H5VDX4_HELBI/29-178                 .................QKRVFLQNMPRWMIEDQSMYINRGIDSSHVIDG-QVARSEGIARERARFRVAIHIANKIKEFYKQSQNAHQK.PYDDAIFTQITQAIAASLDQEIQLGEYINPNNQEVFMLVRVDGYQPARLERLLFNIKALDVATVRLILAKVQAIFKAAL..........
A0A268TD80_9HELI/30-174             ..............ayg-----LKNAPQWVLGGDKNLLS-ATGSAKIKNN-NIGFATTQATNTARAEIASQIATKIESKYKELSSSTED.DVSTEAVQAIRNSVDTTLAGSKRVQTWISD-DGTLWVLVKVDHLDTKLLQENLAKNKALDKAAAKALSQAVDDII----dge.......
E7G593_9HELI/32-181                 ................k-KDVFLQNMPAWMVEDRSMFVTQGIDSSHVIDG-QVERSEGIARERARFRVAEHIANKIKGIYTKDQNADQK.SYDSEVFSEITQAIAASFDKWVQLGEYINPNNQEVFMLMRVDGYSPGVLQDRLEKIESLSTQTIKDIIQSVKTIFKEAI..........
O25318_HELPY/32-181                 .................QRNSFLQDVPYWMLQNRSEYITQGVDSSHIVDGKKTEEIEKIATKRATIRVAQNIVHKLKEAYLSKTNRIKQ.KITNEMFIQMTQPIYDSLMNVDRLGIYINPNNEEVFALVRARGFDKDALSEGLHKM-SLDNQAVSILVAKVEEIFKDSV..........
#=GC seq_cons                       ......................LpshPtWhlpspp.hlspGlDSu+llDG.plstucsIApp+ARhcVAppIAsKIcphYppppNtcpc.shssphhspIspslssoLspthplG.YINssspcVahLV+VcshpsshLpctLhphcuLDstss+hl.ttVptIh..............
//