#=GF ID   ToMV_Hel_N
#=GF AC   PF20896.1
#=GF DE   Tomato mosaic virus helicase, N-terminal domain
#=GF AU   Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   ECOD:3590.1.1
#=GF GA   27.00 27.00;
#=GF TC   27.10 28.80;
#=GF NC   26.80 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF RC   Paper describing PDB structure 3vkw
#=GF RN   [1]
#=GF RM   22573863
#=GF RT   Crystal structure of the superfamily 1 helicase from Tomato
#=GF RT   mosaic virus.
#=GF RA   Nishikiori M, Sugiyama S, Xiang H, Niiyama M, Ishibashi K, Inoue
#=GF RA   T, Ishikawa M, Matsumura H, Katoh E;
#=GF RL   J Virol. 2012;86:7565-7576.
#=GF RC   Paper describing PDB structure 3wrx
#=GF RN   [2]
#=GF RM   25092327
#=GF RT   Structural basis for the recognition-evasion arms race between
#=GF RT   Tomato mosaic virus and the resistance gene Tm-1.
#=GF RA   Ishibashi K, Kezuka Y, Kobayashi C, Kato M, Inoue T, Nonaka T,
#=GF RA   Ishikawa M, Matsumura H, Katoh E;
#=GF RL   Proc Natl Acad Sci U S A. 2014;111:E3486-E3495.
#=GF RC   Paper describing PDB structure 6jim
#=GF RN   [3]
#=GF RM   31000599
#=GF RT   Structural insights into RNA recognition by the Chikungunya
#=GF RT   virus nsP2 helicase.
#=GF RA   Law YS, Utt A, Tan YB, Zheng J, Wang S, Chen MW, Griffin PR,
#=GF RA   Merits A, Luo D;
#=GF RL   Proc Natl Acad Sci U S A. 2019;116:9558-9567.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Tomato mosaic virus (ToMV) generates two large replication
#=GF CC   proteins in the host cell. The smaller one contains the
#=GF CC   methyltransferase domain and the helicase domain (Hel). This
#=GF CC   core helicase domain consists of two RecA domains and an
#=GF CC   N-terminal accessory domain (this entry) containing a flexible
#=GF CC   loop, a long alpha-helix and an antiparallel, six-stranded
#=GF CC   beta-sheet. This N-terminal domain plays a role in the binding
#=GF CC   of the host factors TOM1 and ARL8 required for viral replication
#=GF CC   [1,2]. It is also found in proteins from related virus.
#=GF SQ   11
#=GS RDRP_TMVOM/674-797    AC O93058.1
#=GS POLN_CHIKS/554-711    AC Q8JUX6.1
#=GS G9CU44_9VIRU/693-816  AC G9CU44.1
#=GS RDRP_TMV/674-797      AC P03586.2
#=GS G9CU43_9VIRU/693-816  AC G9CU43.1
#=GS B8PRG6_9VIRU/689-800  AC B8PRG6.1
#=GS RDRP_YOMV/664-787     AC Q66220.2
#=GS POLN_SINDV/559-716    AC P03317.2
#=GS Q8V9A5_9VIRU/664-787  AC Q8V9A5.1
#=GS Q8V9A6_9VIRU/664-787  AC Q8V9A6.1
#=GS POLN_SFV/556-713      AC P08411.2
RDRP_TMVOM/674-797               es--LEQFHMATADSLIRKQMSSIVYTGPIKVQQMKN-------------------------FIDSLVASLSAA-VSNLVKILK------------------DTAAIDLETRQKFGVLDVASRKWLikptAKSHAWGVV---ETHARKYHvallEYDEQGVVTcd.dwrRVAVS.....
POLN_CHIKS/554-711               ..HVVGEYLVLSPQTVLRSQKLSLIHALAEQVKTCTHSGRAGRYAVEAYDGRVLVPSGYAISPEDFQSLSESATMVYNEREFVNRKLHHIAMHGPALNTDEESYELVRAERTEHEYVYDVDQRRCC....KKEEAAGLVLVGDLTNPPYH....EFAYEGLKI......RPACP.....
G9CU44_9VIRU/693-816             .t-DLSDFHMLPADVIAKPQKMAIFYKGSTKQQQMLN-------------------------FLDYMAASLCAT-VNNLQRALK------------------QWWAGDVKNPRDIGVFDCAKGKWItepgKKNHTWGVA---QCHDMSMRivcvDYI-DGKIIpderwkAVAV-s....
RDRP_TMV/674-797                 es--LEQFHMATADSLIRKQMSSIVYTGPIKVQQMKN-------------------------FIDSLVASLSAA-VSNLVKILK------------------DTAAIDLETRQKFGVLDVASRKWLikptAKSHAWGVV---ETHARKYHvallEYDEQGVVTcd.dwrRVAVS.....
G9CU43_9VIRU/693-816             .t-DLSDFHMLPADVIAKPQKMAIFYKGSTKQQQMLN-------------------------FLDYMAASLCAT-VNNLQRALK------------------QWWAGDVKNPRDIGVFDCAKGKWItepgKKNHTWGVA---QCHDMSMRivcvDYI-DGKIIpderwkAVAV-s....
B8PRG6_9VIRU/689-800             .v-DLSDFHGLDTKTIAKPQKMAVIYRGSLKQRQMLN-------------------------FLDYMAASLCAT-VNNLQRALR------------------QWWTGDKRNPKDVGIFDCKRGVWVtepsKKHHTWGVA---QLHDLTFRv..vVLNY-----......-----ngdip
RDRP_YOMV/664-787                ..MDISEFHLKSVDAVKKGAMMSAVYTGKIKVQQMKN-------------------------YVDYLSASLSAT-VSNLCKVLR------------------DVHGVDPESQEKSGVWDVRRGRWLlkpnAKCHAWGVA---EDANHKLVivllNWD-EGKPVcdetwfRLAVS.....
POLN_SINDV/559-716               .r-MIGQYIVVSPNSVLKNAKLAPAHPLADQVKIITHSGRSGRYAVEPYDAKVLMPAGGAVPWPEFLALSESATLVYNEREFVNRKLYHIAMHGPAKNTEEEQYKVTKAELAETEYVFDVDKKRCV....KKEEASGLVLSGELTNPPYH....ELALEGLKT......RPAVP.....
Q8V9A5_9VIRU/664-787             ..MDISEFHLRSVDAVKKGAMMSAVYTGNIKVQQMKN-------------------------FVDYLSASLSAT-VSNLCKVLR------------------DVHGVDPESQEKSGVWDVRRGRWLlkpnAKCHAWGVA---EDANHKLVivllNWD-DGKPVcdqtwyRLAVS.....
Q8V9A6_9VIRU/664-787             ..MDISEFHLRSVDAVKKGAMMSAVYTGNIKVQQMKN-------------------------FVDYLSASLSAT-VSNLCKVLR------------------DVHGVDPESQEKSGVWDVRRGRWLlkpnAKCHAWGVA---EDANHKLVivllNWD-DGKPVcdqtwyRLAVS.....
POLN_SFV/556-713                 .v-LLGNYVVLSPQTVLKSSKLAPVHPLAEQVKIITHNGRAGRYQVDGYDGRVLLPCGSAIPVPEFQALSESATMVYNEREFVNRKLYHIAVHGPSLNTDEENYEKVRAERTDAEYVFDVDKKCCV....KREEASGLVLVGELTNPPFH....EFAYEGLKI......RPSAP.....
#=GC seq_cons                    ...slu-FHhhosDslhKsphhuhlYsGshKVQQMpN.........................FlDahuASLSAT.VsNLp+hL+..................shtulDsEspcc.GVaDVc+t+WlhcPstKsHAWGVs...Espshph+lshl-as.-GhhlsD.pWhRlAVs.....
//