#=GF ID Tox-HNH-EHHH
#=GF AC PF15657.10
#=GF DE HNH/Endo VII superfamily nuclease toxins
#=GF AU Zhang D;0000-0001-8535-7620
#=GF AU de Souza RF;0000-0002-5284-4630
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE [1]
#=GF GA 25.00 25.00;
#=GF TC 25.00 25.50;
#=GF NC 23.80 23.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 22731697
#=GF RT Polymorphic toxin systems: comprehensive characterization of
#=GF RT trafficking modes, processing, mechanisms of action, immunity
#=GF RT and ecology using comparative genomics.
#=GF RA Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL Biol Direct. 2012;7:18.
#=GF DR INTERPRO; IPR028048;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A predicted toxin of the HNH/Endonuclease VII fold present in
#=GF CC bacterial polymorphic toxin systems with a characteristic
#=GF CC conserved [ED]H motif and two histidine residues. In bacterial
#=GF CC polymorphic toxin systems, the toxin is exported by the type 2,
#=GF CC type 5, type 6, type 7 or Photorhabdus virulence cassette
#=GF CC (PVC)-type secretion system [1].
#=GF SQ 101
#=GS A0A6G9H0G3_9ACTN/1514-1604 AC A0A6G9H0G3.1
#=GS A0A6B3VYB8_9BACI/11-77 AC A0A6B3VYB8.1
#=GS A0A1Q5MN46_9ACTN/3-89 AC A0A1Q5MN46.1
#=GS A0A4S5BCU8_9BURK/58-126 AC A0A4S5BCU8.1
#=GS A0A4R4ZK93_9ACTN/2179-2248 AC A0A4R4ZK93.1
#=GS W6RSY8_9CLOT/283-336 AC W6RSY8.1
#=GS A0A1V2QXB0_9PSEU/1369-1438 AC A0A1V2QXB0.1
#=GS A0A6M0H676_9CLOT/1-59 AC A0A6M0H676.1
#=GS A0A3R9YFQ9_9ACTN/1480-1570 AC A0A3R9YFQ9.1
#=GS B2VH58_ERWT9/1254-1322 AC B2VH58.1
#=GS A0A6I6EE79_9GAMM/1466-1541 AC A0A6I6EE79.1
#=GS A0A7W7VT58_KITKI/1035-1106 AC A0A7W7VT58.1
#=GS A0A371AVJ1_9FIRM/350-426 AC A0A371AVJ1.1
#=GS B2VCN1_ERWT9/196-258 AC B2VCN1.1
#=GS D3UYQ4_XENBS/1448-1524 AC D3UYQ4.1
#=GS A0A1I6I597_9FIRM/847-900 AC A0A1I6I597.1
#=GS A0A4R0X2F4_9BURK/16-85 AC A0A4R0X2F4.1
#=GS A0A081ND94_9GAMM/153-223 AC A0A081ND94.1
#=GS A0A4S5A7E8_9ACTN/1283-1344 AC A0A4S5A7E8.1
#=GS A0A3Q8VBB9_9ACTN/1500-1590 AC A0A3Q8VBB9.1
#=GS A0A6G2UMT4_9ACTN/58-127 AC A0A6G2UMT4.1
#=GS A0A1H5NMX3_9ACTN/1449-1535 AC A0A1H5NMX3.1
#=GS Q81H92_BACCR/1-59 AC Q81H92.1
#=GS D4GLX1_PANAM/37-100 AC D4GLX1.1
#=GS W4VDQ5_9FIRM/122-198 AC W4VDQ5.1
#=GS A0A0G3ULF8_9ACTN/1485-1571 AC A0A0G3ULF8.1
#=GS A0A0B6RZG7_BURPL/187-255 AC A0A0B6RZG7.1
#=GS A0A1W6B416_9GAMM/292-354 AC A0A1W6B416.1
#=GS A0A0M8TTL5_9ACTN/675-744 AC A0A0M8TTL5.1
#=GS W1J8Y0_9GAMM/78-146 AC W1J8Y0.1
#=GS A0A1B6AGF3_9ACTN/1516-1598 AC A0A1B6AGF3.1
#=GS A0A0M8QPC1_9ACTN/1496-1586 AC A0A0M8QPC1.1
#=GS A0A085AAB8_9ENTR/230-291 AC A0A085AAB8.1
#=GS A0A369KNA3_9PROT/193-238 AC A0A369KNA3.1
#=GS X2HDX1_9NEIS/1384-1447 AC X2HDX1.1
#=GS A0A6B3W3I3_9BACI/14-69 AC A0A6B3W3I3.1
#=GS A0A1L6I5K8_9BURK/174-243 AC A0A1L6I5K8.1
#=GS A0A4Y9T6H4_9BURK/1025-1086 AC A0A4Y9T6H4.1
#=GS A0A8I0CX55_9PSED/1366-1436 AC A0A8I0CX55.1
#=GS A0A6H0CQW5_9ACTN/1496-1581 AC A0A6H0CQW5.1
#=GS R5YRS6_9FIRM/1-62 AC R5YRS6.1
#=GS A0A815ZG83_9BILA/61-128 AC A0A815ZG83.1
#=GS D8MWY1_ERWBE/1358-1426 AC D8MWY1.1
#=GS A0A0N1GQ16_9ACTN/1498-1588 AC A0A0N1GQ16.1
#=GS B8FA91_DESAL/1997-2058 AC B8FA91.1
#=GS A0A859PSA3_9ENTR/1364-1440 AC A0A859PSA3.1
#=GS D3FRB0_ALKPO/427-498 AC D3FRB0.1
#=GS E0SGM0_DICD3/392-461 AC E0SGM0.1
#=GS A0A3Q8S750_9BACL/203-265 AC A0A3Q8S750.1
#=GS A0A1X7H162_9ACTN/1499-1589 AC A0A1X7H162.1
#=GS A0A1Y0IV00_9BACL/11-75 AC A0A1Y0IV00.1
#=GS A0A6L9Y4Y5_9BURK/1-66 AC A0A6L9Y4Y5.1
#=GS A0A8J3EZ06_9BIFI/2-60 AC A0A8J3EZ06.1
#=GS Q7N2G3_PHOLL/8-76 AC Q7N2G3.1
#=GS A0A844GGD0_9NEIS/119-187 AC A0A844GGD0.1
#=GS A0A1A7NPH4_9PAST/1798-1859 AC A0A1A7NPH4.1
#=GS A0A1W2F7W7_9FIRM/442-506 AC A0A1W2F7W7.1
#=GS A0A1H0J2G9_9ACTN/1186-1268 AC A0A1H0J2G9.1
#=GS A0A7W9QDP7_9ACTN/1510-1596 AC A0A7W9QDP7.1
#=GS A0A0Q5QUR5_9NOCA/1941-2002 AC A0A0Q5QUR5.1
#=GS A0A652KFI8_9ACTN/1459-1528 AC A0A652KFI8.1
#=GS D9SR49_CLOC7/123-198 AC D9SR49.1
#=GS A0A2I5TD64_SERS3/155-216 AC A0A2I5TD64.1
#=GS A0A0B5F3T2_STRA4/1398-1467 AC A0A0B5F3T2.1
#=GS C6WLJ3_ACTMD/1409-1477 AC C6WLJ3.1
#=GS A0A7X1LQ36_9ACTN/1508-1594 AC A0A7X1LQ36.1
#=GS A0A839DYB4_9PSEU/1-61 AC A0A839DYB4.1
#=GS Q7MB60_PHOLL/2900-2961 AC Q7MB60.1
#=GS A0A4U0PWR5_9NEIS/1-55 AC A0A4U0PWR5.1
#=GS A0A7Y6YZN5_9HYPH/211-274 AC A0A7Y6YZN5.1
#=GS D4GLX3_PANAM/1328-1396 AC D4GLX3.1
#=GS A0A4R6JZ98_9ACTN/510-579 AC A0A4R6JZ98.1
#=GS A0A516SIT7_9BURK/2810-2879 AC A0A516SIT7.1
#=GS A0A433HBL9_9BACI/54-116 AC A0A433HBL9.1
#=GS A0A1K2FRZ0_9ACTN/1380-1449 AC A0A1K2FRZ0.1
#=GS A0A445N957_STRNE/1367-1436 AC A0A445N957.1
#=GS A0A0A2EWS3_9PORP/70-138 AC A0A0A2EWS3.1
#=GS A0A1I1AJD4_9CLOT/108-182 AC A0A1I1AJD4.1
#=GS A0A371J1Y4_9FIRM/99-171 AC A0A371J1Y4.1
#=GS A0A1I1BFV7_9CLOT/89-165 AC A0A1I1BFV7.1
#=GS A0A498DLA5_9ACTN/1464-1533 AC A0A498DLA5.1
#=GS A0A7K2XH45_9ACTN/1476-1556 AC A0A7K2XH45.1
#=GS A0A4R6SGT7_LABRH/1390-1469 AC A0A4R6SGT7.1
#=GS A0A370IE61_9NOCA/2134-2196 AC A0A370IE61.1
#=GS A0A0C5WKU7_9GAMM/2299-2364 AC A0A0C5WKU7.1
#=GS B2VCM7_ERWT9/198-268 AC B2VCM7.1
#=GS A0A0J5KZL1_PLUGE/1338-1406 AC A0A0J5KZL1.1
#=GS A0A7X9M2I5_9BACI/91-153 AC A0A7X9M2I5.1
#=GS A0A250I6I6_9DELT/73-143 AC A0A250I6I6.1
#=GS A0A6I6EE66_9GAMM/279-347 AC A0A6I6EE66.1
#=GS A0A0L0KMI3_9ACTN/520-588 AC A0A0L0KMI3.1
#=GS S6HEX9_9GAMM/891-945 AC S6HEX9.1
#=GS A0A1V8ZYK1_SACPI/1411-1490 AC A0A1V8ZYK1.1
#=GS Q0JZD5_CUPNH/1511-1579 AC Q0JZD5.1
#=GS A0A3N2DZX8_9GAMM/3286-3350 AC A0A3N2DZX8.1
#=GS A0A7L4Y1G4_9ACTN/1442-1532 AC A0A7L4Y1G4.1
#=GS F2JTT7_MARM1/246-319 AC F2JTT7.1
#=GS B2VCU1_ERWT9/1344-1417 AC B2VCU1.1
#=GS A0A2M8LPF6_9ACTN/1486-1554 AC A0A2M8LPF6.1
#=GS A0A841I3Q2_9DEIO/81-128 AC A0A841I3Q2.1
#=GS A0A6B2X1K0_9ACTN/1482-1551 AC A0A6B2X1K0.1
A0A6G9H0G3_9ACTN/1514-1604 ........g-YTYSSEATHWGNFRQFETDQ-.........GSRVIVEHTHDPAG----..----QHFH..AGKPKIddsrelvnfgwdngrvqrgdgsfgypedmerYGKINKP.GGDHHFFY...............
A0A6B3VYB8_9BACI/11-77 ........w-ILDSNKRPIMTRELTY-EING.........KKIVIQDHSVGHDF--GG.iGNQPSHHN..VRPIEN...............................TRTGKVE.GMEDHYYF...............
A0A1Q5MN46_9ACTN/3-89 ........g-HVYSSDPTHWGNFRQFGTSN-.........GSRVVVEHTDDPAG----..----PHFH..AGGPKGstiedqsrsgvnf....gwdntvdgygtmerYRAIDKP.GGDHHFFY...............
A0A4S5BCU8_9BURK/58-126 .........KILGPDGKPIMTREYEFTRPNG.........EKVIIQEHSAGHQY-PDG.iGNQGPHFN..VRPTNN...............................PRTGKVP.GTKEHYPF...............
A0A4R4ZK93_9ACTN/2179-2248 .......ql--MNPYGRPIMTREYVFTRSGG.........DRVIIQDHSAGHFYGEGG.vGDQGAHLN..VRPFDT...............................PRTGKVP.GTAQHYEY...............
W6RSY8_9CLOT/283-336 ........p-AVDKRGKPIQGRDYDFGN---.........-GKVIRDHSGGHTFKDDP.tQNRGPHIN..------...............................------D.VNGNHYDY...............
A0A1V2QXB0_9PSEU/1369-1438 .........QIMDENHQPVMFPEEVYLNSDG.........DLIVFQDHYTGHQYGEGG.vGDQPPHVH..VRPYDE...............................SRNGQVP.GAQEHYYY...............
A0A6M0H676_9CLOT/1-59 .........----------MTRELTY-DING.........RKVVIQDHSVGHNFGQGG.iGDQPSHHN..VRPAEN...............................TRTGKVE.GMEDHYYF...............
A0A3R9YFQ9_9ACTN/1480-1570 ........g-YVYSKEMAHWGNFRQFETPQ-.........GSRVVVEHVADPAG----..----PHFH..AGKPKIddsrslvnfgwdnarvqrgdgsfgypehmerYGKINKP.GGDHHFFY...............
B2VH58_ERWT9/1254-1322 .........HVRDKNGIPLQTRQYHFKDQNG.........STVVIQEHSLGHAKATPL..HGAEPHFN..VRPAKN...............................LNTGDVP.GTHGHYNF...............
A0A6I6EE79_9GAMM/1466-1541 ........v-IKDSNFNILESREYHYTRSDG.........SRVVIQEHSAGHTYGPPGtpGNQGPHFN..PRPFDPnt..........................gngSRNGSIN.GSYDHYDF...............
A0A7W7VT58_KITKI/1035-1106 .........QILDENYQPVYFHQEYYETTSG.........DIIVYQDHYTGHSFGDPNgvGDQPPHVH..VRPLDD...............................PRNGVLPpPAEAHYYY...............
A0A371AVJ1_9FIRM/350-426 ........r-ILDANNNFVETRELTY-SVQGkfdvqgnpiDKVVIQDHSYGHYY-NSG.iGNQTSHFN..VRPSTN...............................TKNGAVQ.GMKDHYYF...............
B2VCN1_ERWT9/196-258 ........y-VYDNKFENRT--VYEF-NVDG.........KKKYIIKHEDDKFG----..--RGPHFH..GADDLKe............................npMKPGKYN.QYPGHYPE...............
D3UYQ4_XENBS/1448-1524 ........n-YQYSEDLGSHGRYYEYKDAHG.........HKKVVLEHTADPRA----..--THPHAH..AGQAKTgadprt..................ydfkenrYQKITDP.KTDDHH--iyy............
A0A1I6I597_9FIRM/847-900 ........p-AVDKKGKRMPGKDYDF----G.........DGKVIRDHSGGHEFPDDP.sQNRGPHFN..------...............................------D.PDGNHYDY...............
A0A4R0X2F4_9BURK/16-85 .........PVLEKNSQPIWTKEYQFTRADG.........SAVLVQDHGAGHYYGEGG.vGDQGSHFN..VRPCSN...............................PRTGKVP.RTQAHYPF...............
A0A081ND94_9GAMM/153-223 .....hvvk---DAGGKIIMTLEYYFKNTNG.........KTVVIQDHSAGHVFNQGG.iGDQGAHFN..VRPVEN...............................TRTGQVP.GTKSHYPY...............
A0A4S5A7E8_9ACTN/1283-1344 .........PNRDRRGVVQPGRAYEFDLPAPgg.....gqRTVVVREDAGGHVYRDDP.sQNRGPHFN..------...............................------T.ESKGHYDY...............
A0A3Q8VBB9_9ACTN/1500-1590 ........g-YIYSKDEAHWGNFRQFETDS-.........GSRVVVEHTHDPAG----..----PHFH..AGKPKIddtrnfvnfgwdngrvqrpdgsvgypesmerYAKINKQ.GGDHHLFY...............
A0A6G2UMT4_9ACTN/58-127 .........QIMDASHNPVMTREYTFTRNDG.........SQVIIQDHGYGHYYGEGG.vGDQGSHFN..VHPSEN...............................PRTGKVP.GTAQHYEY...............
A0A1H5NMX3_9ACTN/1449-1535 ........g-YVYSKDPTHWGNFRQFETDN-.........GARVIVEHTHDPAG----..----PHFH..AGAPKGqtpeersrnfvnf....gwnntqegystmerYRALDKP.GGDHHFFY...............
Q81H92_BACCR/1-59 .........----------MTRELTY-EVKG.........QKIIIQDHSEGHKFGEGG.iGDQPPHHN..IRPEYN...............................TRTGQVD.GMEDHYYF...............
D4GLX1_PANAM/37-100 .........KVFDSKYENRT--VWEF-NHSG.........DKKYILMHEDDKFG----..--RGPHLH..TADDLHgn...........................plEKNVRYN.QHPGHIPE...............
W4VDQ5_9FIRM/122-198 ........m-ILGQNKNFVYSRELTY-SVNGkfdaqgnpiSSVVIQDHSYGHTYSSGT..GNQPLHFN..VRPSTN...............................PKNDKVL.GIKEHYYF...............
A0A0G3ULF8_9ACTN/1485-1571 ........g-HVYSSDPTHWGNFRQFETPN-.........GSRVVVEHTDDPAG----..----PHFH..AGGPKGstledqsrsgvnf....gwdntvdgygtmerYRAIDKP.GGDHHFFY...............
A0A0B6RZG7_BURPL/187-255 .......wl--LGDNNKPIMTRELTY-QVGG.........KNVVIQDHSAGHVFGEGG.iGDQPSHHN..VRPEEN...............................TRAGKVQ.GMDDHYYF...............
A0A1W6B416_9GAMM/292-354 ........y-VYDSDFENRT--VYEF-DVNG.........RKKYVILHEEDKYG----..--RGPHFH..AADDLRn............................npMEKGKYN.QYSGHHP-e..............
A0A0M8TTL5_9ACTN/675-744 .......ql--MTENHEPIFYREEVYEHPNG........qDLIVFQDHWFGHQKPGEP..GYQPAHVH..VRPYED...............................TRNGQIP.GCEEHYYY...............
W1J8Y0_9GAMM/78-146 .........KIIGSNGQVIKVRQYHYTNKDG.........KPIVIQEHSLGHEKATPG..HGAEPHFN..VRPITN...............................LGTGDEP.GTHGHYNF...............
A0A1B6AGF3_9ACTN/1516-1598 .......gy--TYSPKPEHWGNFRQF-ELDH.........GSRVVVEHTHDPAG----..----PHFH..AGKPKVddtrhfvnfgw........dntkagyetmerYAKINKP.GGDHHFFY...............
A0A0M8QPC1_9ACTN/1496-1586 ........g-YIYSSDPAHWGHFRQFETDN-.........GSRVVVEHTHDPAG----..----PHFH..AGKPKNddtrslvnfgwdntqiqrpdgtvgypesmerYAKINKP.GGDHHLFY...............
A0A085AAB8_9ENTR/230-291 .........PNVDKRNNPQPGYIYEFDVPRPgg.....gtQKVYIRDDAGGHFFTDDP.sQNRGPHFN..------...............................------D.EKGNHYDY...............
A0A369KNA3_9PROT/193-238 .vdgvvkpr--------------------EG.........KSKVISHHMNGHYYGKGS.eHNRGPHFN..GKDG--...............................-------.--------rhydy..........
X2HDX1_9NEIS/1384-1447 .........KVYDNKYENRT--VWEY-KVDG.........NKKYIILHEEDKFG----..--RGPHFH..TADDLHgd...........................plQPKVRYN.QHGGHIPE...............
A0A6B3W3I3_9BACI/14-69 ..sdnallk----------------FISHR-.........KKKYIIEHREDKFG----..--RGPHFH..GADDLKg............................spLEKGRYN.QYPGHSP-e..............
A0A1L6I5K8_9BURK/174-243 .....vlnp----STKQPVWTREYHYTNSDG.........SKIVIQDHSVGHEFGQGG.vGDQGPHLN..VRPYDN...............................TRTGSVP.GTLDHYGF...............
A0A4Y9T6H4_9BURK/1025-1086 .........KNTDKKGNPQPGRIYEFEVPAPgg.....gtRTVRIRDDSAGHDFGPGN.pQNRGPHFN..------...............................------D.PAKDHYDY...............
A0A8I0CX55_9PSED/1366-1436 ........r-ILDDNGMPIDTRVYQFTRSNG.........SKILIQDHSAGHKFGRVDsiGDHSSHFN..LRPIDK...............................PRKGYIE.GAKKHYPF...............
A0A6H0CQW5_9ACTN/1496-1581 ....lvyap------DPTHWGHFRQFETEN-.........GSRVIVEHTHDPAG----..----PHFH..AGAPKGytteertrnwvnf....gwdntkdgyttmarYRALNKP.GGDHHFFY...............
R5YRS6_9FIRM/1-62 ........m--FDGTSENRI--VYEF-DVSG.........EKKYIIEHPFDKMG----..--RGNHFH..GADATKg............................npFSKGRYN.QYPGHFPE...............
A0A815ZG83_9BILA/61-128 ....kvper------NSREMLRQYNYINNQG.........KPISIRQDNPRKYGHPQG.hGDQGPHFN..AGPTG-...............................-------.--------sklekhfnfdkfnkn
D8MWY1_ERWBE/1358-1426 .........PISDKSGNQIWTREYQFTKTDG.........NKIIIQDHSAGHSY-PGG.iGNQGRHLN..VRPIEN...............................IRTGFVS.GTFDHYEF...............
A0A0N1GQ16_9ACTN/1498-1588 ......ghi---YSPDPAHWGNFRQFETDS-.........GSRVVVEHTNDPAG----..----PHFH..AGKPKIddtrslvnfgwdnarvqrpdgslgypesmerYGKINKP.GGDHHLFY...............
B8FA91_DESAL/1997-2058 .........PNLDKRGNVRPGRAYTF-EVKGkg....gktRTITIRDDAGGDNYGPGN.pQNRGSHIN..------...............................------G.KKGTHYDY...............
A0A859PSA3_9ENTR/1364-1440 ........n-YKYSEDQGSYGRYYEYTDARG.........HKRVIAEHTSDPRA----..--PGPHTH..AGQPKPgadprty.................dfkegryQKIIHPS.TNDHHIYY...............
D3FRB0_ALKPO/427-498 ........n-YEFSSNPTHHGRYFEYETPQ-.........GKRVIVEHINDGRM----..-----HTH..AGKPKDganpfn..................ydfkkerYSNIYGS.NKDHHIYY...............
E0SGM0_DICD3/392-461 ........s-ILGKDGKPIWTREYQFTRQDG.........SKVIIQDHSAGHYYGEGG.vGDQGSHLN..IRPIDN...............................TRTGKVP.GTRGHYGF...............
A0A3Q8S750_9BACL/203-265 ........y-VHDGTSENRK--VYEF-EVDG.........KKKYIIEHRDDKFG----..--RGPHFH..GADDLKg............................npLEKGRYN.QYPGHSP-e..............
A0A1X7H162_9ACTN/1499-1589 ........g-YVYSPDPAHWGNFRQFETDS-.........GSRVVVEHTHDPAG----..----PHFH..AGKPKGddtrslvnfgwdnsriqrpdgtlgypesmerYGKINKS.GGDHHLFY...............
A0A1Y0IV00_9BACL/11-75 ........v-IKDKNGGIIETREYHFTNTKG.........EKIVIQDHGAGHEK----..GGQGPHFN..VRPAGD...............................TRTGKVA.GTKEHYPF...............
A0A6L9Y4Y5_9BURK/1-66 .........----------MTREYHYTTPSG.........EKVVFQEHSLGHVYGPKGtpGNQGPHFN..PRQYDPtt..........................gngYRNKSFP.GISEHYNY...............
A0A8J3EZ06_9BIFI/2-60 .gieydprd--------------------NE.........YTVVIQDHTAGHQFGAEGgkGDQPAHVH..ARPAAN...............................PWTGSID.GAQRHYYF...............
Q7N2G3_PHOLL/8-76 ........f-IRDSKGVAIEARQYHFKDKNG.........STVIIQEHSLGHAKATPL..HGAEPHFN..VRPPDN...............................LNTGDVP.GTHGHYNF...............
A0A844GGD0_9NEIS/119-187 ........t-VLGPNYEPVTTRNYHYTNIDG.........KPVIIQEHSMGHEKATPC..HGAEPHFN..VRPISN...............................PKTGSFP.KTHGHYNF...............
A0A1A7NPH4_9PAST/1798-1859 .........PNVDRRGNTQPGWIYEFDLPKEgg.....gvKKVIIRDDAKGHFFGEND.pQNRGPHFN..------...............................------D.QKGGHYDY...............
A0A1W2F7W7_9FIRM/442-506 ........v-IKDASGNVIYTREYHYTNSNG.........QEIVIQEHSAGHEK----..GDQGSHFN..VRPADN...............................TRTGSVP.GTQDHYSY...............
A0A1H0J2G9_9ACTN/1186-1268 ........m-YLYDPEPTHWGNMRQFETPQ-.........GSRVVVEHTHDPAG----..----SHFH..TGEPKHgadrtgvnfgw........askypsdenferYGKVNKP.GGDHHLFY...............
A0A7W9QDP7_9ACTN/1510-1596 .......gh--VYSPEPTHWGNFRQYETEH-.........GSRVIVEHTDDPAG----..----LHFH..AGGPKGltaeerqrnlvnf....gwdssregyatmerYRAIPKP.GGDHHFFY...............
A0A0Q5QUR5_9NOCA/1941-2002 .........PNFDRRGNLQPGRQYIFQDQSLtg.....eiVERAIRDDAQGHIFPDDP.vQNRGPHFN..TP----...............................-------.--------dgahydy........
A0A652KFI8_9ACTN/1459-1528 .........QVMTDDGRPVMTREYLYTRADG.........SRVIIQDHSAGHYYGEGG.vGDQGRHLN..VRPIEN...............................PRNGHVP.GTARHYEY...............
D9SR49_CLOC7/123-198 ........r-ILDANNNFVETRELTY-SVQGkfdvqgnpiDKVVIQDHSYGHYY-NSG.iGNQPSHFN..VRPSTN...............................TKNGAVQ.GMKDHYY-...............
A0A2I5TD64_SERS3/155-216 .........PNVDRRDNVQPGYIYEFEVPKPgg.....gtQKVYIRDDAGGHFYGDDS.sQNRGAHFN..------...............................------D.EQGNHYDY...............
A0A0B5F3T2_STRA4/1398-1467 dkkldprag----------WGRYYQYDTPQ-.........GMRVVAEHTADPEA----..--PHPHFH..AGQPQKdapr......................didmqRKTYKQI.MPKHHLYY...............
C6WLJ3_ACTMD/1409-1477 .........QVMQDHQPVFFPEEVYL-NNRD.........ELIVFQDHYTGHQFGEGG.vGDQPPHVH..VRPYDN...............................PRNGQVP.GAEEHYYY...............
A0A7X1LQ36_9ACTN/1508-1594 ........g-HVYSSDATHWGNFRQFETEN-.........GSRVVVEHTHDPAG----..----PHFH..AGAPKGftaedrarngvnf....gwdntergygtmerYRALNKP.GGDHHFFY...............
A0A839DYB4_9PSEU/1-61 .........----------MTREHHYARPDG.........SRGIIQDHGVDHDFGAPDgtGNRGAHFN..GRPPDK...............................PCTGAVP.CT------gpfpeh.........
Q7MB60_PHOLL/2900-2961 .........PNVDKRGRLQPGKIYEFDVPKAgg.....gtQTIQIRDDAKGHDFGIND.pQNRGPHFN..------...............................------D.EKGNHYDY...............
A0A4U0PWR5_9NEIS/1-55 .......ms---------QPGRISEFELPAPrg.....gtQTVRFRDDAGSHNFGQGN.pQNRGPHFN..------...............................------D.PLGQHYD-y..............
A0A7Y6YZN5_9HYPH/211-274 .........PNIDKRGNVQPGKIYEYDIIDPnav...ggkRTVKIRDDAEGHLSLDDP.sQNRGPHFN..T-----...............................-------.PDG-----ghydy..........
D4GLX3_PANAM/1328-1396 .........KILDSTGQPIKTRQYEFVDKRG.........QSVFLQEHSLGHTKATSG..HGAEPHFN..LRPLDN...............................LNTGSVP.GTHGHYNF...............
A0A4R6JZ98_9ACTN/510-579 .........PVLDANKQRVMTREYHFTRDDG.........SKVVIQDHSAGHQFGEGG.vGDQGRHLN..VRPGDN...............................TRTGKVE.GTAQHYE-w..............
A0A516SIT7_9BURK/2810-2879 .........PILDENGQPTWSREYTFTNSRG.........QKIVIQDHGTGHKFGQGG.vGDQGPHFN..VRPIDN...............................TRTGKVS.GTQEHYLY...............
A0A433HBL9_9BACI/54-116 ........d-VYDGTNENRR--VYEF-EVDG.........KKKYIIEHREDKFG----..--RGPHFH..GADDLKg............................spLEKGRYN.QYPGHSP-e..............
A0A1K2FRZ0_9ACTN/1380-1449 .......ql--MGDDHKPIYYTEEVYEHPNG........rDLVVFQDHWFGHQKPGEP..GYQPSHVH..VRPFED...............................TRNGQIP.GCEEHYYY...............
A0A445N957_STRNE/1367-1436 .........QIMGDNGQPVMTREYIYTREDG.........KRVIVQDHSAGHDFGEGG.vGNQGRHLN..VRPYEN...............................PRTGKVP.GTAQHYEY...............
A0A0A2EWS3_9PORP/70-138 .........KIIGKDGKIVYTRNYVFKNTKS.........ETIVIKEHSLGHTKATSG..HGAEPHFN..VRPINN...............................TQTGYVE.STYGHYNF...............
A0A1I1AJD4_9CLOT/108-182 .........NYEYSENATYQGRYYEYDTPQ-.........GKKVIVDHTNDVEQ----..---GLHTH..AGKVPNganplty................nfknpdnrYKPINK-.DTDHHIRY...............
A0A371J1Y4_9FIRM/99-171 ..vngefvy-----------SRELTY-SVSGktdaggnpiKQVIIQDHSYGHSYSD-G.iGNQSSHFN..VRPDNN...............................PKTGGVN.GTKEHYYF...............
A0A1I1BFV7_9CLOT/89-165 ........r-ILDANNNFVETRELTY-SVQGkfdvqgnpiDKVVIQDHSYGHYY-NSG.iGNQPSHFN..VRPSTN...............................TKNGAVQ.GMKDHYYF...............
A0A498DLA5_9ACTN/1464-1533 ........r-IVDERGIPIVSREYVFTRADG.........GKVIIQDHSAGHQFGEGG.vGDQGRHFN..VRPYDN...............................PRTGKLP.GTSQHYEY...............
A0A7K2XH45_9ACTN/1476-1556 ........g-YVYSSENSHWGIFRQYETPQ-.........GSRVVVEHTGDPAG----..----PHFH..AGKPKGepdrtfvnfg..........wdnasyrdmerYAKINKT.EGDHHLFY...............
A0A4R6SGT7_LABRH/1390-1469 ........n-YRYSEDRGSHGVYRQFETDN-.........GSRVIAEHTNDPNA----..--PGPHFH..AGEPKGdpsrnfvdf.............gwsdahnrdVERYGQM.GGKHHIFY...............
A0A370IE61_9NOCA/2134-2196 ........a-NVDKQDRVQPGRNYDYTVPAPgg.....gtRQVTIRDDAGGHVFKDDP.vQNRGPHFN..-GPAN-...............................-------.--NS----hydy...........
A0A0C5WKU7_9GAMM/2299-2364 ......kir----DQDGHVEGRVYEFKRQDG.........STATIREHSLGHKL----..DNHGPHFNseVRSADG...............................IKQSLGG.NGDSHTYF...............
B2VCM7_ERWT9/198-268 .........HILGEDHLPLKTREYTFTRPNK.........ESVVIQDHWPGHIYGPQGtpGNQGPHIN..IRPISD...............................TRNGKVV.GTLEHYPF...............
A0A0J5KZL1_PLUGE/1338-1406 .........PIYDSNGKQVWTREYQFTKQDG.........SKVIIQDHSAGHSYPN-G.vGNQGSHLN..VRPIDN...............................IRTGSVP.GTLDHYEF...............
A0A7X9M2I5_9BACI/91-153 .......dv--YDGTTENRR--VYEF-DVDG.........KKKYIIEHREDKFG----..--RGPHFH..GADDLKg............................spLGKGRYN.QYPGHSP-e..............
A0A250I6I6_9DELT/73-143 ........t-IKDKNGKPIMTREYHYKRADG.........KEIVIQDHSSGHQFGEPGgvGDQGPHLN..VRPAID...............................TRNGKVP.GTAAHYPF...............
A0A6I6EE66_9GAMM/279-347 .........KILNNTGQPIKTRQYEFTNSQG.........KPVFIQEHSLGHAKATPL..HGAEPHFN..VRSSEN...............................LNTGSVS.GTHGHYNF...............
A0A0L0KMI3_9ACTN/520-588 .....qimd-----GGNPVMTREYVYTRNDG.........SRVIIQDHGFGHYYNEGG.vGDQGPHFN..VRPWSN...............................PRTGKVP.GTAQHYEY...............
S6HEX9_9GAMM/891-945 ........p-NRNRREEIIPGRQLHF-TINR.........RTITIRNDSAGDYYGPNN.nQNRGPHFN..QGKR--...............................-------.--------mnv............
A0A1V8ZYK1_SACPI/1411-1490 ........d-YRHSEDLGTHGRYMQFETDN-.........GSRVIAEHTSDPNA----..--PGPHFH..AGQPKIdptremvdf.............gwsdrpnseIERYSQI.GGSHHMFY...............
Q0JZD5_CUPNH/1511-1579 ........w-ILGNDKHPIMTRELTY-QLNG.........KNVIIQDHSAGHYYNEGG.vGDQPSHHN..VRPEDN...............................TRTGKVD.GMDDHYHF...............
A0A3N2DZX8_9GAMM/3286-3350 ......kir----DQQGHVEGRVYEFKNADG.........STATIREHTLGHEL----..GNHGSHFNseLRNAQG...............................IKQSLKK.NADSHT--y..............
A0A7L4Y1G4_9ACTN/1442-1532 ........g-YVYSSDRTHWGHFRQFETER-.........GSRVVVEHTHDPAG----..----LHFH..AGKPKGddtasgvnfgwdnskvqhgpdswgypesmvrYGAIDKP.GGDHHFFY...............
F2JTT7_MARM1/246-319 .........KVLDDQGLPVQAREYHFKNIKG.........VSVVIQEHSLGHRKAALG..HGLEPHFN..VRRVDElt..........................gevLNTSSFP.NTHGHYNF...............
B2VCU1_ERWT9/1344-1417 ........r-FLDDNGKVVRTREYEFTNIDG.........KAVYIQEHSLGHAKATPL..HGAEPHFN..VRPIDDls..........................gevLNTGSVL.GTHGHYNF...............
A0A2M8LPF6_9ACTN/1486-1554 ........q-LLDDNHQPIYYREEYYETPSG.........DLIVYQDHWFGHQKPGEP..GYQPPHVH..VRPFDD...............................PRNGQIP.GCEEHYYY...............
A0A841I3Q2_9DEIO/81-128 .........NYRYSEDPGTGGRFFQYETPQ-.........GPRVVVEHMGDPDK----..---PPHFH..AGEPK-...............................-------.--------gns............
A0A6B2X1K0_9ACTN/1482-1551 .........NYVYDPNPGSHGRYYQYETPS-.........GSRVVVEHTRDPNA----..--PNPHFH..AGQPKSgefk.......................vnmmGQRYQQV.GDKHHFYY...............
#=GC seq_cons ..........hhtspspshhsR.apapsssG.........pphlIp-HotGHth......tspsPHFp..sts.ps...............................hpphphs.GsppHa.a...............
//
