#=GF ID Tox-HNH-HHH
#=GF AC PF15637.10
#=GF DE HNH/Endo VII superfamily nuclease toxin with a HHH motif
#=GF AU Zhang D;0000-0001-8535-7620
#=GF AU de Souza RF;0000-0002-5284-4630
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE [1]
#=GF GA 26.10 26.10;
#=GF TC 26.10 26.20;
#=GF NC 25.80 24.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 22731697
#=GF RT Polymorphic toxin systems: comprehensive characterization of
#=GF RT trafficking modes, processing, mechanisms of action, immunity
#=GF RT and ecology using comparative genomics.
#=GF RA Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL Biol Direct. 2012;7:18.
#=GF DR INTERPRO; IPR028915;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A predicted toxin of the HNH/Endonuclease VII fold present in
#=GF CC bacterial polymorphic toxin systems with characteristic
#=GF CC conserved s[GD]xxR and HHH motifs. In bacterial polymorphic
#=GF CC toxin systems, the toxin is exported by the type 2, type 5, type
#=GF CC 6, type 7 or Photorhabdus virulence cassette (PVC)-type
#=GF CC secretion system [1].
#=GF SQ 29
#=GS I8J343_9BACI/546-650 AC I8J343.1
#=GS A0A1T4PPQ7_9BACT/2616-2713 AC A0A1T4PPQ7.1
#=GS A0A222FAL7_9HYPH/2689-2791 AC A0A222FAL7.1
#=GS A0A4Y8A7P3_9SPHI/66-165 AC A0A4Y8A7P3.1
#=GS A0A1S8TNU6_9CLOT/513-615 AC A0A1S8TNU6.1
#=GS L1P5K4_9FLAO/5-66 AC L1P5K4.1
#=GS A0A1G9EWG2_9ACTN/624-715 AC A0A1G9EWG2.1
#=GS A0A0V8JI47_9BACI/1-103 AC A0A0V8JI47.1
#=GS A0A5B8UUF5_9SPHI/2727-2832 AC A0A5B8UUF5.1
#=GS Q82QU7_STRAW/252-355 AC Q82QU7.1
#=GS A0A369PR76_9SPHI/457-560 AC A0A369PR76.1
#=GS A0A7W7YG98_9BACT/129-230 AC A0A7W7YG98.1
#=GS D3IMT1_9BACT/162-263 AC D3IMT1.1
#=GS A0A7L9RTY6_9PROT/1552-1656 AC A0A7L9RTY6.1
#=GS D7VR58_SPHSI/1-48 AC D7VR58.1
#=GS A0A368KMR0_9BACT/98-196 AC A0A368KMR0.1
#=GS A0A3M6QXU4_9BURK/1-103 AC A0A3M6QXU4.1
#=GS A0A368L1I9_9BURK/305-407 AC A0A368L1I9.1
#=GS A0A7G8W6M9_9BURK/31-134 AC A0A7G8W6M9.1
#=GS A0A6S6R835_9FIRM/1-39 AC A0A6S6R835.1
#=GS H3SNR9_9BACL/51-153 AC H3SNR9.1
#=GS A0A0S7BTQ1_9CHLR/32-134 AC A0A0S7BTQ1.1
#=GS A0A4Q7J212_9PSEU/176-281 AC A0A4Q7J212.1
#=GS A0A7W2AQ89_9BACL/49-153 AC A0A7W2AQ89.1
#=GS A0A7L9RSE0_9PROT/562-665 AC A0A7L9RSE0.1
#=GS A0A2A8SHW7_9BACI/71-134 AC A0A2A8SHW7.1
#=GS A0A0V8JGY4_9BACI/493-558 AC A0A0V8JGY4.1
#=GS A0A5C5ZPV0_9BACT/6766-6871 AC A0A5C5ZPV0.1
#=GS A0A368KNI6_9BACT/12-85 AC A0A368KNI6.1
I8J343_9BACI/546-650 .....................PRLTVEMPYVGKGQKNTNAE.GWLRDKDFYWKEMLKK.....Y....PE..AFSKSNRQKIE.L....GF..SP..INNTKFRKHFPQYdlKELYNDTLIHHHIGGGGQAVAVPSKLHP.G.LGGI.HN.........
A0A1T4PPQ7_9BACT/2616-2713 .............inmtpapa--------------RGTNAA.GVPRNANWFFKQQLAA.....N....PE..MFSEANKIKIK.I....NR..NP..VVDAQWIKHNPAA..TKYLGERLIHHHIEGGELAAAIPEKLHRdA.FSEL.H-p........
A0A222FAL7_9HYPH/2689-2791 .....................PSFSVDTSAFTSGSATANGG.--IRNSRQFWTAWLSM.....P....NN..GLSLANQAAVA.S....KR..AP..IVDDDWLKVFPEH..KDFRGQQLVHHHMDYGKYAIPVPRGAHN.N.SPG-.--faywh....
A0A4Y8A7P3_9SPHI/66-165 .....idmtpapaesrtvkla--------------------.--PRNAKYFWEQLLKK.....R....PE..MFSEKNRTYIA.N....KN..FKdiNADDQWLKYNPTH..KAYKFGQLVHHHDEQGYIAYAIPAKVHQ.K.WTSIlH-e........
A0A1S8TNU6_9CLOT/513-615 .....................PKYIVEMPYVGKNKKNSNSQ.GWKRDSKFFFKELQSK.....H....PE..IFGKKNTSLIK.K....GS..IP..IVDEKFIEHFPQY..ADNLDEVIRHHHIGGGGQAMPIPDTLHP.G.YGGI.HN.........
L1P5K4_9FLAO/5-66 ...........elvslsyspa----------------KYKQ.EWDKARKSYWLEQLER.....N....PN..RFSPKNKERIE.K....GL..SP..QIEI---------..----------------------------.-.----.--eiehkatgk
A0A1G9EWG2_9ACTN/624-715 .................lrnk---------AGKTRPISTSM.GFLRSESRFWRKFEEL.....F....SE..DF-----KLIG.K....GR..--..RVTKELAAKYGWD..PKYVGDKLVHHHVENGQLVAAIPEGLHH.ElSGTI.H-a........
A0A0V8JI47_9BACI/1-103 .....................------MPFGGKGEKYTNAE.GWRRDLKYFWSELLDR.....H....PE..AFSPNNRAIIE.GrnpfTD..SP..VNDKVFREYFSQYdfKGVKGDKLIHHHIGGGGQAFPVPQKLHP.G.SGGI.HN.........
A0A5B8UUF5_9SPHI/2727-2832 ..........dniidmanapn-------------PSSYNSL.GWPRDASYFWKQYRNT.....Pi..gKL..ALSKANLTLIK.N....NK..SP..KVDEQWNKVMEKFgnDGELNETVHHHHSIKGRNAFPVPASKHI.G.E---.--deeiam...
Q82QU7_STRAW/252-355 .....................PAEGVDMPWVGRGKGISSSElGYLRDSKYFWPRFQQS.....Y....GS..AISLANAQLIA.S....GQ..AP..RVDATWIEHFPGH..AAYVNDTLEHHHVGQGSRAVPLPSRLHD.A.YTVF.H-p........
A0A369PR76_9SPHI/457-560 ......gtpvdmrpasakngf--------------TIKNS-.--PRNKDYFWKELASK.....R....PE..MFSRTNRSRLT.Q....TRpvAP..IIDEQWIKYNPTH..KSYMGGRLIHHHDEQGHLAFAIPEKVHQ.K.WSKIlH-d........
A0A7W7YG98_9BACT/129-230 ..............itgpaak----------KTKKSNTTSK.GVKRNNPKDWKDTMKLwdavgY....QD..LLSPANRVLIQ.N....EL..VP..IVDDAWIKVHPED..AGLKGEKISIHHVQGLPLNVPLPYSRHK.D.----.--ahk......
D3IMT1_9BACT/162-263 .....................PRYSIDTTTFESGKPTANGG.--LRDNKQFWQKWEKL.....N....PS..SISKNNRWRIE.H....GL..SP..TIDNVWIKEFPEH..GGYKGEILIHHHVDQGKYAVPVPASTHV.G.SGGVwHC.........
A0A7L9RTY6_9PROT/1552-1656 .................pvsi-----NCSNFETLSSTTFTKtGALRDKVQFWRHFREK.....YdtvfPE..IWSETNLIKLR.E....GK..AP..IVDEAWLKYFPEH..AKYAKDKLEHHHINHGNIAIPLPKTMHR.-.----.--tglfd....
D7VR58_SPHSI/1-48 ....................m--------------------.----------------.....-....--..-----------.-....--..--..--NDKWIQYNKTA..KAYKGEKLVHHHHSQGRFAYAIPNKVHL.K.WNRV.--lhv......
A0A368KMR0_9BACT/98-196 .............vgpapsas--------------SNTTRL.GVVRNNPRDWRNLRDVwdqtgV....GD..ILSTRNRQRIA.D....GL..VP..EVDDNWIRWFPGD..EALRGESIPMHHIQGTPLTVPLPASRH-.-.----.--ldahm....
A0A3M6QXU4_9BURK/1-103 ...................mk--YAIDMQSIGTGS-GVNAF.GFRRDSVAFFRGLLRI.....N....PE..LFSSSNQKLIN.N....RL..SP..VVDAQWVQHNPTH..QSYQGAKIVHHHWMQGPVAIPIPEPLHV.Q.W---.--nstlhp...
A0A368L1I9_9BURK/305-407 ..................pga---TIDMRKAP-ESSGTNAA.GFPRNGPWFWRQMAET.....N....PE..YFDAANLAKIR.A....GR..SP..VVNDTWIENFPQH..QGFSRDKLVHHHIDQGPIATPLPETIHQ.K.----.--wykalhp..
A0A7G8W6M9_9BURK/31-134 .....................PAYTIDTSRFTSGTSTSGAG.GGLRNSSQFWKAWTDQ.....I....PQ..SLSPGNAMRAA.D....GL..AP..KIDSTWVSTFPEH..MSFMGDALIHHHVDFGAYASPVPAATHT.S.SSGIwH-l........
A0A6S6R835_9FIRM/1-39 ....................m--------------------.----------------.....-....--..-----------.-....--..--..----------PEY..SKYDGDLLIHHHIGRGGQVAAYPETLHP.G.FGGI.HN.........
H3SNR9_9BACL/51-153 .....................PRLMVEMNYKGKGASGTNSA.GWERNSKKFFKELLKR.....N....PE..FWSEKNTSEIR.R....GR..AP..EVDEHFVKYFPQY..MDYLEDPLRHHHIGEGGQAAALPVTLHP.G.YGGV.HN.........
A0A0S7BTQ1_9CHLR/32-134 .....................DDLLVSMRYNGDYHSSSNSQ.GWDRNSSYYFENLLHN.....H....PE..YFSKKNMIRIN.N....NQ..SP..KVDSQFVKNFPQY..KGYENELLVHHHIGKDGQAVAIPASIHK.G.SGEI.HR.........
A0A4Q7J212_9PSEU/176-281 .....................PKEGISMPWVGKGEGIDSSDlGFLRDSERYWADWVKK.....W....GKngALSQANLAAIA.G....GR..SP..VVDAQWVQVYPQH..KAYLGQVLEHHHVGQGAFAVPLPHDLHK.A.HSVF.H-p........
A0A7W2AQ89_9BACL/49-153 .....................PRLVIEMPYVGKGKANTNSE.GWLRDKNYYWNEMLKK.....H....PE..VFSKANRQKIE.L....GF..SP..INDKKFREHFPQYdiKELYNDTLIHHHIGGGGQAVAVPAKLHP.G.LGGI.HN.........
A0A7L9RSE0_9PROT/562-665 ..lsidcsafkvtpstpltkl--------------------.GVPRDSVQFWKHFREK.....YdtvfPE..IWSETNLGRFR.D....GI..SP..KVDSEWLKYFPEH..GKYLNEILEHHHINHGNIAIPLPDTMHK.G.K---.--lfn......
A0A2A8SHW7_9BACI/71-134 .....................PRLIVEIPYVGKGQKNTNAE.DCLSDKDLYWKEMLEK.....H....PE..AFNKSNKQKME.L....GF..SP..INNPTFRKY----..----------------------------.-.----.--.........
A0A0V8JGY4_9BACI/493-558 ....................k-NLIVEMPFVGKGKSSTNSE.GWLRDHKYYFKELYKQ.....H....PE..YFSKANIENLE.N....GW..AI..KNDAVFRRY----..----------------------------.-.----.--li.......
A0A5C5ZPV0_9BACT/6766-6871 .....................PRHIIDMEPARALAGSTENAfGEVRNANWFWRQLLDK.....Y....PE..MFSAGNRYKIEvL....EL..SP..KVDPKWIEHNPSH..MSFKQDVLHHHHIDHGRTAVPLPVTVHQ.Q.WTSVlH-s........
A0A368KNI6_9BACT/12-85 krvltpfrppnrylienydkl--------------------.----------------.....-....--..-----------.-....KV..SP..RIDDEWIKVFPEH..APFKGDVIIHHHVDFGRYAIPVPRKTHV.G.SSGIwH-t........
#=GC seq_cons ...............................tt.ttsssut.Gh.RspphaWcphhcp.....h....P-..haStsNtttIp.p....sh..uP..hlDspWlchaPpa..tsahs-hLhHHHlstGthAhslPtphH..t..s.h............
//
