#=GF ID Tox-MPTase2
#=GF AC PF15638.10
#=GF DE Metallopeptidase toxin 2
#=GF AU Zhang D;0000-0001-8535-7620
#=GF AU de Souza RF;0000-0002-5284-4630
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE [1]
#=GF GA 25.00 25.00;
#=GF TC 31.30 30.50;
#=GF NC 21.30 20.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 22731697
#=GF RT Polymorphic toxin systems: comprehensive characterization of
#=GF RT trafficking modes, processing, mechanisms of action, immunity
#=GF RT and ecology using comparative genomics.
#=GF RA Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL Biol Direct. 2012;7:18.
#=GF DR INTERPRO; IPR028914;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A zincin-like metallopeptidase domain found in bacterial
#=GF CC polymorphic toxin systems [1].
#=GF SQ 17
#=GS A0A133PV80_9BACT/111-300 AC A0A133PV80.1
#=GS A0A3Q9FQM5_9BACT/9-100 AC A0A3Q9FQM5.1
#=GS A0A374BNB7_9BACT/42-241 AC A0A374BNB7.1
#=GS C9ML59_9BACT/2860-3059 AC C9ML59.1
#=GS A0A133Y166_9BACT/138-335 AC A0A133Y166.1
#=GS F0F943_9BACT/392-593 AC F0F943.1
#=GS A0A2S1LEV4_9FLAO/215-371 AC A0A2S1LEV4.1
#=GS A0A256A8J6_9FLAO/15-195 AC A0A256A8J6.1
#=GS A0A0X7BCU2_9FLAO/946-1137 AC A0A0X7BCU2.1
#=GS A0A133QBV9_9BACT/57-254 AC A0A133QBV9.1
#=GS D9RWK6_PREMB/2773-2972 AC D9RWK6.1
#=GS A0A374BP50_9BACT/4-122 AC A0A374BP50.1
#=GS A0A133Q668_9BACT/368-567 AC A0A133Q668.1
#=GS H6L751_SAPGL/54-181 AC H6L751.1
#=GS F0FB94_9BACT/10-215 AC F0FB94.1
#=GS A0A4R7EQT3_9FLAO/25-210 AC A0A4R7EQT3.1
#=GS H1Q2G1_9BACT/141-288 AC H1Q2G1.1
A0A133PV80_9BACT/111-300 ......................................DYFSISGKFIRSD.KSKDKNIYIRTSSGN..VLLSKYNFK.......--RNLRAMMRITYHYAKEVGLE...................GKAKSIGVKSM-......KSNPEGELAITT.YDNRIRVSTVNGHFKKSMDQIYNFRSTLAHEGFHI--DTPNGVD..............EEVL---VIMK.....EMSRKEFGKTTRSFKDNTAGYLQKELEKLYAVSGRnfYKVIGKAQKMLNKYGAKSSYEFI..........................................
A0A3Q9FQM5_9BACT/9-100 ...............................ggiifnd-------------.---------------..---------.......----------------------...................------------......------------.---KIEVNTKGGGMNKLLNTASNIKNTLVHEYNHQ-KDTREVYDp............yTHQMVPNVSEKraivtQKKHSSWNGTTSEYKMNVNKY--------------..-----------------------sevhek....................................
A0A374BNB7_9BACT/42-241 ......................................DFFNFGGILVKNS.-GQTNNIYVMVSGKP..ILITRLDLG.......NKANRQTVANIIGHYAAQIGISyyak...........ggnpIGNNPIGTVGL-......SVNNNSKVLAFN.QGNNIFVNKYKNKISSLLSNTYNLVNTLVHENTHKKGKYGFKNI..............TNFEHAKVYSA.....QLEHASFSKTTSDFKEAVLNPMASYLKDAIIEDGV..N--DKRVFTLIEKANK-------aikgsgf...................................
C9ML59_9BACT/2860-3059 ......................................DYFNSKGKFIRRT.ETKTNNIYISINGKN..ILPSQLDLK.......IKRNRQVMANIVGHYATAVGISywgk...........gkmaVGRNPQGMVGIA......DTKDETELAAT-.RGANITISVYKGHVSRFMNDYENLQSSLYHESIHKFFSLRGDYSdn.........tslGHVLK--VHIK.....QFENEHFKSATQDFQHAIIDKAADYLTAALRDSNT..RGQVPEAIKKL------------iqlyei....................................
A0A133Y166_9BACT/138-335 ......................................DYFSTSGKFIRSDgNDKDPYIYIQTRKGN..VILSDYNFGn.....yKSGGLRKMMRIVYHYAKKTGAT...................QHATAIGVDAST......PKGTDANTLAYTlNDKIIRVLVKKGYFNKKLSQIYNMSSTLSHENFHT--QIRGKSR..............EEEIQ--VIMR.....QMQAPEFKKTTASFKEGTAGYLQKELQKLYKENNRifNKYIEKASELLKANGVNSVPIY-l.........................................
F0F943_9BACT/392-593 ......................................FHVNGNGNIIKVV.NNNSVNITIVSPDGS.kKYFSDYETKsiflgwgNGKNRQIIANVAAYYAKAIGIK...................---ATVGTIGDI......RKDEPAYYDPKD.NGIWI-PAGENGTPDILLKNKYNLMNTLFHEDMHFQDNHRGMGD..............SHFLHASVVSR.....ASSHWTFARTTQAYKGGQAIYFSQLAMNAYYNPPKdaNYTKQDVLKLISNFNKTNKGNI-r.........................................
A0A2S1LEV4_9FLAO/215-371 yaaslarelndknnffyigsrkatdpssenqastlssv-------------.---------------..---------.......----------------------...................------------......------KFSDGT.KGSVI-TLNSNGGYSKDLDNVNNFKSILKHEIFHVDDNILKTPD..............NLSTHIDVYIN.....AMKHITFKDATRDYQIGTIRSLVRYILNMDKRTDTqrDYPVYEIKQKIDNFNNI------agldf.....................................
A0A256A8J6_9FLAO/15-195 ..............................gdtrvgnm-------------.------VKIQMDGKL..YSPSQLDNS.......VG-SNKAIANIAKYYAKAVGAE...................-NGTIVGTGAT-......DEKSSENPAFTC.NFDNVARINNNGGFSPALDDIDNFKSTMKHEILHQKNNINGVKS..............NFENHAEVYLK.....QMADPSFQNTTKNYKEQIIGSFGNYLLNMNREGYG..QN---AIDSKIETFNS-------lnlgyqiss.................................
A0A0X7BCU2_9FLAO/946-1137 ......................................DHFDSSGNFLYKD.FKKTNNIVIHSGVPNfsQMNDEVQLKdf...tfNKSNYSTLSKIANHYTEEAGVDlgnvhngsisvsdaivtgnKGGQPEGYIENHndgvyrPTDIYGSSTIMNqSGSTITVNLNNGKVDPLLNDANSFTATLDHEGGSI---------..............-----------.....-----------------------------------..-----------------------ghlvnpekkhtdiykdeikkysknatpefkkhlsdnleyykk
A0A133QBV9_9BACT/57-254 ......................................DYFSTSGKFIRSDgNDKDPYIYIQTRKGN..VILSDYNFGn.....yKSGGLRKMMRIVYHYAKKTGAT...................QHATAIGVDAST......PKGTDANTLAYTlNDKIIRVLVKKGYFNKKLSQIYNMSSTLSHENFHT--QIRGKSR..............EEEIQ--VIMR.....QMQAPEFKKTTASFKEGTAGYLQKELQKLYKENNRifNKYIEKASELLKANGVNSVPTY-l.........................................
D9RWK6_PREMB/2773-2972 ......................................VHINGDGRIVKVI.NDHSVYITIVDPKGN.rHSLSSYNISpyfwgigRGDNLQIVANIAGYYAKQAGVH...................---GLVGAKGNE......KLGILAHYDPSD.KGIWLQPSNSNGTVDSWLDNKYDLMNILQHEYFHKLDDQRNAYK..............NHLLHASVDER.....ASRTRTFAHTSDKLKLSVAIEFSELVMNAYYQPN-..NNTKADVMNLIDKFNRNNTGNIF..........................................
A0A374BP50_9BACT/4-122 ....................................rs-------------.---------------..---------.......----------------------...................------------......-------YDYSD.KGIWLQPSNSDGTVDRWLDNKYNLMNTLQHEYFHKLDDQRNTYK..............NHLLHASVDER.....ASRTRTFAHTSDKWKLNVAAEFSEYVMNAYYQPN-..ENTKADVMNLIDKFNRNNTGNIF..........................................
A0A133Q668_9BACT/368-567 ......................................VHINGDGRIVKVI.NDHSAYITIVDPKGN.rHSLSSYNISpyflgigRGDYRQIVANIAGYYAKQAGVH...................---GLVGAKGNE......ILGIFANYDYSD.KGIWLQPSNSDGTVDRWLDNKYNLMNTLQHEYFHKLDDQRNAYK..............NHLLHASVDER.....ASRTRTFAHTSGKWKLNVAAEFSEYVMNAYYQPN-..ENTKADVMNLIDKFNRNNTGNIF..........................................
H6L751_SAPGL/54-181 .....................fgvnnkkgvfsinmgvq-------------.---------------..---------.......----------------------...................------------......------------.----------SGGEMMHSDNIYNLILTLWHEEQHN----QGRGG..............DHYTHFDIEME.....AREHKYFSQTSDKFKKANLVLLRKYVTK-------..-----------------------qptsiiieafkrsvnlstlmeykstfdyysklykknvekfns
F0FB94_9BACT/10-215 ......................................DYFSNKGKFIRRT.ETKTNNIYISINGKN..ILPSQLDLK.......IKRNRQVMANIVGHYATAVGISywgk...........gkmaVGRNPQGMVGIA......DTKNEAELAAT-.RGANITISVYKGHISRFMNNYENLQSSLYHESIHKFFSLRGDYSdn.........tslGHVMK--VHIK.....QFENEHFKSATQEFQQAIIGQAAIYLTAALRDSKT..RGQVPGAIKKINTAIRNTPYELV..........................................
A0A4R7EQT3_9FLAO/25-210 .................................rngka----------RLI.NTDDDEIQILSQNKI..HLLSDFNFS.......--NDLDAAKTIVDYYSSEYQLSiynggtfs..ldpqnfiskQAMYNAGLTENT......LMSVTLTYNSSS.VDINSKFYLLRGRFHQVLDNKYNFINSIGHEYKHYLDNLGFKSKfnngfrgmqsisgsRAELR--AINY.....QQKLPSWDSTTSNYRRSVELYKS------------..-----------------------kql.......................................
H1Q2G1_9BACT/141-288 ...........ktgyiqnvgihylaksdksqfnltvsn-------------.---------------..---------.......----------------------...................-------TGGNI......PQDAVFSNDAGT.SNYDI--YLTNGYVNHSLGNCYDFECVTFHESTHRYDKSTHGGT.............iGEVNA--IIRT.....AIECPAWNYASDNYIQSQASYAAKSLNQYSYNNI-..--IPQDIFQKLN-----------taftgyat..................................
#=GC seq_cons ................................................h....tps..IhI...tt...h..ophpht.........tshphhhpIs.aYupthGhp......................t..Ghhu..........t..tphshts.ps..Ips.spsGthsphLsshYNhhsTLhHE.hHp..shpsthp..............sc.h+..Vh.+.....thcp.pFppTTppaKtushs.hsp.l.ph.hps....p....ch.phlpt....................................................
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